Hospitalization Costs for Patients with Acute Appendicitis: An Update Using Real-World Data from a Large Province in China

References

• Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015;386(10000):1278–1287. doi:10.1016/S0140-6736(15)00275-5
   PubMed Web of Science ®Google Scholar
• Wickramasinghe D, Xavier C, Samarasekera D. The worldwide epidemiology of acute appendicitis: an analysis of the global health data exchange dataset. World J Surg. 2021;45. doi:10.1007/s00268-021-06077-5
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca A Cancer J Clinicians. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis: a systematic review of population-based studies. Ann Surg. 2017;266(2):237–241. doi:10.1097/SLA.0000000000002188
   PubMed Web of Science ®Google Scholar
• Ilves I, Fagerström A, Herzig KH, Juvonen P, Miettinen P, Paajanen H. Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland. World J Gastroenterol. 2014;20(14):4037–4042. doi:10.3748/wjg.v20.i14.4037
   PubMed Web of Science ®Google Scholar
• Viniol A, Keunecke C, Biroga T, et al. Studies of the symptom abdominal pain--A systematic review and meta-analysis. Fam Pract. 2014;31(5):517–529. doi:10.1093/fampra/cmu036
   PubMed Web of Science ®Google Scholar
• Baird DL, Simillis C, Kontovounisios C, Rasheed S, Tekkis PP. Acute appendicitis. BMJ. 2017;357:j1703.
   PubMedGoogle Scholar
• Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15(1):27. doi:10.1186/s13017-020-00306-3
   PubMed Web of Science ®Google Scholar
• Sceats LA, Trickey AW, Morris AM, Kin C, Staudenmayer KL. Nonoperative management of uncomplicated appendicitis among privately insured patients. JAMA Surg. 2019;154(2):141–149. doi:10.1001/jamasurg.2018.4282
   PubMed Web of Science ®Google Scholar
• Song X, Lan L, Zhou T, Yin J, Meng Q. Economic Burden of Major Diseases in China in 2013. Front Public Health. 2021;9:649624. doi:10.3389/fpubh.2021.649624
   PubMed Web of Science ®Google Scholar
• Walędziak M, Lasek A, Wysocki M, et al. Risk factors for serious morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy - results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study. Sci Rep. 2019;9(1):14793. doi:10.1038/s41598-019-51172-2
   PubMedGoogle Scholar
• Malhotra L, Pontarelli EM, Grinberg GG, Isaacs RS, Morris JP, Yenumula PR. Cost analysis of laparoscopic appendectomy in a large integrated healthcare system. Surg Endosc. 2022;36(1):800–807. doi:10.1007/s00464-020-08266-0
   PubMed Web of Science ®Google Scholar
• de Wijkerslooth Elisabeth ML, Wijnhoven WB. Disease burden of appendectomy for appendicitis: a population-based cohort study. Surg Endosc. 2020;34(1):116–125. doi:10.1007/s00464-019-06738-6
   PubMed Web of Science ®Google Scholar
• Sugiura K, Suzuki K, Umeyama T, Omagari K, Hashimoto T, Tamura A. Cost-effectiveness analysis of initial nonoperative management versus emergency laparoscopic appendectomy for acute complicated appendicitis. BMC Health Serv Res. 2020;20(1):1019. doi:10.1186/s12913-020-05839-6
   PubMed Web of Science ®Google Scholar
• Biondi A, Di Stefano C, Ferrara F, Bellia A, Vacante M, Piazza L. Laparoscopic versus open appendectomy: a retrospective cohort study assessing outcomes and cost-effectiveness. World J Emerg Surg. 2016;11(1):44. doi:10.1186/s13017-016-0102-5
   PubMedGoogle Scholar
• Buitrago G, Junca E, Eslava-Schmalbach J, Caycedo R, Pinillos P, Leal LC. Clinical outcomes and healthcare costs associated with laparoscopic appendectomy in a middle-income country with universal health coverage. World J Surg. 2019;43(1):67–74. doi:10.1007/s00268-018-4777-5
   PubMed Web of Science ®Google Scholar
• Alves VHR, Guimarães NM, Soares BS, Ruiz LM, Martins Filho J, Silva RCDD. Cost-benefit analysis of surgical appendectomy in the brazilian public health system. RSD. 2022;11(11):e359111133315. doi:10.33448/rsd-v11i11.33315
