Current Insights on the Impact of Gamma-Hydroxybutyrate (GHB) Abuse

References

• Darke S, Peacock A, Duflou J, Farrell M, Lappin J. Characteristics and circumstances of death related to gamma hydroxybutyrate (GHB). Clin Toxicol. 2020;58(11):1028–1033. doi:10.1080/15563650.2020.1726378
   PubMed Web of Science ®Google Scholar
• Dijkstra BAG, Beurmanjer H, Goudriaan AE, Schellekens AFA, Joosten EAG. Unity in diversity: a systematic review on the GHB using population. Int J Drug Policy. 2021;94:103230. doi:10.1016/j.drugpo.2021.103230
   PubMed Web of Science ®Google Scholar
• Snead OC 3rd, Gibson KM. Gamma-hydroxybutyric acid. N Engl J Med. 2005;352(26):2721–2732. doi:10.1056/NEJMra044047
   PubMed Web of Science ®Google Scholar
• Maitre M, Klein C, Mensah-Nyagan AG. Mechanisms for the specific properties of γ-Hydroxybutyrate in brain. Med Res Rev. 2016;36(3):363–388. doi:10.1002/med.21382
   PubMed Web of Science ®Google Scholar
• World Health Organization. Gamma-hydroxybutyric acid (GHB) critical review report ECoDD. WHO Thirty-fifth Meeting; June 4–8; 2012.
   Google Scholar
• Elliott SP, Fais P. Further evidence for GHB naturally occurring in common non-alcoholic beverages. Forensic Sci Int. 2017;277:e36–e38. doi:10.1016/j.forsciint.2017.05.012
   PubMed Web of Science ®Google Scholar
• Felmlee MA, Morse BL, Morris ME. γ-Hydroxybutyric acid: pharmacokinetics, pharmacodynamics, and toxicology. AAPS J. 2021;23(1):22. doi:10.1208/s12248-020-00543-z
   PubMed Web of Science ®Google Scholar
• Stefani M, Roberts DM. 1,4-Butanediol overdose mimicking toxic alcohol exposure. Clin Toxicol. 2020;58(3):204–207. doi:10.1080/15563650.2019.1617419
   PubMed Web of Science ®Google Scholar
• Absalom N, Eghorn LF, Villumsen IS, et al. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A. 2012;109(33):13404–13409. doi:10.1073/pnas.1204376109
   PubMed Web of Science ®Google Scholar
• Abanades S, Farre M, Segura M, et al. Gamma-hydroxybutyrate (GHB) in humans: pharmacodynamics and pharmacokinetics. Ann N Y Acad Sci. 2006;1074:559–576. doi:10.1196/annals.1369.065
   PubMed Web of Science ®Google Scholar
• Liechti ME, Quednow BB, Liakoni E, et al. Pharmacokinetics and pharmacodynamics of gamma-hydroxybutyrate in healthy subjects. Br J Clin Pharmacol. 2016;81(5):980–988. doi:10.1111/bcp.12863
   PubMed Web of Science ®Google Scholar
• Thai D, Dyer JE, Jacob P, Haller CA. Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin Pharmacol Ther. 2007;81(2):178–184. doi:10.1038/sj.clpt.6100037
   PubMed Web of Science ®Google Scholar
• Blumenfeld M, Suntay RG, Harmel,MH. Sodium gamma-hydroxybutyric acid: a new anesthetic adjuvant. Anesth Analg. 1962;41(6):721–726. doi:10.1213/00000539-196211000-00011
   Web of Science ®Google Scholar
• Rubin BAGN, Giarman NJ. The therapy of experimental influenza in mice with antibiotic lactones and related compounds. Yale J Biol Med. 1947;19(6):1017–1022.
   PubMed Web of Science ®Google Scholar
• Schep LJ, Knudsen K, Slaughter RJ, Vale JA, Mégarbane B. The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol. Clin Toxicol. 2012;50(6):458–470. doi:10.3109/15563650.2012.702218
   PubMed Web of Science ®Google Scholar
• Grela A, Gautam L, Cole MD. A multifactorial critical appraisal of substances found in drug facilitated sexual assault cases. Forensic Sci Int. 2018;292:50–60. doi:10.1016/j.forsciint.2018.08.034
   PubMed Web of Science ®Google Scholar
• European medicines agency. Avaialble from: https://www.ema.europa.eu/en/medicines/human/EPAR/xyrem. Accessed September 25, 2021.
