The Burden of Typhoid Fever in Sub-Saharan Africa: A Perspective

References

• Basnyat B, Qamar FN, Rupali P, Ahmed T, Parry CM. Clinical update: Enteric Fever. BMJ. 2021;372:n437. doi:10.1136/BMJ.N437
   Web of Science ®Google Scholar
• Haselbeck AH, Panzner U, Im J, Baker S, Meyer CG, Marks F. Current perspectives on invasive nontyphoidal Salmonella disease. Curr Opin Infect Dis. 2017;30(5):498. doi:10.1097/QCO.0000000000000398
   PubMed Web of Science ®Google Scholar
• Dougan G, Baker S. Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever. Annu Rev Microbiol. 2014;68:317–336. doi:10.1146/ANNUREV-MICRO-091313-103739
   PubMed Web of Science ®Google Scholar
• Crump J, Sjöund-Karlsson M, Gordon M, Parry C. Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive Salmonella infections. Clin Microbiol Rev. 2015;28(4):901–937. doi:10.1128/CMR.00002-15
   PubMed Web of Science ®Google Scholar
• Cutler D, Miller G. The role of public health improvements in health advances: the twentieth-century United States. Demography. 2005;42(1):1–22. doi:10.1353/DEM.2005.0002
   PubMed Web of Science ®Google Scholar
• World Health Organization. Typhoid and other invasive salmonellosis. Vaccine-preventable diseases, surveillance standards; 2018. Available from: https://www.who.int/immunization/monitoring_surveillance/burden/vpd/WHO_SurveillanceVaccinePreventable_21_Typhoid_R1.pdf?ua=1. Accessed May 6, 2021.
   Google Scholar
• John J, Van Aaart C, Grassly N. The burden of typhoid and paratyphoid in India: systematic review and meta-analysis. PLoS Negl Trop Dis. 2016;10(4):e0004616. doi:10.1371/JOURNAL.PNTD.0004616
   PubMed Web of Science ®Google Scholar
• World Health Organization. Typhoid; 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/typhoid. Accessed May 6, 2021.
   Google Scholar
• Bentsi-Enchill AD, Hombach J. Revised global typhoid vaccination policy. Clin Infect Dis. 2019;68(Suppl 1):S31. doi:10.1093/CID/CIY927
   PubMed Web of Science ®Google Scholar
• World Health Organization. Typhoid vaccines: WHO position paper, March 2018 - recommendations. Vaccine. 2019;37(2):214–216. doi:10.1016/J.VACCINE.2018.04.022
   PubMed Web of Science ®Google Scholar
• Uzoka F-ME, Akwaowo C, Nwafor-Okoli C, et al. Risk factors for some tropical diseases in an African country. BMC Public Health. 2021;21(1):2261. doi:10.1186/S12889-021-12286-3
   PubMed Web of Science ®Google Scholar
• Mweu E, English M. Typhoid fever in children in Africa. Trop Med Int Health. 2008;13(4):532–540. doi:10.1111/J.1365-3156.2008.02031.X
   PubMed Web of Science ®Google Scholar
• Wain J, Hosoglu S. The laboratory diagnosis of enteric fever. J Infect Dev Ctries. 2008;2(06):421–425. doi:10.3855/jidc.155
   PubMedGoogle Scholar
• Parry CM, Wijedoru L, Arjyal A, Baker S. The utility of diagnostic tests for enteric fever in endemic locations. Expert Rev Anti Infect Ther. 2011;9(6):711–725. doi:10.1586/ERI.11.47
   PubMed Web of Science ®Google Scholar
• Mogasale V, Ramani E, Mogasale V, Park J. What proportion of Salmonella Typhi cases are detected by blood culture? A systematic literature review. Ann Clin Microbiol Antimicrob. 2016;15(1). doi:10.1186/S12941-016-0147-Z
   PubMed Web of Science ®Google Scholar
