Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties

References

• National Newborn Screening and Genetics Resource CenterNational newborn screening status report2013 Available from: http://genes-r-us.uthscsa.edu/sites/genes-r-us/files/nbsdisorders.pdfAccessed March 5, 2014
   Google Scholar
• AwadaAVandoneAMAftimosPPersonalized management of patients with solid cancers: moving from patient characteristics to tumor biologyCurr Opin Oncol201224329730422410457
   PubMed Web of Science ®Google Scholar
• Johansen TaberKADickinsonBDWilsonMThe promise and challenges of next-generation genome sequencing for clinical careJAMA Intern Med2014174227528024217348
   PubMed Web of Science ®Google Scholar
• KlitzmanRChungWMarderKAttitudes and practices among internists concerning genetic testingJ Genet Couns20132219010022585186
   PubMed Web of Science ®Google Scholar
• HarveyEKFogelCEPeyrotMChristensenKDTerrySFMcInerneyJDProviders’ knowledge of genetics: a survey of 5915 individuals and families with genetic conditionsGenet Med20079525926717505202
   PubMed Web of Science ®Google Scholar
• BaarsMJHennemanLTen KateLPDeficiency of knowledge of genetics and genetic tests among general practitioners, gynecologists, and pediatricians: a global problemGenet Med20057960561016301861
   PubMed Web of Science ®Google Scholar
• KorfBRFeldmanGWiesnerGLReport of Banbury Summit meeting on training of physicians in medical genetics, October 20–22, 2004Genet Med20057643343816024976
   PubMedGoogle Scholar
• SutherSGoodsonPBarriers to the provision of genetic services by primary care physicians: a systematic review of the literatureGenet Med200352707612644775
   PubMed Web of Science ®Google Scholar
• McInerneyJDEdelmanENissenTReedKScottJAPreparing health professionals for individualized medicinePer Med201295529537
   PubMed Web of Science ®Google Scholar
• FeeroWGGreenEDGenomics education for health care professionals in the 21st centuryJAMA2011306998999021900139
   PubMed Web of Science ®Google Scholar
• SalariKThe dawning era of personalized medicine exposes a gap in medical educationPLoS Med200968e100013819707267
   PubMed Web of Science ®Google Scholar
• ScheunerMTSieverdingPShekellePGDelivery of genomic medicine for common chronic adult diseases: a systematic reviewJAMA2008299111320133418349093
   PubMed Web of Science ®Google Scholar
• GuttmacherAEPorteousMEMcInerneyJDEducating health-care professionals about genetics and genomicsNat Rev Genet20078215115717230201
   PubMed Web of Science ®Google Scholar
• Secretary’s Advisory Committee on Genetics, Health, and SocietyGenetics Education and TrainingBethesda (MD)Department of Health and Human Services2011 Available from: http://osp.od.nih.gov/sites/default/files/SACGHS_education_report_2011.pdfAccessed March 5, 2014
   Google Scholar
• HamiltonABOishiSYanoEMGammageCEMarshallNJScheunerMTFactors influencing organizational adoption and implementation of clinical genetic servicesGenet Med201416323824523949572
   PubMed Web of Science ®Google Scholar
• TachéSVSönnichsenAAshcroftDMPrevalence of adverse drug events in ambulatory care: a systematic reviewAnn Pharmacother2011457–897798921693697
   PubMed Web of Science ®Google Scholar
• LazarouJPomeranzBCoreyPNIncidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studiesJAMA199827915120012059555760
   PubMed Web of Science ®Google Scholar
• EvansWEMcLeodHLPharmacogenomics: drug disposition, drug targets and side effectsN Engl J Med2003348653854912571262
   PubMed Web of Science ®Google Scholar
• GriceGRSeatonTLWoodlandAMMcLeodHLDefining the opportunity for pharmacogenetic intervention in primary carePharmacogenomics200671616516354125
   PubMed Web of Science ®Google Scholar
• US Food and Drug AdministrationTable of pharmacogenomic bio-markers in drug labeling Available from: http://www.fda.gov/drugs/scienceresearch/researchareas/pharmacogenetics/ucm083378.htmAccessed March 5, 2014
   Google Scholar
• FruehFWAmurSMummaneniPPharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: prevalence of related drug usePharmacotherapy200828899299818657016
   PubMed Web of Science ®Google Scholar
• StanekEJSandersCLJohansen TaberKAAdoption of phar-macogenomic testing by US physicians: results of a nationwide surveyClin Pharmacol Ther201291345045822278335
   PubMed Web of Science ®Google Scholar
• HagaSBBurkeWGinsburgGSMillsRAgansRPrimary care physicians’ knowledge of and experience with pharmacogenetic testingClin Genet201282438839422698141
   PubMed Web of Science ®Google Scholar
• McDonaghEMWhirl-CarrilloMGartenYAltmanRBKleinTEFrom pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resourceBiomark Med201125679580622103613
