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Review

Analgosedation in neonates: what we know and how we act

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Pages 51-61 | Published online: 21 Nov 2013

References

  • Anand KJ, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl J Med. 1987;317(21):1321–1329.
  • Hohmeister J, Kroll A, Wollgarten-Hadamek I, et al. Cerebral processing of pain in school-aged children with neonatal nociceptive input: an exploratory fMRI study. Pain. 2010;150(2):257–267.
  • Walker SM, Franck LS, Fitzgerald M, Myles J, Stocks J, Marlow N. Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. Pain. 2009; 141(1–2):79–87.
  • Bellieni CV Iantorno L, Perrone S, et al. Even routine painful procedures can be harmful for the newborn. Pain. 2009;147(1–3):128–131.
  • Allegaert K, Tibboel D, van den Anker J. Pharmacological treatment of neonatal pain: in search of a new equipoise. Semin Fetal Neonatal Med. 2013;18(1):42–47.
  • Davidson AJ. Anesthesia and neurotoxicity to the developing brain: the clinical relevance. Paediatr Anaesth. 2011;21(7):716–721.
  • Soriano SG, Anand KJ, Rovnaghi CR, Hickey PR. Of mice and men: should we extrapolate rodent experimental data to the care of human neonates? Anesthesiology. 2005;102(4):866–868.
  • Durrmeyer X, Vutskits L, Anand KJ, Rimensberger PC. Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data. Pediatr Res. 2010;67(2):117–127.
  • Thewissen L, Allegaert K. Analgosedation in neonates: do we still need additional tools after 30 years of clinical research? Arch Dis Child Educ Pract Ed. 2011;96(3):112–118.
  • Johnston CC, Fernandes AM, Campbell-Yeo M. Pain in neonates is different. Pain. 2011;152 Suppl 3:S65–S73.
  • Worley A, Fabrizi L, Boyd S, Slater R. Multi-modal pain measurements in infants. J Neurosci Methods. 2012;205(2):252–257.
  • Fabrizi L, Worley A, Patten D, et al. Electrophysiological measurements and analysis of nociception in human infants. J Vis Exp. 2011;58:3118.
  • Van Dijk M, Ceelie I, Tibboel D. Endpoints in pediatric pain studies. Eur J Clin Pharmacol. 2011;67 Suppl 1:61–66.
  • Allegaert K, Tibboel D. Shouldn’t we reconsider procedural techniques to prevent neonatal pain ? Eur J Pain. 2007;11(8):910–912.
  • Ceelie I, van Dijk M, Bax NM, de Wildt SN, Tibboel D. Does minimal access major surgery in the newborn hurt less? An evaluation of cumulative opioid doses. Eur J Pain. 2011;15(6):615–620.
  • Campbell-Yeo M, Fernandes A, Johnston C. Procedural pain management for neonates using nonpharmacological strategies: part 2: mother-driven interventions. Adv Neonatal Care. 2011;11(5): 312–318.
  • Lago P, Garetti E, Merazzi D, et al. Guidelines for procedural pain in the newborn. Acta Paediatr. 2009;98(6):932–939.
  • Ceelie I, de Wildt SN, de Jong M, Ista E, Tibboel D, van Dijk M. Protocolized post-operative pain management in infants: do we stick to it? Eur J Pain. 2012;16(5):760–766.
  • Carbajal R, Rousset A, Danan C, et al. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008;300(1):60–70.
  • Simons SH, van Dijk M, Anand KS, Roofthooft D, van Lingen RA, Tibboel D. Do we still hurt newborn babies? A prospective study of procedural pain and analgesia in neonates. Arch Pediatr Adolesc Med. 2003;157(11):1058–1064.
  • Lago P, Garetti E, Boccuzzo G, et al. Procedural pain in neonates: the state of the art in the implementation of national guidelines in Italy. Paediatr Anaesth. 2013;23(5):407–414.
  • Lago P, Boccuzzo G, Garetti E, et al. Pain management during invasive procedures at Italian NICUs: has anything changes in the last five years. J Matern Fetal Neonatal Med. 2013;26(3):303–305.
