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ORIGINAL RESEARCH

Serum Lipids, Insulin-Like Growth Factor Binding Protein-3 and Treatment Outcomes in Women with and without Cervical Lesions in South Western Uganda: A Cohort Study

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Pages 91-105 | Received 08 Nov 2023, Accepted 22 Dec 2023, Published online: 28 Dec 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca a Cancer J Clinicians. 2021;71(3):209–249. doi:10.3322/caac.21660
  • Bruni L, Albero G, Serrano B, et al. ICO/IARC information centre on HPV and cancer (HPV information centre). Hum Papillom Rel Dis World Summ Rep. 2019;17:6.
  • Ronco G, Montanari G, Aimone V, et al. Estimating the sensitivity of cervical cytology: errors of interpretation and test limitations. Cytopathology. 1996;7(3):151–158. doi:10.1046/j.1365-2303.1996.39382393.x
  • World Health Organization. Assessing National Capacity for the Prevention and Control of Noncommunicable Diseases: Report of the 2019 Global Survey. World Health Organization; 2020.
  • Anorlu RI. Cervical cancer: the sub-Saharan African perspective. Rep Health Matters. 2008;16(32):41–49. doi:10.1016/S0968-8080(08)32415-X
  • Denny L, Quinn M, Sankaranarayanan R. Screening for cervical cancer in developing countries. Vaccine. 2006;24:S71–S7. doi:10.1016/j.vaccine.2006.05.121
  • Sankaranarayanan R. Screening for cancer in low-and middle-income countries. Anna Global Health. 2014;80(5):412–417. doi:10.1016/j.aogh.2014.09.014
  • World Health Organization. Cervical cancer country profiles. World Health Organization; 2021. Available from: https://www.who.int/publications/m/item/cervical-cancer-country-profiles. Accessed December 23, 2023.
  • Nakisige C, Schwartz M, Ndira AO. Cervical cancer screening and treatment in Uganda. Gynecol Oncol Rep. 2017;20:37–40. doi:10.1016/j.gore.2017.01.009
  • World Health Organization. Screening as well as vaccination is essential in the fight against cervical cancer. Erişim adresi; 2014. Available from: http://www.who.int/reproductivehealth/topics/cancers/fight-cervical-cancer/en/Erişim.tarihi. Accessed December 23, 2023.
  • Yee PCG, de Souza P, Khachigian ML. Current and potential treatments for cervical cancer. Curr Cancer Drug Targets. 2013;13(2):205–220. doi:10.2174/1568009611313020009
  • Bogani G, Sopracordevole F, Ciavattini A, et al. HPV persistence after cervical surgical excision of high‐grade cervical lesions. Can Cytopathol. 2023. doi:10.1002/cncy.22760
  • Preetha A, Banerjee R, Huilgol N. Surface activity, lipid profiles and their implications in cervical cancer. J Cancer Res Ther. 2005;1(3):180–186. doi:10.4103/0973-1482.19600
  • Jiang Q, Wang L, Jin M, Shou Y, Zhu H, Li A. The clinical value of lipid abnormalities in early stage cervical cancer. Int J Gene Med. 2022;15:3903–3914. doi:10.2147/IJGM.S352934
  • Serrano M-L, Sánchez-Gómez M, Bravo -M-M. Cervical scrapes levels of insulin-like growth factor-II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer. Hormone Metab Res. 2010;42(13):977–981. doi:10.1055/s-0030-1267175
  • Ingermann AR, Yang Y-F, Han J, et al. Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer. J Biol Chem. 2010;285(39):30233–30246. doi:10.1074/jbc.M110.122226
  • Mehta HH, Gao Q, Galet C, et al. IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res. 2011;71(15):5154–5163. doi:10.1158/0008-5472.CAN-10-4513
  • Mohanraj L, Kim H-S, Li W, et al. IGFBP-3 inhibits cytokine-induced insulin resistance and early manifestations of atherosclerosis. PLoS One. 2013;8(1):e55084. doi:10.1371/journal.pone.0055084
  • Min H-K, Maruyama H, Jang BK, et al. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. THE FASEB Journal. 2016;30(12):4071. doi:10.1096/fj.201600427R
  • Kim M, Cai Q, Oh Y. Therapeutic potential of alpha-1 antitrypsin in human disease. Ann Pediatr Endocrinol Metab. 2018;23(3):131. doi:10.6065/apem.2018.23.3.131
  • Pollak M. Insulin-like growth factor physiology and cancer risk. Eur J Cancer. 2000;36(10):1224–1228. doi:10.1016/S0959-8049(00)00102-7
  • Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001;131(11):3109S–3120S. doi:10.1093/jn/131.11.3109S
  • Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J National Cancer Inst. 2000;92(18):1472–1489. doi:10.1093/jnci/92.18.1472
  • Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J National Cancer Inst. 2002;94(13):972–980. doi:10.1093/jnci/94.13.972
  • Uganda Ministry of Health. Mbarara Regional Referral Hospital. Uganda Ministry of Health; 2016.
