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Review

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

ORCID Icon, ORCID Icon, &
Pages 81-91 | Published online: 19 May 2021

References

  • Beaver PC, Snyder H, Carrera G, Dent J, Lafferty I. Chronic eosinophilia due to visceral larva migrans. Pediatrics. 1952;9:7–19.
  • Taylor MRH, Keane CT, O’Connor P, Girdwood RW, Smith H. Clinical features of covert toxocariasis. Scand J Infect Dis. 1987;19:696–699. doi:10.3109/00365548709117206
  • Rubinsky-Elefant G, Hirata CE, Yamamoto JH, Ferreira MU. Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Ann Trop Med Parasitol. 2010;104:3–23. doi:10.1179/136485910x12607012373957
  • Torgerson PR, Macpherson CNL. The socioeconomic burden of parasitic zoonoses: global trends. Vet Parasitol. 2011;182:79–95. doi:10.1016/j.vetpar.2011.07.017
  • Fialho PM, Corrêa CR. A systematic review of toxocariasis: a neglected but high-prevalence disease in Brazil. Am J Trop Med Hyg. 2016;94:1193–1199. doi:10.4269/ajtmh.15-0733
  • Smith H, Holland C, Taylor M, Magnaval JF, Schantz P, Maizels R. How common is human toxocariasis? Towards standardizing our knowledge. Trends Parasitol. 2009;25:182–188. doi:10.1016/j.pt.2009.01.006
  • Raissi V, Sohrabi Z, Getso M, et al. Risk factors and prevalence of toxocariasis in pregnant women and diabetic patients compared to healthy adults in Ilam Province, Western Iran. EXCLI J. 2018;17:983–988. doi:10.17179/excli2018-1630
  • Raissi V, Masoumi M, Ibrahim A, et al. Spatial analysis of Toxocara spp. eggs in soil as a potential for serious human infection. Comp Immunol Microbiol Inf Dis. 2021;75:101619. doi:10.1016/j.cimid.2021.101619
  • Zyoud SH. Global toxocariasis research trends from 1932 to 2015: a bibliometric analysis. Health Res Policy Syst. 2017;15:14. doi:10.1186/s12961-017-0178-8
  • Chieffi PP, Santos SV, Queiroz ML, Lescano SA. Human toxocariasis: contribution by Brazilian researchers. Rev Inst Med Trop Sao Paulo. 2009;51:301–308. doi:10.1590/s0036-46652009000600001
  • Overgaauw PA. Aspects of Toxocara epidemiology: toxocarosis in dogs and cats. Crit Rev Microbiol. 1997;23:233–251. doi:10.3109/10408419709115138
  • Fava NMN, Cury MC, Santos HA, et al. Phylogenetic relationships among Toxocara spp. and Toxascaris sp. from different regions of the world. Vet Parasitol. 2020;282:109133. doi:10.1016/j.vetpar.2020.109133
  • Dantas-Torres F, Otranto D. Dogs, cats, parasites, and humans in Brazil: opening the black box. Parasit Vectors. 2014;7:22. doi:10.1186/1756-3305-7-22
  • Ramos DGS, Zocco BKA, Torres MM, Braga IA, Pacheco RC, Sinkoc AL. Helminths parasites of stray dogs (Canis lupus familiaris) from Cuiabá, Midwestern of Brazil. Semin Cienc Agrar. 2015;36:889–894. doi:10.5433/1679-0359.2015v36n2p889
  • Lima VF, Cringoli G, Rinaldi L, et al. A comparison of mini-FLOTAC and FLOTAC with classic methods to diagnosing intestinal parasites of dogs from Brazil. Parasitol Res. 2015;114:3529–3533. doi:10.1007/s00436-015-4605-x
  • Regis SC, Mendonça LR, Silva Ndos S, Dattoli VC, Alcântara-Neves NM, Barrouin-Melo SM. Seroprevalence and risk factors for canine toxocariasis by detection of specific IgG as a marker of infection in dogs from Salvador, Brazil. Acta Trop. 2011;120:46–51. doi:10.1016/j.actatropica.2011.05.011
