180
Views
3
CrossRef citations to date
0
Altmetric
Review

Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability

Pages 97-107 | Published online: 08 Jun 2015

References

  • LebwohlMTopical application of calcipotriene and corticosteroids: combination regimensJ Am Acad Dermatol1997373 pt 2S55S589344186
  • ReichKBewleyAWhat is new in topical therapy for psoriasis?J Eur Acad Dermatol Venereol201125Suppl 4152021507079
  • MasonARMasonJCorkMDooleyGHancockHTopical treatments for chronic plaque psoriasisCochrane Database Syst Rev20133CD005028
  • FlemingCGanslandtCGuentherLCalcipotriol plus betamethasone dipropionate gel compared with its active components in the same vehicle and the vehicle alone in the treatment of psoriasis vulgaris: a randomised, parallel group, double-blind, exploratory studyEur J Dermatol201020446547120413372
  • WhiteSVenderRThaçiDUse of calcipotriene cream (Dovonex cream) following acute treatment of psoriasis vulgaris with the calcipotriene/betamethasone dipropionate two-compound product (Taclonex): a randomized, parallel-group clinical trialAm J Clin Dermatol20067317718416734505
  • GuentherLVan de KerkhofPCSnellmanEEfficacy and safety of a new combination of calcipotriol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: a randomized, double-blind, vehicle-controlled clinical trialBr J Dermatol2002147231632312174105
  • KaufmannRBibbyAJBissonnetteRA New Calcipotriol/Betamethasone Dipropionate Formulation (Daivobet(TM)) Is an Effective Once-Daily Treatment for Psoriasis vulgarisDermatology2002205438939312444337
  • LangleyRGuptaAPappKWexlerDØsterdalMCurčićDCalcipotriol plus Betamethasone Dipropionate Gel Compared with Tacalcitol Ointment and the Gel Vehicle Alone in Patients with Psoriasis Vulgaris: A Randomized, Controlled Clinical TrialDermatology2011222214815621293107
  • CarrascosaJMVanaclochaFBorregoLRevisión actualizada del tratamiento tópico de la psoriasis. [Update of the topical treatment of psoriasis]Actas dermo-sifiliográficas2009100319020019457304
  • BottomleyJMTaylorRSRyttovJThe effectiveness of two-compound formulation calcipotriol and betamethasone dipropionate gel in the treatment of moderately severe scalp psoriasis: a systematic review of direct and indirect evidenceCurr Med Res Opin201127125126821142838
  • GirolomoniGVenaGAAyalaFConsensus on the use of the fixed combination calcipotriol/betamethasone dipropionate in the treatment of plaque psoriasisG Ital Dermatol Venereol2012147660962423149707
  • KragballeKAustadJBarnesLA 52-week randomized safety study of a calcipotriol/betamethasone dipropionate two-compound product (Dovobet/Daivobet/Taclonex) in the treatment of psoriasis vulgarisBr J Dermatol200615461155116016704648
  • LugerTACambazardFLarsenFGA study of the safety and efficacy of calcipotriol and betamethasone dipropionate scalp formulation in the long-term management of scalp psoriasisDermatology2008217432132818787325
  • GuentherLCFixed-dose combination therapy for psoriasisAm J Clin Dermatol200452717715109271
  • KragballeKvan de KerkhofPPooled safety analysis of calcipotriol plus betamethasone dipropionate gel for the treatment of psoriasis on the body and scalpJ Eur Acad Dermatol Venereol201428Suppl 2102124684739
  • McCormackPLCalcipotriol/betamethasone dipropionate: a review of its use in the treatment of psoriasis vulgaris of the trunk, limbs and scalpDrugs201171670973021504248
  • World Health OrganizationAdherence to Long-Term Therapies: Evidence for ActionSwitzerlandWorld Health Organization2003
  • GuentherLCTreatments for scalp psoriasis with emphasis on calcipotriol plus betamethasone dipropionate gel (Xamiol)Skin Therapy Lett200914414
  • ClareusBWHouwingRSindrupJHWigchertSThe DESIRE study – psoriasis patients’ satisfaction with topical treatment using a fixed combination of calcipotriol and betamethasone dipropionate in daily clinical practiceEur J Dermatol200919658158519726275
