99
Views
16
CrossRef citations to date
0
Altmetric
Review

Clinical impact of recent genetic discoveries in osteoporosis

&
Pages 75-85 | Published online: 04 Oct 2013

References

  • United States Bone and Joint InitiativeThe burden of musculoskeletal diseases in the United States2011 Available from: http://www.boneandjointburden.org/Accessed September 4, 2013
  • NguyenNDAhlborgHGCenterJREismanJANguyenTVResidual lifetime risk of fractures in women and menJ Bone Miner Res20072278178817352657
  • BurgeRDawson-HughesBSolomonDHWongJBKingATostesonAIncidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025J Bone Miner Res20072246547517144789
  • NIH Consensus Development PanelOsteoporosis prevention, diagnosis, and therapyJAMA200128578579511176917
  • PeacockMTurnerCHEconsMJForoudTGenetics of osteoporosisEndocr Rev20022330332612050122
  • NgMYShamPCPatersonADChanVKungAWEffect of environmental factors and gender on the heritability of bone mineral density and bone sizeAnn Hum Genet20067042843816759177
  • ChesnutCH3rdIs osteoporosis a pediatric disease? Peak bone mass attainment in the adolescent femalePublic Health Rep1989Suppl 10450542517701
  • WattsNBClinical utility of biochemical markers of bone remodelingClin Chem1999451359136810430819
  • TostesonANGottliebDJRadleyDCFisherESMeltonLJ3rdExcess mortality following hip fracture: the role of underlying health statusOsteoporos Int2007181463147217726622
  • HaentjensPMagazinerJColon-EmericCSMeta-analysis: excess mortality after hip fracture among older women and menAnn Intern Med201015238039020231569
  • SterlingRSGender and race/ethnicity differences in hip fracture incidence, morbidity, mortality, and functionClin Orthop Relat Res20114691913191821161737
  • PongchaiyakulCNguyenNDJonesGCenterJREismanJANguyenTVAsymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective studyJ Bone Miner Res2005201349135516007332
  • HallbergIRosenqvistAMKartousLLöfmanOWahlströmOTossGHealth-related quality of life after osteoporotic fracturesOsteoporos Int20041583484115045468
  • AdachiJDAdamiSGehlbachSGLOW InvestigatorsImpact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in womenMayo Clin Proc20108580681320634496
  • SolimeoSLSilvermanSLCalderonADNguyenAGoldDTMeasuring health-related quality of life (HRQOL) in osteoporotic males using the male OPAQOsteoporos Int20122384185221528362
  • BlackDMDelmasPDEastellRHORIZON Pivotal Fracture TrialOnce-yearly zoledronic acid for treatment of postmenopausal osteoporosisN Engl J Med20073561809182217476007
  • LylesKWColon-EmericCSMagazinerJSHORIZON Recurrent Fracture TrialZoledronic acid and clinical fractures and mortality after hip fractureN Engl J Med20073571799180917878149
  • BonoCMEinhornTAOverview of osteoporosis: pathophysiology and determinants of bone strengthEur Spine J200312Suppl 2S90S9613680312
  • BouxseinMLSeemanEQuantifying the material and structural determinants of bone strengthBest Pract Res Clin Rheumatol20092374175319945686
  • World Health OrganizationAssessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study GroupWorld Health Organ Tech Rep Ser199484311297941614
  • Martinez-MorilloMGradosDHolgadoSPremenopausal osteoporosis: how to treat?Reumatol Clin20128939722089064
  • National Osteoporosis FoundationClinician’s Guide to Prevention and Treatment of OsteoporosisWashington, DCNational Osteoporosis Foundation2008
  • MariniFBrandiMLPharmacogenetics of osteoporosis: future perspectivesCalcif Tissue Int20098433734719271099
  • MariniFBrandiMLPharmacogenetics of osteoporosis: what is the evidence?Curr Osteoporos Rep20121022122722760517
  • CompstonJClinical and therapeutic aspects of osteoporosisEur J Radiol20097138839119660883
  • KingABFiorentinoDMMedicare payment cuts for osteoporosis testing reduced use despite tests’ benefit in reducing fracturesHealth Aff (Millwood)2011302362237022147865