• Dougan G. Typhoid in Africa and vaccine deployment. Lancet Glob Heal. 2017;5(3):e236–e237. doi:10.1016/S2214-109X(17)30045-1
   PubMed Web of Science ®Google Scholar
• Parry CM, Wijedoru L, Arjyal A, Baker S. The utility of diagnostic tests for enteric fever in endemic locations. Expert Rev Anti Infect Ther. 2014;9(6):711–725. doi:10.1586/ERI.11.47
   Web of Science ®Google Scholar
• Andrews JR, Khanam F, Rahman N, et al. Plasma immunoglobulin a responses against 2 Salmonella Typhi antigens identify patients with typhoid fever. Clin Infect Dis. 2019;68(6):949–955. doi:10.1093/CID/CIY578
   PubMed Web of Science ®Google Scholar
• Najib MA, Mustaffa KMF, Ong EBB, et al. Performance of immunodiagnostic tests for typhoid fever: a systematic review and meta-analysis. Pathog. 2021;10(9):1184. doi:10.3390/PATHOGENS10091184
   PubMed Web of Science ®Google Scholar
• Kim J-H, Im J, Parajulee P, et al. A systematic review of typhoid fever occurrence in Africa. Clin Infect Dis. 2019;69(Suppl 6):S492–S498. doi:10.1093/CID/CIZ525
   PubMed Web of Science ®Google Scholar
• Stanaway JD, Reiner RC, Blacker BF, et al. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis. 2019;19(4):369–381. doi:10.1016/S1473-3099(18)30685-6
   PubMed Web of Science ®Google Scholar
• Marchello CS, Birkhold M, Crump JA. Complications and mortality of typhoid fever: a global systematic review and meta-analysis. J Infect. 2020;81(6):902–910. doi:10.1016/J.JINF.2020.10.030
   PubMed Web of Science ®Google Scholar
• Antillón M, Warren JL, Crawford FW, et al. The burden of typhoid fever in low- and middle-income countries: a meta-regression approach. PLoS Negl Trop Dis. 2017;11(2):e0005376. doi:10.1371/JOURNAL.PNTD.0005376
   PubMed Web of Science ®Google Scholar
• Marchello CS, Hong CY, Crump JA. Global typhoid fever incidence: a systematic review and meta-analysis. Clin Infect Dis. 2019;68(Suppl 2):S105–S116. doi:10.1093/CID/CIY1094
   PubMed Web of Science ®Google Scholar
• GBD results tool | gHDx. Available from: http://ghdx.healthdata.org/gbd-results-tool. Accessed November 7, 2021.
   Google Scholar
• Britto C, Pollard AJ, Voysey M, Blohmke CJ. An appraisal of the clinical features of pediatric enteric fever: systematic review and meta-analysis of the age-stratified disease occurrence. Clin Infect Dis. 2017;64(11):1604–1611. doi:10.1093/CID/CIX229
   PubMed Web of Science ®Google Scholar
• Andrews JR, Vaidya K, Bern C, et al. High rates of enteric fever diagnosis and lower burden of culture-confirmed disease in peri-urban and rural Nepal. J Infect Dis. 2018;218(Suppl 4):S214–S221. doi:10.1093/INFDIS/JIX221
   PubMed Web of Science ®Google Scholar
• Breiman RF, Cosmas L, Njuguna H, et al. Population-based incidence of typhoid fever in an urban informal settlement and a rural area in Kenya: implications for typhoid vaccine use in Africa. PLoS One. 2012;7(1):e29119. doi:10.1371/JOURNAL.PONE.0029119
   PubMed Web of Science ®Google Scholar
• Gibani MM, Britto C, Pollard AJ. Typhoid and paratyphoid fever: a call to action. Curr Opin Infect Dis. 2018;31(5):440–448. doi:10.1097/QCO.0000000000000479
   PubMed Web of Science ®Google Scholar
• Marks F, Kalckreuth V, Aaby P, et al. Incidence of invasive Salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study. Lancet Glob Heal. 2017;5(3):e310–e323. doi:10.1016/S2214-109X(17)30022-0
