Current perspectives on cardioembolic ischemic stroke in very old patients

References

• Russo T, Felzani G, Marini C. Stroke in the very old: a systematic review of studies on incidence, outcome, and resource use. J Aging Res. 2011;2011:108785.
   PubMedGoogle Scholar
• Tabereaux PB, Brass LM, Concato J, Bravata DM. Hospital admissions for stroke among the very old in the USA. Neuroepidemiology. 2008;31:93–99.
   Web of Science ®Google Scholar
• Rojas JI, Zurrú MC, Romano M, Patrucco L, Cristiano E. Acute ischemic stroke and transient ischemic attack in the very old. Risk factors and stroke subtype between patients older than 80 years and patients aged less than 80 years. Eur J Neurol. 2007;14:895–899.
   PubMed Web of Science ®Google Scholar
• Campio EW. The oldest old. N Engl J Med. 1994;330:1819–1820.
   Web of Science ®Google Scholar
• Arboix A, Miguel M, Císcar E, García-Eroles L, Massons J, Balcells M. Cardiovascular risk factors in patients aged 85 or older with ischemic stroke. Clin Neurol Neurosurg. 2006;108:638–643.
   PubMed Web of Science ®Google Scholar
• Arboix A, Alió J. Cardioembolic stroke: an update. Expert Rev Cardiovasc Ther. 2011;9:367–379.
   PubMedGoogle Scholar
• Ferro JM. Cardioembolic stroke: an update. Lancet Neurol. 2003;2:177–188.
   PubMed Web of Science ®Google Scholar
• Bhatnagar P, Sinha D, Parker RA, Guyler P, O’Brien A. Intravenous thrombolysis in acute ischaemic stroke: a systematic review and meta-analysis to aid decision making in patients over 80 years of age. J Neurol Neurosurg Psychiatry. 2011;82:712–717.
   PubMed Web of Science ®Google Scholar
• Olindo S, Cabre P, Deschamps R, et al. Acute stroke in the very elderly. Epidemiological features, stroke subtypes, management, and outcome in Martinique, French West Indies. Stroke. 2003;34:1593–1597.
   PubMed Web of Science ®Google Scholar
• Arboix A, Vall-Llosera A, García-Eroles L, Massons J, Oliveres M, Targa C. Clinical features and functional outcome of intracerebral hemorrhage in patients aged 85 and older. J Am Geriatr Soc. 2002;50:449–454.
   PubMed Web of Science ®Google Scholar
• Sharma JC, Fletcher S, Vassallo M. Strokes in the elderly. Higher acute and 3-month mortality. An explanation. Cerebrovasc Dis. 1999;9:2–9.
   PubMed Web of Science ®Google Scholar
• Bhalla A, Grieve R, Tilling K, Rudd AG, Wolfe CDA. Older stroke patients in Europe: stroke care and determinants of outcome. Age Ageing. 2004;33:618–624.
   PubMed Web of Science ®Google Scholar
• Khoo CW, Lip GYH. Clinical outcomes of acute stroke patients with atrial fibrillation. Expert Rev Neurother. 2009;7:371–374.
   Google Scholar
• Weir NU. An update on cardioembolic stroke. Postgrad Med J. 2008;84:133–142.
   PubMed Web of Science ®Google Scholar
• Ferro JM. Brain embolism. Answers to practical questions. J Neurol. 2003;250:139–147.
   PubMed Web of Science ®Google Scholar
• Hornig CR, Brainin M, Mast H. Cardioembolic stroke: results from three current stroke data banks. Neuroepidemiology. 1994;13:318–323.
   PubMed Web of Science ®Google Scholar
• Doufekias E, Segal AZ, Kizer JR. Cardiogenic and aortogenic brain embolism. J Am Coll Cardiol. 2008;51:1049–1059.