   Google Scholar
• United States Food and Drug Administration. Avaiailbe from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021196s030lbl.pdf. Accessed September 25, 2021.
   Google Scholar
• Skala K, Caputo F, Mirijello A, et al. Sodium oxybate in the treatment of alcohol dependence: from the alcohol withdrawal syndrome to the alcohol relapse prevention. Expert Opin Pharmacother. 2014;15(2):245–257. doi:10.1517/14656566.2014.863278
   PubMed Web of Science ®Google Scholar
• Busardò FP, Kyriakou C, Napoletano S, Marinelli E, Zaami S. Clinical applications of sodium oxybate (GHB): from narcolepsy to alcohol withdrawal syndrome. Eur Rev Med Pharmacol Sci. 2015;19(23):4654–4663.
   PubMed Web of Science ®Google Scholar
• de Jong CA, Kamal R, Dijkstra BA, de Haan HA. Gamma-hydroxybutyrate detoxification by titration and tapering. Eur Addict Res. 2012;18(1):40–45. doi:10.1159/000333022
   PubMed Web of Science ®Google Scholar
• Dijkstra BA, Kamal R, van Noorden MS, de Haan H, Loonen AJ, De Jong CA. Detoxification with titration and tapering in gamma-hydroxybutyrate (GHB) dependent patients: the Dutch GHB monitor project. Drug Alcohol Depend. 2017;170:164–173. doi:10.1016/j.drugalcdep.2016.11.014
   PubMed Web of Science ®Google Scholar
• Beurmanjer H, Luykx JJ, De Wilde B, et al. Tapering with pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-dependent patients: a matched-subject observational study of treatment-as-usual in Belgium and The Netherlands. CNS Drugs. 2020;34(6):651–659. doi:10.1007/s40263-020-00730-8
   PubMed Web of Science ®Google Scholar
• Gallimberti L, Schifano F, Forza G, Miconi L, Ferrara SD. Clinical efficacy of gamma-hydroxybutyric acid in treatment of opiate withdrawal. Eur Arch Psychiatry Clin Neurosci. 1994;244(3):113–114. doi:10.1007/BF02191883
   PubMed Web of Science ®Google Scholar
• Rosen MI, Pearsall HR, Woods SW, Kosten TR. The effect of gamma-hydroxybutyric acid on naloxone-precipitated opiate withdrawal. Neuropsychopharmacology. 1996;14(3):187–193. doi:10.1016/0893-133X(95)00087-T
   PubMed Web of Science ®Google Scholar
• Geldenhuys FG, Sonnendecker EW, De Klrk MC. Experience with sodium-gamma-4-hydroxybutyric acid (gamma-OH) in obstetrics. J Obstet Gynaecol Br Commonw. 1968;75(4):405–413. doi:10.1111/j.1471-0528.1968.tb00137.x
   PubMedGoogle Scholar
• World. Health Organization Commission on Narcotic Drugs Fifty-eighth session. Note by the Secretariat on the scope of control of substances: proposed scheduling recommendations initiated by WHO; 2015. Available from: https://www.unodc.org/documents/commissions/CND/CND_Sessions/CND_58/ECN72015_8_eV1501009.pdf. Accesed December 20, 2021.
   Google Scholar
• World Drug Report. United Nations publication, Sales No. E.21.XI.8; 2021. Available from: https://www.unodc.org/unodc/en/data-and-analysis/wdr2021.html. Accessed December 20, 2021.
   Google Scholar
• Australian Institute of Health and Welfare. National Drug Strategy Household Survey. Statistics series no. 32. PHE 270; 2019. Available from: https://www.aihw.gov.au/reports/illicit-use-of-drugs/national-drug-strategy-household-survey-2019/contents/summary. Accessed December 20, 2021.
   Google Scholar
• Center for behavioural health statistics and quality. Results from the 2019 national survey on drug use and health: detailed tables. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2020 [cited December 20, 2021]. Avaialble from: https://www.samhsa.gov/data/. Accessed January 6, 2021.
   Google Scholar
• European Monitoring Centre for Drugs and Drug Addiction. European drug report 2021: trends and developments. Luxembourg: Publications Office of the European Union; 2021.
   Google Scholar
• WODC Repository. National drug monitor; 2020. Availalbe from: https://repository.wodc.nl/handle/20.500.12832/3035. Accessed December 20, 2021.