   PubMed Web of Science ®Google Scholar
• Cruz Espinoza L, Nichols C, Adu-Sarkodie Y, et al. Variations of invasive Salmonella infections by population size in Asante Akim North Municipal, Ghana. Clin Infect Dis. 2016;62(Suppl 1):s17–s22. doi:10.1093/CID/CIV787
   PubMed Web of Science ®Google Scholar
• Park SE, Toy T, Cruz Espinoza LM, et al. The Severe Typhoid Fever in Africa program: study design and methodology to assess disease severity, host immunity, and carriage associated with invasive salmonellosis. Clin Infect Dis. 2019;69(Suppl 6):S422–S434. doi:10.1093/CID/CIZ715
   PubMed Web of Science ®Google Scholar
• Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ. Typhoid Fever. N Engl J Med. 2002;347(22):1770–1782. doi:10.1056/NEJMRA020201
   Google Scholar
• Pieters Z, Saad NJ, Antillón M, Pitzer VE, Bilcke J. Case fatality rate of enteric fever in endemic countries: a systematic review and meta-analysis. Clin Infect Dis. 2018;67(4):628–638. doi:10.1093/CID/CIY190
   PubMed Web of Science ®Google Scholar
• Birkhold M, Coulibaly Y, Coulibaly O, et al. Morbidity and mortality of typhoid intestinal perforation among children in Sub-Saharan Africa 1995–2019: a scoping review. World J Surg. 2020;44(9):2892. doi:10.1007/S00268-020-05567-2
   PubMed Web of Science ®Google Scholar
• Feasey NA, Gaskell K, Wong V, et al. Rapid emergence of multidrug resistant, H58-lineage Salmonella Typhi in Blantyre, Malawi. PLoS Negl Trop Dis. 2015;9(4):e0003748. doi:10.1371/JOURNAL.PNTD.0003748
   PubMed Web of Science ®Google Scholar
• Phoba M, De Boeck H, Ifeka B, et al. Epidemic increase in Salmonella bloodstream infection in children, Bwamanda, the Democratic Republic of Congo. Eur J Clin Microbiol Infect Dis. 2014;33(1):79–87. doi:10.1007/S10096-013-1931-8
   PubMed Web of Science ®Google Scholar
• Breiman R. The rapidly re-emerging burden of endemic typhoid fever in the 21st Century: a preventable by-product of massive urbanization in the developing world? Int J Infect Dis. 2014;21:54. doi:10.1016/J.IJID.2014.03.531
   Web of Science ®Google Scholar
• Contini S. Typhoid intestinal perforation in developing countries: still unavoidable deaths? World J Gastroenterol. 2017;23(11):1925–1931. doi:10.3748/WJG.V23.I11.1925
   PubMed Web of Science ®Google Scholar
• Mogasale V, Desai SN, Mogasale VV, Park JK, Leon Ochiai R, Wierzba TF. Case fatality rate and length of hospital stay among patients with typhoid intestinal perforation in developing countries: a systematic literature review. PLoS One. 2014;9(4):e93784. doi:10.1371/JOURNAL.PONE.0093784
   PubMed Web of Science ®Google Scholar
• Butler T, Islam A, Kabir I, Jones P. Patterns of morbidity and mortality in typhoid fever dependent on age and gender: review of 552 hospitalized patients with diarrhea. Rev Infect Dis. 1991;13(1):85–90. doi:10.1093/CLINIDS/13.1.85
   PubMedGoogle Scholar
• Azmatullah A, Qamar FN, Thaver D, Zaidi AKM, Bhutta ZA. Systematic review of the global epidemiology, clinical and laboratory profile of enteric fever. J Glob Health. 2015;5(2). doi:10.7189/JOGH.05.020407
   PubMed Web of Science ®Google Scholar