   PubMed Web of Science ®Google Scholar
• Arboix A, Massons J, Garcia-Eroles L, Targa C, Parra O, Oliveres M. Trends in clinical features and early outcome in patients with acute cardieombolic stroke subtype over a 19-year period. Neurol India. 2012;60:288–293.
   Web of Science ®Google Scholar
• Arboix A, Garcia-Eroles L, Comes E, et al. Importance of cardiovascular risk profile for in-hospital mortality due to cerebral infarction. Rev Esp Cardiol. 2008;6:1020–1029.
   Google Scholar
• Arboix A, Garcia-Eroles L, Massons J, Oliveres M, Pujades R, Targa C. Atrial fibrillation and stroke: clinical presentation of cardioembolic versus atherothrombotic infarction. Int J Cardiol. 2000;73:33–42.
   PubMed Web of Science ®Google Scholar
• Murtagh B, Smalling RW. Cardioembolic stroke. Curr Atherosclr Rep. 2006;8:310–316.
   PubMedGoogle Scholar
• Carrera E, Maeder-Ingvar M, Rossetti AO, Devuyst G, Bogousslavsky J. Trends in risk factors, patterns and causes in hospitalized strokes over 25 years: The Lausanne Stroke Registry. Cerebrovasc Dis. 2007;24:97–103.
   Web of Science ®Google Scholar
• Asplund K, Carlberg B, Sundström G. Stroke in the elderly. Observations in a population-based sample of hospitalized patients. Cerebrovasc Dis. 1992;2:152–157.
   Web of Science ®Google Scholar
• Arboix A, Alió J. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev. 2010;6:150–161.
   PubMedGoogle Scholar
• Arboix A, Vericat MC, Pujades R, Massons J, García-Eroles L, Oliveres M. Cardioembolic infarction in The Sagrat Cor-Alianza Hospital of Barcelona Stroke Registry. Acta Neurol Scand. 1997;96:407–412.
   PubMed Web of Science ®Google Scholar
• Zhang L, Harrison JK, Goldstein LB. Echocardiography for the detection of cardiac sources of embolism in patients with stroke or transient ischemic attack. J Stroke Cerebrovasc Dis. 2012;21:577–582.
   Web of Science ®Google Scholar
• Wolf Ph A, Abott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke. 1991;22:983–988.
   Web of Science ®Google Scholar
• The European Stroke Organization (ESO) Executive Committee and the ESO Writing Committee. ESO Guidelines for management of ischaemic stroke 2008. Cerebrovasc Dis. 2008;25:457–507.
   Web of Science ®Google Scholar
• Pujadas RC, Arbox A, Casañas-Muñoz R, Anguera-Ferrando N. Specific cardiac disorders in 402 consecutive patients with ischaemic cardioembolic stroke. Int J Cardiol. 2004;95:129–134.
   PubMed Web of Science ®Google Scholar
• Santamarina E, Penalba A, García Ustrell X, Pellisé A. Cardiac workup of ischemic stroke. Curr Cardiol Rev. 2010;6:175–183.
   Google Scholar
• Sposato LA, Klein FR, Jauregui A, Ferrua M, Klin P, Zamora R, et al. Newly diagnosed atrial fibrilation after acute ischemic stroke and transient ischemic attack: importance of immediate and prolonged continous cardiac monitoring. J Stroke Cerebrovasc Dis. 2012;21:210–216.
   PubMed Web of Science ®Google Scholar
• Young KC, Benesch CG. Transesophageal ecocardiography screening in subjects with a first cerebrovascular ischemic event. J Stroke Cerebrovasc Dis. 2011;20:503–509.
   Web of Science ®Google Scholar
• Montaner J, Perea-Gainza M, Delgado P, et al. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke. 2008;39:2280–2287.
   PubMed Web of Science ®Google Scholar
• Foerch C, Montaner J, Furie KL, Ning MM, Lo EH. Searching for oracles? Blood biomarkers in acute stroke. Neurology. 2009;73:393–399.
