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Review

The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review

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Pages 185-200 | Published online: 30 Jul 2014

References

  • CaspiAMoffittTEGene-environment interactions in psychiatry: joining forces with neuroscienceNat Rev Neurosci20067758359016791147
  • BelskyJJonassaintCPluessMStantonMBrummettBWilliamsRVulnerability genes or plasticity genes?Mol Psychiatry200914874675419455150
  • BelskyJPluessMBeyond diathesis stress: differential susceptibility to environmental influencesPsychol Bull2009135688590819883141
  • van IjzendoornMHBelskyJBakermans-KranenburgMJSerotonin transporter genotype 5 HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studiesTransl Psychiatry20122e14722872162
  • BeaverKMNedelecJLWildeMLippoffCJacksonDExamining the association between MAOA genotype and incarceration, anger and hostility: The moderating influences of risk and protective factorsJ Res Pers2011453279284
  • ScarrSMccartneyKHow people make their own environments: a theory of genotype greater than environment effectsChild Dev19835424244356683622
  • O’ConnorTGDeater-DeckardKFulkerDRutterMPlominRGenotype-environment correlations in late childhood and early adolescence: antisocial behavioral problems and coercive parentingDev Psychol19983459709819779743
  • JohnsonWPenkeLSpinathFMHeritability in the era of molecular genetics: some thoughts for understanding genetic influences on behavioural traitsEur J Pers2011254254266
  • RutterMBiological implications of gene-environment interactionJ Abnorm Child Psychol200836796997518642072
  • PlominRBergemanCSThe nature of nurture: genetic influence on “environmental” measuresBehav Brain Sci1991143373386
  • Gallardo-PujolDPeredaNPerson-environment transactions: personality traits moderate and mediate the effects of child sexual victimization on psychopathologyPersonal Ment Health20137210211324343936
  • ZiermansTDumontheilIRoggemanCWorking memory brain activity and capacity link MAOA polymorphism to aggressive behavior during developmentTransl Psychiatry20122e8522832821
  • WakschlagLSKistnerEOPineDSInteraction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behaviorMol Psychiatry201015992893719255579
  • KnafoAIsraelSEbsteinRPHeritability of children’s prosocial behavior and differential susceptibility to parenting by variation in the dopamine receptor D4 geneDev Psychopathol2011231536721262039
  • CaspiASugdenKMoffittTEInfluence of life stress on depression: moderation by a polymorphism in the 5 -HTT geneScience2003301563138638912869766
  • CaspiAMcClayJMoffittTERole of genotype in the cycle of violence in maltreated childrenScience2002297558285185412161658
  • QianQJLiuJWangYFYangLGuanLLFaraoneSVAttention Deficit Hyperactivity Disorder comorbid oppositional defiant disorder and its predominately inattentive type: evidence for an association with COMT but not MAOA in a Chinese sampleBehav Brain Funct20095819228412
  • LangleyKTuricDRiceFTesting for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behaviorAm J Med Genet B Neuropsychiatr Genet2008147B1495317579368
  • LiDShamPCOwenMJHeLMeta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD)Hum Mol Genet200615142276228416774975
  • GorwoodPLe StratYRamozNDubertretCMoalicJMSimonneauMGenetics of dopamine receptors and drug addictionHum Genet2012131680382222350797
  • CaspiAMoffittTECannonMModeration of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interactionBiol Psychiatry200557101117112715866551
  • Priess-GrobenHAHydeJS5-HTTLPR X stress in adolescent depression: moderation by MAOA and genderJ Abnorm Child Psychol201341228129422836288
  • ReifARöslerMFreitagCMNature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environmentNeuropsychopharmacology200732112375238317342170
  • MartinezDBroftALaruelleMImaging neurochemical endophenotypes: promises and pitfallsPharmacogenomics20012322323711535111
  • BarnettJHScorielsLMunafòMRMeta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphismBiol Psychiatry200864213714418339359
  • GottesmanIIGouldTDThe endophenotype concept in psychiatry: etymology and strategic intentionsAm J Psychiatry2003160463664512668349
  • MoffittTECaspiARutterMStrategy for investigating interactions between measured genes and measured environmentsArch Gen Psychiatry200562547348115867100