• Cruz Espinoza LM, McCreedy E, Holm M, et al. Occurrence of typhoid fever complications and their relation to duration of illness preceding hospitalization: a systematic literature review and meta-analysis. Clin Infect Dis. 2019;69(Suppl 6):S435–S448. doi:10.1093/CID/CIZ477
   PubMed Web of Science ®Google Scholar
• Jeon HJ, Marks F, Sugimoto J, et al. Surge of typhoid intestinal perforations as possible result of COVID-19–associated delays in seeking care, Madagascar. Emerg Infect Dis. 2021;27(12):3163–3165. doi:10.3201/EID2712.210516
   PubMed Web of Science ®Google Scholar
• Keddy KH, Smith AM, Sooka A, et al. The burden of typhoid fever in South Africa: the potential impact of selected interventions. Am J Trop Med Hyg. 2018;99(3 Suppl):55. doi:10.4269/AJTMH.18-0182
   PubMed Web of Science ®Google Scholar
• Bulage L, Masiira B, Ario AR, et al. Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoid fever, Kampala Uganda, 2015. BMC Infect Dis. 2017;17(1). doi:10.1186/S12879-017-2720-2
   Web of Science ®Google Scholar
• Chalya P, Mabula J, Koy M, et al. Typhoid intestinal perforations at a University teaching hospital in Northwestern Tanzania: a surgical experience of 104 cases in a resource-limited setting. World J Emerg Surg. 2012;7(1):4. doi:10.1186/1749-7922-7-4
   PubMed Web of Science ®Google Scholar
• Parry CM, Thompson C, Vinh H, et al. Risk factors for the development of severe typhoid fever in Vietnam. BMC Infect Dis. 2014;14(1):1–9. doi:10.1186/1471-2334-14-73
   PubMed Web of Science ®Google Scholar
• Kaljee LM, Pach A, Garrett D, Bajracharya D, Karki K, Khan I. Social and economic burden associated with typhoid fever in Kathmandu and surrounding areas: a Qualitative Study. J Infect Dis. 2018;218(suppl_4):S243–S249. doi:10.1093/INFDIS/JIX122
   PubMed Web of Science ®Google Scholar
• Luthra K, Watts E, Debellut F, Pecenka C, Bar-Zeev N, Constenla D. A review of the economic evidence of typhoid fever and typhoid vaccines. Clin Infect Dis. 2019;68(Suppl 2):S83–S95. doi:10.1093/cid/ciy1122
   PubMed Web of Science ®Google Scholar
• Antillón M, Bilcke J, Paltiel AD, Pitzer VE. Cost-effectiveness analysis of typhoid conjugate vaccines in five endemic low- and middle-income settings. Vaccine. 2017;35(27):3506. doi:10.1016/J.VACCINE.2017.05.001
   PubMed Web of Science ®Google Scholar
• Bhutta ZA. Current concepts in the diagnosis and treatment of typhoid fever. BMJ Br Med J. 2006;333(7558):78. doi:10.1136/BMJ.333.7558.78
   PubMed Web of Science ®Google Scholar
• Argimón S, Yeats CA, Goater RJ, et al. A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch. Nat Commun. 2021;12(1):1–12. doi:10.1038/s41467-021-23091-2
   PubMed Web of Science ®Google Scholar
• Azhar AB, Khalid A, Shah S. The implications of extensive drug-resistant typhoid fever: a Case Report. Cureus. 2019;11(6). doi:10.7759/CUREUS.5032
   Web of Science ®Google Scholar
• Mather RG, Hopkins H, Parry CM, Dittrich S. Redefining typhoid diagnosis: what would an improved test need to look like? BMJ Glob Heal. 2019;4(5). doi:10.1136/BMJGH-2019-001831
   PubMed Web of Science ®Google Scholar
• Rowe B, Ward LR, Threlfall EJ. Multidrug-resistant Salmonella Typhi: a worldwide epidemic. Clin Infect Dis. 1997;24(Suppl 1):S106–S109. doi:10.1093/clinids/24.Supplement_1.S106