   Google Scholar
• Carrillo montenegro AF, Aristizabal Rojas S, Pulido Segura JA, et al. Single incision laparoscopic appendectomy with surgical-glove port is cost-effective and reliable in complicated acute appendicitis: a casecontrol multicenter study in Colombia. Heliyon. 2023;9(1):e12972. doi:10.1016/j.heliyon.2023.e12972
   PubMed Web of Science ®Google Scholar
• De Almeida Leite RM, Seo DJ, Gomez-Eslava B, et al. Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis. JAMA Surg. 2022;157(9):828. doi:10.1001/jamasurg.2022.2937
   PubMed Web of Science ®Google Scholar
• Clement KD, Emslie K, Maniam P, Wilson MSJ. What is the operative cost of managing acute appendicitis in the NHS: the impact of stump technique and perioperative imaging. World J Surg. 2020;44(3):749–754. doi:10.1007/s00268-019-05306-2
   PubMed Web of Science ®Google Scholar
• Rogers EB, Davenport DL, Parrish J, Bernard AC. Variability in hospital costs for short stay emergent laparoscopic appendectomy. Surg Open Sci. 2022;10:223–227. doi:10.1016/j.sopen.2022.10.007
   PubMedGoogle Scholar
• Kim KH, Lee SC, Lee SK, Choi BJ, Jeong W, Kim SJ. Does Korea’s current diagnosis-related group-based reimbursement system appropriately classify appendectomy patients? Ann Surg Treat Res. 2016;91(2):66. doi:10.4174/astr.2016.91.2.66
   PubMed Web of Science ®Google Scholar
• Sheng LY, Gao LM, Zhou L. Influencing factors on hospitalization expenses of inpatients with acute appendicitis. Chinese Rural Health Service Administration; 2013. Available from: http://en.cnki.com.cn/Article_en/CJFDTotal-ZNWS201305010.htm. Accessed August 7, 2022.
   Google Scholar
• Wei X, Zou G, Zhang H, et al. Implementation of the Chinese national microscopy centre policy: health facility survey in Shandong Province. Tropical Medicine and International Health. 2011;16(7):847–853. doi:10.1111/j.1365-3156.2011.02769.x
   PubMed Web of Science ®Google Scholar
• Yeh CC, Wu SC, Liao CC, Su LT, Hsieh CH, Li TC. Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study. Surg Endosc. 2011;25(9):2932–2942. doi:10.1007/s00464-011-1645-x
   PubMed Web of Science ®Google Scholar
• Ali A, Mobarak Z, Al-Jumaily M, et al. Cost-utility analysis of antibiotic therapy versus appendicectomy for acute uncomplicated appendicitis. Int J Environ Res Public Health. 2021;18(16):8473. doi:10.3390/ijerph18168473
   PubMed Web of Science ®Google Scholar
• Xue J, Wang H, Li N, et al. Path Analysis of hospitalization expenses of 2164 appendicitis patients at county-level public hospitals in Anhui Province, China. 2020.
   Google Scholar
• Xu Y, Zeng P, Zhao H, Wang K, Bian J, He P. Decision tree model of factors influencing hospitalization costs in patients with acute appendicitis. Chongqing Med. 2015;44(31):4403–4405.
   Google Scholar
• Wang E, Jootun R, Foster A. Management of acute appendicitis in an acute surgical unit: a cost analysis. ANZ J Surg. 2018;88(12):1284–1288. doi:10.1111/ans.14727
   PubMed Web of Science ®Google Scholar
• Wu J, Counihan T, Eko F, Ryb G, Drager L, Goldwater E. Ideal timing of surgery for acute uncomplicated appendicitis. N Am J Med Sci. 2013;5(1):22–27. doi:10.4103/1947-2714.106186
   PubMedGoogle Scholar
• Papandria D, Goldstein SD, Rhee D, et al. Risk of perforation increases with delay in recognition and surgery for acute appendicitis. J Surg Res. 2013;184(2):723–729. doi:10.1016/j.jss.2012.12.008
   PubMed Web of Science ®Google Scholar
• Shakya YR, Shakya S, Napit D, Dahal S, Malla BR. The trend and outcomes of laparoscopic appendectomy for complicated appendicitis in Nepal: a retrospective study from 2014 to 2018 in a University Hospital. Kathmandu Univ Med J. 2019;68(4):306–310.
