Polypharmacy, Medication-Related Burden and Antiretroviral Therapy Adherence in People Living with HIV Aged 50 and Above: A Cross-Sectional Study in Hunan, China

References

• Trickey A, May MT, Vehreschild J-J, et al. Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. Lancet HIV. 2017;4(8):e349–e356. doi:10.1016/S2352-3018(17)30066-8
   PubMed Web of Science ®Google Scholar
• UNAIDS. AIDSinfo | UNAIDS Global data on HIV epidemiology and response; 2021.
   Google Scholar
• Smit M, Brinkman K, Geerlings S, et al. Future challenges for clinical care of an ageing population infected with HIV: a modelling study. Lancet Infect Dis. 2015;15(7):810–818. doi:10.1016/S1473-3099(15)00056-0
   PubMed Web of Science ®Google Scholar
• Qiao YC, Xu Y, Jiang DX, et al. Epidemiological analyses of regional and age differences of HIV/AIDS prevalence in China, 2004–2016. Int J Infect Dis. 2019;81:215–220. doi:10.1016/j.ijid.2019.02.016
   PubMed Web of Science ®Google Scholar
• Leng SX, Margolick JB. Aging, sex, inflammation, frailty, and CMV and HIV infections. Cell Immunol. 2020;348:104024. doi:10.1016/j.cellimm.2019.104024
   PubMed Web of Science ®Google Scholar
• Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230. doi:10.1186/s12877-017-0621-2
   PubMed Web of Science ®Google Scholar
• Freedman SF, Johnston C, Faragon JJ, Siegler EL, Del CT. Older HIV-infected adults. Complex patients (III): polypharmacy. Eur Geriatr Med. 2019;10(2):199–211. doi:10.1007/s41999-018-0139-y
   PubMed Web of Science ®Google Scholar
• Ssonko M, Stanaway F, Mayanja HK, et al. Polypharmacy among HIV positive older adults on anti-retroviral therapy attending an urban clinic in Uganda. BMC Geriatr. 2018;18(1):125. doi:10.1186/s12877-018-0817-0
   PubMed Web of Science ®Google Scholar
• Bastida C, Grau A, Márquez M, et al. Polypharmacy and potential drug-drug interactions in an HIV-infected elderly population. Farm Hosp. 2017;41(5):618–624. doi:10.7399/fh.10778
   PubMed Web of Science ®Google Scholar
• Chen R, Chen J, Tang Q, et al. Use of comedications and potential drug-drug interactions in people living with HIV in China. J Infect Chemother. 2020;26(7):722–728. doi:10.1016/j.jiac.2020.04.003
   PubMed Web of Science ®Google Scholar
• Awad A, Alhadab A, Albassam A. Medication-related burden and medication adherence among geriatric patients in Kuwait: a cross-sectional study. Front Pharmacol. 2020;11:1296. doi:10.3389/fphar.2020.01296
   PubMed Web of Science ®Google Scholar
• Hogg RS. Understanding the HIV care continuum. Lancet HIV. 2018;5(6):e269–e270. doi:10.1016/S2352-3018(18)30102-4
   PubMed Web of Science ®Google Scholar
• Su BB, Ma JX, Song W, Yuan J, Dong XY, Wan J. Analysis of comorbidity and polypharmacy in middle-aged and elderly patients. Natl Med J China. 2020;100(25):1983–1987.
   Google Scholar
• Jiménez Z, Sánchez-Conde M, Brañas F. HIV infection as a cause of accelerated aging and frailty. Rev Esp Geriatr Gerontol. 2018;53(2):105–110. doi:10.1016/j.regg.2017.04.007
   PubMedGoogle Scholar
• Dan L. World AIDS day was staged by Hunan Government; 2019.
   Google Scholar
• Sun Q. Medical statistics. B, Renwei Building, No.19 panjiayuan Nanli, Chaoyang District, Beijing: People’s Medical Publishing House; 2014.
   Google Scholar
• Katusiime B, Corlett SA, Krska J. Development and validation of a revised instrument to measure burden of long-term medicines use: the Living with Medicines Questionnaire version 3. Patient Relat Outcome Meas. 2018;9:155–168. doi:10.2147/PROM.S151143
   PubMed Web of Science ®Google Scholar
• Wang Y. Cross-Cultural Adaptation and Application of Chinese Version of the Living with Medicines Questionnaire in Elderly Patients with Chronic Diseases [master]. Zhengzhou University; 2020.