   PubMed Web of Science ®Google Scholar
• Arboix A, Oliveres M, Massons J, Pujades R, Garcia-Eroles L. Early differentiation of cardioembolic from atherothrombotic cerebral infarction: a multivariate analysis. Eur J Neurol 1999;6:677–683.
   PubMed Web of Science ®Google Scholar
• Lodder J, Krijne-Kubat B, Broekman J. Cerebral hemorrhagic infarction at autopsy: cardiac embolic cause and the relationship to the cause of death. Stroke. 1986;17:626–629.
   PubMed Web of Science ®Google Scholar
• Caplan LR, Hier DB, D’Cruz I. Cerebral embolism in the Michael Reese stroke Registry. Stroke. 1984;14:530–536.
   Web of Science ®Google Scholar
• Arboix A, García-Eroles L, Massons J, Oliveres M. Predictive clinical factors of in-hospital mortality in 231 consecutive patients with cardioembolic cerebral infarction. Cerebrovasc Dis. 1998;8:8–13.
   PubMed Web of Science ®Google Scholar
• Cerebral Embolism Task Force. Cardiogenic brain embolism. Arch Neurol. 1986;43:71–84.
   PubMed Web of Science ®Google Scholar
• Arboix A, García Eroles L, Oliveres M, Massons JB, Targa C. Clinical predictors of early embolic recurrence in presumed cardioembolic infarction. Cerebrovasc Dis. 1988;8:345–353.
   Google Scholar
• Yamanouchi H, Shimada H, Tomonaga M, Matsushita S. Recurrence of embolic stroke in non-valvular atrial fibrillation (NVAF). An autopsy study. Acta Neurol Scand. 1989;80:123–129.
   PubMed Web of Science ®Google Scholar
• Sacco RL, Shi T, Zamanillo MC, Kargman DE. Predictors of mortality and recurrence after hospitalized cerebral infarction in an urban community: The Northern Manhattan Stroke Study. Neurology. 1994;44:626–634.
   PubMed Web of Science ®Google Scholar
• Sacco RL, Foulkes MA, Mohr JP, Wolf PA, Hier DB, Price TR. Determinants of early recurrence of cerebral infarction. The Stroke Data Bank. Stroke. 1989;20:983–989.
   PubMed Web of Science ®Google Scholar
• Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke registry: analysis of 1.000 consecutive patients with first stroke. Stroke. 1988;19:1083–1092.
   PubMed Web of Science ®Google Scholar
• Syme PD, Byrne AW, Chen R, Devenny R, Forbes JF. Community-based stroke incidence in a Scottish population: the Scottish Borders Stroke Study. Stroke. 2005;36:1837–1843.
   PubMed Web of Science ®Google Scholar
• The Paul Coverdell prototype Registries Writing Group. Acute stroke care in the US. Results from 4 pilot prototypes of The Paul Coverdell National Acute Stroke Registry. Stroke. 2005;36:1232–1240.
   Web of Science ®Google Scholar
• Ghandehari K, Izadi Z. The Khorasan Stroke Registry: results of five-year hospital-based study. Cerebrovasc Dis. 2007;23:132–139.
   PubMed Web of Science ®Google Scholar
• Grau AJ, Weimar C, Buggle F, et al. Risk factors, outcome, and treatment in subtypes of ischemic stroke: The German Stroke Data Bank. Stroke. 2001;32:2559–2599.
   PubMed Web of Science ®Google Scholar
• Benbir G, Uluduz D, Ince B, Bozluolcay M. Atherothrombotic ischemic stroke in patients with atrial fibrillation. Clin Neurol Neurosurg. 2007;109:485–490.
   PubMed Web of Science ®Google Scholar
• Lavy S, Stern S, Melamed E, Cooper G, Keren A, Levy P. Effect of chronic atrial fibrillation on regional cerebral blood flow. Stroke. 1980;11:35–38.