  • Merigueti Y, Santarém VA, Ramires LM, et al. Protective and risk factors associated with the presence of Toxocara spp. eggs in dog hair. Vet Parasitol. 2017;244:39–43. doi:10.1016/j.vetpar.2017.07.020
  • Manini MP, Marchioro AA, Colli CM, Nishi L, Falavigna-Guilherme AL. Association between contamination of public squares and seropositivity for Toxocara spp. in children. Vet Parasitol. 2012;188:48–52. doi:10.1016/j.vetpar.201203.011
  • Santarém VA, Pereira VC, Alegre BC. Contamination of public parks in Presidente Prudente (São Paulo, Brazil) by Toxocara spp. eggs. Rev Bras Parasitol Vet. 2012;3:323–325. doi:10.1590/S1984-29612012000300029
  • Marques JP, Guimarães CR, Boas AV, Carnaúba PU, Moraes J. Contamination of public parks and squares from Guarulhos (São Paulo State, Brazil) by Toxocara spp. and Ancylostoma spp. Rev Inst Med Trop Sao Paulo. 2012;54:267–271. doi:10.1590/S0036-466.520120005500006
  • Ribeiro LM, Dracz RM, Mozzer LR, Lima WDS. Soil contamination in public squares in Belo Horizonte, Minas Gerais, by canine parasites in different developmental stages. Rev Inst Med Trop Sao Paulo. 2013;55:229–231. doi:10.1590/S0036-46652013000400002
  • Sprenger LK, Green KT, Molento MB. Geohelminth contamination of public areas and epidemiological risk factors in Curitiba, Brazil. Rev Bras Parasitol Vet. 2014;23:69–73. doi:10.1590/S1984-29612014009
  • Capella GDA, Pinto NB, Perera SC, et al. Environmental contamination by parasitic forms in a socially vulnerable community in southern Rio Grande do Sul state: a serious public health problem. Braz J Vet Res Anim Sci. 2018;55:1–8e132007. doi:10.11606/issn.1678-4456.bjvras.2018.132007
  • Mello CCS, Nizoli LQ, Ferraz A, Chagas BC, Azario WJD, Villela MM. Helminth eggs with zoonotic potential in the vicinity of public schools in southern Brazil. Rev Bras Parasitol Vet. 2020;29(1):e016419. doi:10.1590/S1984-29612019102
  • Leon IF, Strothmann AL, Islabão CL, Jeske S, Villela MM. Geohelminths in the soil of the Laguna dos Patos in Rio Grande do Sul state, Brazil. Braz J Biol. 2020;80:839–843. doi:10.1590/15196984.222590
  • Queiroz ML, Viel TA, Papa CH, Lescano SA, Chieffi PP. Behavioral changes in Rattus norvegicus coinfected by Toxocara canis and Toxoplasma gondii. Rev Inst Med Trop Sao Paulo. 2013;55:51–53. doi:10.1590/s0036-46652013000100009
  • Colli CM, Rubinsky-Elefant G, Paludo ML, et al. Serological, clinical and epidemiological evaluation of toxocariasis in urban areas of south Brazil. Rev Inst Med Trop Sao Paulo. 2010;52:69–74. doi:10.1590/S0036-46652010000200002
  • Dattoli VC, Freire SM, Mendonça LR, Santos PC, Meyer R, Alcantara-Neves NM. Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre. Trop Med Int Health. 2011;16:514–517. doi:10.1111/j.1365-3156.2010.02719.x
  • Souza RF, Dattoli VC, Mendonça LR, et al. [Prevalence and risk factors of human infection by Toxocara canis in Salvador, State of Bahia, Brazil]. Rev Soc Bras Med Trop. 2011;44::516–519. doi:10.1590/S0037-86822011000400024
  • Prestes-Carneiro LE, Rubinsky-Elefant G, Ferreira AW, et al. Seroprevalence of toxoplasmosis, toxocariasis and cysticercosis in a rural settlement, São Paulo State, Brazil. Pathog Glob Health. 2013;107:88–95. doi:10.1179/2047773213Y.0000000079
  • Negri EC, Santarém VA, Rubinsky-Elefant G, Giuffrida R. AntiToxocara spp. antibodies in an adult healthy population: serosurvey and risk factors in Southeast Brazil. Asian Pac J Trop Biomed. 2013;3:211–216. doi:10.1016/S2221-1691(13)60052-0
