Patient knowledge, perceptions, and acceptance of generic medicines: a comprehensive review of the current literature

References

• Dunne S, Shannon B, Dunne C, Cullen W. A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study. BMC Pharmacol Toxicol. 2013;14(1):1.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Glossary of Globalization, Trade and Health Terms. 2012. Available from: http://www.who.int/trade/glossary/story034/en/index.html. Accessed January 30, 2014.
   Google Scholar
• The US Food and Drug Administration. FDA Center for Drug Evaluation and Research. Office of Generic Drugs. Facts about generic drugs. 2012. Available from: http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/UnderstandingGenericDrugs/ucm167991.htm. Accessed January 30, 2014.
   Google Scholar
• European Generic Medicines Association. EGA fact sheet on generic medicines: assured quality, safety and efficacy of generic medicines. Available from: http://www.egagenerics.com/images/factsheet/EGA_factsheet_01.pdf. Accessed January 30, 2014.
   Google Scholar
• Galgatte UC, Jamdade VR, Aute PP, Chaudhari PD. Study on requirements of bioequivalence for registration of pharmaceutical products in USA, Europe and Canada. Saudi Pharm J. Epub 2013 May 31.
   Google Scholar
• Shafie AA, Hassali MA. Price comparison between innovator and generic medicines sold by community pharmacies in the state of Penang, Malaysia. Journal of Generic Medicines. 2008;6(1):35–42.
   Google Scholar
• Matin Y. SCRIP’s Complete Guide to the World Generic Drugs Market. Richmond, UK: PJB Publications Ltd; 1999.
   Google Scholar
• European Generic Medicines Association. EGA fact sheet on generic medicines: frequently asked questions (FAQs). http://www.egagenerics.com/images/factsheet/EGA_factsheet_06.pdf. Accessed January 30, 2014.
   Google Scholar
• Simoens S, Coster SD. Sustaining generic medicines markets in Europe. Research Centre for Pharmaceutical Care and Pharmaco-economics, Katholieke Universiteit Leuven 2006. Available from: http://212.85.101.126/images/publikacje/7_pl.pdf. Accessed January 30, 2014.
   Google Scholar
• Sheppard A. Generic medicines: essential contributors to the long-term health of society. IMS Health. Available from: http://www.imshealth.com/imshealth/Global/Content/Document/Market_Measurement_TL/Generic_Medicines_GA.pdf. Accessed January 30, 2014.
   Google Scholar
• Alrasheedy AA, Hassali MA, Aljadhey H, Ibrahim MIM, Al-Tamimi SK. Is there a need for a formulary of clinically interchangeable medicines to guide generic substitution in Saudi Arabia? J Young Pharm. 2013;5(2):73–75.
   Google Scholar
• Godman B, Malmström R, Bennie M, et al. Prescribing restrictions – a necessary strategy among some European countries to enhance future prescribing efficiency? Rev Health Care. 2012;3(1):5–16.
   Google Scholar
• Godman B, Shrank W, Wettermark B, et al. Use of generics – a critical cost containment measure for all health care professionals in Europe? Pharmaceuticals. 2010;3(8):2470–2494.
   Google Scholar
• Godman B, Wettermark B, Bishop I, Burkhardt T, Fürst J, Garuoliene K. European payer initiatives to reduce prescribing costs through use of generics. GaBi J. 2012;1(1):22–27.
   Google Scholar
• Ministry of Health Labour and Welfare of Japan. Policy report: promotion of the use of generic drugs. 2012. Available from: http://www.mhlw.go.jp/english/policy_report/2012/09/120921.html. Accessed January 30, 2014.
   Google Scholar
• Sermet C, Andrieu V, Godman B, Van Ganse E, Haycox A, Reynier J-P. Ongoing pharmaceutical reforms in France. Appl Health Econ Health Policy. 2010;8(1):7–24.
   PubMedGoogle Scholar
• Simoens S, De Coster S. Sustaining generic medicines markets in Europe. Journal of Generic Medicines. 2006;3(4):257–268.
