Recent advances in the management of neonatal jaundice

References

• Maisels MJ, Kring E. Length of stay, jaundice, and hospital readmission. Pediatrics. 1998;101(6):995–998.
   PubMed Web of Science ®Google Scholar
• Escobar GJ, Greene JD, Hulac P, et al. Rehospitalisation after birth hospitalisation: patterns among infants of all gestations. Arch Dis Child. 2005;90(2):125–131.
   PubMed Web of Science ®Google Scholar
• Watchko JF. Indirect hyperbilirubinemia in the neonate. In: Maisels MJ, Watchko JF, editors. Neonatal Jaundice. Amsterdam, The Netherlands: Harwood Academic Publishers; 2000:51–66.
   Google Scholar
• Maisels MJ. Jaundice. In: MacDonald MG, Seshia MMK, Mullett MD, editors. Neonatology: Pathophysiology and Management of the Newborn. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:768–846.
   Google Scholar
• Newman TB, Escobar GJ, Gonzales VM, Armstrong MA, Gardner MN, Folck BF. Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organization. Pediatrics. 1999; 104(5 Pt 2):1198–1203.
   PubMed Web of Science ®Google Scholar
• Bhutani VK, Johnson LH, Jeffrey Maisels M, et al. Kernicterus: epidemiological strategies for its prevention through systems-based approaches. J Perinatol. 2004;24(10):650–662.
   PubMedGoogle Scholar
• Shapiro SM. Kernicterus. In: Stevenson DK, Maisels MJ, Watchko JF, editors. Care of the Jaundiced Neonate. New York: McGraw-Hill; 2012:229–242.
   Google Scholar
• Watchko JF. Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular Med. 2006; 8(4):513–529.
   Web of Science ®Google Scholar
• Watchko JF, Tiribelli C. Bilirubin-induced neurologic damage – mechanisms and management approaches. N Engl J Med. 2013;369(21):2021–2030.
   PubMed Web of Science ®Google Scholar
• Volpe JJ. . Bilirubin and brain injury. In: Volpe JJ, editor. Neurology of the Newborn. 5th ed. Philadelphia: Saunders/Elsevier; 2008:619–651.
   Google Scholar
• American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297–316.
   PubMed Web of Science ®Google Scholar
• Ahdab-Barmada M, Moossy J. The neuropathology of kernicterus in the premature neonate: diagnostic problems. J Neuropathol Exp Neurol. 1984;43(1):45–56.
   Web of Science ®Google Scholar
• Ahdab Barmada M. The neuropathology of kernicterus: definitions and debate. In: Maisels MJ, Watchko JF, editors. Neonatal Jaundice. Amsterdam: Harwood Academic Publishers; 2000:75–88.
   Google Scholar
• Bhutani VK, Zipursky A, Blencowe H, et al. Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels. Pediatr Res. 2013;74(Suppl 1):86–100.
   PubMedGoogle Scholar
• Olusanya BO, Ogunlesi TA, Slusher TM. Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? Arch Dis Child. 2014. Epub ahead of print. Available from: http://dx.doi.org/10.1136/archdischild-2013-305506.
   Google Scholar
• Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko JF. Hyperbilirubinemia in the newborn infant ≥35 weeks’ gestation: an update with clarifications. Pediatrics. 2009;124(4):1193–1198.
   PubMed Web of Science ®Google Scholar
• Maisels MJ, Newman TB. Prevention, screening, and postnatal management of neonatal hyperbilirubinemia. In: Stevenson DK, Maisels MJ, Watchko JF, editors. Care of the Jaundiced Neonate. New York, NY: McGraw Hill; 2012:175–194.
   Google Scholar
• Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999; 103(1):6–14.
   PubMed Web of Science ®Google Scholar
• Maisels MJ, Stevenson DK, Watchko JF, McDonagh AF. Phototherapy and other treatments. In: Stevenson DK, Maisels MJ, Watchko JF, editors. Care of the Jaundiced Neonate. New York, NY: McGraw Hill; 2012:195–227.