   PubMed Web of Science ®Google Scholar
• Park SE, Pham DT, Boinett C, et al. The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. Nat Commun. 2018;9(1):1–10. doi:10.1038/s41467-018-07370-z
   PubMed Web of Science ®Google Scholar
• Mashe T, Gudza-Mugabe M, Tarupiwa A, et al. Laboratory characterisation of Salmonella enterica serotype Typhi isolates from Zimbabwe, 2009–2017. BMC Infect Dis. 2019;19(1):1–9. doi:10.1186/S12879-019-4114-0
   PubMed Web of Science ®Google Scholar
• Olaru ID, Mtapuri-Zinyowera S, Feasey N, Ferrand RA, Kranzer K. Typhoid Vi-conjugate vaccine for outbreak control in Zimbabwe. Lancet Infect Dis. 2019;19(9):930. doi:10.1016/S1473-3099(19)30425-6
   PubMed Web of Science ®Google Scholar
• Kariuki S, Dyson ZA, Mbae C, et al. Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya. Elife. 2021;10. doi:10.7554/ELIFE.67852
   PubMed Web of Science ®Google Scholar
• Klemm EJ, Shakoor S, Page AJ, et al. Emergence of an extensively drug-resistant Salmonella enterica serovar Typhi clone harboring a promiscuous plasmid encoding resistance to fluoroquinolones and third-generation cephalosporins. MBio. 2018;9(1). doi:10.1128/mBio.00105-18
   PubMed Web of Science ®Google Scholar
• Qamar FN, Yousafzai MT, Khalid M, et al. Outbreak investigation of ceftriaxone-resistant Salmonella enterica serotype Typhi and its risk factors among the general population in Hyderabad, Pakistan: a matched case-control study. Lancet Infect Dis. 2018;18(12):1368–1376. doi:10.1016/S1473-3099(18)30483-3
   PubMed Web of Science ®Google Scholar
• Qamar FN, Yousafzai MT, Dehraj IF, et al. Antimicrobial resistance in typhoidal Salmonella: surveillance for enteric fever in Asia project, 2016–2019. Clin Infect Dis. 2020;71(Suppl3):S276–S284. doi:10.1093/CID/CIAA1323
   PubMed Web of Science ®Google Scholar
• Aslam F, Yue Y, Aziz M. Introduction of typhoid vaccine in the expanded immunization program of Pakistan. Hum Vaccin Immunother. 2021;17(7):2132. doi:10.1080/21645515.2020.1869496
   PubMed Web of Science ®Google Scholar
• Yousafzai MT, Karim S, Qureshi S, et al. Effectiveness of typhoid conjugate vaccine against culture-confirmed Salmonella enterica serotype Typhi in an extensively drug-resistant outbreak setting of Hyderabad, Pakistan: a cohort study. Lancet Glob Heal. 2021;9(8):e1154–e1162. doi:10.1016/S2214-109X(21)00255-2
   PubMed Web of Science ®Google Scholar
• Neuzil KM, Pollard AJ, Marfin AA. Introduction of typhoid conjugate vaccines in Africa and Asia. Clin Infect Dis. 2019;68(Suppl 1):S27. doi:10.1093/CID/CIY878
   PubMed Web of Science ®Google Scholar
• Sahastrabuddhe S, Saluja T. Overview of the typhoid conjugate vaccine pipeline: current status and future plans. Clin Infect Dis. 2019;68(Suppl 1):S22–S26. doi:10.1093/CID/CIY884
   PubMed Web of Science ®Google Scholar
• Syed KA, Saluja T, Cho H, et al. Review on the recent advances on typhoid vaccine development and challenges ahead. Clin Infect Dis. 2020;71(Suppl 2):S141–S150. doi:10.1093/CID/CIAA504
   PubMed Web of Science ®Google Scholar
• World Health Organization. Comparison table of WHO-prequalified typhoid conjugate vaccines (‎TCV); 2021. Available from: https://apps.who.int/iris/handle/10665/345367. Accessed November 11, 2021.