   Google Scholar
• Advisory Council on the Misuse of Drugs. An assessment of the harms of gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and closely related compounds. Available from: https://www.gov.uk/government/publications/assessment-of-the-harms-of-gamma-hydroxybutyric-acid-gamma-butyrolactone-and-closely-related-compounds. Accessed December 20, 2021.
   Google Scholar
• Hammoud MA, Bourne A, Maher L, et al. Intensive sex partying with gamma-hydroxybutyrate: factors associated with using gamma-hydroxybutyrate for chemsex among Australian gay and bisexual men - results from the Flux Study. Sex Health. 2018;15(2):123–134. doi:10.1071/SH17146
   PubMed Web of Science ®Google Scholar
• Edmundson C, Heinsbroek E, Glass R, et al. Sexualised drug use in the United Kingdom (UK): a review of the literature. Int J Drug Policy. 2018;55:131–148. doi:10.1016/j.drugpo.2018.02.002
   PubMed Web of Science ®Google Scholar
• Peacock AU, Karlsson A, Price O, et al. Australian drug trends 2020: key findings from the Illicit Drug Reporting System (IDRS) interviews. Available from: https://ndarc.med.unsw.edu.au/resource/australian-drug-trends-2020-key-findings-national-illicit-drug-reporting-system-idrs. Accessed December 20, 2021.
   Google Scholar
• Arunogiri S, Moayeri F, Crossin R, et al. Trends in gamma-hydroxybutyrate-related harms based on ambulance attendances from 2012 to 2018 in Victoria, Australia. Addiction. 2020;115(3):473–479.
   PubMed Web of Science ®Google Scholar
• Andresen H, Aydin BE, Mueller A, Iwersen-Bergmann S. An overview of gamma-hydroxybutyric acid: pharmacodynamics, pharmacokinetics, toxic effects, addiction, analytical methods, and interpretation of results. Drug Test Anal. 2011;3(9):560–568. doi:10.1002/dta.254
   PubMed Web of Science ®Google Scholar
• Galicia M, Dargan PI, Dines AM, et al. Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication. Toxicol Lett. 2019;314:37–42. doi:10.1016/j.toxlet.2019.07.001
   PubMed Web of Science ®Google Scholar
• Dietze P, Horyniak D, Agius P, et al. Effect of intubation for gamma-hydroxybutyric acid overdose on emergency department length of stay and hospital admission. Acad Emerg Med. 2014;21(11):1226–1231. doi:10.1111/acem.12516
   PubMed Web of Science ®Google Scholar
• van Helmond L, Gresnigt FMJ. Safety of withholding intubation in gamma-hydroxybutyrate- and gamma-butyrolactone-intoxicated coma patients in the emergency department. Eur J Emerg Med. 2020;27(3):223–227. doi:10.1097/MEJ.0000000000000649
   PubMed Web of Science ®Google Scholar
• Karlsson ASR, Peacock A Use of GHB amongst sentinel samples of people who regularly use illicit drugs in Adelaide, South Australia, 2020. Drug Trends Bulletin Series. Sydney: National Drug and Alcohol Research Centre, UNSW Sydney; 2021. Available from: https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/South%20Australia%20GHB%20Use%20FINAL.pdf. Accessed December 20, 2021.
   Google Scholar
• Amsterdam JV, Brunt TM, Pereira FR, Crunelle CL, Brink WVD. Cognitive impairment following clinical or recreational use of gamma-hydroxybutyric acid (GHB). A systematic review. Curr Neuropharmacol. 2021. doi:10.2174/1570159X19666210610094352
   Web of Science ®Google Scholar
• Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. Treatment Episode Data Set (TEDS): 2019. Admissions to and discharges from publicly funded substance use treatment. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2021. Available from: https://www.samhsa.gov/data/sites/default/files/reports/rpt35314/2019_TEDS_Proof.pdf. Accessed December 8, 2021.