   Google Scholar
• Watchko JF. Exchange transfusion in the management of neonatal hyperbilirubinemia. In: Maisels MJ, Watchko JF, editors. Neonatal Jaundice. Amsterdam, The Netherlands: Harwood Academic Publishers; 2000:169–176.
   Google Scholar
• Keren R, Luan X, Friedman S, Saddlemire S, Cnaan A, Bhutani VK. A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infants. Pediatrics. 2008;121(1):e170–e179.
   Web of Science ®Google Scholar
• Newman TB, Liljestrand P, Escobar GJ. Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns. Arch Pediatr Adolesc Med. 2005;159(2):113–119.
   Google Scholar
• Maisels MJ, Deridder JM, Kring EA, Balasubramaniam M. Routine transcutaneous bilirubin measurements combined with clinical risk factors improve the prediction of subsequent hyperbilirubinemia. J Perinatol. 2009;29(9):612–617.
   Web of Science ®Google Scholar
• Eggert LD, Wiedmeier SE, Wilson J, Christensen RD. The effect of instituting a prehospital-discharge newborn bilirubin screening program in an 18-hospital health system. Pediatrics. 2006;117(5):e855–e862.
   PubMed Web of Science ®Google Scholar
• Mah MP, Clark SL, Akhigbe E, et al. Reduction of severe hyperbilirubinemia after institution of predischarge bilirubin screening. Pediatrics. 2010;125(5):e1143–e1148.
   PubMed Web of Science ®Google Scholar
• Kuzniewicz MW, Wickremasinghe AC, Wu YW, et al. Incidence, etiology, and outcomes of hazardous hyperbilirubinemia in newborns. Pediatrics. 2014;134(3):504–509.
   PubMed Web of Science ®Google Scholar
• Maisels MJ. Transcutaneous bilirubinometry. Neoreviews. 2006;7(5):e217–e225.
   Google Scholar
• Ahlfors CE, Wennberg RP, Ostrow JD, Tiribelli C. Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice. Clin Chem. 2009;55(7):1288–1299.
   PubMed Web of Science ®Google Scholar
• Ahlfors CE. Predicting bilirubin neurotoxicity in jaundiced newborns. Curr Opin Pediatr. 2010;22(2):129–133.
   Web of Science ®Google Scholar
• Ip S, Chung M, Kulig J, et al; American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004;114(1):e130–e153.
   PubMed Web of Science ®Google Scholar
• Newman TB, Liljestrand P, Jeremy RJ, et al; Jaundice and Infant Feeding Study Team. Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more. N Engl J Med. 2006;354(18):1889–1900.
   PubMed Web of Science ®Google Scholar
• Watchko JF. Neonatal hyperbilirubinemia – what are the risks? N Engl J Med. 2006;354(18):1947–1949.
   Web of Science ®Google Scholar
• Gamaleldin R, Iskander I, Seoud I, et al. Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia. Pediatrics. 2011;128(4):e925–e931.
   PubMed Web of Science ®Google Scholar
• Oh W, Stevenson DK, Tyson JE, et al; NICHD Neonatal Research Network Bethesda MD. Influence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants. Acta Paediatr. 2010;99(5):673–678.
   PubMed Web of Science ®Google Scholar
• Iskander I, El Houchi S, El Shenawy A, et al. Validation of bilirubin/albumin ratio as a predictor of bilirubin-induced neurologic dysfunction (BIND). Presented at: Pediatric Academic Societies Annual Meeting; May 7, 2013. Washington, DC.
   Google Scholar
• Johnson L, Bhutani VK, Karp K, Sivieri EM, Shapiro SM. Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). J Perinatol. 2009;29(Suppl 1):S25–S45.