   Google Scholar
• Patel PD, Patel P, Liang Y, et al. Safety and efficacy of a typhoid conjugate vaccine in Malawian children. N Engl J Med. 2021;385(12):1104–1115. doi:10.1056/NEJMOA2035916
   PubMed Web of Science ®Google Scholar
• Shakya M, Colin-Jones R, Theiss-Nyland K, et al. Phase 3 efficacy analysis of a typhoid conjugate vaccine trial in Nepal. N Engl J Med. 2019;381(23):2209–2218. doi:10.1056/NEJMOA1905047
   PubMed Web of Science ®Google Scholar
• Qadri F, Khanam F, Liu X, et al. Protection by vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh: a cluster-randomised trial. Lancet. 2021;398(10301):675–684. doi:10.1016/S0140-6736(21)01124-7
   PubMed Web of Science ®Google Scholar
• Shakya M, Voysey M, Theiss-Nyland K, et al. Efficacy of typhoid conjugate vaccine in Nepal: final results of a phase 3, randomised, controlled trial. Lancet Glob Heal. 2021;9(11):e1561. doi:10.1016/S2214-109X(21)00346-6
   PubMed Web of Science ®Google Scholar
• Haselbeck AH, Tadesse BT, Park J, et al. Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana (TyVEGHA) using a cluster-randomized controlled Phase IV trial: trial design and population baseline characteristics. Vaccines. 2021;9(3):281. doi:10.3390/VACCINES9030281
   Web of Science ®Google Scholar
• Soble A, Patel Z, Sosler S, Hampton L, Johnson H. Gavi support for typhoid conjugate vaccines: moving from global investments to country introduction. Clin Infect Dis. 2020;71(Suppl 2):S160–S164. doi:10.1093/CID/CIAA342
   PubMed Web of Science ®Google Scholar
• Carey ME, Diaz ZI, Broadstock M, Bailey R, Bentsi-Enchill AD, Larson HJ. Toward Control? The prospects and challenges of typhoid conjugate vaccine introduction. Clin Infect Dis. 2019;69(Suppl 5):S408–S411. doi:10.1093/CID/CIZ483
   PubMed Web of Science ®Google Scholar
• Shakya M, Neuzil KM, Pollard AJ. Prospects of future typhoid and paratyphoid vaccines in endemic countries. J Infect Dis. 2021;224(Supplement_7):S770–S774. doi:10.1093/INFDIS/JIAB393
   PubMed Web of Science ®Google Scholar
• International Vaccine Access Center (IVAC). Johns Hopkins Bloomberg School of Public Health. VIEW-hub. Available from: https://view-hub.org/. Accessed December 4, 2021.
   Google Scholar
• Balasubramanian R, Im J, Lee JS, et al. The global burden and epidemiology of invasive non-typhoidal Salmonella infections. Hum Vaccin Immunother. 2019;15(6):1421–1426. doi:10.1080/21645515.2018.1504717
   PubMed Web of Science ®Google Scholar
• Martin LB, Simon R, MacLennan CA, Tennant SM, Sahastrabuddhe S, Khan MI. Status of paratyphoid fever vaccine research and development. Vaccine. 2016;34(26):2900–2902. doi:10.1016/J.VACCINE.2016.03.106
   PubMed Web of Science ®Google Scholar
• Uzzell CB, Troman CM, Rigby J, et al. Environmental surveillance for Salmonella Typhi as a tool to estimate the incidence of typhoid fever in low-income populations. medRxiv. 2021. doi:10.1101/2021.05.21.21257547
   Google Scholar
• Marotta C, Nacareia U, Estevez AS, et al. Mozambican adolescents and youths during the COVID-19 pandemic: knowledge and awareness gaps in the provinces of sofala and tete. Healthc. 2021;9(3). doi:10.3390/HEALTHCARE9030321
   Google Scholar
• Henley P, Igihozo G, Wotton L. One Health approaches require community engagement, education, and international collaborations—a lesson from Rwanda. Nat Med. 2021;27(6):947–948. doi:10.1038/s41591-021-01350-5
   PubMed Web of Science ®Google Scholar