   Google Scholar
• Phan V, Arunogiri S, Lubman D. The assessment and management of gamma hydroxybutyrate use in general practice. Aust J Gen Pract. 2020;49:73–78. doi:10.31128/AJGP-05-19-4953
   PubMed Web of Science ®Google Scholar
• Durgahee S, Allen G, Williams H. The “G” men: a profile of GBL/GHB users in an area of high drug-related mortality. Ir J Psychol Med. 2014;31(4):275–280. doi:10.1017/ipm.2014.39
   PubMedGoogle Scholar
• Brunt TM, Koeter MW, Hertoghs N, van Noorden MS, Van den brink W. Sociodemographic and substance use characteristics of gamma hydroxybutyrate (GHB) dependent inpatients and associations with dependence severity. Drug Alcohol Depend. 2013;131(3):316–319. doi:10.1016/j.drugalcdep.2012.12.023
   PubMed Web of Science ®Google Scholar
• Tay EM, Graham RI, Day RO. Severe GHB withdrawal delirium managed with dexmedetomidine. Med J Aust. 2016;205(6):251–252. doi:10.5694/mja16.00269
   PubMed Web of Science ®Google Scholar
• Bell J, Collins R. Gamma-butyrolactone (GBL) dependence and withdrawal. Addiction. 2011;106(2):442–447. doi:10.1111/j.1360-0443.2010.03145.x
   PubMed Web of Science ®Google Scholar
• McDonough M. GHB dependence: lessons from a small case series. J Alcohol Drug Depend. 2013;112. doi:10.4172/2329-6488.1000112
   Google Scholar
• Cappetta M, Murnion BP. Inpatient management of gamma-hydroxybutyrate withdrawal. Australas Psychiatry. 2019;27(3):284–287. doi:10.1177/1039856218822748
   PubMed Web of Science ®Google Scholar
• Dyer JE, Roth B, Hyma BA. Gamma-hydroxybutyrate withdrawal syndrome. Ann Emerg Med. 2001;37(2):147–153. doi:10.1067/mem.2001.112985
   PubMed Web of Science ®Google Scholar
• Kamal RM, van Noorden MS, Wannet W, Beurmanjer H, Dijkstra BA, Schellekens A. Pharmacological treatment in gamma-Hydroxybutyrate (GHB) and gamma-Butyrolactone (GBL) dependence: detoxification and relapse prevention. CNS Drugs. 2017;31(1):51–64. doi:10.1007/s40263-016-0402-z
   PubMed Web of Science ®Google Scholar
• Lingford-Hughes A, Patel Y, Bowden-Jones O, et al. Improving GHB withdrawal with baclofen: study protocol for a feasibility study for a randomised controlled trial. Trials. 2016;17(1):472. doi:10.1186/s13063-016-1593-9
   PubMed Web of Science ®Google Scholar
• Abdulrahim D, Bowden-Jones O; on behalf of the NEPTUNE Expert Group. Guidance on the management of acute and chronic harms of club drugs and novel psychoactive substances. novel psychoactive treatment UK network (Neptune). London; 2015. Available from: http://neptune-clinical-guidance.co.uk/wp-content/uploads/2015/03/NEPTUNE-Guidance-March-2015.pdf. Accessed December 20, 2021.
   Google Scholar
• Sivilotti ML, Burns MJ, Aaron CK, Greenberg MJ. Pentobarbital for severe gamma-butyrolactone withdrawal. Ann Emerg Med. 2001;38(6):660–665. doi:10.1067/mem.2001.119454
   PubMed Web of Science ®Google Scholar
• Ghio L, Cervetti A, Respino M, Belvederi Murri M, Amore M. Management and treatment of gamma butyrolactone withdrawal syndrome: a case report and review. J Psychiatr Pract. 2014;20(4):294–300. doi:10.1097/01.pra.0000452567.84825.07
   PubMed Web of Science ®Google Scholar
• McDonough M, Kennedy N, Glasper A, Bearn J. Clinical features and management of gamma-hydroxybutyrate (GHB) withdrawal: a review. Drug Alcohol Depend. 2004;75(1):3–9. doi:10.1016/j.drugalcdep.2004.01.012
   PubMed Web of Science ®Google Scholar
• Vos CF, Pop-Purceleanu M, van den Berg MJW, Schellekens AFA. Successful treatment of severe, treatment resistant GHB withdrawal through thiopental-coma. Subst Abus. 2021;42(1):33–38. doi:10.1080/08897077.2020.1827124
   PubMed Web of Science ®Google Scholar
