Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise

References

• LauDCDouketisJDMorrisonKMHramiakIMSharmaAMUrE2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and childrenCMAJ20071768S1S1317420481
   PubMed Web of Science ®Google Scholar
• KopelmanPGObesity as a medical problemNature2000404677863564310766250
   PubMed Web of Science ®Google Scholar
• KellyTYangWChenCSReynoldsKHeJGlobal burden of obesity in 2005 and projections to 2030Int J Obes (Lond)20083291431143718607383
   PubMed Web of Science ®Google Scholar
• WangYBeydounMALiangLCaballeroBKumanyikaSKWill all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemicObesity (Silver Spring)200816102323233018719634
   PubMed Web of Science ®Google Scholar
• ZhangPZhangXBrownJGlobal healthcare expenditure on diabetes for 2010 and 2030Diabetes Res Clin Pract201087329330120171754
   PubMed Web of Science ®Google Scholar
• ShawJESicreeRAZimmetPZGlobal estimates of the prevalence of diabetes for 2010 and 2030Diabetes Res Clin Pract201087141419896746
   PubMed Web of Science ®Google Scholar
• KameiYMiuraSSuzukiMSkeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic controlJ Biol Chem200427939411144112315272020
   PubMed Web of Science ®Google Scholar
• MuoioDMNewgardCBObesity-related derangements in metabolic regulationAnnu Rev Biochem20067536740116756496
   PubMed Web of Science ®Google Scholar
• DysonPAThe therapeutics of lifestyle management on obesityDiabetes Obes Metab2010121194194620880340
   PubMed Web of Science ®Google Scholar
• KelleyDEHeJMenshikovaEVRitovVBDysfunction of mitochondria in human skeletal muscle in type 2 diabetesDiabetes200251102944295012351431
   PubMed Web of Science ®Google Scholar
• KimJYHicknerRCCortrightRLDohmGLHoumardJALipid oxidation is reduced in obese human skeletal muscleAm J Physiol Endocrinol Metab20002795E1039E104411052958
   PubMed Web of Science ®Google Scholar
• RitovVBMenshikovaEVHeJFerrellREGoodpasterBHKelleyDEDeficiency of subsarcolemmal mitochondria in obesity and type 2 diabetesDiabetes200554181415616005
   PubMed Web of Science ®Google Scholar
• MenshikovaEVRitovVBFerrellREAzumaKGoodpasterBHKelleyDECharacteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesityJ Appl Physiol20071031212717332268
   PubMed Web of Science ®Google Scholar
• MoothaVKLindgrenCMErikssonKFPGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesNat Genet200334326727312808457
   PubMed Web of Science ®Google Scholar
• PattiMEButteAJCrunkhornSCoordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1Proc Natl Acad Sci U S A2003100148466847112832613
   PubMed Web of Science ®Google Scholar
• HollowayGPBonenASprietLLRegulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individualsAm J Clin Nutr2009891455S462S19056573
   PubMed Web of Science ®Google Scholar
• LinJWuHTarrPTTranscriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibresNature2002418689979780112181572
   PubMed Web of Science ®Google Scholar
• WuZPuigserverPAnderssonUMechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Cell199998111512410412986
   PubMed Web of Science ®Google Scholar
• HandschinCSpiegelmanBMPeroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismEndocr Rev200627772873517018837
   PubMed Web of Science ®Google Scholar
• Gerhart-HinesZRodgersJTBareOMetabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1 alphaEMBO J20072671913192317347648
   PubMed Web of Science ®Google Scholar
• CantoCAuwerxJPGC-1 alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureCurr Opin Lipidol20092029810519276888
   PubMed Web of Science ®Google Scholar
• GuarenteLSirtuins as potential targets for metabolic syndromeNature2006444712186887417167475
   PubMed Web of Science ®Google Scholar
• PhilpAChenALanDSirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) deacetylation following endurance exerciseJ Biol Chem201128635305613057021757760
   PubMed Web of Science ®Google Scholar
• HermanKMCraigCLGauvinLKatzmarzykPTTracking of obesity and physical activity from childhood to adulthood: the Physical Activity Longitudinal StudyInt J Pediatr Obes20094428128819922043
   PubMed Web of Science ®Google Scholar
• BoykoEJde CourtenMZimmetPZChitsonPTuomilehtoJAlbertiKGFeatures of the metabolic syndrome predict higher risk of diabetes and impaired glucose tolerance: a prospective study in MauritiusDiabetes Care20002391242124810977013
   PubMed Web of Science ®Google Scholar
• HollowayGPMitochondrial function and dysfunction in exercise and insulin resistanceAppl Physiol Nutr Metab200934344044619448712
   PubMed Web of Science ®Google Scholar