  • Santos PC, Lehmann LM, Lorenzi C, et al. The seropositivity of Toxocara spp. antibodies in pregnant women attended at the university hospital in southern Brazil and the factors associated with infection. PLoS One. 2015;10:e0131058. doi:10.1371/journal.pone.0131058
  • Pereira LC, Elefant GR, Nóbrega YM, et al. Toxocara spp. seroprevalence in pregnant women in Brasília, Brazil. Rev Soc Bras Med Trop. 2016;49:641–643. doi:10.1590/0037-8682-0106-2016
  • Araújo AC, Villela MM, Sena-Lopes A, et al. Seroprevalence of Toxoplasma gondii and Toxocara canis in a human rural population of Southern Rio Grande do Sul. Rev Inst Med Trop Sao Paulo. 2018;60:e28. doi:10.1590/s1678-9946201860028
  • Correa CR, Bismarck CM. Toxocariasis: incidence, prevalence and the time serum remains positive in school children from Campinas, SP, Brazil. J Trop Pediatr. 2010;56:215–216. doi:10.1093/tropej/fmp095
  • Santarém VA, Leli FN, Rubinsky-Elefant G, Giuffrida R. Protective and risk factors for toxocariasis in children from two different social classes of Brazil. Rev Inst Med Trop Sao Paulo. 2011;53:67–72. doi:10.1590/s0036-46652011000200002
  • Fragoso RP, Monteiro MB, Lemos EM, Pereira FE. Anti-Toxocara antibodies detected in children attending elementary school in Vitoria, State of Espírito Santo, Brazil: prevalence and associated factors. Rev Soc Bras Med Trop. 2011;44:461–466. doi:10.1590/s003786822011000400012
  • Marchioro AA, Colli CM, Mattia S, et al. Avaliação eosinofílica e soropositividade para anticorpos IgG anti-Toxocara em crianças atendidas pelo Sistema Único de Saúde [Eosinophilic count and seropositivity for IgG antibodies to Toxocara  spp. in chidren assisted at the public health service. 52 - Clinical and ultrasound liver impairment in children with toxocariasis]. Rev Paul Pediatr. 2011;29:80–84. doi:10.1590/S0103-05822011000100013
  • Mattia S, Colli CM, Adami CM, et al. Seroprevalence of Toxocara infection in children and environmental contamination of urban areas in Paraná State, Brazil. J Helminthol. 2012;86:440–445. doi:10.1017/S0022149X11000666
  • Mendonça LR, Figueiredo CA, Esquivel R, et al. Seroprevalence and risk factors for Toxocara infection in children from an urban large setting in Northeast Brazil. Acta Trop. 2013;128:90–95. doi:10.1016/j.actatropica.2013.06.018
  • Guilherme EV, Marchioro AA, Araujo SM, et al. Toxocariasis in children attending a public health service pneumology unit in Paraná State, Brazil. Rev Inst Med Trop Sao Paulo. 2013;55:189–192. doi:10.1590/s0036-46652013000300009
  • Schoenardie ER, Scaini CJ, Brod CS, et al. Seroprevalence of Toxocara infection in children from southern Brazil. J Parasitol. 2013;99:537–539. doi:10.1645/ge-3182
  • Oliart-Guzmán H, Delfino BM, Martins AC, et al. Epidemiology and control of child toxocariasis in the western Brazilian Amazon - a population-based study. Am J Trop Med Hyg. 2014;90:670–681. doi:10.4269/ajtmh.13-0506
  • Cassenote AJ, Lima AR, Pinto Neto JM, Rubinsky-Elefant G. Seroprevalence and modifiable risk factors for Toxocara spp. in Brazilian school children. PLoS Negl Trop Dis. 2014;8:e2830. doi:10.1371/journal.pntd.0002830
  • Marchioro AA, Colli CM, Ferreira EC, Viol BM, Araújo SM, Falavigna-Guilherme AL. Risk factors associated with toxoplasmosis and toxocariasis in populations of children from nine cities in southern Brazil. J Helminthol. 2015;89:428–432. doi:10.1017/s0022149x14000212
