References
- International Diabetes FederationIDF Diabetes Atlas5th ed2011 Available from: http://www.idf.org/diabetesatlas
- BourneRRStevensGAWhiteRAVision Loss Expert GroupCauses of vision loss worldwide, 1990–2010: a systematic analysisLancet Glob Health201316e339e34925104599
- AhmadiehHShoeibiNEntezariMMonshizadehRIntravitreal bevacizumab for prevention of early postvitrectomy hemorrhage in diabetic patients: a randomized clinical trialOphthalmology2009116101943194819699531
- ChenELoomanMLaouriMBurden of illness of diabetic macular edema: literature reviewCurr Med Res Opin20102671587159720429823
- NguyenQDBrownDMMarcusDMRISE and RIDE Research GroupRanibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDEOphthalmology2012119478980122330964
- AbouammohMARanibizumab injection for diabetic macular edema: meta-analysis of systemic safety and systematic reviewCan J Ophthalmol201348431732323931473
- BandelloFCasalinoGLoewensteinAGoldsteinMPelayesDBattaglia ParodiMPharmacological approach to diabetic macular edemaOphthalmic Res2014512889524356667
- BoyerDSHopkinsJJSorofJEhrlichJSAnti-vascular endothelial growth factor therapy for diabetic macular edemaTher Adv Endocrinol Metab20134615116924324855
- PatelliFRadicePGiacomottiEDiabetic macular edemaDev Ophthalmol20145416417325196766
- YangJWangXFuhGComparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor AMol Pharm201411103421343025162961
- StewartMWRosenfeldPJPredicted biological activity of intravitreal VEGF TrapBr J Ophthalmol200892566766818356264
- RajendramRFraser-BellSKainesAA 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3Arch Ophthalmol2012130897297922491395
- DoDVSchmidt-ErfurthUGonzalezVHThe DA VINCI Study: phase 2 primary results of VEGF Trap-Eye in patients with diabetic macular edemaOphthalmology201111891819182621546089
- MartinDFMaguireMGYingGSGrunwaldJEFineSLJaffeGJRanibizumab and bevacizumab for neovascular age-related macular degenerationN Engl J Med2011364201897190821526923
- KorobelnikJFDoDVSchmidt-ErfurthUIntravitreal aflibercept for diabetic macular edemaOphthalmology2014
- NguyenQDShahSMKhwajaAAREAD-2 Study GroupTwo-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) studyOphthalmology2010117112146215120855114
- MassinPBandelloFGarwegJGSafety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II studyDiabetes Care201033112399240520980427
- MitchellPBandelloFSchmidt-ErfurthURESTORE Study GroupThe RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edemaOphthalmology2011118461562521459215
- CampochiaroPABrownDMPearsonAFAME Study GroupSustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edemaOphthalmology2012119102125213222727177
- BoyerDSYoonYHBelfortRJrOzurdex MEAD Study GroupThree-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edemaOphthalmology2014121101904191424907062
- LoboCLBernardesRCFigueiraJPde AbreuJRCunha-VazJGThree-year follow-up study of blood-retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative diabetic retinopathyArch Ophthalmol2004122221121714769598
- NunesSRibeiroLLoboCCunha-VazJThree different phenotypes of mild nonproliferative diabetic retinopathy with different risks for development of clinically significant macular edemaInvest Ophthalmol Vis Sci20135474595460423745006
- Cunha-VazJRibeiroLLoboCPhenotypes and biomarkers of diabetic retinopathyProg Retin Eye Res2014419011124680929
- JešićMSajićSJešićMMicroalbuminuria in relation to metabolic control and blood pressure in adolescents with type 1 diabetesArchives of medical science2011761037104122328888
- ArarNHFreedmanBIAdlerSGFamily Investigation of Nephsropathy and Diabetes Research GroupHeritability of the severity of diabetic retinopathy: the FIND-Eye studyInvest Ophthalmol Vis Sci20084993839384518765632
- ChenJLLuvianoDMChenJCYuFSarrafDComparison of diabetic retinopathy phenotype between Latinos and BlacksJ Diabetes Complications200923637137518599323
- YohannanJBittencourtMSepahYJAssociation of retinal sensitivity to integrity of photoreceptor inner/outer segment junction in patients with diabetic macular edemaOphthalmology201312061254126123499060
- Cunha-VazJPhenotypes and biomarkers of diabetic retinopathy. Personalized medicine for diabetic retinopathy: the Weisenfeld awardInvest Ophthalmol Vis Sci20145585412541925169433