  • OrtonneJPGanslandtCTanJNordinPKragballeKSegaertSQuality of life in patients with scalp psoriasis treated with calcipotriol/betamethasone dipropionate scalp formulation: a randomized controlled trialJ Eur Acad Dermatol Venereol200923891992619453810
  • SaracenoRCamploneGD’AgostinoMEfficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol(R) gel) in the treatment of scalp psoriasis: results from a study in 885 patientsJ Dermatolog Treat2014251303323621170
  • SticherlingMEickeCAngerTPracticability of combined treatment with calcipotriol/betamethasone gel (Daivobet(R) Gel) and improvement of quality of life in patients with psoriasisJ Dtsch Dermatol Ges201311542042723437972
  • van de KerkhofPCMThe impact of a two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet/Dovobet) on the quality of life in patients with psoriasis vulgaris: a randomized controlled trialBr J Dermatol2004151366366815377355
  • SaracenoRAndreassiLAyalaFEfficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet) versus calcipotriol (Daivonex) in the treatment of psoriasis vulgaris: a randomized, multicentre, clinical trialJ Dermatolog Treat200718636136517934937
  • AugustinMMrowietzUBonnekohBTopical long-term therapy of psoriasis with vitamin D(3) analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practiceJ Dtsch Dermatol Ges2014128667682
  • AugustinMRadtkeMvan EngenARuedigCLappCMoehlingUPharmacoeconomic model of topical treatment options of mild to moderate psoriasis vulgaris in GermanyJ Dtsch Dermatol Ges20097432933819243481
  • GamoRLópez-EstebaranzJLTerapia biológica y psoriasis. [Biologic therapy and psoriasis]Actas dermo-sifiliográficas200697111716540046
  • PuigLCarrascosaJMCarreteroGSpanish Psoriasis Group of the Spanish Academy of Dermatology and VenereologySpanish evidence-based guidelines on the treatment of psoriasis with biologic agents, 2013. Part 1: on efficacy and choice of treatment. Spanish Psoriasis Group of the Spanish Academy of Dermatology and VenereologyActas dermo-sifiliográficas2013104869470924018211
  • ThaçiDOrtonneJPChimentiSA phase IIIb, multicentre, randomized, double-blind, vehicle-controlled study of the efficacy and safety of adalimumab with and without calcipotriol/betamethasone topical treatment in patients with moderate to severe psoriasis: the BELIEVE studyBr J Dermatol2010163240241120377585
  • KircikLHTopical calcipotriene 0.005% and betamethasone dipropionate 0.064% maintains efficacy of etanercept after step-down dose in patients with moderate-to-severe plaque psoriasis: results of an open label trialJ Drugs Dermatol201110887888221818509
  • VenaGAGalluccioAPezzaMVestitaMCassanoNCombined treatment with low-dose cyclosporine and calcipotriol/betamethasone dipropionate ointment for moderate-to-severe plaque psoriasis: a randomized controlled open-label studyJ Dermatolog Treat201223425526021756153
  • LinYKSeeLCHuangYHEfficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: a randomized, observer-blind, vehicle-controlled trialPhytomedicine20142171015102024680615
  • ZhangLBaiYSongPYouLYangDEffect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome typeChin J Integr Med200915214114419407953
  • ZhouNBaiYPManXHEffect of new Pulian ointment in treating psoriasis of blood-heat syndrome: a randomized controlled trialChin J Integr Med200915640941420082244
  • WenZHXuanMLYanYHChinese medicine combined with calcipotriol betamethasone and calcipotriol ointment for psoriasis vulgaris (CMCBCOP): study protocol for a randomized controlled trialTrials20141529425052161
  • BagelJLeviETyringSKnucklesMLReal-life treatment profile of calcipotriene and betamethasone dipropionate topical suspension in patients with psoriasis vulgarisJ Drugs Dermatol201413111374137925607705