• HickeyMSWeidnerMDGaviganKEZhengDTyndallGLHoumardJAThe insulin action-fiber type relationship in humans is muscle group-specificAm J Physiol19952691 Pt 1E150E1547631770
   PubMed Web of Science ®Google Scholar
• SimoneauJAColbergSRThaeteFLKelleyDESkeletal-muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese womenFASEB J1995922732787781930
   PubMed Web of Science ®Google Scholar
• HoumardJAEganPCNeuferPDElevated skeletal muscle glucose transporter levels in exercise-trained middle-aged menAm J Physiol19912614 Pt 1E437E4431928336
   PubMed Web of Science ®Google Scholar
• SimoneauJAVeerkampJHTurcotteLPKelleyDEMarkers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight lossFASEB J199913142051206010544188
   PubMed Web of Science ®Google Scholar
• KelleyDEGoodpasterBWingRRSimoneauJASkeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight lossAm J Physiol19992776 Pt 1E1130E114110600804
   PubMedGoogle Scholar
• AsmannYWStumpCSShortKRSkeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemiaDiabetes200655123309331917130474
   PubMed Web of Science ®Google Scholar
• ThyfaultJPKrausRMHicknerRCHowellAWWolfeRRDohmGLImpaired plasma fatty acid oxidation in extremely obese womenAm J Physiol Endocrinol Metab20042876E1076E108115280153
   PubMed Web of Science ®Google Scholar
• PetersenKFShulmanGIPathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitusAm J Cardiol2002905A11G18G
   PubMed Web of Science ®Google Scholar
• HollandWLKnottsTAChavezJAWangLHoehnKLSummersSALipid mediators of insulin resistanceNutr Rev2007656 Pt 2S39S4617605313
   PubMed Web of Science ®Google Scholar
• GoodpasterBHTheriaultRWatkinsSCKelleyDEIntramuscular lipid content is increased in obesity and decreased by weight lossMetabolism200049446747210778870
   PubMed Web of Science ®Google Scholar
• PanDALilliojaSKriketosADSkeletal muscle triglyceride levels are inversely related to insulin actionDiabetes19974669839889166669
   PubMed Web of Science ®Google Scholar
• TimmersSSchrauwenPde VogelJMuscular diacylglycerol metabolism and insulin resistancePhysiol Behav200894224225118207474
   PubMed Web of Science ®Google Scholar
• SummersSACeramides in insulin resistance and lipotoxicityProg Lipid Res2006451427216445986
   PubMed Web of Science ®Google Scholar
• DefronzoRAFerranniniEInsulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular diseaseDiabetes Care19911431731942044434
   PubMed Web of Science ®Google Scholar
• GoodpasterBHHeJWatkinsSKelleyDESkeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletesJ Clin Endocrinol Metab200186125755576111739435
   PubMed Web of Science ®Google Scholar
• Samocha-BonetDHeilbronnLKLichtenbergDCampbellLVDoes skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?Trends Endocrinol Metab2010212838819854062
   PubMed Web of Science ®Google Scholar
• SchrauwenPHesselinkMKOxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetesDiabetes20045361412141715161742
   PubMed Web of Science ®Google Scholar
• FurukawaSFujitaTShimabukuroMIncreased oxidative stress in obesity and its impact on metabolic syndromeJ Clin Invest2004114121752176115599400
   PubMed Web of Science ®Google Scholar
• RobertsCKSindhuKKOxidative stress and metabolic syndromeLife Sci20098421–2270571219281826
   PubMed Web of Science ®Google Scholar
• WenzTRossiSGRotundoRLSpiegelmanBMMoraesCTIncreased muscle PGC-1 alpha expression protects from sarcopenia and metabolic disease during agingProc Natl Acad Sci U S A200910648204052041019918075
   PubMed Web of Science ®Google Scholar
• BruceCRThrushABMertzVAEndurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid contentAm J Physiol Endocrinol Metab20062911E99E10716464906
   PubMed Web of Science ®Google Scholar
• GibalaMJLittleJPvan EssenMShort-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performanceJ Physiol2006575Pt 390191116825308
   PubMed Web of Science ®Google Scholar
• FerraraNRinaldiBCorbiGExercise training promotes SIRT1 activity in aged ratsRejuvenation Res200811113915018069916
   PubMed Web of Science ®Google Scholar
• PuigserverPSpiegelmanBMPeroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulatorEndocr Rev2003241789012588810
   PubMed Web of Science ®Google Scholar
• ScarpullaRCNuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivatorAnn N Y Acad Sci2008114732133419076454
   PubMed Web of Science ®Google Scholar
• LiraVABentonCRYanZBonenAPGC-1 alpha regulation by exercise training and its influences on muscle function and insulin sensitivityAm J Physiol Endocrinol Metab20102992E145E16120371735
   PubMed Web of Science ®Google Scholar