- BaiYMaJXGuoJMuller cell-derived VEGF is a significant contributor to retinal neovascularizationJ Pathol2009219444645419768732
- HietalaKForsblomCSummanenPGroopPHHeritability of proliferative diabetic retinopathyDiabetes20085782176218018443200
- Clustering of long-term complications in families with diabetes in the diabetes control and complications trialThe Diabetes Control and Complications Trial Research GroupDiabetes19974611182918399356033
- Simo-ServatOHernandezCSimoRGenetics in diabetic retinopathy: current concepts and new insightsCurr Genomics201314528929924403848
- GrassiMATikhomirovARamalingamSReplication analysis for severe diabetic retinopathyInvest Ophthalmol Vis Sci20125342377238122427569
- HuangYCLinJMLinHJGenome-wide association study of diabetic retinopathy in a Taiwanese populationOphthalmology2011118464264821310492
- FuYPHallmanDMGonzalezVHIdentification of diabetic retinopathy genes through a genome-wide association study among Mexican-Americans from Starr County, TexasJ Ophthalmol20102010ii:861291
- ImperatoreGHansonRLPettittDJKobesSBennettPHKnowlerWCSib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes GroupDiabetes19984758218309588456
- LookerHCNelsonRGChewEGenome-wide linkage analyses to identify Loci for diabetic retinopathyDiabetes20075641160116617395753
- RandLIKrolewskiASAielloLMWarramJHBakerRSMakiTMultiple factors in the prediction of risk of proliferative diabetic retinopathyN Engl J Med198531323143314383864010
- CruickshanksKJVadheimCMMossSEGenetic marker associations with proliferative retinopathy in persons diagnosed with diabetes before 30 yr of ageDiabetes19924178798851612203
- AbharySHewittAWBurdonKPCraigJEA systematic meta-analysis of genetic association studies for diabetic retinopathyDiabetes20095892137214719587357
- ChiuCMossCFThe role of the external ear in vertical sound localization in the free flying bat, Eptesicus fuscusJ Acoust Soc Am200712142227223517471736
- HudsonBISticklandMHFutersTSGrantPJEffects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathyDiabetes20015061505151111375354
- TongZYangZPatelSGenetics of Diabetes and Diabetic Complication Study GroupPromoter polymorphism of the erythropoi-etin gene in severe diabetic eye and kidney complicationsProc Natl Acad Sci U S A2008105196998700318458324
- ChoSEHongKSShinGJChungWSThe methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in KoreaClinical Chemistry and Laboratory Medicine20064491070107516958597
- NakaiKItohCNakaiKHabanoWGurwitzDCorrelation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CADAm J Cardiovasc Drugs20011535336114728017
- MalaguarneraGGaglianoCGiordanoMHomocysteine serum levels in diabetic patients with non proliferative, proliferative and without retinopathyBiomed Res Int2014201419149724877066
- AydemirOTürkçüoğluPGülerMPlasma and vitreous homocysteine concentrations in patients with proliferative diabetic retinopathyRetina200828574174318463519
- GoldsteinMLeibovitchIYeffimovIGavendoSSelaBALoewensteinAHyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathyEye200418546046515131674
- LiangSPanMHuNAssociation of angiotensin-converting enzyme gene 2350 G/A polymorphism with diabetic retinopathy in Chinese Han populationMol Biol Rep201340146346823065222
- ManeaSARobciucAGujaCHeltianuCIdentification of gene variants in NOS3, ET-1 and RAS that confer risk and protection against microangiopathy in type 2 diabetic obese subjectsBiochem Biophys Res Commun2011407348649021406182
- dos SantosKGCananiLHGrossJLTschiedelBSoutoKERoisenbergIThe -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetesMol Genet Metab200688328028416545977
- WangJYangMMLiYBLiuGDTengYLiuXMAssociation of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patientsMediators Inflamm2013201374843523864767
- ChenMLinWRLuCHChimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patientsJ Diabetes Complications201428446046324854763
- ArndtCLeclercqINazeyrollasPAssociation of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patientsDiabetes and Metabolism2014
- TavernaMJSolaAGuyot-ArgentonCeNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathyDiabet Med200219324024511918626
