Advanced search
Publication Cover
Patient Preference and Adherence Volume 17, 2023 - Issue
Submit an article Journal homepage
148
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Awareness of HBV Functional Cure and Attitude Toward Related Clinical Trials Among Patients with Chronic Hepatitis B in China

Zhongping Duan1 Fourth Department of Hepatology Center, Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China
,
Jinling Dong1 Fourth Department of Hepatology Center, Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China
,
Ying Liu2 iGandan, the Portal for All Liver Disease Caring, Beijing, People’s Republic of China
,
Haiyang Zhou2 iGandan, the Portal for All Liver Disease Caring, Beijing, People’s Republic of China
,
Shuli Duan2 iGandan, the Portal for All Liver Disease Caring, Beijing, People’s Republic of China
,
Weihong Liu3 Brii Biosciences Inc., Beijing, People’s Republic of China
,
Rico Liang3 Brii Biosciences Inc., Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0009-0005-1934-9119
ORCID Icon &
Yue Ding3 Brii Biosciences Inc., Beijing, People’s Republic of China
 show all
Pages 2063-2072 | Received 25 May 2023, Accepted 11 Aug 2023, Published online: 22 Aug 2023

References

  • GBD 2019 Hepatitis B Collaborators. Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet Gastroenterol Hepatol. 2022;7(9):796–829.
  • Lee MH, Yang HI, Liu J, et al. Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles. Hepatology. 2013;58(2):546–554. doi:10.1002/hep.26385
  • Yip TC, Wong GL, Chan HL, et al. HBsAg seroclearance further reduces hepatocellular carcinoma risk after complete viral suppression with nucleos(t)ide analogues. J Hepatol. 2019;70(3):361–370. doi:10.1016/j.jhep.2018.10.014
  • Anderson RT, Choi HSJ, Lenz O, et al. Association between seroclearance of hepatitis B surface antigen and long-term clinical outcomes of patients with chronic hepatitis B virus infection: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2021;19(3):463–472. doi:10.1016/j.cgh.2020.05.041
  • Marcellin P, Wong DK, Sievert W, et al. Ten-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B virus infection. Liver Int. 2019;39(10):1868–1875. doi:10.1111/liv.14155
  • Hou J, Ning Q, Duan Z, et al. 3-year Treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for chronic HBV infection in China. J Clin Transl Hepatol. 2021;9(3):324–334. doi:10.14218/JCTH.2020.00145
  • Hou J, Wang G, Wang F, et al. Guideline of prevention and treatment for chronic hepatitis B (2015 update). J Clin Transl Hepatol. 2017;5(4):297–318. doi:10.14218/JCTH.2016.00019
  • Lok AS, Zoulim F, Dusheiko G, Ghany MG. Hepatitis B cure: from discovery to regulatory approval. Hepatology. 2017;66(4):1296–1313. doi:10.1002/hep.29323
  • Cornberg M, Lok AS, Terrault NA, Zoulim F; The 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty. Guidance for design and endpoints of clinical trials in chronic hepatitis B - report from the 2019 EASL-AASLD HBV treatment endpoints conference. J Hepatol. 2020;72(3):539–557. doi:10.1016/j.jhep.2019.11.003
  • Jeng WJ, Lok ASF. What will it take to cure hepatitis B? Hepatol Commun. 2023;7(4):e0084. doi:10.1097/HC9.0000000000000084
  • Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association. Guidelines for the prevention and treatment of chronic hepatitis B (version 2022). Chin J Hepatol. 2022;30(12):1309–1331.
  • Yip TC, Lai MS, Hui VM, et al. Similar risk of hepatocellular carcinoma in non-cirrhotic patients who archived HBsAg seroclearance before the age of 50 and the general population. Poster presented at: Annual Meeting of Asian Pacific Association for the Study of the Liver; February 15–19; 2023; Taipei.
  • Im YR, Jagdish R, Leith D, et al. Prevalence of occult hepatitis B virus infection in adults: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2022;7(10):932–942. doi:10.1016/S2468-1253(22)00201-1
  • Ning Q, Han M, Sun Y, et al. Switching from entecavir to pegIFN alfa-2a in patients with HBeAg-positive chronic hepatitis B: a randomised open-label trial (OSST trial). J Hepatol. 2014;61(4):777–784. doi:10.1016/j.jhep.2014.05.044
  • Hu P, Shang J, Zhang W, et al. HBsAg loss with peg-interferon alfa-2a in hepatitis B patients with partial response to nucleos(t)ide analog: new switch study. J Clin Transl Hepatol. 2018;6(1):25–34. doi:10.14218/JCTH.2017.00072
  • Ning Q, Wu D, Wang GQ, et al. Roadmap to functional cure of chronic hepatitis B: an expert consensus. J Viral Hepat. 2019;26(10):1146–1155. doi:10.1111/jvh.13126
  • Gan W. Functional cure based on pegylated interferon α-2b therapy in nucleoside analog-suppressed HBeAg negative chronic hepatitis B: a multicenter real-world study (Everest Project in China) – 4 year data update. Presented at: Annual Meeting of American Association for the Study of Liver Diseases; November 6; 2022; Washington, DC.
  • Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560–1599. doi:10.1002/hep.29800
  • Lampertico P, Agarwal K, Berg T; European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370–398. doi:10.1016/j.jhep.2017.03.021
  • Sarin SK, Kumar M, Lau GK, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int. 2016;10(1):1–98. doi:10.1007/s12072-015-9675-4

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.