• HolloszyJORegulation by exercise of skeletal muscle content of mitochondria and GLUT4J Physiol Pharmacol200859Suppl 751819258654
   PubMed Web of Science ®Google Scholar
• GibalaMMolecular responses to high-intensity interval exerciseAppl Physiol Nutr Metab200934342843219448710
   PubMed Web of Science ®Google Scholar
• WrightDCHanDGarcia-RovesPMGeigerPCJonesTEHolloszyJOExercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1 alpha expressionJ Biol Chem2007282119419917099248
   PubMed Web of Science ®Google Scholar
• PerryCGLallyJHollowayGPHeigenhauserGJBonenASprietLLRepeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscleJ Physiol2010588Pt 234795481020921196
   PubMed Web of Science ®Google Scholar
• HandschinCRheeJLinJDTarrPTSpiegelmanBMAn autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1 alpha expression in muscleProc Natl Acad Sci U S A2003100127111711612764228
   PubMed Web of Science ®Google Scholar
• PuigserverPRheeJLinJCytokine stimulation of energy expenditure through p38 MAP kinase activation of PPAR gamma coactivator-1Mol Cell20018597198211741533
   PubMed Web of Science ®Google Scholar
• JaegerSHandschinCSt-PierreJSpiegelmanBMAMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1 alphaProc Natl Acad Sci U S A200710429120171202217609368
   PubMed Web of Science ®Google Scholar
• WrightDCGeigerPCHanDHJonesTEHolloszyJOCalcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1 alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activationJ Biol Chem200728226187931879917488713
   PubMed Web of Science ®Google Scholar
• RodgersJTLerinCHaasWGygiSPSpiegelmanBMPuigserverPNutrient control of glucose homeostasis through a complex of PGC-1 alpha and SIRT1Nature2005434702911311815744310
   PubMed Web of Science ®Google Scholar
• CantoCGerhart-HinesZFeigeJNAMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityNature200945872411056106019262508
   PubMed Web of Science ®Google Scholar
• Dali-YoucefNLagougeMFroelichSKoehlCSchoonjansKAuwerxJSirtuins: the “magnificent seven,” function, metabolism and longevityAnn Med200739533534517701476
   PubMed Web of Science ®Google Scholar
• YangTSauveAANAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicityAAPS J200684E632E64317233528
   PubMed Web of Science ®Google Scholar
• FlickFLuscherBRegulation of sirtuin function by posttranslational modificationsFront Pharmacol201232922403547
   PubMed Web of Science ®Google Scholar
• NemotoSFergussonMMFinkelTSIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1 alphaJ Biol Chem200528016164561646015716268
   PubMed Web of Science ®Google Scholar
• CantoCJiangLQDeshmukhASInterdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscleCell Metab201011321321920197054
   PubMed Web of Science ®Google Scholar
• BanksASKonNKnightCSirT1 gain of function increases energy efficiency and prevents diabetes in miceCell Metab20088433334118840364
   PubMed Web of Science ®Google Scholar
• BordoneLCohenDRobinsonASIRT1 transgenic mice show phenotypes resembling calorie restrictionAging Cell20076675976717877786
   PubMed Web of Science ®Google Scholar
• PflugerPTHerranzDVelasco-MiguelSSerranoMTschopMHSirt1 protects against high-fat diet-induced metabolic damageProc Natl Acad Sci U S A2008105289793979818599449
   PubMed Web of Science ®Google Scholar
• GurdBJYoshidaYMcFarlanJTNuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscleAm J Physiol Regul Integr Comp Physiol20113011R67R7521543634
   PubMed Web of Science ®Google Scholar
• LagougeMArgmannCGerhart-HinesZResveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alphaCell200612761109112217112576
   PubMed Web of Science ®Google Scholar
• ZschoernigBMahlknechtUSIRTUIN 1: regulating the regulatorBiochem Biophys Res Commun2008376225125518774777
   PubMed Web of Science ®Google Scholar
• SauveAAWolbergerCSchrammVLBoekeJDThe biochemistry of sirtuinsAnnu Rev Biochem20067543546516756498
   PubMed Web of Science ®Google Scholar
• HardieDGAMP-activated/SNF1 protein kinases: conserved guardians of cellular energyNat Rev Mol Cell Biol200781077478517712357
   PubMed Web of Science ®Google Scholar
• RevolloJRGrimmAAImaiSThe NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cellsJ Biol Chem200427949507545076315381699
   PubMed Web of Science ®Google Scholar
• YangHYangTBaurJANutrient-sensitive mitochondrial NAD+ levels dictate cell survivalCell200713061095110717889652
   PubMed Web of Science ®Google Scholar
• CostfordSRBajpeyiSPasaricaMSkeletal muscle NAMPT is induced by exercise in humansAm J Physiol Endocrinol Metab20102981E117E12619887595
   PubMed Web of Science ®Google Scholar