  • Losacco V Cuttini M, Greisen G, et al. Heel blood sampling in European neonatal intensive care units: compliance with pain management guidelines. Arch Dis Child. 2011;96(1):F65–F68.
  • Gradin M, Eriksson M; NeoOpioid Investigators Group. Neonatal pain assessment in Sweden – a fifteen-year follow up. Acta Paediatr. 2011;100(2):204–208.
  • Larsson BA, Tannfeldt G, Lagercrantz H, Olsson GL. Venipuncture in more effective and less painful than heel lancing for blood tests in neonates. Pediatrics. 1998;101(5):882–886.
  • Ogawa S, Ogihara T, Fujiwara E, et al. Venepuncture is preferable to heel lance for blood sampling in term neonates. Arch Dis Child Fetal Neonatal Ed. 2005;90(5):F432–F436.
  • Cordero L, Sananes M, Ayers LW. Mechanically ventilated newborns: a comparison of two airway suctioning regimens. Pediatr Res. 1998;43(Suppl 4):210.
  • Dunbar AE 3rd, Sharek PJ, Mickas NA, et al. Implementation and case-study results of potentially better practices to improve pain management of neonates. Pediatrics. 2006;118 Suppl 2:S87–S94.
  • Cordero L, Sananes M, Ayers LW. A comparison of two airway suctioning frequencies in mechanically ventilated, very-low-birthweight infants. Respir Care. 2001;46(8):783–788.
  • Taylor JE, Hawley G, Flenady V, Woodgate PG. Tracheal suctioning without disconnection in intubated ventilated neonates. Cochrane Database Syst Rev. 2011;12:CD003065.
  • Cone S, Pickler RH, Grap MJ, McGrath J, Wiley PM. Endotracheal suctioning in preterm infants using four-handed versus routine care. J Obstet Gynecol Neonatal Nurs. 2013;42(1):92–104.
  • Gillies D, Spence K. Deep versus shallow suction of endotracheal tubes in ventilated neonates and young infants. Cochrane Database Syst Rev. 2011;7:CD003309.
  • Naughton KA. The combined use of sucrose and nonnutritive sucking for procedural pain in both term and preterm neonates: an integrative review of the literature. Adv Neonatal Care. 2013;13(1):9–19.
  • Carbajal R, Chauvet X, Couderc S, Olivier-Martin M. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates. BMJ 1999;319(7222):1393–1397.
  • Bueno M, Yamada J, Harrison D, et al. A systematic review and metaanalyses of nonsucrose sweet solutions for pain relief in neonates. Pain Res Manag. 2013;18(3):153–161.
  • Stevens B, Yamada J, Lee GY, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2013;1:CD001069.
  • Marin Gabriel MA, Del Rey Hurtado de Mendoza B, Jiménez Figueroa L, et al. Analgesia with breastfeeding in addition to skin-to-skin contact during heel prick. Arch Dis Child Fetal Neonatal Ed. 2013;98(6):F499–F503.
  • Prasopkittikun T, Tilokskulchai F Management of pain form heel stick in neonates: an analysis of research conducted in Thailand. J Perinat Neonat Nurs. 2003;17(4):304–312.
  • Corff KE, Seideman R, Venkataraman PS, Lutes L, Yates B. Facilitated tucking: a nonpharmacologic comfort measure for pain in preterm neonates. J Obstet Gynecol Neonatal Nurs. 1995;24(2):143–147.
  • Fearon I, Kisilevsky BS, Mains SM, Muir DW, Tranmer J. Swaddling after heel lance: age-specific effects on behavioral recovery in preterm infants. J Dev Behav Pediatr. 1997;18(4):222–232.
  • Ward-Larson C, Horn RA, Gosnell F. The efficacy of facilitated tucking for relieving procedural pain of endotracheal suctioning in very low birth weight infants. MCN Am J Matern Child Nurs. 2004;29(3):151–156.