   PubMed Web of Science ®Google Scholar
• Petersen P, Kastrup J, Videbaek R, Boysen G. Cerebral blood flow before and after cardioversion of atrial fibrillation. J Cereb Blood Flow Metab. 1989;9:422–425.
   PubMed Web of Science ®Google Scholar
• Friedman PJ. Atrial fibrillation after stroke in the elderly. Stroke. 1991;22:209–214.
   PubMed Web of Science ®Google Scholar
• Arboix A, García-Plata C, García-Eroles L, et al. Clinical study of 99 patients with pure sensory stroke. J Neurol. 2005;252:156–162.
   PubMed Web of Science ®Google Scholar
• Arboix A, Blanco-Rojas L, Martí-Vilalta JL. Advancements in understanding the mechanisms of symptomatic lacunar ischemic stroke: translation of knowledge to prevention strategies. Expert Rev Neurother. 2014;14:261–276.
   PubMed Web of Science ®Google Scholar
• Arboix A, Font A, Garro C, Comes E, Massons J. Recurrent lacunar infarction following a previous lacunar stroke: a clinical study of 122 patients. J Neurol Neurosurg Psychiatry. 2007;78:1392–1394.
   PubMed Web of Science ®Google Scholar
• Chamorro A, Sacco RL, Mohr JP, et al. Clinical computed tomographic correlations of lacunar infarction in the Stroke Data Bank. Stroke. 1991;22:175–181.
   PubMed Web of Science ®Google Scholar
• The SPS3 Investigators, Benavente OR, Hart RG, et al. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012;367:817–825.
   Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta JL. Presumed cardioembolic lacunar infarcts. Stroke. 1991;23:1841–1842.
   Web of Science ®Google Scholar
• Ay H, Oliveira-Filho J, Buonanno FS, et al. Diffusion-weighted imaging identifies a subset of lacunar infarction associated with embolic source. Stroke. 1999;30:2644–2650.
   Web of Science ®Google Scholar
• Cacciatore A, Russo LS Jr. Lacunar infarction as an embolic complication of cardiac and arch angiography. Stroke. 1991;22:1603–1605.
   PubMed Web of Science ®Google Scholar
• Arboix A, Rexach M, Subirà M, Pujadas R. Complex aortic atheroma plaques: study of 71 patients with lacunar infarcts. Med Clin (Barc). 2012;138:160–164.
   PubMed Web of Science ®Google Scholar
• Kazui S, Levi CR, Jones EF, Quang L, Calafiore P, Donnan GA. Risk factors for lacunar stroke: a case-control transesophageal study. Neurology. 2000;5:1385–1387.
   Google Scholar
• Wessels T, Röttger C, Jauss M, Kaps M, Traupe H, Stolz E. Identification of embolic stroke patterns by diffusion-weighted MRI n clinical defined lacunar stroke syndromes. Stroke. 2005;36:757–761.
   Web of Science ®Google Scholar
• Jung DK, Devuyst G, Maeder P, Bogousslavsy J. Atrial fibrillation with subcortical infarcts. J Neurol Neurosurg Psychiatry. 2001;70:344–349.
   Web of Science ®Google Scholar
• Seifert T, Enzinger C, Storch MK, Pichler G, Niederkorn K, Fazekas F. Acute small subcortical infarctions on diffusion weighted MRI: clinical presentation and aetiology. J Neurol Neurosurg Psychiatry. 2005;76:1520–1524.
   Web of Science ®Google Scholar
• Lodder J, Bamford JM, Sandercock PAG, Jones LN, Warlow CP. Are hypertension or cardiac embolism likely causes of lacunar infarction? Stroke. 1990;21:375–381.
   PubMed Web of Science ®Google Scholar
• Capmany RP, Ibañez MO, Pesquer XJ. Complex atheromatous of the aortic arch in cerebral infarction. Curr Cardiol Rev. 2010;6:184–193.