   Google Scholar
• Mannheimer SB, Mukherjee R, Hirschhorn LR, et al. The CASE adherence index: a novel method for measuring adherence to antiretroviral therapy. Aids Care. 2006;18(7):853–861. doi:10.1080/09540120500465160
   PubMed Web of Science ®Google Scholar
• Morowatisharifabad MA, Movahed E, Farokhzadian J, et al. Antiretroviral therapy adherence based on information, motivation, and behavioral skills model and its association with depression among HIV-positive patients: health promotion strategy towards the 909090 target. J Educ Health Promot. 2019;8:192. doi:10.4103/jehp.jehp_42_19
   PubMedGoogle Scholar
• Guaraldi G, Milic J, Mussini C. Aging with HIV. Curr HIV/AIDS Rep. 2019;16(6):475–481. doi:10.1007/s11904-019-00464-3
   PubMed Web of Science ®Google Scholar
• Bertrand L, Velichkovska M, Toborek M. Cerebral vascular toxicity of antiretroviral therapy. J Neuroimmune Pharmacol. 2021;16(1):74–89. doi:10.1007/s11481-019-09858-x
   PubMed Web of Science ®Google Scholar
• Bulsara SM, Wainberg ML, Rogers K, McAloon J, Grove R, Newton-John T. The role of comorbidity on retention in HIV care. Aids Behav. 2021;25(5):1532–1541. doi:10.1007/s10461-020-02992-1
   PubMed Web of Science ®Google Scholar
• Harmon JL, McGee KS. Addressing polypharmacy in older adults living with HIV. J Assoc Nurses AIDS Care. 2019;30(1):73–79. doi:10.1097/JNC.0000000000000028
   PubMed Web of Science ®Google Scholar
• Womack JA, Murphy TE, Rentsch CT, et al. Polypharmacy, hazardous alcohol and illicit substance use, and serious falls among PLWH and uninfected comparators. J Acquir Immune Defic Syndr. 2019;82(3):305–313. doi:10.1097/QAI.0000000000002130
   PubMed Web of Science ®Google Scholar
• Niikawa H, Okamura T, Ito K, et al. Association between polypharmacy and cognitive impairment in an elderly Japanese population residing in an urban community. Geriatr Gerontol Int. 2017;17(9):1286–1293. doi:10.1111/ggi.12862
   PubMed Web of Science ®Google Scholar
• Halloran MO, Boyle C, Kehoe B, et al. Polypharmacy and drug-drug interactions in older and younger people living with HIV: the POPPY study. Antivir Ther. 2019;24(3):193–201. doi:10.3851/IMP3293
   PubMed Web of Science ®Google Scholar
• Wang Y, Li X, Jia D, et al. Exploring polypharmacy burden among elderly patients with chronic diseases in Chinese community: a cross-sectional study. BMC Geriatr. 2021;21(1):308. doi:10.1186/s12877-021-02247-1
   PubMed Web of Science ®Google Scholar
• Tordoff JM, Brenkley C, Krska J, Smith A. Exploring medicines burden among adults in New Zealand: a cross-sectional survey. Patient Prefer Adherence. 2019;13:2171–2184. doi:10.2147/PPA.S231202
   PubMed Web of Science ®Google Scholar
• Demain S, Gonçalves AC, Areia C, et al. Living with, managing and minimising treatment burden in long term conditions: a systematic review of qualitative research. PLoS One. 2015;10(5):e125457. doi:10.1371/journal.pone.0125457
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang F, Wu T, et al. polypharmacy and related factors in elderly patients with functional dyspepsia. Chin J Health Stat. 2021;38(03):432–435.
   Google Scholar
• Eton DT, Ramalho DOD, Egginton JS, et al. Building a measurement framework of burden of treatment in complex patients with chronic conditions: a qualitative study. Patient Relat Outcome Meas. 2012;3:39–49. doi:10.2147/PROM.S34681
   PubMedGoogle Scholar
• Zidan A, Awaisu A, El-Hajj MS, Al-Abdulla SA, Figueroa D, Kheir KN. Medication-related burden among patients with chronic disease conditions: perspectives of patients attending non-communicable disease clinics in a primary healthcare setting in Qatar. Pharmacy. 2018;6(3). doi:10.3390/pharmacy6030085
   Web of Science ®Google Scholar
• Haugstvedt A, Wentzel-Larsen T, Rokne B, Graue M. Perceived family burden and emotional distress: similarities and differences between mothers and fathers of children with type 1 diabetes in a population-based study. Pediatr Diabetes. 2011;12(2):107–114. doi:10.1111/j.1399-5448.2010.00661.x
   PubMed Web of Science ®Google Scholar
• Zou XZ. Discussion on chronic diseases management from perspective of medical insurance. Med Soc. 2018;31(02):42–44.
   Google Scholar
• Ye H, Wen J, Zheng J. Analysis of chronic disease long prescription in Shanghai based on the stakeholders theory. Chin Hosp. 2016;20(04):52–54.
   Google Scholar
• Krska J, Corlett SA, Katusiime B. Complexity of medicine regimens and patient perception of medicine burden. Pharmacy. 2019;7(1). doi:10.3390/pharmacy7010018
   Web of Science ®Google Scholar
• Chapman RH, Petrilla AA, Benner JS, Schwartz JS, Tang SS. Predictors of adherence to concomitant antihypertensive and lipid-lowering medications in older adults: a retrospective, cohort study. Drugs Aging. 2008;25(10):885–892. doi:10.2165/00002512-200825100-00008
   PubMed Web of Science ®Google Scholar
• Gray SL, Mahoney JE, Blough DK. Medication adherence in elderly patients receiving home health services following hospital discharge. Ann Pharmacother. 2001;35(5):539–545. doi:10.1345/aph.10295
   PubMed Web of Science ®Google Scholar
• Zolnierek KB, Dimatteo MR. Physician communication and patient adherence to treatment: a meta-analysis. Med Care. 2009;47(8):826–834. doi:10.1097/MLR.0b013e31819a5acc
   PubMed Web of Science ®Google Scholar
• Edmonds KA, Aspiras OG, Rose JP, et al. Cross-sectional evaluation of perceived health care provider engagement, self-efficacy, and ART adherence in people living with HIV/AIDS. Aids Care. 2021;33(2):154–158. doi:10.1080/09540121.2019.1703889
   PubMed Web of Science ®Google Scholar
• Becker N, Poudel KC, Cordeiro LS, Sayer AG, Sibiya TE, Sibeko LN. A quantitative analysis of food insecurity and other barriers associated with ART nonadherence among women in rural communities of Eswatini. PLoS One. 2021;16(8):e256277. doi:10.1371/journal.pone.0256277
   Web of Science ®Google Scholar