  • BovenschenHJErcegAvan Vlijmen-WillemsIvan de KerkhofPCSeygerMMPulsed dye laser versus treatment with calcipotriol/betamethasone dipropionate for localized refractory plaque psoriasis: effects on T-cell infiltration, epidermal proliferation and keratinizationJ Dermatolog Treat2007181323917365265
  • Calzavara-PintonPRossiMTSalaRVenturiniMThe separate daily application of tacalcitol 4 microg/g ointment and budesonide 0.25 mg/g cream is more effective than the single daily application of a two compound ointment containing calcipotriol 50 microg/g and betamethasone dipropionate 0.5 mg/gG Ital Dermatol Venereol2011146429529921785396
  • CassanoNMiracapilloACovielloCLoconsoleFBellinoMVenaGATreatment of psoriasis vulgaris with the two-compound product calcipotriol/betamethasone dipropionate followed by different formulations of calcipotriolClin Drug Investig2006264227233
  • CassanoNVenaGATreatment of scalp psoriasis with betamethasone dipropionate and calcipotriol two-compound productActa Derm Venereol2007871858617225026
  • EichenfieldLFGanslandtCKurvitsMSchlessingerJSafety and efficacy of calcipotriene plus betamethasone dipropionate topical suspension in the treatment of extensive scalp psoriasis in adolescents ages 12 to 17 yearsPediatr Dermatol2015321283525412565
  • GooderhamMDebarreJKeddy-GrantJXuZKurvitsMGoodfieldMSafety and efficacy of calcipotriol plus betamethasone dipropionate gel in the treatment of scalp psoriasis in adolescents 12–17 years of ageBr J Dermatol201417161470147724980277
  • JemecGBEvan de KerkhofPCMEnevoldAGanslandtCSignificant one week efficacy of a calcipotriol plus betamethasone dipropionate scalp formulationJ Eur Acad Dermatol Venereol2011251273220456557
  • JemecGBGanslandtCOrtonneJA new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trialJ Am Acad Dermatol200859345546318694678
  • KragballeKAustadJBarnesLEfficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgarisDermatology2006213431932617135738
  • KragballeKHoffmannVOrtonneJPTanJNordinPSegaertSEfficacy and safety of calcipotriol plus betamethasone dipropionate scalp formulation compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized controlled trialBr J Dermatol2009161115916619416259
  • KragballeKNoerrelundKLLuiHEfficacy of once-daily treatment regimens with calcipotriol/betamethasone dipropionate ointment and calcipotriol ointment in psoriasis vulgarisBr J Dermatol200415061167117315214905
  • LambertJHolCWVinkJReal-life effectiveness of once-daily calcipotriol and betamethasone dipropionate gel vs ointment formulations in psoriasis vulgaris: 4- and 12-week interim results from the PRO-long studyJ Eur Acad Dermatol Venereol201428121723173124533503
  • OrtonneJKaufmannRLechaMGoodfieldMEfficacy of treatment with calcipotriol/betamethasone dipropionate followed by calcipotriol alone compared with tacalcitol for the treatment of psoriasis vulgaris: a randomised, double-blind trialDermatology2004209430831315539894
  • PappKAGuentherLBoydenBEarly onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasisJ Am Acad Dermatol2003481485412522370
  • Queille-RousselCHoffmannVGanslandtCHansenKKComparison of the antipsoriatic effect and tolerability of calcipotriol-containing products in the treatment of psoriasis vulgaris using a modified psoriasis plaque testClin Drug Investig2012329613619
  • ReichKZschockeIBachelezHEfficacy of a fixed combination of calcipotriol/betamethasone dipropionate topical gel in adult patients with mild to moderate psoriasis: blinded interim analysis of a phase IV, multicenter, randomized, controlled, prospective studyJ Eur Acad Dermatol Venereol Epub20141026
  • TyringSMendozaNAppellMA calcipotriene/betamethasone dipropionate two-compound scalp formulation in the treatment of scalp psoriasis in Hispanic/Latino and Black/African American patients: results of the randomized, 8-week, double-blind phase of a clinical trialInt J Dermatol201049111328133320964660