  • Silva MB, Amor ALM, Santos LN, et al. Risk factors for Toxocara spp. seroprevalence and its association with atopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil. Acta Trop. 2017;174:158–164. doi:10.1016/j.actatropica.2016.04.005
  • Araújo GMS, Walcher DL, Previtali IF, et al. Frequency of enteroparasitic infections and serum positivity for Toxocara spp. in children from a public day care center in southern Brazil. Braz J Biol. 2020;80:305–310. doi:10.1590/1519-6984.200952
  • Santos PC, Telmo PL, Lehmann LM, et al. Risk and other factors associated with toxoplasmosis and toxocariasis in pregnant women from southern Brazil. J Helminthol. 2017a;91:534–538. doi:10.1017/s0022149x16000481
  • Santos PC, Telmo PL, Lehmann LM, et al. Frequency of Toxocara spp. antibodies in umbilical cords of newborns attended at the University Hospital in Southern Brazil and factors associated with infection. Acta Trop. 2017b;170:43–47. doi:10.1016/j.actatropica.2017.02.003
  • Mattos GT, Santos PC, Telmo PL, Berne ME, Scaini CJ. Human toxocariasis: prevalence and factors associated with biosafety in research laboratories. Am J Trop Med Hyg. 2016;95:1428–1431. doi:10.4269/ajtmh.16-0196
  • Mendonça LR, Veiga RV, Dattoli VC, et al. Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. PLoS Negl Trop Dis. 2012;6:e1886. doi:10.1371/journal.pntd.0001886
  • Carvalho EAA, Lunardi Rocha R, Pinto da silva RA. Comprometimento hepático clínico e ultrassonográfico em crianças com toxocaríase. Rev Med Minas Gerais. 2015;25:523–528. doi:10.5935/2238-3182.20150117
  • Zaia MG, Oliveira SR, Castro CA, et al. Toxocara canis and the allergic process. Mem Inst Oswaldo Cruz. 2015;110:726–731. doi:10.1590/0074-02760150051
  • Silva DCCE, Medeiros YRC, Kametani EI, et al. Loeffler syndrome in the differential diagnosis of severe asthma. Pediatr Pulmonol. 2016;51(S42):S59–S60. doi:10.1002/ppul.23409
  • Grama DF, Lescano SZ, Pereira Mota KC, et al. Seroprevalence of Toxocara spp. in children with atopy. Trans R Soc Trop Med Hyg. 2014;108:797–803. doi:10.1093/trstmh/tru165
  • Cadore PS, Zhang L, Lemos Lde L, et al. Toxocariasis and childhood asthma: a case-control study. J Asthma. 2016;53:601–606. doi:10.3109/02770903.2015.1064951
  • Fialho PM, Corrêa CRS. Toxocaríase, asma e índice de massa corporal em crianças e adolescentes em Campinas-SP, 1996 a 1998. Epidemiol Serv Saúde[Toxocariasis, asthma and body mass index in children and adolescent in Campinas, São Paulo State, Brazil, 1996-1998. 79 - Ultrasonographic findings in ocular toxocariasis]. 2014;23:361–368. doi:10.5123/S1679-49742014000200018
  • Fialho PM, Correa CRS, Lescano SZ. Asthma and seroconversion from Toxocara spp. infection: which comes first? Biomed Res Int. 2018;2018:4280792. doi:10.1155/2018/4280792
  • Fialho PM, Correa CRS, Lescano SZ. Seroprevalence of toxocariasis in children with urticaria: a population-based study. J Trop Pediatr. 2017;63:352–357. doi:10.1093/tropej/fmw094
  • Recuero JK, Binda G, Kiszewski AE. Eosinophilic panniculitis associated with toxocariasis in a child. An Bras Dermatol. 2019;94:243–254. doi:10.1590/abd1806-4841.20198172
  • Salvador S, Ribeiro R, Winckler MI, Ohlweiler L, Riesgo R. Pediatric neurotoxocariasis with concomitant cerebral, cerebellar, and peripheral nervous system involvement: case report and review of the literature. J Pediatr (Rio J). 2010;86:531–534. doi:10.2223/jped.2037