   Google Scholar
• Dylst P, Vulto A, Simoens S. Demand-side policies to encourage the use of generic medicines: an overview. Expert Rev Pharmacoecon Outcomes Res. 2013;13(1):59–72.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, The PG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
   PubMed Web of Science ®Google Scholar
• Ganther J, Kreling D. Consumer perceptions of risk and required cost savings for generic prescription drugs. J Am Pharm Assoc (Wash). 2000;40(3):378–383.
   Google Scholar
• Sansgiry SS, Bhosle M, Pope N. Consumer perceptions regarding generic drug substitution: an exploratory study. J Pharm Mark Manage. 2005;17(1):77–91.
   Google Scholar
• Iosifescu A, Halm EA, McGinn T, Siu AL, Federman AD. Beliefs about generic drugs among elderly adults in hospital-based primary care practices. Patient Educ Couns. 2008;73(2):377–383.
   PubMed Web of Science ®Google Scholar
• Shrank WH, Cox ER, Fischer MA, Mehta J, Choudhry NK. Patients’ perceptions of generic medications. Health Aff (Millwood). 2009;28(2):546–556.
   PubMed Web of Science ®Google Scholar
• Shrank WH, Cadarette SM, Cox E, et al. Is there a relationship between patient beliefs or communication about generic drugs and medication utilization? Med Care. 2009;47(3):319–325.
   PubMed Web of Science ®Google Scholar
• Papsdorf TB, Ablah E, Ram S, Sadler T, Liow K. Patient perception of generic antiepileptic drugs in the Midwestern United States. Epilepsy Behav. 2009;14(1):150–153.
   Web of Science ®Google Scholar
• Keenum AJ, DeVoe JE, Chisolm DJ, Wallace LS. Generic medications for you, but brand-name medications for me. Res Social Adm Pharm. 2012;8(6):574–578.
   PubMed Web of Science ®Google Scholar
• Sewell K, Andreae S, Luke E, Safford MM. Perceptions of and barriers to use of generic medications in a rural African American population, Alabama, 2011. Prev Chronic Dis. 2012;9:E142.
   PubMed Web of Science ®Google Scholar
• Kohli E, Buller A. Factors influencing consumer purchasing patterns of generic versus brand name over-the-counter drugs. South Med J. 2013;106(2):155–160.
   PubMed Web of Science ®Google Scholar
• Pereira JA, Holbrook AM, Dolovich L, et al. Are brand-name and generic warfarin interchangeable? A survey of Ontario patients and physicians. Can J Clin Pharmacol. 2005;12(3):e229–e239.
   Google Scholar
• Hassali MA, Kong D, Stewart K. Generic medicines: perceptions of consumers in Melbourne, Australia. Int J Pharm Pract. 2005;13(4):257–264.
   Google Scholar
• Bulsara C, McKenzie A, Sanfilippo F, Holman CAJ, Emery JE. ‘Not the full Monty’: a qualitative study of seniors’ perceptions of generic medicines in Western Australia. Aust J Prim Health. 2010;16(3):240–245.
   Web of Science ®Google Scholar
• Ibrahim R, McKinnon RA, Ngo SN. Knowledge and perceptions of community patients about generic medicines. Journal of Pharmacy Practice and Research. 2012;42(4):283–286.
   Google Scholar
• Ngo SN, Stupans I, McKinnon RA. Generic substitution in the treatment of epilepsy: patient attitudes and perceptions. Epilepsy Behav. 2013;26(1):64–66.
   Web of Science ®Google Scholar
• Babar ZU, Stewart J, Reddy S, et al. An evaluation of consumers’ knowledge, perceptions and attitudes regarding generic medicines in Auckland. Pharm World Sci. 2010;32(4):440–448.
   Google Scholar
• Al-Gedadi NA, Hassali MA, Shafie AA. A pilot survey on perceptions and knowledge of generic medicines among consumers in Penang, Malaysia. Pharm Pract (Internet). 2008;6(2):93–97.
   Google Scholar
• Thomas R, Vitry A. Consumers’ perception of generic medicines in community pharmacies in Malaysia. South Med Rev. 2009;2(2):20–23.
   Google Scholar
• Abzakh AA, Ling KC, Alkilani K. The impact of perceived risks on the consumer resistance towards generic drugs in the Malaysia pharmaceutical industry. International Journal of Business and Management. 2013;8(3):42–50.