   PubMedGoogle Scholar
• Huber AH, Zhu B, Kwan T, Kampf JP, Hegyi T, Kleinfeld AM. Fluorescence sensor for the quantification of unbound bilirubin concentrations. Clin Chem. 2012;58(5):869–876.
   PubMed Web of Science ®Google Scholar
• Hegyi T, Kathiravan S, Stahl GE, Huber AH, Kleinfeld A. Unbound free fatty acids from preterm infants treated with intralipid decouples unbound from total bilirubin potentially making phototherapy ineffective. Neonatology. 2013;104(3):184–187.
   PubMed Web of Science ®Google Scholar
• Huber AH, Hegyi T, Kleinfeld AM. Free fatty acids (FFA) produced from intralipid and sulfisoxazole displace similar amounts of bilirubin from albumin. Presented at: Pediatric Academic Societies Annual Meeting; May 6, 2014; Vancouver, British Columbia.
   Google Scholar
• Ahlfors CE. Criteria for exchange transfusion in jaundiced newborns. Pediatrics. 1994;93(3):488–494.
   Web of Science ®Google Scholar
• Hulzebos CV, Dijk PH, van Imhoff DE, et al; BARTrial Study Group. The bilirubin albumin ratio in the management of hyperbilirubinemia in preterm infants to improve neurodevelopmental outcome: a randomized controlled trial – BARTrial. PLoS ONE. 2014;9(6):e99466.
   Web of Science ®Google Scholar
• Nakamura H, Koda T, Yokota T, et al. Bilirubin/albumin molar ratios at the critical level of serum unbound bilirubin in hyperbilirubinemic neonates. Presented at: Pediatric Academic Societies Annual Meeting; May 7, 2014; Vancouver, British Columbia.
   Google Scholar
• Ahlfors CE, Amin SB, Parker AE. Unbound bilirubin predicts abnormal automated auditory brainstem response in a diverse newborn population. J Perinatol. 2009;29(4):305–309.
   PubMed Web of Science ®Google Scholar
• Amin SB, Lamola AA. Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates. Semin Perinatol. 2011;35(3):134–140.
   PubMed Web of Science ®Google Scholar
• Bender GJ, Cashore WJ, Oh W. Ontogeny of bilirubin-binding capacity and the effect of clinical status in premature infants born at less than 1300 grams. Pediatrics. 2007;120(5):1067–1073.
   Web of Science ®Google Scholar
• Lamola AA, Du L, Bhutani VK. Albumin binding capacity for bilirubin increases with gestational age and validates recent expert recommendations for interventions. Presented at: Pediatric Academic Societies Annual Meeting; May 6, 2014; Vancouver, British Columbia.
   Google Scholar
• Lasky RE, Church MW, Orlando MS, et al. The effects of aggressive vs conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants. Pediatr Res. 2012;71(1):77–84.
   Web of Science ®Google Scholar
• Hsai DY, Allen FH, Gellis SS, Diamond LK. Erythroblastosis fetalis – studies of serum bilirubin in relation to kernicterus. N Engl J Med. 1952;247:668–671.
   Web of Science ®Google Scholar
• Kaplan M, Hammerman C. Hemolytic disorders and their management. In: Stevenson DK, Maisels MJ, Watchko JF, editors. Care of the Jaundiced Neonate. New York: McGraw-Hill; 2012:145–173.
   Google Scholar
• Christensen RD, Lambert DK, Henry E, et al. Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system. Blood Cells Mol Dis. 2013;50(2):105–109.
   Web of Science ®Google Scholar
• Maisels MJ, Kring E. The contribution of hemolysis to early jaundice in normal newborns. Pediatrics. 2006;118(1):276–279.
   Web of Science ®Google Scholar
• Christensen RD, Nussenzveig RH, Yaish HM, Henry E, Eggert LD, Agarwal AM. Causes of hemolysis in neonates with extreme hyperbilirubinemia. J Perinatol. 2014;34(8):616–619.