  • Hill S, Engle S, Jorgensen J, Kralik A, Whitman K. Effects of facilitated tucking during routine care of infants born preterm. Pediatr Phys Ther. 2005;17(2):158–163.
  • Axelin A, Salanterä S, Lehtonen L. ‘Facilitated tucking by parents’ in pain management of preterm infants – a randomized crossover trial. Early Hum Dev. 2006;82(4):241–247.
  • Liaw JJ, Yang L, Katherine Wang KW, Chen CM, Chang YC, Yin T. Non-nutritive sucking and facilitated tucking relieve preterm infant pain during heel-stick procedures: a prospective, randomised controlled crossover trial. Int J Nurs Stud. 2012;49(3):300–309.
  • Cignacco EL, Sellam G, Stoffel L, et al. Oral sucrose and ‘facilitated tucking’ for repeated pain relief in preterms: a randomized controlled trial. Pediatrics. 2012;129(2):299–308.
  • Liaw JJ, Yang L, Lee CM, Fan HC, Chang YC, Cheng LP. Effects of combined use of non-nutritive sucking, oral sucrose, and facilitated tucking on infant behavioural states across heel-stick procedures: a prospective, randomised controlled trial. Int J Nurs Stud. 2013;50(7): 883–894.
  • Sundaram B, Shrivatava S, Pandian JS, Singh VP. Facilitated tucking on pain in pre-term newborns during neonatal intensive care: a single blinded randomized controlled cross-over pilot trial. J Pediatr Rehabil Med. 2013;6(1):19–27.
  • Gerull R, Cignacco E, Stoffel L, Sellam G, Nelle M. Physiological parameters after nonpharmacological analgesia in preterm infants: a randomized trial. Acta Paediatr. 2013;102(8):e368–e373.
  • Bellieni CV, Tei M, Coccina F, Buonocore G. Sensorial saturation for infants’ pain. J Matern Fetal Neonatal Med. 2012;25 Suppl 1:79–81.
  • Su F, Hammer GB. Dexmedetomidine: pediatric pharmacology, clinical uses and safety. Expert Opin Drug Saf. 2011;10(1):55–66.
  • Dilek O, Yasemin G, Atci M. Preliminary experience with dexme-detomidine in neonatal anaesthesia. J Anaesth Clin Pharmacol. 2011;27(1):17–22.
  • Schnabel A, Reichl SU, Poepping DM, Kranke P, Pogatzki-Zahn EM, Zahn PK. Efficacy and safety of intraoperative dexmedetomidine for acute postoperative pain in children: a meta-analysis of randomized controlled trials. Paediatr Anaesth. 2013;23(2):170–179.
  • Lam F, Bhutta AT, Tobias JD, Gossett JM, Morales L, Gupta P. Hemodynamic effects of dexmedetomidine in critically ill neonates and infants with heart disease. Pediatr Cardiol. 2012;33(7):1069–1077.
  • Su F, Nicolson SC, Gastonguay MR, et al. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesth Analg. 2010;110(5):1383–1392.
  • Van den Anker JN, Tibboel D. Pain relief in neonates: when to use intravenous paracetamol? Arch Dis Child. 2011;96(6):573–574.
  • Gibb IA, Anderson BJ. Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration. Arch Dis Child. 2009;93(3):241–247.
  • Allegaert K, Naulaers G, Vanhaesebrouck S, Anderson BJ. The paracetamol concentration-effect relation in neonates. Paediatr Anaesth. 2013;23(l):45–50.
  • Ceelie I, de Wildt SN, van Dijk M, et al. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. JAMA. 2013;309(2):149–154.
  • Shah V Taddio A, Ohlsson A. Randomised controlled trial of paracetamol for heel prick pain in neonates. Arch Dis Child Fetal Neonatal Ed. 1998;79(3):F209–F211.
  • Van Lingen RA, Quak CM, Deinum HT, et al. Effects of rectally administered paracetamol on infants delivered by vacuum extraction. Eur J Obstet Gynecol Reprod Biol. 2001;94(1):73–78.
  • Tinner EM, Hoesli I, Jost K, et al. Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response. J Pediatr. 2013;162(1):62–66.
