A review of safety and efficacy of zonisamide for treatment of pediatric partial epilepsy

References

• Peters DH, Sorkin EM. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993;45(5):760–787.
   PubMed Web of Science ®Google Scholar
• Kochak GM, Page JG, Buchanan RA, Peters R, Padgett CS. Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures. J Clin Pharmacol. 1998;38(2):166–171.
   Web of Science ®Google Scholar
• Afra P, Adamolekun B. Update on once-daily zonisamide monotherapy in partial seizures. Neuropsychiatr Dis Treat. 2014;10:493–498.
   Web of Science ®Google Scholar
• Rösler TW, Arias-Carrión O, Höglinger GU. Zonisamide: aspects in neuroprotection. Exp Neurol. 2010;224(2):336–339.
   PubMed Web of Science ®Google Scholar
• Zonegran® (zonisamide) capsules [package insert]. Woodcliff Lake, NJ: Eisai Pharmaceuticals Inc.; 2006.
   Google Scholar
• Minami T, Ieiri I, Ohtsubo K, et al. Influence of additional therapy with zonisamide (Excegran) on protein binding and metabolism of carbamazepine. Epilepsia. 1994;35(5):1023–1025.
   Web of Science ®Google Scholar
• Tasaki K, Minami T, Ieiri I, et al. Drug interactions of zonisamide with phenytoin and sodium valproate: serum concentrations and protein binding. Brain Dev. 1995;17(3):182–185.
   Web of Science ®Google Scholar
• Ojemann LM, Shastri RA, Wilensky AJ, et al. Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy. Ther Drug Monit. 1986;8(3):293–296.
   Web of Science ®Google Scholar
• Italiano D, Pezzella M, Coppola A, et al. A pilot open-label trial of zonisamide in Unverricht-Lundborg disease. Mov Disord. 2011;26(2):341–343.
   PubMed Web of Science ®Google Scholar
• Striano P, Belcastro V. Treating myoclonic epilepsy in children: state-of-the-art. Expert Opin Pharmacother. 2013;14(10):1355–1361.
   PubMed Web of Science ®Google Scholar
• Zaccara G, Specchio LM. Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature. Neuropsychiatr Dis Treat. 2009;5:249–259.
   PubMed Web of Science ®Google Scholar
• Hoy SM. Zonisamide: a review of its use in the management of adults with partial seizures. Drugs. 2013;73(12):1321–1338.
   Web of Science ®Google Scholar
• Leppik IE. Three new drugs for epilepsy: levetiracetam, oxcarbazepine, and zonisamide. J Child Neurol. 2002;17 Suppl 1:S53–S57.
   Google Scholar
• Schulze-Bonhage A. Zonisamide in the treatment of epilepsy. Expert Opin Pharmacother. 2010;11(1):115–126.
   PubMed Web of Science ®Google Scholar
• Kito M, Maehara M, Watanabe K. Mechanisms of T-type calcium channel blockade by zonisamide. Seizure. 1996;5(2):115–119.
   PubMed Web of Science ®Google Scholar
• Mula M. Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults. Drug Des Dev Ther. 2013;7:397–402.
   Web of Science ®Google Scholar
• Brodie MJ, Ben-Menachem E, Chouette I, Giorgi L. Zonisamide: its pharmacology, efficacy and safety in clinical trials. Acta Neurol Scand Suppl. 2012;(194):19–28.
   PubMedGoogle Scholar
• Guerrini R, Rosati A, Segieth, J, Pellacani S, Bradshaw K, Giorgi L. A randomized phase III trial of adjunctive zonisamide in pediatric patients with partial epilepsy. Epilepsia. 2013;54(8):1473–1480.
   PubMed Web of Science ®Google Scholar
• Kluger G, Zsoter, A, Holthausen H. Long-term use of zonisamide in refractory childhood-onset epilepsy. Eur J Paediatr Neurol. 2008;12(1):19–23.
   Web of Science ®Google Scholar
• Coppola G, Grosso S, Verrotti A, et al. Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study. Epilepsy Res. 2009;83(2–3):112–116.
   Web of Science ®Google Scholar
• Guerrini R, Rosati A, Bradshaw K, Giorgi L. Adjunctive zonisamide therapy in the long-term treatment of children with partial epilepsy: results of an extension study of a phase III, randomized, double bind, placebo-controlled trial. Epilepsia. 2014;55(4):568–578.
   PubMed Web of Science ®Google Scholar
• Shinnar S, Pellock JM, Conry JA. Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy. Eur J Paediatr Neurol. 2009;13(1):3–9.