  • Ahn HK, Shin JW, Ahn HY, et al. Metabolic components and recurrence in early-stage cervical cancer. Tumor Biol. 2015;36(3):2201–2207. doi:10.1007/s13277-014-2831-y
  • Kim M, Kim I-H, Lim MK, Kim Y, Park B. Increased prevalence of metabolic syndrome in adult cancer survivors: asian first report in community setting. Cancer Epidemiol. 2019;58:130–136. doi:10.1016/j.canep.2018.12.006
  • Fleiss JL, Levin B, Paik MC. Statistical Methods for Rates and Proportions. john wiley & sons; 2013.
  • Wu X, Tortolero-Luna G, Zhao H, Phatak D, Spitz MR, Follen M. Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix. Clin Cancer Res. 2003;9(9):3356–3361.
  • Lee SW, Lee SY, Lee SR, Ju W, Kim SC. Plasma levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with cervical neoplasia. J Gynecol Oncol. 2010;21(3):174–180. doi:10.3802/jgo.2010.21.3.174
  • Conover CA, Powell DR. Insulin-like growth factor (IGF)-binding protein-3 blocks IGF-I-induced receptor down-regulation and cell desensitization in cultured bovine fibroblasts. Endocrinology. 1991;129(2):710–716. doi:10.1210/endo-129-2-710
  • Ssedyabane F, Ngonzi J, Kajabwangu R, Najjuma JN, Tusubira D, Randall TC. Association between obesity and cervical intraepithelial neoplasia: results from a case control study in south western Uganda. BMC Womens Health. 2023;23(1):1–8.
  • Cohen SS, Park Y, Signorello LB, et al. A pooled analysis of body mass index and mortality among African Americans. PLoS One. 2014;9(11):e111980. doi:10.1371/journal.pone.0111980
  • Bumrungthai S, Ekalaksananan T, Kleebkaow P, et al. Mathematical modelling of cervical precancerous lesion grade risk scores: linear regression analysis of cellular protein biomarkers and human papillomavirus E6/E7 RNA staining patterns. Diagnostics. 2023;13(6):1084. doi:10.3390/diagnostics13061084
  • Trabert B, Wentzensen N, Felix AS, et al. Metabolic syndrome and risk of endometrial cancer in the United States: a study in the SEER–medicare linked database. Cancer Epidemiol Biomarkers Prev. 2015;24(1):261–267. doi:10.1158/1055-9965.EPI-14-0923
  • Huang X, Zhao Q, Yang P, et al. Metabolic syndrome and risk of cervical human papillomavirus incident and persistent infection. Medicine. 2016;95:9.
  • Molokwu JC, Penaranda E, Lopez DS, et al. Association of metabolic syndrome and human papillomavirus infection in men and women residing in the United States. Cancer Epidemiol Biomarkers Prev. 2017;26(8):1321–1327. doi:10.1158/1055-9965.EPI-17-0129
  • Bergerot CD, Costas-Muñiz R, Lee D, Philip EJ. Social Support as a Protective Factor for Patients with Cancer During the Pandemic. Taylor & Francis; 2022:473–474.