  • Viola GR, Giacomin MF, França CM, Sallum AM, Jacob CM, Silva CA. Chronic polyarthritis as isolated manifestation of toxocariasis. Rev Bras Reumatol. 2016;56:185–187. doi:10.1016/j.rbre.2014.07.005
  • Brito T, Chieffi PP, Peres BA, et al. Immunohistochemical detection of toxocaral antigens in human liver biopsies. Int J Surg Pathol. 1994;2:117–124. doi:10.1177/106689699400200206
  • Moreira GM, Telmo Pde L, Mendonça M, et al. Human toxocariasis: current advances in diagnostics, treatment, and interventions. Trends Parasitol. 2014;30:456–464. doi:10.1016/j.pt.2014.07.003
  • Felicetti CPD, Sinnott F, Monte LG, et al. Diagnostic potential of AntiRTE30 polyclonal antibodies In a blocking Elisa for Toxocara canis detection. J Parasitol. 2019;105:64–68. doi:10.1645/17-59
  • Rubinsky-Elefant G, Hoshino-Shimizu S, Jacob CM, Sanchez MC, Ferreira AW. Potential immunological markers for diagnosis and therapeutic assessment of toxocariasis. Rev Inst Med Trop Sao Paulo. 2011;53:61–65. doi:10.1590/s0036-46652011000200001
  • Peixoto PL, Nascimento E, Cançado GG, et al. Identification of candidate antigens from adult stages of Toxocara canis for the serodiagnosis of human toxocariasis. Mem Inst Oswaldo Cruz. 2011;106:200–206. doi:10.1590/s0074-02762011000200014
  • Carvalho EA, Rocha RL. Visceral larva migrans syndromes associated with toxocariasis: epidemiology, clinical and laboratory aspects of human toxocariasis. Curr Trop Med Rep. 2014;1:74–79. doi:10.1007/s40475-013-0011-6
  • Zhan B, Ajmera R, Geiger SM, et al. Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis. Trop Med Int Health. 2015;20:1787–1796. doi:10.1111/tmi.12607
  • Roldán WH, Elefant GR, Ferreira AW. Deglycosylation of Toxocara excretory-secretory antigens improves the specificity of the serodiagnosis for human toxocariasis. Parasite Immunol. 2015;37:557–567. doi:10.1111/pim.12248
  • Roldán WH, Elefant GR, Ferreira AW. Immunoglobulin M antibodies are not specific for serodiagnosis of human toxocariasis. Parasite Immunol. 2017;39:e12447. doi:10.1111/pim.12447
  • Santos LMD, Cerqueira MP, Gaboardi GC, et al. Evaluation of Toxocara canis glycosylated TES produced in Pichia pastoris for immunodiagnosis of human toxocariasis. Braz Arch Biol Technol. 2020;63:e20190148. doi:10.1590/1678-4324-2020190148
  • Santos LMD, Magalhães CG, Telmo PL, et al. Sensitivity and specificity of recombinant proteins in Toxocara spp. for serodiagnosis in humans: differences in adult and child populations. PLoS One. 2018;13:e0208991. doi:10.1371/journal.pone.0208991
  • Sperotto RL, Kremer FS, Aires berne ME, et al. Proteomic analysis of Toxocara canis excretory and secretory (TES) proteins. Mol Biochem Parasitol. 2017;211:39–47. doi:10.1016/j.molbiopara.2016.09.002
  • Silva MB, Urrego AJ, Oviedo Y, et al. The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics. Vet Parasitol. 2018;259:25–34. doi:10.1016/j.vetpar.2018.06.015
  • Rubinsky-Elefant G, Yamamoto JH, Hirata CE, Prestes-Carneiro LE. Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil. Jpn J Ophthalmol. 2018;62:77–83. doi:10.1007/s10384-017-0543-8
  • Souto FMS, Giampietro BV, Takiuti JT, Campos LMA, Hirata CE, Yamamoto JH. Clinical features of paediatric uveitis at a tertiary referral centre in São Paulo, SP, Brazil. Br J Ophthalmol. 2019;103:636–640. doi:10.1136/bjophthalmol-2018-312313