   Web of Science ®Google Scholar
• Stevenson DK, Vreman HJ, Oh W, et al. Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Clin Chem. 1994;40(10):1934–1939.
   PubMed Web of Science ®Google Scholar
• Herschel M, Karrison T, Wen M, Caldarelli L, Baron B. Evaluation of the direct antiglobulin (Coombs’) test for identifying newborns at risk for hemolysis as determined by end-tidal carbon monoxide concentration (ETCOc); and comparison of the Coombs’ test with ETCOc for detecting significant jaundice. J Perinatol. 2002;22(5):341–347.
   Google Scholar
• Tidmarsh GF, Wong RJ, Stevenson DK. End-tidal carbon monoxide and hemolysis. J Perinatol. 2014;34(8):577–581.
   Web of Science ®Google Scholar
• Stevenson DK, Vreman HJ, Wong RJ. Bilirubin production and its measurement. In: Stevenson DK, Maisels MJ, Watchko JF, editors. Care of the Jaundiced Neonate. New York: McGraw-Hill; 2012:29–39.
   Google Scholar
• Amin SB, Bhutani VK, Watchko JF. Apnea in acute bilirubin encephalopathy. Semin Perinatol. Epub September 16, 2014.
   Google Scholar
• Maisels MJ, Watchko JF, Bhutani VK, Stevenson DK. An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation. J Perinatol. 2012;32(9):660–664.
   PubMed Web of Science ®Google Scholar
• Amin SB. Clinical assessment of bilirubin-induced neurotoxicity in premature infants. Semin Perinatol. 2004;28(5):340–347.
   Web of Science ®Google Scholar
• Johnson L, Brown AK, Bhutani V. BIND – a clinical score for bilirubin-induced neurologic dysfunction in newborns. Pediatrics. 1999;104:746–747.
   Web of Science ®Google Scholar
• Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2008;358(9):920–928.
   PubMed Web of Science ®Google Scholar
• Tan KL. The pattern of bilirubin response to phototherapy for neonatal hyperbilirubinaemia. Pediatr Res. 1982;16(8):670–674.
   Web of Science ®Google Scholar
• Vandborg PK, Hansen BM, Greisen G, Ebbesen F. Dose-response relationship of phototherapy for hyperbilirubinemia. Pediatrics. 2012;130(2):e352–e357.
   Web of Science ®Google Scholar
• Lamola AA, Bhutani VK, Wong RJ, Stevenson DK, McDonagh AF. The effect of hematocrit on the efficacy of phototherapy for neonatal jaundice. Pediatr Res. 2013;74(1):54–60.
   Web of Science ®Google Scholar
• Lamola AA, Russo M. Fluorescence excitation spectrum of bilirubin in blood: a model for the action spectrum for phototherapy of neonatal jaundice. Photochem Photobiol. 2014;90(2):294–296.
   Web of Science ®Google Scholar
• Ebbesen F, Madsen P, Støvring S, Hundborg H, Agati G. Therapeutic effect of turquoise versus blue light with equal irradiance in preterm infants with jaundice. Acta Paediatr. 2007;96(6):837–841.
   Web of Science ®Google Scholar
• Ebbesen F, Agati G, Pratesi R. Phototherapy with turquoise versus blue light. Arch Dis Child Fetal Neonatal Ed. 2003;88(5):F430–F431.
   Web of Science ®Google Scholar
• Seidman DS, Moise J, Ergaz Z, et al. A prospective randomized controlled study of phototherapy using blue and blue-green light-emitting devices, and conventional halogen-quartz phototherapy. J Perinatol. 2003;23(2):123–127.
   Google Scholar
• Mreihil K, McDonagh AF, Nakstad B, Hansen TW. Early isomerization of bilirubin in phototherapy of neonatal jaundice. Pediatr Res. 2010;67(6):656–659.
   Web of Science ®Google Scholar
• Maisels MJ, Watchko JF. Treatment of jaundice in low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 2003;88(6):F459–F463.