  • Santesso N, Schünemann H, Blumenthal P, et al. World health organization guidelines: use of cryotherapy for cervical intraepithelial neoplasia. Int J Gynecol Obstet. 2012;118(2):97–102. doi:10.1016/j.ijgo.2012.01.029
  • Randall TC, Sauvaget C, Muwonge R, Trimble EL, Jeronimo J. Worthy of further consideration: an updated meta-analysis to address the feasibility, acceptability, safety and efficacy of thermal ablation in the treatment of cervical cancer precursor lesions. Preventive Med. 2019;118:81–91. doi:10.1016/j.ypmed.2018.10.006
  • Jacob M, Broekhuizen FF, Castro W, Sellors J. Experience using cryotherapy for treatment of cervical precancerous lesions in low-resource settings. Int J Gynaecol Obstet off Organ Int Fed Gynaecol Obstet. 2005;89:S13–20. doi:10.1016/j.ijgo.2005.01.026
  • Luciani S, Gonzales M, Munoz S, Jeronimo J, Robles S. Effectiveness of cryotherapy treatment for cervical intraepithelial neoplasia. Int J Gynaecol Obstet off Organ Int Fed Gynaecol Obstet. 2008;101(2):172–177. doi:10.1016/j.ijgo.2007.11.013
  • Cremer ML, Conzuelo-Rodriguez G, Cherniak W, Randall T. Ablative therapies for cervical intraepithelial neoplasia in low-resource settings: findings and key questions. J Glob Oncol. 2018;4:1–10. doi:10.1200/JGO.18.00093
  • Pasek M, Suchocka L, Gąsior K. Model of social support for patients treated for cancer. Cancers. 2021;13(19):4786. doi:10.3390/cancers13194786
  • Usta YY. Importance of social support in cancer patients. Asian Pac J Cancer Prev. 2012;13:3569–3572. doi:10.7314/APJCP.2012.13.8.3569
  • Korotkin BD, Hoerger M, Voorhees S, Allen CO, Robinson WR, Duberstein PR. Social support in cancer: how do patients want us to help? J Psychosoc Oncol. 2019;37(6):699–712. doi:10.1080/07347332.2019.1580331
  • Hofman A, Zajdel N, Klekowski J, Chabowski M. Improving social support to increase QoL in lung cancer patients. Cancer Manage Res. 2021;13:2319–2327. doi:10.2147/CMAR.S278087
  • Mapanga W, Singh E, Feresu SA, Girdler-Brown B. Treatment of pre-and confirmed cervical cancer in HIV-seropositive women from developing countries: a systematic review. Syst Rev. 2020;9:1–16. doi:10.1186/s13643-020-01345-2
  • Arpey NC, Gaglioti AH, Rosenbaum ME. How socioeconomic status affects patient perceptions of health care: a qualitative study. J Prim Care Community Health. 2017;8(3):169–175. doi:10.1177/2150131917697439
  • Vetterlein MW, Löppenberg B, Karabon P, et al. Impact of travel distance to the treatment facility on overall mortality in US patients with prostate cancer. Cancer. 2017;123(17):3241–3252. doi:10.1002/cncr.30744
  • Ambroggi M, Biasini C, Del Giovane C, Fornari F, Cavanna L. Distance as a barrier to cancer diagnosis and treatment: review of the literature. oncologist. 2015;20(12):1378–1385. doi:10.1634/theoncologist.2015-0110
  • Fraenkel E, Lazurova I. IGF-1 and IGFBP3 as indirect markers of hepatic insulin resistance and their relation to metabolic syndrome parameters in liver steatosis patients. Endoc Regul. 2023;57(1):69–79. doi:10.2478/enr-2023-0009
  • Adachi Y, Nojima M, Mori M, et al. Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and the incidence of malignant neoplasms in a nested case-control study. Cancer Prev Res (Phila). 2020;13(4):385–394. doi:10.1158/1940-6207.CAPR-19-0375
  • Kucera R, Topolcan O, Pecen L, et al. Reference values of IGF1, IGFBP3 and IGF1/IGFBP3 ratio in adult population in the Czech Republic. Clin Chim Acta. 2015;444:271–277. doi:10.1016/j.cca.2015.02.036
  • Pfeffer CM, Singh ATK. Apoptosis: a target for anticancer therapy. Int J Mol Sci. 2018;19(2):448. doi:10.3390/ijms19020448