• AndersonRMLatorre-EstevesMNevesARYeast life-span extension by calorie restriction is independent of NAD fluctuationScience200330256532124212614605207
   PubMed Web of Science ®Google Scholar
• ChabiBAdhihettyPJO’LearyMFMenziesKJHoodDARelationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuseJ Appl Physiol200910761730173519797682
   PubMed Web of Science ®Google Scholar
• GurdBJYoshidaYLallyJHollowayGPBonenAThe deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesisJ Physiol2009587Pt 81817182819237425
   PubMed Web of Science ®Google Scholar
• KimJChenJLouZDBC1 is a negative regulator of SIRT1Nature2008451717858358618235501
   PubMed Web of Science ®Google Scholar
• EscandeCChiniCCNinVDeleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in miceJ Clin Invest2010120254555820071779
   PubMed Web of Science ®Google Scholar
• KimEJKhoJHKangMRUmSJActive regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activityMol Cell200728227729017964266
   PubMed Web of Science ®Google Scholar
• NinVEscandeCChiniCCRole of deleted in breast cancer 1 (DBC1) in SIRT1 activation induced by protein kinase A and AMP activated protein kinaseJ Biol Chem532012 [Epub ahead of print.]
   Web of Science ®Google Scholar
• Gerhart-HinesZDominyJEJrBlattlerSMThe cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+Mol Cell201144685186322195961
   PubMed Web of Science ®Google Scholar
• SasakiTMaierBKoclegaKDPhosphorylation regulates SIRT1 functionPLoS One2008312e402019107194
   PubMed Web of Science ®Google Scholar
• NasrinNKaushikVKFortierEJNK1 phosphorylates SIRT1 and promotes its enzymatic activityPLoS One2009412e841420027304
   PubMed Web of Science ®Google Scholar
• YangYFuWChenJSIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stressNat Cell Biol20079111253126217934453
   PubMed Web of Science ®Google Scholar
• LiuXWangDZhaoYMethyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)Proc Natl Acad Sci U S A201110851925193021245319
   PubMed Web of Science ®Google Scholar
• KornbergMDSenNHaraMRGAPDH mediates nitrosylation of nuclear proteinsNat Cell Biol201012111094110020972425
   PubMed Web of Science ®Google Scholar
• AndersonRMBittermanKJWoodJGMedvedikOSinclairDANicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiaeNature2003423693618118512736687
   PubMed Web of Science ®Google Scholar
• CantoCAuwerxJCaloric restriction, SIRT1 and longevityTrends Endocrinol Metab200920732533119713122
   PubMed Web of Science ®Google Scholar
• FeigeJNLagougeMCantoCSpecific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidationCell Metab20088534735819046567
   PubMed Web of Science ®Google Scholar
• SmithJJKenneyRDGagneDJSmall molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivoBMC Syst Biol200933119284563
   PubMed Web of Science ®Google Scholar
• HowitzKTBittermanKJCohenHYSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature2003425695419119612939617
   PubMed Web of Science ®Google Scholar
• BorraMTSmithBCDenuJMMechanism of human SIRT1 activation by resveratrolJ Biol Chem200528017171871719515749705
   PubMed Web of Science ®Google Scholar
• PacholecMBleasdaleJEChrunykBSRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1J Biol Chem2010285118340835120061378
   PubMed Web of Science ®Google Scholar
• ChenSLiJZhangZEffects of resveratrol on the amelioration of insulin resistance in KKAy miceCan J Physiol Pharmacol201290223724222309033
   PubMed Web of Science ®Google Scholar
• ParkSJAhmadFPhilpAResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesCell2012148342143322304913
   PubMed Web of Science ®Google Scholar
• MilneJCLambertPDSchenkSSmall molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesNature2007450717071271618046409
   PubMed Web of Science ®Google Scholar
• DaiHKustigianLCarneyDSIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activatorJ Biol Chem201028543326953270320702418
   PubMed Web of Science ®Google Scholar
• BaurJAPearsonKJPriceNLResveratrol improves health and survival of mice on a high-calorie dietNature2006444711733734217086191
   PubMed Web of Science ®Google Scholar
• PearsonKJBaurJALewisKNResveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanCell Metab20088215716818599363
   PubMed Web of Science ®Google Scholar
• TimmersSKoningsEBiletLCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humansCell Metab201114561262222055504
   PubMed Web of Science ®Google Scholar
• CrandallJPOramVTrandafirescuGPilot study of resveratrol in older adults with impaired glucose toleranceJ Gerontol A Biol Sci Med Sci142012 [Epub ahead of print.]