   Web of Science ®Google Scholar
• Morris BH, Oh W, Tyson JE, et al; NICHD Neonatal Research Network. Aggressive vs conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008;359(18):1885–1896.
   PubMed Web of Science ®Google Scholar
• Tyson JE, Pedroza C, Langer J, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Does aggressive phototherapy increase mortality while decreasing profound impairment among the smallest and sickest newborns? J Perinatol. 2012;32(9):677–684.
   Web of Science ®Google Scholar
• Arnold C, Pedroza C, Tyson JE. Phototherapy in ELBW newborns: does it work? Is it safe? The evidence from randomized clinical trials. Semin Perinatol. 2014;38(7):452–464.
   Web of Science ®Google Scholar
• Lipsitz PJ, Gartner LM, Bryla DA. Neonatal and infant mortality in relation to phototherapy. Pediatrics. 1985;75(2 Pt 2):422–426.
   Web of Science ®Google Scholar
• Hansen TWR. Let there be light-but should there be less? J Perinatol. 2012;32(9):649–651.
   Web of Science ®Google Scholar
• Valaes T. Bilirubin distribution and dynamics of bilirubin removal by exchange transfusion. Acta Paediatr. 1963;52(6):604–605.
   Web of Science ®Google Scholar
• Sproul A, Smith L. Bilirubin equilibration during exchange transfusion in hemolytic disease of the newborn. J Pediatr. 1964;65(1):12–26.
   Web of Science ®Google Scholar
• Watchko JF. 50 years ago in the Journal of Pediatrics: Bilirubin equilibration during exchange transfusion in hemolytic disease of the newborn. J Pediatr. 2014;165(1):64.
   Web of Science ®Google Scholar
• Harris MC, Bernbaum JC, Polin JR, Zimmerman R, Polin RA. Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia. Pediatrics. 2001;107(5):1075–1080.
   Web of Science ®Google Scholar
• Hansen TWR, Nietsch L, Norman E, et al. Reversibility of acute intermediate phase bilirubin encephalopathy. Acta Paediatr. 2009;98(10):1689–1694.
   Web of Science ®Google Scholar
• Ackerman BD, Dyer GY, Taylor PM. Decline in serum bilirubin concentration coincident with clinical onset of kernicterus. Pediatrics. 1971;48(4):647–650.
   Web of Science ®Google Scholar
• Sims ME. Legal briefs: Kernicterus still preventable. Neo Reviews. 2011;12(12):e727–e730.
   Google Scholar
• Gottstein R, Cooke RWI. Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn. Arch Dis Child Fetal Neonatal Ed. 2003;88(1):F6–F10.
   Web of Science ®Google Scholar
• Smits-Wintjens VEHJ, Walther FJ, Rath MEA, et al. Intravenous immunoglobulin in neonates with rhesus hemolytic disease: a randomized controlled trial. Pediatrics. 2011;127(4):680–686.
   Web of Science ®Google Scholar
• Santos MC, Sá C, Gomes SC Jr, Camacho LA, Moreira ME. The efficacy of the use of intravenous human immunoglobulin in Brazilian newborns with rhesus hemolytic disease: a randomized double-blind trial. Transfusion. 2013;53(4):777–782.
   Web of Science ®Google Scholar
• Alcock GS, Liley H. Immunoglobin infusion for isoimmune hemolytic jaundice in neonates. Cochrane Database Syst Rev. 2002;(3):CD003313.
   Google Scholar
• Schulz S, Wong RJ, Vreman HJ, Stevenson DK. Metalloporphyrins – an update. Front Pharmacol. 2012;3:68.
   Web of Science ®Google Scholar
• Wong RJ, Espadas C, Inayathullah M, et al. Polymeric particulate delivery of zinc protoporphyrin for the chemoprevention of neonatal jaundice. Presented at: Pediatric Academic Societies Annual Meeting; May 7, 2014; Vancouver, British Columbia.
   Google Scholar