  • Van IjzendoornMHBakermans-KranenburgMJDifferential susceptibility experiments: going beyond correlational evidence: comment on beyond mental health, differential susceptibility articlesDev Psychol201248376977422545852
  • BrunnerHGNelenMBreakefieldXORopersHHvan OostBAAbnormal behavior associated with a point mutation in the structural gene for monoamine oxidase AScience199326251335785808211186
  • PitonAPoquetHRedinC20 ans après: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognitionEur J Hum Genet201422677678324169519
  • SabolSZHuSHamerDA functional polymorphism in the monoamine oxidase A gene promoterHum Genet199810332732799799080
  • TaylorAKim-CohenJMeta-analysis of gene-environment interactions in developmental psychopathologyDev Psychopathol20071941029103717931432
  • NilssonKWSjöbergRLWargeliusHLLeppertJLindströmLOrelandLThe monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumptionAddiction2007102338939817298646
  • DucciFEnochMAHodgkinsonCInteraction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult womenMol Psychiatry200813333434717592478
  • SjöbergRLDucciFBarrCSA non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behaviorNeuropsychopharmacology200833242543017429405
  • EnochMASteerCDNewmanTKGibsonNGoldmanDEarly life stress, MAOA, and gene-environment interactions predict behavioral disinhibition in childrenGenes Brain Behav201091657419804559
  • AslundCNordquistNComascoELeppertJOrelandLNilssonKWMaltreatment, MAOA, and delinquency: sex differences in gene-environment interaction in a large population-based cohort of adolescentsBehav Genet201141226227220734127
  • FergussonDMBodenJMHorwoodLJMillerALKennedyMAMAOA, abuse exposure and antisocial behaviour: 30-year longitudinal studyBr J Psychiatry2011198645746321628708
  • NilssonKWComascoEÅslundCNordquistNLeppertJOrelandLMAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumptionAddict Biol201116234735520731636
  • RetiIMXuJZYanofskiJMonoamine oxidase A regulates antisocial personality in whites with no history of physical abuseCompr Psychiatry201152218819421295226
  • CicchettiDRogoschFAThibodeauELThe effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genesDev Psychopathol201224390792822781862
  • FergussonDMBodenJMHorwoodLJMillerAKennedyMAModerating role of the MAOA genotype in antisocial behaviourBr J Psychiatry2012200211612322297589
  • SimonsRLLeiMKStewartEASocial adversity, genetic variation, street code, and aggression: a geneticlly informed model of violent behaviorYouth Violence Juv Justice201210132423785260
  • HillJBreenGQuinnJTibuFSharpHPicklesAEvidence for interplay between genes and maternal stress in utero: monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5 weeksGenes Brain Behav201312438839623480342
  • HartDMarmorsteinNRNeighborhoods and genes and everything in between: understanding adolescent aggression in social and biological contextsDev Psychopathol200921396197319583892
  • VerhoevenFEBooijLKruijtAWCeritHAntypaNDoesWThe effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggressionBrain Behav20122680681323170243
  • SadehNJavdaniSVeronaEAnalysis of monoaminergic genes, childhood abuse, and dimensions of psychopathyJ Abnorm Psychol2013122116717922985017
  • HaberstickBCLessemJMHewittJKMAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviorsBiol Psychiatry2014751253023726513
  • PrichardZMackinnonAJormAFEastealSNo evidence for interaction between MAOA and childhood adversity for antisocial behaviorAm J Med Genet B Neuropsychiatr Genet2008147B222823218023041
  • Va n der VegtEJOostraBAArias-VásquezAvan der EndeJVerhulstFCTiemeierHHigh activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adopteesPsychiatr Genet200919420921119398936
  • LeeSSDeviant peer affiliation and antisocial behavior: interaction with monoamine oxidase A (MAOA) genotypeJ Abnorm Child Psychol201139332133221152968
  • NikulinaVWidomCSBrzustowiczLMChild abuse and neglect, MAOA, and mental health outcomes: a prospective examinationBiol Psychiatry201271435035722030358
  • VanyukovMMMaherBSDevlinBThe MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interactionPsychiatr Genet200717632333218075472
  • SjöbergRLNilssonKWWargeliusHLLeppertJLindströmLOrelandLAdolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factorsAm J Med Genet B Neuropsychiatr Genet2007144B215916417034017