  • Lago A, Andrade R, Muccioli C, Belfort R Jr. Optical coherence tomography in presumed subretinal Toxocara granuloma: case report. Arq Bras Oftalmol. 2006;69:403–405. doi:10.1590/s0004-27492006000300022
  • Morais FB, Maciel AL, Arantes TE, Muccioli C, Allemann N. Achados ultrassonográficos em toxocaríase ocular. Arq Bras Oftalmol. 2012;75:43–47. doi:10.1590/s0004-27492012000100009
  • Lescano SA, Nakhle MC, Ribeiro MC, Chieffi PP. IgG antibody responses in mice coinfected with Toxocara canis and other helminths or protozoan parasites. Rev Inst Med Trop Sao Paulo. 2012;54:145–152. doi:10.1590/s0036-46652012000300006
  • Schoenardie ER, Scaini CJ, Avila LF, et al. Determination of IgG avidity in BALB/c mice experimentally infected with Toxocara canis. Rev Bras Parasitol Vet. 2014;23:403–406. doi:10.1590/s1984-29612014060
  • Resende NM, Gazzinelli-Guimarães PH, Barbosa FS, et al. New insights into the immunopathology of early Toxocara canis infection in mice. Parasit Vectors. 2015;8:354. doi:10.1186/s13071-015-0962-7
  • Raposo RS, Santarém VA, Merigueti YF, et al. Kinetic and avidity of IgY anti-Toxocara antibodies in experimentally infected chickens. Exp Parasitol. 2016;171:33–41. doi:10.1016/j.exppara.2016.09.009
  • Bin LLC, Santarém VA, Laposy CB, Rubinsky-Elefant G, Roldán WH, Giuffrida R. Kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with Toxocara canis. Bras J Vet Parasitol. 2016;25:99–104. doi:10.1590/S1984-29612015067
  • Fonseca GRE, Santos SVD, Chieffi PP, Paula FM, Gryschek RCB, Lescano SAZ. Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response. Mem Inst Oswaldo Cruz. 2017;112:382–386. doi:10.1590/0074-02760160341
  • Rodolpho JMA, Camillo L, Araújo MSS, et al. Robust phenotypic activation of eosinophils during experimental Toxocara canis infection. Front Immunol. 2018;9:64. doi:10.3389/fimmu.2018.00064
  • Santos LMD, de Moura MQ, Azevedo ML, et al. Reactivity of recombinant Toxocara canis TES-30/120 in experimentally infected mice. Parasite Immunol. 2018;40:e12568. doi:10.1111/pim.12568
  • Moura MQ, Macedo MRP, Terto W, et al. Detection of Toxocara canis DNA in tissues of experimentally infected mice. Acta Trop. 2018;187:51–56. doi:10.1016/j.actatropica.2018.07.017
  • Moura MQ, Terto W, Avila L, et al. Quantification of Toxocara canis DNA by qPCR in mice inoculated with different infective doses. Parasitol Int. 2020;78:102134. doi:10.1016/j.parint.2020.102134
  • Garcés LFS, Santiago LF, Santos SPO, et al. Immunogenicity and protection induced by recombinant Toxocara canis proteins in a murine model of toxocariasis. Vaccine. 2020;38:4762–4772. doi:10.1016/j.vaccine.2020.04.072
  • Rassier GL, Borsuk S, Pappen F, et al. Toxocara spp. seroprevalence in sheep from southern Brazil. Parasitol Res. 2013;112:3181–3186. doi:10.1007/s00436-013-3499-8
  • Dutra GF, Pinto NS, De avila LF, et al. Risk of infection by the consumption of liver of chickens inoculated with low doses of Toxocara canis eggs. Vet Parasitol. 2014;203:87–90. doi:10.1016/j.vetpar.2014.03.025
  • Campos-da-silva DR, da Paz JS, Fortunato VR, Beltrame MA, Valli LC, Pereira FE. Natural infection of free-range chickens with the ascarid nematode Toxocara sp. Parasitol Res. 2015;114:4289–4293. doi:10.1007/s00436-015-4669-7