   PubMedGoogle Scholar
• Macleod MR, Amarenco P, Davis SM, Donnan GA. Atheroma of the aortic arch: an important and poorly recognized factor in the aetiology of stroke. Lancet Neurol. 2004;3:408–414.
   PubMed Web of Science ®Google Scholar
• Sharifkazemi MB, Aslani A, Zamirian M, Moaref AR. Significance of aortic atheroma in elderly patients with ischemic stroke: A hospital-based study and literature review. Clin Neurol Neurosurg. 2007;109:311–316.
   PubMed Web of Science ®Google Scholar
• Jung JM, Kwon JY, Kim HJ, et al. Ischemic lesion burden and characteristics of aortic atheroma. J Stroke Cerebrovasc Dis. 2014;23:278–282.
   Web of Science ®Google Scholar
• Amarenco P, Davis S, Jones EF, et al; for the Aortic Arch Related Cerebral Hazard Trial Investigators. Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques. Stroke. 2014;45:1248–1257.
   PubMed Web of Science ®Google Scholar
• Pujadas R, Arboix A, Anguera N, Rafel J, Sagués F, Casañas R. Mitral annular calcification as a marker of complex aortic atheroma in patients with stroke of uncertain etiology. Echocardiography. 2008;25:124–131.
   PubMed Web of Science ®Google Scholar
• Gaillard N, Deltour S, Vilotijevic B, et al. Detection of paroxysmal atrial fibrillation with transtelephonic EKG in TIA or stroke patients. Neurology. 2010;74:1666–1670.
   PubMed Web of Science ®Google Scholar
• Miller DK, Khan MA, Schultz LR, Simpson JR, Katramados AM, Russman AN, Mitsias PD. Outpatients cardiac telemetry detects a high rate of atrial fibrillation in criptogenetic stroke. J Neurol Sci.2013;174:57–61.
   Google Scholar
• Wann LS, Curtis AB, January CT, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline):a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;123:104–123.
   PubMed Web of Science ®Google Scholar
• Ustrell X, Pellisé A. Cardiac workup of ischemic stroke. Curr Cardiol Rev. 2010;6:175–183.
   PubMedGoogle Scholar
• Serena J, Marti-Fàbregas J, Santamarina E, et al. Recurrent stroke and massive right-to-left shunt: results from the prospective Spanish multicenter (CODICIA) study. Stroke. 2008;39:3131–3136.
   PubMed Web of Science ®Google Scholar
• National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581–1587.
   PubMed Web of Science ®Google Scholar
• IST-3 Collaborative Group, Sandercock P, Wardlaw JM, Lindley RI, et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]):a randomised controlled trial. Lancet. 2012;379:2352–2363.
   PubMed Web of Science ®Google Scholar
• Jauch EC, Saver JL, Adams HP Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870–947.
   PubMed Web of Science ®Google Scholar
• Levine SR, Gorman M. “Telestroke”. The application of telemedicine for stroke. Stroke. 1999;30:464–469.
   PubMed Web of Science ®Google Scholar
• Wahlgren N, Ahmed N, Davalos A, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST):an observational study. Lancet. 2007;369:275–282.
   PubMed Web of Science ®Google Scholar
• Hacke W, Kaste M, Fieschi C, Von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Asutralasian Acute Stroke Study Investigators. Lancet. 1998;325:1245–1251.
   Google Scholar
• Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA. 1999;282:2003–2011.
   PubMed Web of Science ®Google Scholar
• Smith WS, Sung G, Saver J, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the multi MERCI trial. Stroke. 2008;39:1205–1212.
   PubMed Web of Science ®Google Scholar
• Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. 2005;36:1432–1438.
   PubMed Web of Science ®Google Scholar
• Furie KL, Kasner SE, Adams RJ, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack. A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:227–276.