- AbharySBurdonKPCassonRJGogginMPetrovskyNPCraigJEAssociation between erythropoietin gene polymorphisms and diabetic retinopathyArch Ophthalmol2010128110210620065225
- GongJYDengDTSunYHAssociation of platelet glycoprotein receptor alpha2beta1 integrin and glycoprotein IIIa gene polymorphisms with diabetic retinopathy: evidence from 3007 subjectsCurr Eye Res2014301824979111
- KatakamiNMatsuhisaMKanetoHMonocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetesDiabetes Res Clin Pract2010891e9e1220488574
- YigitSKarakusNInanirAAssociation of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathyMol Vis2013191626163023901246
- Mankoc RamusSKumseTGlobocnik PetrovicMPetrovicDCilensekISNP rs2073618 of the osteoprotegerin gene is associated with diabetic retinopathy in Slovenian patients with type 2 diabetesBiomed Res Int2013201336407324228244
- NgZXKuppusamyURIqbalTChuaKHReceptor for advanced glycation end-product (RAGE) gene polymorphism 2245G/A is associated with pro-inflammatory, oxidative-glycation markers and sRAGE in diabetic retinopathyGene2013521222723323545311
- ZhangHMChenLLWangLAssociation of 1704G/T and G82S polymorphisms in the receptor for advanced glycation end products gene with diabetic retinopathy in Chinese populationJ Endocrinol Invest200932325826219542745
- SobrinLGreenTSimXFamily Investigation of Nephropathy and Diabetes-Eye Research Group, Wellcome Trust Case Control Consortium 2Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)Invest Ophthalmol Vis Sci201152107593760221873659
- LuoJZhaoLChenAYTCF7L2 variation and proliferative diabetic retinopathyDiabetes20136272613261723434931
- BrondaniLAde SouzaBMDuarteGCThe UCP1 -3826A/G polymorphism is associated with diabetic retinopathy and increased UCP1 and MnSOD2 gene expression in human retinaInvest Ophthalmol Vis Sci201253127449745723033381
- CrispimDFagundesNJdos SantosKGPolymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitusClin Endocrinol2010725612619
- HanLZhangLXingWThe associations between VEGF gene polymorphisms and diabetic retinopathy susceptibility: a meta-analysis of 11 case-control studiesJ Diabetes Res2014201480580124868559
- IshidaSUsuiTYamashiroKVEGF164 is proinflammatory in the diabetic retinaInvest Ophthalmol Vis Sci20034452155216212714656
- FunatsuHYamashitaHSakataKVitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edemaOphthalmology2005112580681615878060
- PetrovicMGKorosecPKosnikMLocal and genetic determinants of vascular endothelial growth factor expression in advanced proliferative diabetic retinopathyMol Vis2008141382138718682813
- VincentiVCassanoCRocchiMPersicoGAssignment of the vascular endothelial growth factor gene to human chromosome 6p21.3Circulation1996938149314958608615
- BroganIJKhanNIsaacKHutchinsonJAPravicaVHutchinsonIVNovel polymorphisms in the promoter and 5’ UTR regions of the human vascular endothelial growth factor geneHum Immunol199960121245124910626738
- StevensASodenJBrenchleyPERalphSRayDWHaplotype analysis of the polymorphic human vascular endothelial growth factor gene promoterCancer Res200363481281612591731
- WatsonCJWebbNJBottomleyMJBrenchleyPEIdentification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein productionCytokine20001281232123510930302
- AwataTKuriharaSTakataNFunctional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetesBiochem Biophys Res Commun2005333367968515963467
- El-ShazlySFEl-BradeyMHTameeshMKVascular endothelial growth factor gene polymorphism prevalence in patients with diabetic macular oedema and its correlation with anti-vascular endothelial growth factor treatment outcomesClin Experiment Ophthalmol201442436937823927080
- HuezIBornesSBressonDCreancierLPratsHNew vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiationMol Endocrinol200115122197221011731620
- FeghhiMNikzamirAEsteghamatiAMahmoudiTYekaninejadMSRelationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetesTransl Res20111582859121757152
- BledaSDe HaroJVarelaCEsparzaLFerrueloAAcinFVascular endothelial growth factor polymorphisms are involved in the late vascular complications in Type II diabetic patientsDiab Vasc Dis Res201291687422064697