  • Chung S-H, Franceschi S, Lambert P. Estrogen and ERα: culprits in cervical cancer? Trends Endocrinol Metab. 2010;21(8):504–511. doi:10.1016/j.tem.2010.03.005
  • Baker R, Dauner JG, Rodriguez AC, et al. Increased plasma levels of adipokines and inflammatory markers in older women with persistent HPV infection. Cytokine. 2011;53(3):282–285. doi:10.1016/j.cyto.2010.11.014
  • Lee DY, Lee TS. Associations between metabolic syndrome and gynecologic cancer. Obstet Gynecol Sci. 2020;63(3):215–224. doi:10.5468/ogs.2020.63.3.215
  • Cowey S, Hardy R. The metabolic syndrome: a high-risk state for cancer? Am J Pathol. 2006;169(5):1505–1522. doi:10.2353/ajpath.2006.051090
  • Raju K, Punnayanapalya SS, Mariyappa N, Eshwarappa SM, Anjaneya C, Kai LJ. Significance of the plasma lipid profile in cases of carcinoma of cervix: a tertiary hospital based study. Asian Pac J Cancer Prev. 2014;15(8):3779–3784. doi:10.7314/APJCP.2014.15.8.3779
  • Tulinius H, Sigfússon N, Sigvaldason H, Bjarnadóttir K, Tryggvadottir L. Risk factors for malignant diseases: a cohort study on a population of 22,946 Icelanders. Cancer Epidemiol. 1997;6(11):863–873.
  • Sun Y, Meng H, Jin Y, et al. Serum lipid profile in gynecologic tumors: a retrospective clinical study of 1550 patients. Eu J Gynaecol Oncol. 2016;37(3):348–352.
  • Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X. Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J National Cancer Inst. 1999;91(2):151–156. doi:10.1093/jnci/91.2.151
  • S-H O, Lee O-H, Schroeder CP, et al. Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor–independent urokinase-type plasminogen activator inhibition. Mol Cancer Ther. 2006;5(11):2685–2695. doi:10.1158/1535-7163.MCT-06-0142
  • Pollak MN, Schernhammer ES, Hankinson SE. Insulin-like growth factors and neoplasia. Nat Rev Cancer. 2004;4(7):505–518. doi:10.1038/nrc1387
  • Kuhn H, Bräunlich J, Hammerschmidt S, Wirtz H. Candidate genes upregulated in density dependent growth inhibition of lung cancer cells. Int j Oncol. 2004;25(5):1481–1487.
  • Han J-Y, Choi BG, Choi JY, Lee SY, Ju SY. The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer. 2006;54(2):227–234. doi:10.1016/j.lungcan.2006.07.014
  • Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor I and risk of breast cancer. Lancet. 1998;351(9113):1393–1396. doi:10.1016/S0140-6736(97)10384-1
  • Chen B, Liu S, Xu W, Wang X, Zhao W, Wu J. IGF-I and IGFBP-3 and the risk of lung cancer: a meta-analysis based on nested case-control studies. J Exp Clin Cancer Res. 2009;28:1–6. doi:10.1186/1756-9966-28-89
  • Adachi Y, Nojima M, Mori M, et al. Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study. Tumor Biol. 2016;37:15125–15132. doi:10.1007/s13277-016-5360-z
  • Le HT, Lee HJ, Cho J, et al. Insulin-like growth factor binding protein-3 exerts its anti-metastatic effect in aerodigestive tract cancers by disrupting the protein stability of vimentin. Cancers. 2021;13(5):1041. doi:10.3390/cancers13051041
  • Luo Q, Shi W, Dou B, et al. XBP1-IGFBP3 signaling pathway promotes NSCLC invasion and metastasis. Front Oncol. 2021;11:654995. doi:10.3389/fonc.2021.654995
  • Luo -L-L, Zhao L, Wang Y-X, et al. Insulin-like growth factor binding protein-3 is a new predictor of radiosensitivity on esophageal squamous cell carcinoma. Sci Rep. 2015;5(1):17336. doi:10.1038/srep17336
  • Cheung SC, Long X, Liu L, et al. Inhibition of human MCF-7 breast cancer cells and HT-29 colon cancer cells by rice-produced recombinant human insulin-like growth binding protein-3 (rhIGFBP-3). PLoS One. 2013;8(10):e77516. doi:10.1371/journal.pone.0077516