   PubMed Web of Science ®Google Scholar
• Tan HJ, Martland TR, Appleton RE, Kneen R. Effectiveness and tolerability of zonisamide in children with epilepsy: a retrospective review. Seizure. 2010;19(1):31–35.
   PubMed Web of Science ®Google Scholar
• Mandelbaum DE, Bunch M, Kugler SL, Venkatasubramanian A, Wollack JB. Broad-spectrum efficacy of zonisamide at 12 months in children with intractable epilepsy. J Child Neurol. 2005;20(7):594–597.
   Web of Science ®Google Scholar
• Lee YJ, Kang HC, Seo JH, Lee JS, Kim HD. Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy. Brain Dev. 2010;32(3):208–212.
   PubMed Web of Science ®Google Scholar
• Faught E. Review of United States and European clinical trials of zonisamide in the treatment of refractory partial-onset seizures. Seizure. 2004;13 Suppl 1:S59–S65; discussion S71–S72.
   Google Scholar
• Villanueva V, Serrano-Castro PJ. [Zonisamide in the epilepsy treatment: a literature review from add-on therapy to monotherapy]. Rev Neurol. 2013;56(8):429–438. Spanish.
   Web of Science ®Google Scholar
• Cox JH, Seri S, Cavanna AE. Zonisamide as a treatment for partial epileptic seizures: a Systematic review. Adv Ther. 2014;31(3):276–288.
   Web of Science ®Google Scholar
• Seki T, Kumagai N, Maezawa M. Effects of zonisamide monotherapy in children with epilepsy. Seizure. 2004;13 Suppl 1:26–32; discussion S33.
   Google Scholar
• Kothare SV, Kaleyias J, Mostofi N, et al. Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy. Pediatr Neurol. 2006;34(5):351–354.
   PubMed Web of Science ®Google Scholar
• Eun SH, Kim HD, Eun BL, et al. Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy. Seizure. 2011;20(7):558–563.
   PubMed Web of Science ®Google Scholar
• Wilfong AA. Zonisamide monotherapy for epilepsy in children and young adults. Pediatr Neurol. 2005;32(2):77–80.
   Web of Science ®Google Scholar
• Kim HL, Aldridge J, Rho JM. Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center. J Child Neurol. 2005;20(3):212–219.
   Web of Science ®Google Scholar
• Iinuma K, Haginoya K. Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey. Seizure. 2004;13 Suppl 1:S34–S39; discussion S40.
   Google Scholar
• Cavanna AE, Seri S. Psychiatric adverse effects of zonisamide in patients with epilepsy and mental disorders comorbidities. Epilepsy Behav. 2013;29(2):281–284.
   Web of Science ®Google Scholar
• Kondo T, Kaneko S, Amano Y, Egawa I. Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy. Epilepsia. 1996;37(12):1242–1244.
   Web of Science ®Google Scholar
• Wilfong AA, Willmore LJ. Zonisamide – a review of experience and use in partial seizures. Neuropsychiatr Dis Treat. 2006;2(3):269–280.
   PubMedGoogle Scholar
• Marinas A, Villanueva V, Giràldez BG, Molins A, Salas-Puig J, Serratosa JM. Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy. Epileptic Disord. 2009;11(1):61–66.
   PubMed Web of Science ®Google Scholar
• Brodie MJ, Duncan R, Vespignani H, Solyom A, Bitenskyy V, Lucas C. Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures. Epilepsia. 2005;46(1):31–41.
   Web of Science ®Google Scholar
• You SJ, Kang HC, Kim HD, Lee HS, Ko TS. Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience. Brain Dev. 2008;30(4):287–290.
   PubMed Web of Science ®Google Scholar
• Sackellares JC, Ramsay RE, Wilder BJ, Browne TR 3rd, Shellenberger MK. Randomized, controlled clinical trial of zonisamide as adjuctive treatment for refractory partial seizures. Epilepsia. 2004; 45(6):610–617.
   PubMed Web of Science ®Google Scholar
• Lu Y, Xiao Z, Yu W, Xiao F, Xiao Z, Hu Y, Chen Y, Wang X. Efficacy and safety of adjunctive zonisamide in adult patients with refractory partial-onset epilepsy: a randomized, double-blind, placebo-controlled trial. Clin Drug Investig. 2011;31:221–229.
   PubMed Web of Science ®Google Scholar
• Wallander KM, Ohman I, Zonisamide DM. Pharmacokinetics, Efficacy, and Adverse Events in Children with Epilepsy. Neuropediatrics. Epub 2014 Aug 18.
   Google Scholar