- WangHChengJWZhuLSMeta-analysis of association between the -2578C/A polymorphism of the vascular endothelial growth factor and retinopathy in type 2 diabetes in Asians and CaucasiansOphthalmic Res20145211824751925
- GongJYSunYHAssociation of VEGF gene polymorphisms with diabetic retinopathy: a meta-analysisPLoS One2013812e8406924376787
- CarterJGCherryJWilliamsKTurnerSBatesDOChurchillAJSplicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye diseaseCurr Eye Res201136432833521309690
- VelosoCEde AlmeidaLNRecchiaFMPelayesDNehemyMBVEGF gene polymorphism and response to intravitreal ranibizumab in neovascular age-related macular degenerationOphthalmic Res20145111824157918
- LoteryAJGibsonJCreeAJAlternative Treatments to Inhibit VEGF in Patients with Age-Related Choroidal Neovascularisation (IVAN) Study GroupPharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-related macular degeneration in the IVAN StudyOphthalmology2013120122637264324070809
- AbediFWickremasingheSRichardsonAJVariants in the VEGFA gene and treatment outcome after anti-VEGF treatment for neovascular age-related macular degenerationOphthalmology2013120111512123149126
- HagstromSAYingGSPauerGJComparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research GroupVEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: comparison of age-related macular degeneration treatments trials (CATT)JAMA Ophthalmol2014132552152724652518
- DabirSSDasDNallathambiJMangaleshSYadavNKSchoutenJSDifferential systemic gene expression profile in patients with diabetic macular edema: responders versus nonresponders to standard treatmentIndian J Ophthalmol2014621667324492504
- El-BabMFZakiNSMojaddidiMAAl-BarryMEl-BeshbishyHADiabetic retinopathy is associated with oxidative stress and mitigation of gene expression of antioxidant enzymesInt J Gen Med2013679980624092995
- MastropasquaRTotoLCipolloneFSantovitoDCarpinetoPMastropasquaLRole of microRNAs in the modulation of diabetic retinopathyProg Retin Eye Res201443C9210725128741
- KatoMCastroNENatarajanRMicroRNAs: potential mediators and biomarkers of diabetic complicationsFree Radic Biol Med201364859423770198
- JainRKDudaDGWillettCGBiomarkers of response and resistance to antiangiogenic therapyNat Rev Clin Oncol20096632733819483739
- SnydermanRWilliamsRSProspective medicine: the next health care transformationAcad Med200378111079108414604864
- ChawlaNVDavisDABringing big data to personalized healthcare: a patient-centered frameworkJ Gen Intern Med201328Suppl 3S660S66523797912
- ChenJJLinWJChenHCPharmacogenomic biomarkers for personalized medicinePharmacogenomics201314896998023746190
- InzucchiSEBergenstalRMBuseJBManagement of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)Diabetes Care20123561364137922517736
- NiuWQiYWuZLiuYZhuDJinWA meta-analysis of receptor for advanced glycation end products gene: four well-evaluated polymorphisms with diabetes mellitusMol Cell Endocrinol2012358191722402134
- NiuWQiYAn updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathyDiabetes Res Clin Pract201295111011822056717
- MaedaMYamamotoIFukudaMMTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patientsJ Diabetes Complications200822211912518280442
- MaedaMYamamotoIFukudaMMTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevationDiabetes Care200326254754812547903
- GlauberHSRisheNKarnieliEIntroduction to personalized medicine in diabetes mellitusRambam Maimonides Med J201451e000224498509
- Aerpio TherapeuticsThe TIME-2 Study: A Phase 2 Study of AKB-9778, A Novel Tie-2 Activator, in Patients with Diabetic Macular Edema2014 Available from: https://clinicaltrials.gov/ct2/show/NCT02050828
- River Vision Development CorporationA Phase 1, Open-Label Study of Teprotumumab in Patients with Diabetic Macular Edema (DME)2014
- Guzman-AranguezALomaPPintorJSmall-interfering RNAs (siRNAs) as a promising tool for ocular therapyBr J Pharmacol2013170473074723937539
- VaccaODarcheMSchafferDVAAV-mediated gene delivery in Dp71-null mouse model with compromised barriersGlia201462346847624382652
- AdhiMCashmanSMKumar-SinghRAdeno-associated virus mediated delivery of a non-membrane targeted human soluble CD59 attenuates some aspects of diabetic retinopathy in micePLoS One2013810e7966124167638