   PubMed Web of Science ®Google Scholar
• KuoGMMaJDLeeKCInstitutional Profile: University of California San Diego Pharmacogenomics Education Program (PharmGenEd™): bridging the gap between science and practicePharmacogenomics201112214915321332308
   PubMed Web of Science ®Google Scholar
• HicksJKCrewsKRHoffmanJMA clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical recordClin Pharmacol Ther201292556356622990750
   PubMed Web of Science ®Google Scholar
• PulleyJMDennyJCPetersonJFOperational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT projectClin Pharmacol Ther2012921879522588608
   PubMed Web of Science ®Google Scholar
• JohnsonJABurkleyBMLangaeeTYClare-SalzlerMJKleinTEAltmanRBImplementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping arrayClin Pharmacol Ther201292443743922910441
   PubMed Web of Science ®Google Scholar
• O’DonnellPHBushASpitzJThe 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomicsClin Pharmacol Ther201292444644922929923
   PubMed Web of Science ®Google Scholar
• American Medical Association, Critical Path Institute, Arizona Center for Research and Education on TherapeuticsPharmacogenomics: Increasing the Safety and Effectiveness of Drug TherapyChicagoAMA2011 Available from: http://www.ama-assn.org/resources/doc/genetics/pgx-brochure-2011.pdfAccessed March 5, 2013
   Google Scholar
• American Medical Association, Critical Path Institute, Arizona Center for Research and Education on TherapeuticsPersonalized Health Care Report 2008: Warfarin and Genetic TestingChicagoAMA2008 Available from: http://www.ama-assn.org/resources/doc/genetics/warfarin-brochure.pdfAccessed March 5, 2014
   Google Scholar
• GeneFacts.orgPharmacogenetics fact sheets Available from: http://genefacts.org/index.php?option=com_content&view=article&id=392&Itemid=457Accessed March 5, 2014
   Google Scholar
• RayTFDA/AMA launch free online course aiming to improve basic PGx literacy2007 Available from: http://www.genomeweb.com/dxpgx/fdaama-launch-free-online-course-aiming-improve-basic-pgx-literacyAccessed March 5, 2014
   Google Scholar
• JohnsonJPharmacogenetics in clinical practice: how far have we come and where are we going?Pharmacogenomics201314783584323651030
   PubMed Web of Science ®Google Scholar
• ManolioTAChisholmRLOzenbergerBImplementing genomic medicine in the clinic: the future is hereGenet Med201315425826723306799
   PubMed Web of Science ®Google Scholar
• CrewsKRHicksJKPuiCHRellingMVEvansWEPharmacogenomics and individualized medicine: translating science into practiceClin Pharmacol Ther201292446747522948889
   PubMed Web of Science ®Google Scholar
• SchumockGTWaltonSMParkHYFactors that influence prescribing decisionsAnn Pharmacother200438455756214966259
   PubMed Web of Science ®Google Scholar
• NutescuEAParkHYWaltonSMFactors that influence prescribing within a therapeutic drug classJ Eval Clin Pract200511435736516011648
   PubMed Web of Science ®Google Scholar
• SelkirkCGWeissmanSMAndersonAHulickPJPhysicians’ preparedness for integration of genomic and pharmacogenetic testing into practice within a major healthcare systemGenet Test Mol Biomarkers201317321922523390885
   PubMed Web of Science ®Google Scholar
• BonterKDesjardinsCCurrierNPunJAshburyFDPersonalised medicine in Canada: a survey of adoption and practice in oncology, cardiology and family medicineBMJ Open201111e000110
   PubMed Web of Science ®Google Scholar
• FargherEAEddyCNewmanWPatients’ and healthcare professionals’ views on pharmacogenetic testing and its future delivery in the NHSPharmacogenomics20078111511151918034616
   PubMed Web of Science ®Google Scholar
• BartholowMTop 200 drugs of 2012Pharm Times2013797 Available from: http://www.pharmacytimes.com/publications/issue/2013/July2013/Top-200-Drugs-of-2012Accessed March 5, 14
   Google Scholar
• GreenJSO’BrienTJChiappinelliVAHarralsonAFPharmacogenomics instruction in US and Canadian medical schools: implications for per-sonalized medicinePharmacogenomics20101191331134020860470
   PubMed Web of Science ®Google Scholar
• GurwitzDLunshofJEDedoussisGPharmacogenomics education: International Society of Pharmacogenomics recommendations for medical, pharmaceutical, and health schools deans of educationPharmacogenomics J20055422122515852053
   PubMed Web of Science ®Google Scholar
• KorfBGenetics and genomics education: the next generationGenet Med201113320120221283012
   PubMed Web of Science ®Google Scholar
• Howard Hughes Medical Institute, American Association of Medical CollegesScientific Foundations for Future Physicians: Report of the AAMC-HHMI CommitteeWashingtonAAMC2009 Available from: https://www.aamc.org/download/271072/data/scientificfoundationsfor-futurephysicians.pdfAccessed June 16, 2014