  • KinnallyELHuangYYHaverlyRParental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult womenPsychiatr Genet200919312613319357553
  • Prom-WormleyECEavesLJFoleyDLMonoamine oxidase A and childhood adversity as risk factors for conduct disorder in femalesPsychol Med200939457959018752729
  • PardiniMKruegerFHodgkinsonCPrefrontal cortex lesions and MAO-A modulate aggression in penetrating traumatic brain injuryNeurolog y2011761210381045
  • MonroeSMReidMWGene-environment interactions in depression research: genetic polymorphisms and life-stress polyproceduresPsychol Sci2008191094795619000200
  • LeaRChambersGMonoamine oxidase, addiction, and the “warrior” gene hypothesisN Z Med J20071201250U244117339897
  • KimHSShermanDKMojaverianTGene–culture interaction: oxytocin receptor polymorphism (OXTR) and emotion regulationSoc Psychol Personal Sci201126665672
  • ChiaoJYBlizinskyKDCulture-gene coevolution of individualism-collectivism and the serotonin transporter geneProc Biol Sci2010277168152953719864286
  • GuoGOuXMRoettgerMShihJCThe VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activityEur J Hum Genet200816562663418212819
  • BeaverKMWrightJPBoutwellBBBarnesJCDelisiMVaughnMGExploring the association between the 2-repeat allele of the MAOA gene promoter polymorphism and psychopathic personality traits, arrests, incarceration, and lifetime antisocial behaviorPers Individ Dif2013542164168
  • EmeRMale life-course-persistent antisocial behavior: the most important pediatric mental health problemArch Pediatr Adolesc Med2010164548648720439801
  • LiJJLeeSLatent class analysis of antisocial behavior: interaction of serotonin transporter genotype and maltreatmentJ Abnorm Child Psychol201038678980120405199
  • TikkanenRAuvinen-LintunenLDucciFPsychopathy, PCL-R, and MAOA genotype as predictors of violent reconvictionsPsychiatry Res2011185338238620850185
  • McDermottRTingleyDCowdenJFrazzettoGJohnsonDDMonoamine oxidase A gene (MAOA) predicts behavioral aggression following provocationProc Natl Acad Sci U S A200910672118212319168625
  • KuepperYGrantPWielpuetzCHennigJMAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocationBehav Brain Res2013247737823499704
  • WilliamsKDOstracism: The kiss of social deathSoc Personal Psychol Compass200711236247
  • Gallardo-PujolDAndrés-PueyoAMaydeu-OlivaresAMAOA genotype, social exclusion and aggression: an experimental test of a gene-environment interactionGenes Brain Behav201312114014523067570
  • EisenbergerNIWayBMTaylorSEWelchWTLiebermanMDUnderstanding genetic risk for aggression: clues from the brain’s response to social exclusionBiol Psychiatry20076191100110817137563
  • Alia-KleinNGoldsteinRZKriplaniABrain monoamine oxidase A activity predicts trait aggressionJ Neurosci200828195099510418463263
  • FowlerJSAlia-KleinNKriplaniAEvidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjectsBiol Psychiatry200762435535817141746
  • Meyer-LindenbergABuckholtzJWKolachanaBNeural mechanisms of genetic risk for impulsivity and violence in humansProc Natl Acad Sci U S A2006103166269627416569698
  • HuizingaDHaberstickBCSmolenAChildhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotypeBiol Psychiatry200660767768317008143
  • BuckholtzJWMeyer-LindenbergAMAOA and the neurogenetic architecture of human aggressionTrends Neurosci200831312012918258310
  • BuckholtzJWCallicottJHKolachanaBGenetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personalityMol Psychiatry200813331332417519928
  • DukeAABègueLBellREisenlohr-MoulTRevisiting the serotonin-aggression relation in humans: a meta-analysisPsychol Bull201313951148117223379963
  • AharoniEVincentGMHarenskiCLNeuroprediction of future rearrestProc Natl Acad Sci U S A2013110156223622823536303
  • NadelhofferTBibasSGraftonSNeuroprediction, violence, and the law: setting the stageNeuroethics201051679925083168
  • WeitzelJNBlazerKRMacdonaldDJCulverJOOffitKGenetics, genomics, and cancer risk assessment: state of the art and future directions in the era of personalized medicineCA Cancer J Clin Epub8192011
  • MoffittTEThe new look of behavioral genetics in developmental psychopathology: gene-environment interplay in antisocial behaviorsPsychol Bull2005131453355416060801
  • RutterMPlominRPathways from science findings to health benefitsPsychol Med200939452954218700990