   Google Scholar
• Hoshi S, Kimura H. Questionnaire on the awareness of generic drugs among outpatients and medical staff. Drug Discov Ther. 2008;2(3):194–199.
   Google Scholar
• Kobayashi E, Karigome H, Sakurada T, Satoh N, Ueda S. Patients’ attitudes towards generic drug substitution in Japan. Health Policy. 2011;99(1):60–65.
   PubMed Web of Science ®Google Scholar
• Ahire K, Shukla M, Gattani M, Singh V, Singh M. A survey-based study in current scenario of generic and branded medicines. Int J Pharm Pharm Sci. 2013;5(3).
   Google Scholar
• Sharrad AK, Hassali MA. Consumer perception on generic medicines in Basrah, Iraq: preliminary findings from a qualitative study. Res Social Adm Pharm. 2011;7(1):108–112.
   Web of Science ®Google Scholar
• Toklu HZ, Dülger GA, Hidiroğlu S, et al. Knowledge and attitudes of the pharmacists, prescribers and patients towards generic drug use in Istanbul, Turkey. Pharm Pract (Granada). 2012;25(35):36–45.
   Google Scholar
• El-Dahiyat F, Kayyali R. Evaluating patients’ perceptions regarding generic medicines in Jordan. Journal of Pharmaceutical Policy and Practice. 2013;6(1):3.
   Google Scholar
• Al Ameri M, Mohamed W, Makramalla E, Shalhoub B, Tucker A, Johnston A. Renal patients’ views on generic prescribing and substitution: example from the United Arab Emirates. East Mediterr Health J. 2013;19(4):373–381.
   Web of Science ®Google Scholar
• Albarraq A. Consumers’ perceptions on generic medicines in Taif city, Saudi Arabia. Saudi Journal for Health Sciences. 2013;2(1):18–22.
   Google Scholar
• Heikkilä R, Mäntyselkä P, Hartikainen-Herranen K, Ahonen R. Customers’ and physicians’ opinions of and experiences with generic substitution during the first year in Finland. Health Policy. 2007;82(3):366–374.
   PubMed Web of Science ®Google Scholar
• Halme M, Linden K, Kääriä K. Patients’ preferences for generic and branded over-the-counter medicines. Patient. 2009;2(4):243–255.
   PubMedGoogle Scholar
• Heikkilä R, Mäntyselkä P, Ahonen R. Do people regard cheaper medicines effective? Population survey on public opinion of generic substitution in Finland. Pharmacoepidemiol Drug Saf. 2011;20(2):185–191.
   PubMed Web of Science ®Google Scholar
• Heikkilä R, Mäntyselkä P, Ahonen R. Price, familiarity, and availability determine the choice of drug – a population-based survey five years after generic substitution was introduced in Finland. BMC Pharmacol Toxicol. 2011;11(1):20.
   Google Scholar
• Heikkilä R, Mäntyselkä P, Ahonen R. Why people refuse generic substitution: a population survey of public opinion on generic substitution in Finland. Drugs and Therapy Perspectives. 2012;28(8):24–26.
   Google Scholar
• Rozano Suplet M, Gómez Suárez M, Díaz Martín AM. Customer perceptions of perceived risk in generic drugs: the Spanish market. Innovar. 2009;19(34):53–64.
   Google Scholar
• Sicras-Mainar A, Navarro-Artieda R. Physicians’ and patients’ opinions on the use of generic drugs. J Pharmacol Pharmacother. 2012;3(3):268–270.
   Google Scholar
• Figueiras MJ, Marcelino D, Cortes MA. People’s views on the level of agreement of generic medicines for different illnesses. Pharm World Sci. 2008;30(5):590–594.
   PubMed Web of Science ®Google Scholar
• Figueiras MJ, Alves NC, Marcelino D, Cortes MA, Weinman J, Horne R. Assessing lay beliefs about generic medicines: development of the generic medicines scale. Psychol Health Med. 2009;14(3):311–321.
   PubMed Web of Science ®Google Scholar
• Figueiras MJ, Cortes MA, Marcelino D, Weinman J. Lay views about medicines: the influence of the illness label for the use of generic versus brand. Psychol Health. 2010;25(9):1121–1128.