  • van de KerkhofPCMHoffmannVAnsteyAA new scalp formulation of calcipotriol plus betamethasone dipropionate compared with each of its active ingredients in the same vehicle for the treatment of scalp psoriasis: a randomized, double-blind, controlled trialBr J Dermatol2009160117017619067709
  • van GeelMJMulKOostveenAMvan de KerkhofPCMde JongEMGJSeygerMMBCalcipotriol/betamethasone dipropionate ointment in mild-to-moderate paediatric psoriasis: long-term daily clinical practice data in a prospective cohortBr J Dermatol2014171236336924593129
  • AffleckAGBottomleyJMAulandMJacksonPRyttovJCost effectiveness of the two-compound formulation calcipotriol and betamethasone dipropionate gel in the treatment of scalp psoriasis in ScotlandCurr Med Res Opin201127126928421142836
  • AnsteyAVKragballeKRetrospective assessment of PASI 50 and PASI 75 attainment with a calcipotriol/betamethasone dipropionate ointmentInt J Dermatol200645897097516911387
  • BalkrishnanRBhosleMJFleischerABFeldmanSRPrior authorization for topical psoriasis treatments: is it cost-beneficial for managed care?J Dermatolog Treat201021317818419821787
  • BottomleyJMAulandMEMoraisJBoydGDouglasWSCost-effectiveness of the two-compound formulation calcipotriol and betamethasone dipropionate compared with commonly used topical treatments in the management of moderately severe plaque psoriasis in ScotlandCurr Med Res Opin20072381887190117610804
  • FentonCPloskerGLCalcipotriol/betamethasone dipropionate: a review of its use in the treatment of psoriasis vulgarisAm J Clin Dermatol20045646347815663344
  • FreemanKMarumMBottomleyJMAulandMJacksonPRyttovJA psoriasis-specific model to support decision making in practice – UK experienceCurr Med Res Opin201127120522321142835
  • KragballeKvan de KerkhofPCMConsistency of data in six phase III clinical studies of a two-compound product containing calcipotriol and betamethasone dipropionate ointment for the treatment of psoriasisJ Eur Acad Dermatol Venereol2006201394416405606
  • McCormackPLSpotlight on calcipotriene/betamethasone dipropionate in psoriasis vulgaris of the trunk, limbs, and scalpAm J Clin Dermatol201112642142421967117
  • MurphyGReichKIn touch with psoriasis: topical treatments and current guidelinesJ Eur Acad Dermatol Venereol201125Suppl 43821507077
  • NeriLMiracapilloATreatment adherence and real-life effectiveness of topical therapy in patients with mild or moderate psoriasis: uptake of scientific evidence in clinical practice and dermatologists’ preferences for alternative treatment optionsG Ital Dermatol Venereol20151501192625521808
  • ParslewRTraulsenJEfficacy and local safety of a calcipotriol/betamethasone dipropionate ointment in elderly patients with psoriasis vulgarisEur J Dermatol2005151373915701591
  • SegaertSDuvoldLBCalcipotriol cream: a review of its use in the management of psoriasisJ Dermatolog Treat200617632733717853305
  • ShepherdJTaheriAFeldmanSROnce-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulationClin Cosmet Investig Dermatol201371922
  • VakirlisEKastanisAIoannidesDCalcipotriol/betamethasone dipropionate in the treatment of psoriasis vulgarisTher Clin Risk Manag20084114114818728704
  • van de KerkhofPCMWaselNKragballeKCambazardFMurraySA two-compound product containing calcipotriol and betamethasone dipropionate provides rapid, effective treatment of psoriasis vulgaris regardless of baseline disease severityDermatology2005210429429915942215
  • van de KerkhofPde PeuterRRyttovJJansenJPMixed treatment comparison of a two-compound formulation (TCF) product containing calcipotriol and betamethasone dipropionate with other topical treatments in psoriasis vulgarisCurr Med Res Opin201127122523821142833