  • Oliveira AC, Rubinsky-Elefant G, Merigueti Y, Batista ADS, Santarém VA. Frequency of anti-Toxocara antibodies in broiler chickens in southern Brazil. Rev Bras Parasitol Vet. 2018;27:141–145. doi:10.1590/s1984-296120180025
  • Santos LMD, Donassolo RA, Berne ME, et al. The serodiagnostic potential of recombinant proteins TES-30 and TES-120 in an indirect ELISA in the diagnosis of toxocariasis in cattle, horses, and sheep. PLoS One. 2019;14:e0213830. doi:10.1371/journal.pone.0213830
  • Magnaval JF, Gligman LT, Dorchies P, Morassin B. Highlights of human toxocariasis. Korean J Parasitol. 2001;39:1–11. doi:10.3347/kjp.2001.39.1.1
  • Lescano SA, Santos SV, Assis JM, Chieffi PP. Efficacy of nitazoxanide against Toxocara canis: larval recovery and humoral immune response in experimentally infected mice. Rev Inst Med Trop Sao Paulo. 2015;57:337–341. doi:10.1590/s0036-46652015000400011
  • Mata-Santos T, Pinto NF, Mata-Santos HA, et al. Anthelmintic activity of lapachol, β-lapachone and its derivatives against Toxocara canis larvae. Rev Inst Med Trop Sao Paulo. 2015;57:197–204. doi:10.1590/s0036-46652015000300003
  • Mata-Santos T, Mata-Santos HA, Carneiro PF, et al. Toxocara canis: anthelmintic activity of quinone derivatives in murine toxocarosis. Parasitology. 2016;143:507–517. doi:10.1017/s0031182016000068
  • Sinott FA, Sena-Lopes A, Leal KS, et al. Essential oil from Brazilian Red Propolis exhibits anthelmintic activity against larvae of Toxocara cati. Exp Parasitol. 2019;200:37–41. doi:10.1016/j.exppara.2019.03.014xz
  • Avila LFC, Da Fonseca JS, Dutra GF, et al. Evaluation of the immunosuppressive effect of cyclophosphamide and dexamethasone in mice with visceral toxocariasis. Parasitol Res. 2012;110:443–447. doi:10.1007/s00436-011-2510-5
  • Avila LFC, Conceição FR, Telmo PL, et al. Saccharomyces boulardii reduces infection intensity of mice with toxocariasis. Vet Parasitol. 2012;187:337–340. doi:10.1016/j.vetpar.2012.01.002
  • Avila LF, Telmo Pde L, Martins LH, et al. Protective effect of the probiotic Saccharomyces boulardii in Toxocara canis infection is not due to direct action on the larvae. Rev Inst Med Trop Sao Paulo. 2013;55:363–365. doi:10.1590/s0036-46652013000500012
  • Avila LFC, De leon PM, De moura MQ, Berne ME, Scaini CJ, Leivas Leite FP. Modulation of IL-12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice. Parasite Immunol. 2016;38:326–330. doi:10.1111/pim.12314
  • Moura MQ, Da silva terto WD, Jeske ST, et al. Evaluation of the transcription of interleukin-12 in the intestinal mucosa of mice subjected to experimental toxocariasis and supplemented with Saccharomyces boulardii. Vet Parasitol. 2017;242:59–62. doi:10.1016/j.vetpar.2017.05.012
  • Walcher DL, Cruz LAX, De lima Telmo P, et al. Lactobacillus rhamnosus reduces parasite load on Toxocara canis experimental infection in mice, but has no effect on the parasite in vitro. Parasitol Res. 2018;117:597–602. doi:10.1007/s00436-017-5712-7
  • Braga FR, Ferreira SR, Araújo JV, et al. Predatory activity of Pochonia chlamydosporia fungus on Toxocara (syn. Neoascaris) vitulorum eggs. Trop Anim Health Prod. 2010;42:309–314. doi:10.1007/s11250-009-9422-8
  • Carvalho RO, Araújo JV, Braga FR, Araujo JM, Alves CD. Ovicidal activity of Pochonia chlamydosporia and Paecilomyces lilacinus on Toxocara canis eggs. Vet Parasitol. 2010;169:123–127. doi:10.1016/j.vetpar.2009.12.037