• van Noorden MS, Mol T, Wisselink J, Kuijpers W, Dijkstra BAG. Treatment consumption and treatment re-enrollment in GHB-dependent patients in The Netherlands. Drug Alcohol Depend. 2017;176:96–101. doi:10.1016/j.drugalcdep.2017.02.026
   PubMed Web of Science ®Google Scholar
• Beurmanjer H, Kamal RM, de Jong CAJ, Dijkstra BAG, Schellekens AFA. Baclofen to prevent relapse in Gamma-Hydroxybutyrate (GHB)-dependent patients: a multicentre, open-label, non-randomized, controlled trial. CNS Drugs. 2018;32(5):437–442. doi:10.1007/s40263-018-0516-6
   PubMed Web of Science ®Google Scholar
• Drückler S, Speulman J, van Rooijen M, De Vries HJC. Sexual consent and chemsex: a quantitative study on sexualised drug use and non-consensual sex among men who have sex with men in Amsterdam, the Netherlands. Sex Transm Infect. 2021;97(4):268–275. doi:10.1136/sextrans-2020-054840
   PubMed Web of Science ®Google Scholar
• Hockenhull J, Murphy KG, Paterson S. An observed rise in γ-hydroxybutyrate-associated deaths in London: evidence to suggest a possible link with concomitant rise in chemsex. Forensic Sci Int. 2017;270:93–97. doi:10.1016/j.forsciint.2016.11.039
   PubMed Web of Science ®Google Scholar
• Stuart D. Chemsex: origins of the word, a history of the phenomenon and a respect to the culture. Drugs Alcohol Today. 2019;19(1):3–10. doi:10.1108/DAT-10-2018-0058
   Web of Science ®Google Scholar
• Liakoni E, Dempsey DA, Meyers M, et al. Effect of γ-hydroxybutyrate (GHB) on driving as measured by a driving simulator. Psychopharmacology. 2018;235(11):3223–3232. doi:10.1007/s00213-018-5025-2
   PubMed Web of Science ®Google Scholar
• Jones AW, Holmgren A, Kugelberg FC. Driving under the influence of gamma-hydroxybutyrate (GHB). Forensic Sci Med Pathol. 2008;4(4):205–211. doi:10.1007/s12024-008-9040-1
   PubMed Web of Science ®Google Scholar
• Griffiths A, Hadley L. The prevalence of gamma-hydroxybutyrate (GHB) in motor vehicle drivers and its co-administration with amphetamine type substances (ATS) in Queensland, Australia (2011–2018). Forensic Sci Int. 2019;303:109958. doi:10.1016/j.forsciint.2019.109958
   PubMed Web of Science ®Google Scholar
• Addolorato G, Lesch OM, Maremmani I, et al. Post-marketing and clinical safety experience with sodium oxybate for the treatment of alcohol withdrawal syndrome and maintenance of abstinence in alcohol-dependent subjects. Expert Opin Drug Saf. 2020;19(2):159–166. doi:10.1080/14740338.2020.1709821
   PubMed Web of Science ®Google Scholar
• Busardò FP, Jones AW. Interpreting γ-hydroxybutyrate concentrations for clinical and forensic purposes. Clin Toxicol. 2019;57(3):149–163. doi:10.1080/15563650.2018.1519194
   PubMed Web of Science ®Google Scholar
• Busardò FP, Varì MR, Di Trana A, Malaca S, Carlier J, Di Luca NM. Drug-facilitated sexual assaults (DFSA): a serious underestimated issue. Eur Rev Med Pharmacol Sci. 2019;23(24):10577–10587. doi:10.26355/eurrev_201912_19753
   PubMed Web of Science ®Google Scholar
• Steuer AE, Raeber J, Simbuerger F, et al. Towards extending the detection window of gamma-hydroxybutyric acid-an untargeted metabolomics study in serum and urine following controlled administration in healthy men. Metabolites. 2021;11(3). doi:10.3390/metabo11030166
   Web of Science ®Google Scholar
• Busardò FP, Pichini S, Zaami S, Pacifici R, Kintz P. Hair testing of GHB: an everlasting issue in forensic toxicology. Clin Chem Lab Med. 2018;56(2):198–208. doi:10.1515/cclm-2017-0397
   PubMed Web of Science ®Google Scholar
• Bertol E, Mari F, Lachi A, Tespio G, Vaiano F. Determination of endogenous GHB levels in chest and pubic hair. Forensic Sci Int. 2021;325:110857. doi:10.1016/j.forsciint.2021.110857
   PubMed Web of Science ®Google Scholar