   PubMed Web of Science ®Google Scholar
• Figueiras M, Marcelino DS, Claudino A, Cortes MA, Maroco J, Weinman J. Patients’ illness schemata of hypertension: the role of beliefs for the choice of treatment. Psychol Health. 2010;25(4):507–517.
   PubMed Web of Science ®Google Scholar
• Quintal C, Mendes P. Underuse of generic medicines in Portugal: an empirical study on the perceptions and attitudes of patients and pharmacists. Health Policy. 2012;104(1):61–68.
   Web of Science ®Google Scholar
• Palagyi M, Lassanova M. Patients’ attitudes towards experience with use of generics in Slovakia, performance of generic substitution. Bratisl Lek Listy. 2008;109(7):324–328.
   Web of Science ®Google Scholar
• Frisk P, Rydberg T, Carlsten A, Ekedahl A. Patients’ experiences with generic substitution: a Swedish pharmacy survey. J Pharm Health Serv Res. 2011;2(1):9–15.
   Google Scholar
• Kjoenniksen I, Lindbaek M, Granas AG. Patients’ attitudes towards and experiences of generic drug substitution in Norway. Pharm World Sci. 2006;28(5):284–289.
   PubMedGoogle Scholar
• Toverud E-L, Røise AK, Hogstad G, Wabø I. Norwegian patients on generic antihypertensive drugs: a qualitative study of their own experiences. Eur J Clin Pharmacol. 2011;67(1):33–38.
   Web of Science ®Google Scholar
• Lebanova H, Manolov D, Getov I. Patients’ attitudes about generics – Bulgarian perspective. Marmara Pharm J. 2012;16:36–40.
   Google Scholar
• Himmel W, Simmenroth-Nayda A, Niebling W, et al. What do primary care patients think about generic drugs? Int J Clin Pharmacol Ther. 2005;43(10):472–479.
   PubMed Web of Science ®Google Scholar
• Hensler K, Uhlmann C, Porschen T, Benecke R, Rösche J. Generic substitution of antiepileptic drugs – a survey of patients’ perspectives in Germany and other German-speaking countries. Epilepsy Behav. 2013;27(1):135–139.
   Web of Science ®Google Scholar
• Al Ameri MN, Whittaker C, Tucker A, Yaqoob M, Johnston A. A survey to determine the views of renal transplant patients on generic substitution in the UK. Transpl Int. 2011;24(8):770–779.
   PubMed Web of Science ®Google Scholar
• Rathe J, Larsen P, Andersen M, et al. Associations between generic substitution and patients’ attitudes, beliefs and experiences. Eur J Clin Pharmacol. 2013;69(10):1827–1836.
   PubMed Web of Science ®Google Scholar
• Roman B. Patients’ attitudes towards generic substitution of oral atypical antipsychotics. CNS Drugs. 2009;23(8):693–701.
   PubMed Web of Science ®Google Scholar
• Gill L, Helkkula A, Cobelli N, White L. How do customers and pharmacists experience generic substitution? International Journal of Pharmaceutical and Healthcare Marketing. 2010;4(4):375–395.
   Google Scholar
• Denoth A, Pinget C, Wasserfallen J-B. Citizens’ preferences for brand name drugs for treating acute and chronic conditions. Appl Health Econ Health Policy. 2011;9(2):81–87.
   Google Scholar
• Gossell-Williams M, Harriott K. Generic substitution in Jamaica: challenges to improving effectiveness. WHO Drug Information. 2007;21(4):294–299.
   Google Scholar
• Patel A, Gauld R, Norris P, Rades T. “This body does not want free medicines”: South African consumer perceptions of drug quality. Health Policy Plan. 2010;25(1):61–69.
   Web of Science ®Google Scholar
• Bertoldi AD, Barros AJ, Hallal PC. [Generic drugs in Brazil: known by many, used by few]. Cad Saude Publica. 2005;21(6):1808–1815. Portuguese.
   Google Scholar
• Hassali MA, Shafie AA, Jamshed S, Ibrahim MI, Awaisu A. Consumers’ views on generic medicines: a review of the literature. Int J Pharm Pract. 2009;17(2):79–88.
   PubMedGoogle Scholar
• Gaither CA, Kirking DM, Ascione FJ, Welage LS. Consumers’ views on generic medications. J Am Pharm Assoc. 2001;41(5):729–736.
   Google Scholar