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ORIGINAL RESEARCH

Evaluation of Serum NLRC4 as a Potential Prognostic Biochemical Marker in Humans with Severe Traumatic Brain Injury: A Prospective Cohort Study

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Pages 439-454 | Received 14 Jan 2023, Accepted 15 Mar 2023, Published online: 23 Mar 2023

References

  • Stocchetti N, Carbonara M, Citerio G, et al. Severe traumatic brain injury: targeted management in the intensive care unit. Lancet Neurol. 2017;16(6):452–464. doi:10.1016/S1474-4422(17)30118-7
  • Geeraerts T, Velly L, Abdennour L, et al. Management of severe traumatic brain injury (first 24hours). Anaesth Crit Care Pain Med. 2018;37(2):171–186. doi:10.1016/j.accpm.2017.12.001
  • Kowalski RG, Hammond FM, Weintraub AH, et al. Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury. JAMA Neurol. 2021;78(5):548–557. doi:10.1001/jamaneurol.2021.0084
  • Capizzi A, Woo J, Verduzco-Gutierrez M. Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management. Med Clin North Am. 2020;104(2):213–238. doi:10.1016/j.mcna.2019.11.001
  • Rakhit S, Nordness MF, Lombardo SR, Cook M, Smith L, Patel MB. Management and challenges of severe traumatic brain injury. Semin Respir Crit Care Med. 2021;42(1):127–144. doi:10.1055/s-0040-1716493
  • Wang KK, Yang Z, Zhu T, et al. An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert Rev Mol Diagn. 2018;18(2):165–180. doi:10.1080/14737159.2018.1428089
  • Posti JP, Tenovuo O. Blood-based biomarkers and traumatic brain injury-A clinical perspective. Acta Neurol Scand. 2022;146(4):389–399. doi:10.1111/ane.13620
  • Sulhan S, Lyon KA, Shapiro LA, Huang JH. Neuroinflammation and blood-brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets. J Neurosci Res. 2020;98(1):19–28. doi:10.1002/jnr.24331
  • Kursun O, Yemisci M, van den Maagdenberg AMJM, Karatas H. Migraine and neuroinflammation: the inflammasome perspective. J Headache Pain. 2021;22(1):55. doi:10.1186/s10194-021-01271-1
  • Mason DR, Beck PL, Muruve DA. Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases. J Innate Immun. 2012;4(1):16–30. doi:10.1159/000334247
  • Duncan JA, Canna SW. The NLRC4 Inflammasome. Immunol Rev. 2018;281(1):115–123. doi:10.1111/imr.12607
  • Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214(5):1351–1370. doi:10.1084/jem.20150237
  • Gan H, Zhang L, Chen H, et al. The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats. Exp Mol Med. 2021;53(11):1807–1818. doi:10.1038/s12276-021-00702-y
  • Poh L, Kang SW, Baik SH, et al. Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke. Brain Behav Immun. 2019;75:34–47. doi:10.1016/j.bbi.2018.09.001
  • Yan XJ, Li YB, Liu W, Wu HY, Yu GF. Elevated serum complement C1q levels after traumatic brain injury and its association with poor prognosis. Neuropsychiatr Dis Treat. 2022;18:47–55. doi:10.2147/NDT.S348682
  • Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol. 2016;16(7):407–420. doi:10.1038/nri.2016.58
  • Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–687. doi:10.1038/nm.3893
  • Lünemann JD, Malhotra S, Shinohara ML, Montalban X, Comabella M. Targeting Inflammasomes to treat neurological diseases. Ann Neurol. 2021;90(2):177–188. doi:10.1002/ana.26158
  • Sundaram B, Kanneganti TD. Advances in understanding activation and function of the NLRC4 inflammasome. Int J Mol Sci. 2021;22(3):1048. doi:10.3390/ijms22031048
  • Jin P, Qi D, Cui Y, et al. Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage. J Neuroinflammation. 2022;19(1):198. doi:10.1186/s12974-022-02558-z
  • Zhang X, Huang T, Lang L, Yu L. Effects of lysophosphatidic acid receptor 5 on NLRC4 inflammasome in brain tissues of transient cerebral ischemia/reperfusion rat. Hum Exp Toxicol. 2022;41:9603271221078870. doi:10.1177/09603271221078870
  • Habib P, Harms J, Zendedel A, Beyer C, Slowik A. Gonadal hormones E2 and P mitigate cerebral ischemia-induced upregulation of the AIM2 and NLRC4 inflammasomes in rats. Int J Mol Sci. 2020;21(13):4795. doi:10.3390/ijms21134795
  • Ding W, Cai C, Zhu X, Wang J, Jiang Q. Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation. Int Immunopharmacol. 2022;108:108913. doi:10.1016/j.intimp.2022.108913