   PubMed Web of Science ®Google Scholar
• von Kummer R, Gerber J. IMS-3, synthesis, and MR rescue: no disaster, but down to earth. Clin Neuroradiol. 2013;23:1–3.
   Web of Science ®Google Scholar
• Arboix A, Garcia-Eroles L, Oliveres M, Targa C, Balcells M, Massons J. Pretreatment with statins improves early outcome in patients with first-ever ischemic stroke: pleiotropic effect of statins or a beneficial effect of hypercholesterolemia? BMC Neurol. 2010;10:47.
   PubMed Web of Science ®Google Scholar
• Molina CA, Chamorro A, Rovira A, et al. REVASCAT: a randomized trial of revascularization with SOLITAIRE FR® device vs best medical therapy in the treatment of acute stroke due to anterior circulation large vessel occlusion presenting within eight-hours of symptom onset. Int J Stroke. 2013; doi:10.1111/ijs.12157.
   Web of Science ®Google Scholar
• Furie KL, Goldstein LB, Albers GW, et al. Oral antithrombotic agents for the prevention of stroke in nonvalvular atrial fibrillation. A Science Advisory for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2012;43:3442–3453.
   PubMed Web of Science ®Google Scholar
• Guia de Diagnòstic i tractament de les Malalties Vasculars Cerebrals. En: Guies Mèdiques oficials de diagnòstic i tractament. 2nd ed. Barcelona: Societat Catalana de Neurologia; 2011.
   Google Scholar
• Andersen KK, Andersen ZJ, Olsen TS. Age- and gender-specific prevalence of cardiovascular risk factors in 40,102 patients with first-ever ischemic stroke: a Nationwide Danish Study. Stroke. 2010;41:2768–2774.
   PubMed Web of Science ®Google Scholar
• Camm AJ, Lip GY, De Caterina R, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J. 2012;33:2719–2747.
   PubMed Web of Science ®Google Scholar
• Cairns JA, Connolly S, McMurtry S, Stephenson M, Talajic M. Canadian Cardiovascular Society atrial fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial fibrillation and flutter. Can J Cardiol. 2011;27(1):74–90.
   PubMed Web of Science ®Google Scholar
• Culeras A, Messé SR, Chaturvedi S, Kase CS, Gronseth G. Summary of evidence-based guideline update: prevention of stroke in nonvalvular atrial fibrillation. Report of the Guideline Subcommittee of the American Academy of Neurology. Neurology. 2014;82(8):716–724.
   Web of Science ®Google Scholar
• Baron TH, Kamath PS, McBane RD. Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med. 2013;368(22):2113–2124.
   PubMed Web of Science ®Google Scholar
• The European Stroke Organisation (ESO) Executive Committee and the ESO Writing Committee. Guidelines for management of ischemic stroke and transient ischemic attack 2008. Cerebrovasc Dis. 2008;25(5):457–507.
   Web of Science ®Google Scholar
• Font MA, Arboix A, Krupinski J. Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke. Curr Cardiol Rev. 2010;6(3):238–244.
   PubMedGoogle Scholar
• Lubitz SA, Yi BA, Ellinor PT. Genetics of atrial fibrillation. Heart Fail Clin. 2010;6(2):239–247.
   Google Scholar
• Luo M, Li J, Lai R, et al. Varainet rs 1906591 on chromosome 4q25 confers increased risk of cardioembolic stroke in Chinese patents. J Clin Neurosci. 2014;21(10):1740–1743.
   Web of Science ®Google Scholar
• Traylor M, Farrall M, Holliday EG, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration):a meta-analysis of genome-wide association studies. Lancet Neurol. 2012;11(11):951–962.
   PubMed Web of Science ®Google Scholar
• Santamarina E, Penalba A, García-Berrocoso T, et al. Biomarker level improves the diagnosis of embolia source in ischemic stroke of unknown origin. J Neurol. 2012;259(12):2538–2545.
   PubMed Web of Science ®Google Scholar