   Google Scholar
• Ruiz-Patiño A, Rey S, Molina G, Dominguez LC, Rugeles S. Cost-effectiveness of laparoscopic versus open appendectomy in developing nations: a Colombian analysis. J Surg Res. 2018;224:33–37. doi:10.1016/j.jss.2017.11.007
   PubMed Web of Science ®Google Scholar
• Adisa A, Kachapila M, Ekwunife C, et al. A prospective, observational cost comparison of laparoscopic and open appendicectomy in three tertiary hospitals in Nigeria. World J Surg. 2023. doi:10.1007/s00268-023-07148-5
   PubMed Web of Science ®Google Scholar
• Fuentes S, Núñez-Alfonsel J, Pradillos-Serna JM, et al. Quality of life in pediatric minimally invasive surgery: cost-utility analysis of laparoscopic versus open appendectomy. J Laparoendosc Adv Surg Tech. 2022;32(2):219–225. doi:10.1089/lap.2021.0495
   PubMed Web of Science ®Google Scholar
• Di Saverio S, Birindelli A, Kelly MD. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016;11(1). doi:10.1186/s13017-016-0090-5
   Google Scholar
• Jaschinski T, Mosch C, Eikermann M, Neugebauer EA. Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials. BMC Gastroenterol. 2015;15(1). doi:10.1186/s12876-015-0277-3
   PubMedGoogle Scholar
• Yu MC, Feng Y-J, Wang W, Fan W, Cheng H-T, Xu J. Is laparoscopic appendectomy feasible for complicated appendicitis ?A systematic review and meta-analysis. Int J Surg. 2017;40:187–197. doi:10.1016/j.ijsu.2017.03.022
   PubMed Web of Science ®Google Scholar
• Harnoss JC, Zelienka I, Probst P, et al. Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015 CRD42015016882). Ann Surg. 2017;265(5):889–900. doi:10.1097/SLA.0000000000002039
   PubMed Web of Science ®Google Scholar
• Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018;320(12):1259. doi:10.1001/jama.2018.13201
   PubMed Web of Science ®Google Scholar
• Sippola S, Grönroos J, Tuominen R, et al. Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. Br J Surg. 2017;104(10):1355–1361. doi:10.1002/bjs.10575
   PubMed Web of Science ®Google Scholar
• Flum DR, Davidson GH, Monsell SE. A randomized trial comparing antibiotics with Appendectomy for Appendicitis. N Engl J Med. 2020;383(20):1907–1919. doi:10.1056/NEJMoa2014320
   PubMed Web of Science ®Google Scholar
• Wang J, Wang P, Wang X, Zheng Y, Xiao Y. Use and prescription of antibiotics in primary health care settings in China. JAMA Intern Med. 2014;174(12):1914. doi:10.1001/jamainternmed.2014.5214
   PubMed Web of Science ®Google Scholar
• Liu Y, Kong Q, Yuan S, van de Klundert J. Factors influencing choice of health system access level in China: a systematic review. PLoS One. 2018;13(8):e0201887.
   PubMed Web of Science ®Google Scholar
• Li Z, Ma Z. Construction and scale development of willingness to utilize primary care services: a study from China. RMHP. 2023;16:2171–2185. doi:10.2147/RMHP.S428369
   Google Scholar
• Han L, Zeng L, Duan Y, et al. Improving the applicability and feasibility of clinical practice guidelines in primary care: recommendations for guideline development and implementation. RMHP. 2021;14:3473–3482. doi:10.2147/RMHP.S311254
   Google Scholar
• Li X, Krumholz HM, Yip W, et al. Quality of primary health care in China: challenges and recommendations. Lancet. 2020;395(10239):1802–1812. doi:10.1016/S0140-6736(20)30122-7
   PubMed Web of Science ®Google Scholar
• Fan Z. Differences and Predictors of departure ways for discharge patients in Sichuan province based on Hierarchy Medical System. Jiangxi Univ Chin Med. 2020. doi:10.27180/d.cnki.gjxzc.2020.000005
   Google Scholar