  • Hiura E, Del Carmen Garcia Lopes A, da Paz JS, et al. Fungi predatory activity on embryonated Toxocara canis eggs inoculated in domestic chickens (Gallus gallus domesticus) and destruction of second stage larvae. Parasitol Res. 2015;114:3301–3308. doi:10.1007/s00436-015-4553-5
  • Maia Filho FS, Fonseca AOS, Persici BM, et al. Trichoderma virens as a biocontrol of Toxocara canis: in vivo evaluation. Rev Iberoam Micol. 2017;34:32–35. doi:10.1016/j.riam.2016.06.004
  • Maia Filho FS, Nunes Vieira J, Aires Berne ME, et al. Fungal ovicidal activity on Toxocara canis eggs. Rev Iberoam Micol. 2013;30:226–230. doi:10.1016/j.riam.2012.12.009
  • Verocai GG, Tavares PV, De A. ribeiro F, Correia TR, Scott FB. Effects of disinfectants on Toxocara canis embryogenesis and larval establishment in mice tissues. Zoonoses Public Health. 2010;57:e213–6. doi:10.1111/j.1863-2378.2010.01330.x
  • Merigueti Y, da Silva Raposo R, Zampieri BP, de Lima Cerazo LM, Pereira L, Santarém VA. Dispersion and infectivity of Toxocara canis eggs after passage through chicken intestine. Parasitol Res. 2018;117:3481–3486. doi:10.1007/s00436-018-6045-x
  • von Sohsten AL, Vieira da Silva A, Rubinsky-Elefant G, et al. Chickens bred extensively as sentinels from soil contamination by Toxocara. Exp Parasitol. 2020;211:107852. doi:10.1016/j.exppara.2020.107852
  • Aguiar PS, Furtado RD, de Avila LF, et al. Transmammary infection in BALB/c mice with chronic toxocariasis. Parasitol Int. 2015;64:145–147. doi:10.1016/j.parint.2014.04.010
  • Telmo PL, Avila LF, Santos CA, et al. Elevated trans-mammary transmission of Toxocara canis larvae in BALB/c mice. Rev Inst Med Trop Sao Paulo. 2015;57:85–87. doi:10.1590/s0036-46652015000100013
  • Santos SV, Yazawa santos FH, Zevallos lescano SA, et al. Migration pattern of Toxocara canis larvae in experimentally infected male and female Rattus norvegicus. Rev Soc Bras Med Trop. 2017;50:698–700. doi:10.1590/0037-8682-0076-2017
  • Flecher MC, Musso C, Martins IV, Pereira FE. Larval migration of the ascarid nematode Toxocara canis following infection and re-infection in the gerbil Meriones unguiculatus. J Helminthol. 2016;90:569–576. doi:10.1017/s0022149x15000760
  • Cox DM, Holland CV. The influence of mouse strain, infective dose and larval burden in the brain on activity in Toxocara-infected mice. J Helminthol. 2001a;75:23–32. doi:10.1079/JOH200027
  • Cox DM, Holland CV. Relationship between three intensity levels of Toxocara canis larvae in the brain effects on exploration, anxiety, learning and memory in the murine host. J Helminthol. 2001b;75:33–41. doi:10.1079/JOH200028
  • Santos SV, Moura JV, Lescano SA, Castro JM, Ribeiro MC, Chieffi PP. Behavioural changes and muscle strength in Rattus norvegicus experimentally infected with Toxocara cati and T. canis. J Helminthol. 2015;89:465–470. doi:10.1017/s0022149x14000303
  • Corrêa FM, Chieffi PP, Lescano SA, Santos SV. Behavioral and memory changes in Mus musculus coinfected by Toxocara canis and Toxoplasma gondii. Rev Inst Med Trop Sao Paulo. 2014;56:353–356. doi:10.1590/s0036-46652014000400014
  • Silva AM, Chieffi PP, Da silva WL, et al. The hamster (Mesocricetus auratus) as an experimental model of toxocariasis: histopathological, immunohistochemical, and immunoelectron microscopic findings. Parasitol Res. 2015;114:809–821. doi:10.1007/s00436-014-4246-5