   Web of Science ®Google Scholar
• GhanimHSiaCLKorzeniewskiKA resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate mealJ Clin Endocrinol Metab20119651409141421289251
   PubMed Web of Science ®Google Scholar
• HaskellWLLeeIMPateRRPhysical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart AssociationMed Sci Sports Exerc20073981423143417762377
   PubMed Web of Science ®Google Scholar
• GurdBJDeacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesisAppl Physiol Nutr Metab201136558959721888529
   PubMed Web of Science ®Google Scholar
• BentonCRWrightDCBonenAPGC-1 alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptionsAppl Physiol Nutr Metab200833584386218923559
   PubMed Web of Science ®Google Scholar
• KoltaiESzaboZAtalayMExercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged ratsMech Ageing Dev20101311212819913571
   PubMed Web of Science ®Google Scholar
• LiLPanRLiRMitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is requiredDiabetes201160115716720929977
   PubMed Web of Science ®Google Scholar
• LjubicicVJosephAMAdhihettyPJMolecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscleAging (Albany, NY)20091981883020157569
   PubMedGoogle Scholar
• SuwaMNakanoHRadakZKumagaiSEndurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein expressions in rat skeletal muscleMetabolism200857798699818555842
   PubMed Web of Science ®Google Scholar
• GuerraBGuadalupe-GrauAFuentesTSIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestionEur J Appl Physiol2010109473174320217115
   PubMed Web of Science ®Google Scholar
• LittleJPSafdarAWilkinGPTarnopolskyMAGibalaMJA practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanismsJ Physiol2010588Pt 61011102220100740
   PubMed Web of Science ®Google Scholar
• GurdBJLittleJPPerryCGDoes SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?J Appl Physiol2012112592692822096123
   PubMed Web of Science ®Google Scholar
• DumkeCLDavisJMMurphyEASuccessive bouts of cycling stimulates genes associated with mitochondrial biogenesisEur J Appl Physiol2009107441942719657668
   PubMed Web of Science ®Google Scholar
• MenshikovaEVRitovVBToledoFGFerrellREGoodpasterBHKelleyDEEffects of weight loss and physical activity on skeletal muscle mitochondrial function in obesityAm J Physiol Endocrinol Metab20052884E818E82515585590
   PubMed Web of Science ®Google Scholar
• GoodpasterBHKatsiarasAKelleyDEEnhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesityDiabetes20035292191219712941756
   PubMed Web of Science ®Google Scholar
• KnowlerWCBarrett-ConnorEFowlerSEReduction in the incidence of type 2 diabetes with lifestyle intervention or metforminN Engl J Med2002346639340311832527
   PubMed Web of Science ®Google Scholar
• LaaksonenDELindstromJLakkaTAPhysical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention studyDiabetes200554115816515616024
   PubMed Web of Science ®Google Scholar
• HawleyJAGibalaMJExercise intensity and insulin sensitivity: how low can you go?Diabetologia20095291709171319557385
   PubMed Web of Science ®Google Scholar
• TjonnaAELeeSJRognmoOAerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot studyCirculation2008118434635418606913
   PubMed Web of Science ®Google Scholar
• WolffEGaudlitzKvon LindenbergerBLPlagJHeinzAStrohleAExercise and physical activity in mental disordersEur Arch Psychiatry Clin Neurosci2011261Suppl 2S186S19121935629
   PubMed Web of Science ®Google Scholar
• PekmeziDWDemark-WahnefriedWUpdated evidence in support of diet and exercise interventions in cancer survivorsActa Oncol201150216717821091401
   PubMed Web of Science ®Google Scholar
• PedersenBKSaltinBEvidence for prescribing exercise as therapy in chronic diseaseScand J Med Sci Sports200616Suppl 136316451303
   PubMed Web of Science ®Google Scholar
• WarburtonDENicolCWBredinSSHealth benefits of physical activity: the evidenceCMAJ2006174680180916534088
   PubMed Web of Science ®Google Scholar