  • Kuhn H, Frille A, Petersen MA, et al. IGFBP3 inhibits tumor growth and invasion of lung cancer cells and is associated with improved survival in lung cancer patients. Transl Oncol. 2023;27:101566. doi:10.1016/j.tranon.2022.101566
  • Friedrich N, Haring R, Nauck M, et al. Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J Clin Endocrinol Metab. 2009;94(5):1732–1739. doi:10.1210/jc.2008-2138
  • Gomez J-M, Mourot B, Fostier A, Le Gac F. Growth hormone receptors in ovary and liver during gametogenesis in female rainbow trout (Oncorhynchus mykiss). Reproduction. 1999;115(2):275–285. doi:10.1530/jrf.0.1150275
  • Hoyo C, Grubber J, Demark-Wahnefried W, et al. Predictors of variation in serum IGFI and IGFBP3 levels in healthy African American and white men. J Natl Med Assoc. 2009;101(7):711–716. doi:10.1016/S0027-9684(15)30981-0
  • Ssedyabane F, Ngonzi J, Kajabwangu R, Najjuma JN, Tusubira D, Randall TC. Association between obesity and cervical intraepithelial neoplasia: results from a case control study in south western Uganda. BMC Women’s Health. 2023;23(1):1–8. doi:10.1186/s12905-023-02315-1
  • Dassonville O, Formento J, Francoual M, et al. Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. J clin oncol. 1993;11(10):1873–1878. doi:10.1200/JCO.1993.11.10.1873
  • Gillani SW, Zaghloul HA, Ansari IA, et al. Multivariate analysis on the effects of diabetes and related clinical parameters on cervical cancer survival probability. Sci Rep. 2019;9(1):1084. doi:10.1038/s41598-018-37694-1
  • Harding JL, Sooriyakumaran M, Anstey KJ, et al. Hypertension, antihypertensive treatment and cancer incidence and mortality: a pooled collaborative analysis of 12 Australian and New Zealand cohorts. J Hypertens. 2016;34(1):149–155. doi:10.1097/HJH.0000000000000770
  • Dirat B, Bochet L, Dabek M, et al. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 2011;71(7):2455–2465. doi:10.1158/0008-5472.CAN-10-3323
  • Bochet L, Lehuédé C, Dauvillier S, et al. Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. Cancer Res. 2013;73(18):5657–5668. doi:10.1158/0008-5472.CAN-13-0530
  • Lin F, Zheng R, Yu C, Su Y, Yan X, Qu F. Predictive role of serum cholesterol and triglycerides in cervical cancer survival. Int J Gynecologic Cancer. 2021;31(2):171–176. doi:10.1136/ijgc-2020-001333
  • Porta C, Marino A, Consonni FM, et al. Metabolic influence on the differentiation of suppressive myeloid cells in cancer. Carcinogenesis. 2018;39(9):1095–1104. doi:10.1093/carcin/bgy088
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. cell. 2011;144(5):646–674. doi:10.1016/j.cell.2011.02.013
  • Allott EH, Howard LE, Cooperberg MR, et al. Serum lipid profile and risk of prostate cancer recurrence: results from the SEARCH database. Cancer Epidemiol Biomarkers Prev. 2014;23(11):2349–2356. doi:10.1158/1055-9965.EPI-14-0458
  • Lofterød T, Mortensen ES, Nalwoga H, et al. Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes. BMC Cancer. 2018;18:1–11. doi:10.1186/s12885-018-4568-2
  • Vernieri C, Pusceddu S, Fucà G, et al. Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs). Int J Cancer. 2019;144(7):1704–1712. doi:10.1002/ijc.32042
  • Solomon KR, Freeman MR. The complex interplay between cholesterol and prostate malignancy. Urol Clin. 2011;38(3):243–259. doi:10.1016/j.ucl.2011.04.001
  • Bogani G, Sopracordevole F, Ciavattini A, et al. Duration of human papillomavirus persistence and its relationship with recurrent cervical dysplasia. Eur J Cancer Prev. 2023;32(6):525–532. doi:10.1097/CEJ.0000000000000822