   Google Scholar
• NickolaTJGreenJSHarralsonAFO’BrienTJThe current and future state of pharmacogenomics medical education in the USAPharmacogenomics201213121419142522966890
   PubMed Web of Science ®Google Scholar
• KhouryMJCoatesRJEvansJPEvidence-based classification of recommendations on use of genomic tests in clinical practice: dealing with insufficient evidenceGenet Med2010121168068320975567
   PubMed Web of Science ®Google Scholar
• Indiana University Division of Clinical PharmacologyP450 drug interaction table Available from: http://medicine.iupui.edu/clinpharm/ddis/main-tableAccessed March 5, 2014
   Google Scholar
• Pharmacogenomics Knowledge Base [website on the Internet] Available from: http://www.pharmgkb.orgAccessed March 5, 2014
   Google Scholar
• OdzalgaEOdzalgaANeeraAThe smartphone in medicine: a review of current and potential use among physicians and studentsJ Med Internet Res2012145e12823017375
   PubMed Web of Science ®Google Scholar
• PutzerGJParkYAre physicians likely to adopt emerging mobile technologies? Attitudes and innovation factors affecting smartphone use in the Southeastern United StatesPerspect Health Inf Manag201291b
   PubMedGoogle Scholar
• DresslerLGIntegrating personalized genomic medicine into routine clinical care: addressing the social and policy issues of pharmacog-enomic testingNC Med J2013746509513
   Google Scholar
• PetersonJFBowtonEFieldJRElectronic health record design and implementation for pharmacogenomics: a local perspectiveGenet Med2013151083384124009000
   PubMed Web of Science ®Google Scholar
• OverbyCLTarczy-HornochPHoathJIKaletIJVeenstraDLFeasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision supportBMC Bioinformatics201011Suppl 9S1021044357
   PubMed Web of Science ®Google Scholar
• TonerBCleveland clinic rolls out EHR-based program to alert docs about PGx tests for azathioprine, abacavir2013 Available from: http://cdnwww.genomeweb.com/clinical-genomics/cleveland-clinic-rolls-out-ehr-based-program-alert-docs-about-pgx-tests-azathiopAccessed March 5, 2014
   Google Scholar
• BellGCCrewsKRWilkinsonMRDevelopment and use of active clinical decision support for preemptive pharmacogenomicsJ Am Med Inform Assoc201421e1e93e9923978487
   PubMed Web of Science ®Google Scholar
• SchildcroutJSDennyJCBowtonEOptimizing drug outcomes through pharmacogenetics: a case for preemptive genotypingClin Pharmacol Ther201292223524222739144
   PubMed Web of Science ®Google Scholar
• O’ConnorSKFerreriSPMichaelsNMExploratory planning and implementation of a pilot pharmacogenetic program in a community pharmacyPharmacogenomics201213895596222676199
   PubMed Web of Science ®Google Scholar
• TeagardenRJStanekEJOn pharmacogenomics in pharmacy benefit managementPharmacotherapy201232210311122392418
   PubMed Web of Science ®Google Scholar
• FerreriSPGrecoAJMichaelsNMImplementation of a phar-macogenomics service in a community pharmacyJ Am Pharm Assoc (2003)201454217218024632932
   PubMed Web of Science ®Google Scholar
• MillsRHagaSBClinical delivery of pharmacogenetic testing services: a proposed partnership between genetic counselors and pharmacistsPharmacogenomics201314895796823746189
   PubMed Web of Science ®Google Scholar
• CallardANewmanWPayneKDelivering a pharmacogenetic service: is there a role for genetic counselors?J Genet Couns201221452753522052043
   PubMed Web of Science ®Google Scholar
• McCulloughKBFormeaCMBergKDAssessment of the pharmacogenomics educational needs of pharmacistsAm J Pharm Educ20117535121655405
   PubMed Web of Science ®Google Scholar
• KuoGMLeeKCMaJDImplementation and outcomes of a live continuing education program on pharmacogenomicsPharmacogenomics201314888589523746183
   PubMed Web of Science ®Google Scholar
• EpsteinRSMoyerTPAubertREWarfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness Study)J Am Coll Cardiol201055252804281220381283
   PubMed Web of Science ®Google Scholar
• MallalSPhillipsECarosiGHLA-B*5701 screening for hypersensitivity to abacavirN Engl J Med2008358656857918256392
   PubMed Web of Science ®Google Scholar
• KimmelSEFrenchBAndersonJLRationale and design of the Clarification of Optimal Anticoagulation through Genetics trialAm Heart J2013166343544124016491
   PubMed Web of Science ®Google Scholar
• van SchieRMWadeliusMIKamaliFGenotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial designPharmacogenomics200910101687169519842940
   PubMed Web of Science ®Google Scholar
• ManolioTAMurrayMFThe growing role of professional societies in educating clinicians in genomicsGenet Med Epub262014
   Web of Science ®Google Scholar