  • UherRThe implications of gene-environment interactions in depression: will cause inform cure?Mol Psychiatry200813121070107818679406
  • UherRGenes, environment, and individual differences in responding to treatment for depressionHarv Rev Psychiatry201119310912421631158
  • CollinsFHas the revolution arrived?Nature2010464728967467520360716
  • LesterKJEleyTCTherapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disordersBiol Mood Anxiety Disord201331423388219
  • ReifARichterJStraubeBMAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapyMol Psychiatry201419112212823319006
  • CicchettiDRogoschFAGene × Environment interaction and resilience: effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genesDev Psychopathol201224241142722559122
  • CicchettiDRogoschFATothSLThe effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacyDev Psychopathol201123235737223786683
  • MunafòMRClarkTGMooreLRPayneEWaltonRFlintJGenetic polymorphisms and personality in healthy adults: a systematic review and meta-analysisMol Psychiatry20038547148412808427
  • BernetWVnencak-JonesCLFarahanyNMontgomerySABad nature, bad nurture, and testimony regarding MAOA and SLC6A4 genotyping at murder trialsJ Forensic Sci20075261362137117944904
  • FeresinELighter Sentence for Murderer with “Bad Genes.”London, UKNature Publishing Group2014 Available from: http://www.nature.com/news/2009/091030/full/news.2009.1050.htmlAccessed May 28, 2014
  • PioroMMykitiukRFinklerLNiskerJUnderstanding the use of “genetic predisposition” in canadian legal decisionsMcGill J Law Heal201371165
  • FarahanyNAColemanJEJrGenetics and responsibility: to know the criminal from the crimeLaw Contemp Probl200669115164
  • BaumMLThe monoamine oxidase A (MAOA) genetic predisposition to impulsive violence: is it relevant to criminal trials?Neuroethics201162287306
  • HungCFLungFWHungTHMonoamine oxidase A gene polymorphism and suicide: an association study and meta-analysisJ Affect Disord2012136364364922041522
  • CaspiAHoutsRMBelskyDWThe p Factor: one general psychopathology factor in the structure of psychiatric disorders?Clin Psychol Sci201322119137
  • van IjzendoornMHBelskyJBakermans-KranenburgMJSerotonin transporter genotype 5HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studiesTransl Psychiatry20122e14722872162
  • KinnallyELHuangYHaverlyRParental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult womenPsychiatr Genet200919312613319357553
  • WederNYangBZDouglas-PalumberiHMAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of traumaBiol Psychiatry200965541742418996506
  • GrayNSSnowdenRJMacCullochSPhillipsHTaylorJMacCullochMJRelative efficacy of criminological, clinical, and personality measures of future risk of offending in mentally disordered offenders: a comparative study of HCR-20, PCL:SV, and OGRSJ Consult Clin Psychol200472352353015279535
  • HudsonJLLesterKJLewisCMPredicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical informationJ Child Psychol Psychiatry201354101086109423772677
  • DoehrmannOGhoshSSPolliFEPredicting treatment response in social anxiety disorder from functional magnetic resonance imagingJAMA Psychiatry2013701879722945462
  • LesterKJEleyTCTherapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disordersBiol Mood Anxiety Disord201331423388219
  • EbsteinRPThe molecular genetic architecture of human personality: beyond self-report questionnairesMol Psychiatry200611542744516534505
  • NilssonKWWargeliusH-LSjöbergRLLeppertJOrelandLThe MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviourDrug Alcohol Depend2008931–2516218029114
  • BeachSRBrodyGHGunterTDPackerHWernettPPhilibertRAChild maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorderJ Fam Psychol2010241122020175604
  • DerringerJKruegerRFIronsDEIaconoWGHarsh discipline, childhood sexual assault, and MAOA genotype: an investigation of main and interactive effects on diverse clinical externalizing outcomesBehav Genet201040563964820364435
  • EdwardsACDodgeKALatendresseSJMAOA-uVNTR and early physical discipline interact to influence delinquent behaviorJ Child Psychol Psychiatry201051667968719951362
  • McGrathLMMustanskiBMetzgerAA latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotypeArch Womens Ment Health201215426928222610759
  • WilliamsLMGattJMKuanSAA polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial indexNeuropsychopharmacology20093471797180919194374