  • Penido MG, Garra R, Sammartino M, Pereira e Silva Y. Remifentanil in neonatal intensive care and anaesthesia practice. Acta Paediatr. 2010; 99(10):1454–1463.
  • Pereira e Silva Y, Gomez RS, Marcatto Ide O, Maximo TA, Barbosa RF, Simoes e Silva AC. Morphine versus remifentanil for intubating preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2007;92(4): F293–F294.
  • Welzing L, Kribs A, Huenseler C, Eifinger F, Mehler K, Roth B. Remifentanil for INSURE in preterm infants: a pilot study for evaluation of efficacy and safety aspects. Acta Paediatr. 2009;98(9): 1416–1420.
  • Choog K, AlFaleh K, Doucette J, et al. Remifentanil for endotracheal intubation in neonates: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2010;95(2):F80–F84.
  • Hume-Smith J, Mc Cormack, Montgomery C, et al. The effect of age on the dose of remifentanil for tracheal intubation in infants and children. Paediatr Anaesth. 2010;20(1):19–27.
  • Norman E, Wikström S, Hellström-Westas L, Turpeinen U, Hämäläinen E, Fellman V Rapid sequence induction is superior to morphine for intubation of preterm infants: a randomized controlled trial. J Pediatr. 2011;159(6):893.e1–899.e1.
  • Lago P Tiozzo C, Buccuzzo G, Allegro A, Zacchello F Remifentanil for percutaneous intravenous central catheter placement in preterm infants: a randomized controlled trial. Paediatr Anaesth. 2008;18(8):736–744.
  • Allegaert K, Thewissen L, van den Anker JN. Remifentanil in neonates: a promising compound in search of its indications? Pediatr Neonatol 2012;53(6):387–388.
  • Cronin CM, Baker GR, Lee SK, Ohlsson A, McMillan DD, Seshia MM. Canadian Neonatal Network EPIQ Study Group. Reflections on knowledge translation in Canadian NICUs using the EPIQ method. Healthc Q. 2011;14(3):8–16.
  • Johnston C, Barrington KJ, Taddio A, Carbajal R, Filion F. Pain in Canadian NICUs: have we improved over the past 12 years? Clin J Pain. 2011;27(3):225–232.
  • Zhu LM, Stinson J, Palozzi L, et al. Improvements in pain outcomes in a Canadian pediatric teaching hospital following implementation of a multifaceted knowledge translation initiative. Pain Res Manag. 2012;17(3):173–179.
  • Deindl P, Unterasinger L, Kappler G, et al. Successful implementation of a neonatal pain and sedation protocol at 2 NICUs. Pediatrics. 2013; 132(1):e211–e218.
  • Taddio A, Shah V, Leung E, et al. Knowledge translation of the HELPinKIDS clinical practice guideline for managing childhood vaccination pain: usability and knowledge uptake of educational materials directed to new parents. BMC Pediatr. 2013;13:23.
  • Montirosso R, del Prete, Bellu R, et al. Level of NICU quality of developmental care and neurobehavioral performance in very preterm infants. Pediatrics. 2012;129(5):e1129–e1137.
  • Storm H. Skin conductance and the stress response from heel stick in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2000;83(2): F143–F147.
  • Valkenburg AJ, Niehof SP, van Dijk M, Verhaar EJ, Tibboel D. Skin conductance peaks could result from changes in vital parameters unrelated to pain. Pediatr Res. 2012;71(4 Pt 1):375–379.
  • Bellieni CV, Taddio A, Linebarger JS, Lantos JD. Should an IRB approve a placebo-controlled randomized trial of analgesia for procedural pain in neonates? Pediatrics. 2012;130(3):550–553.
  • Weimer K, Gulewitsch MD, Schwille-Kiuntke J, Klosterhalfen S, Enck P Placebo effects in children: a review. Pediatr Res. 2013;74(1):96–102.
  • Anand KJ. Pain panacea for opiophobia in infants? JAMA. 2013;309(2): 183–184.