  • O’MalleyCDJohnstonSSLenhartGCherkowskiGPalmerLMorganSLTrends in dual-energy x-ray absorptiometry in the United States, 2000–2009J Clin Densitom20111410010721787516
  • TannerSBDual-energy x-ray absorptiometry in clinical practice: new guidelines and concernsCurr Opin Rheumatol20112338538821637082
  • MarshallDJohnellOWedelHMeta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fracturesBMJ1996312125412598634613
  • JohnellOKanisJAOdenAPredictive value of BMD for hip and other fracturesJ Bone Miner Res2005201185119415940371
  • JonesGNguyenTSambrookPKellyPJEismanJAProgressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology studyBMJ19943096916957950520
  • SmithJAVentoJASpencerRPTendlerBEAortic calcification contributing to bone densitometry measurementJ Clin Densitom1999218118310499978
  • NguyenNDEismanJACenterJRNguyenTVRisk factors for fracture in nonosteoporotic men and womenJ Clin Endocrinol Metab20079295596217164302
  • NishiyamaKKMacdonaldHMHanleyDABoydSKWomen with previous fragility fractures can be classified based on bone microarchitecture and finite element analysis measured with HR-pQCTOsteoporos Int2013241733174023179565
  • Dawson-HughesBLookerACTostesonANJohanssonHKanisJAMeltonLJ3rdThe potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: an update in NHANES 2005–2008Osteoporos Int20122381182021717247
  • SamelsonEJHannanMTEpidemiology of osteoporosisCurr Rheumatol Rep20068768316515770
  • KielDPRosenCJDempsterDAge-Related Bone Loss Chapter 20John Wiley & Sons Inc2009
  • LaneNEEpidemiology, etiology, and diagnosis of osteoporosisAm J Obstet Gynecol2006194S3S1116448873
  • MitchellBDKammererCMSchneiderJLPerezRBauerRLGenetic and environmental determinants of bone mineral density in Mexican Americans: results from the San Antonio Family Osteoporosis StudyBone20033383984614623060
  • FaulknerKGWackerWKBardenHSFemur strength index predicts hip fracture independent of bone density and hip axis lengthOsteoporos Int20061759359916447009
  • PulkkinenPJämsäTLochmüllerEMKuhnVNieminenMTEcksteinFExperimental hip fracture load can be predicted from plain radiography by combined analysis of trabecular bone structure and bone geometryOsteoporos Int20081954755817891327
  • MichaëlssonKMelhusHFermHAhlbomAPedersenNLGenetic liability to fractures in the elderlyArch Intern Med20051651825183016157825
  • DengHWChenWMReckerSGenetic determination of Colles’ fracture and differential bone mass in women with and without Colles’ fractureJ Bone Miner Res2000151243125210893672
  • AndrewTAntioniadesLScurrahKJMacgregorAJSpectorTDRisk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMDJ Bone Miner Res200520677415619671
  • SeemanEHopperJLBachLAReduced bone mass in daughters of women with osteoporosisN Engl J Med19893205545582915666
  • HuiSLKollerDLForoudTMEconsMJJohnstonCCPeacockMHeritability of changes in bone size and bone mass with age in premenopausal white sistersJ Bone Miner Res2006211121112516813533
  • ShafferJRKammererCMDressenASBruderJMBauerRLMitchellBDRate of bone loss is greater in young Mexican American men than women: the San Antonio Family Osteoporosis studyBone201047495420347056
  • BrownLBStreetenEAShapiroJRGenetic and environmental influences on bone mineral density in pre- and post-menopausal womenOsteoporos Int2005161849185615997421
  • KellyPJNguyenTHopperJPocockNSambrookPEismanJChanges in axial bone density with age: a twin studyJ Bone Miner Res1993811178427043
  • ChristianJCYuPLSlemendaCWJohnstonCCJrHeritability of bone mass: a longitudinal study in aging male twinsAm J Hum Genet1989444294332916585
  • ShafferJRKammererCMBruderJFive-year change in bone mineral density is heritable in Mexican Americans: The San Antonio Family Osteoporosis StudyJ Bone Miner Res200520Suppl 1S67
  • MakoveyJNguyenTVNaganathanVWarkJDSambrookPNGenetic effects on bone loss in peri- and postmenopausal women: a longitudinal twin studyJ Bone Miner Res2007221773178017620052
  • MitchellBDYerges-ArmstrongLMThe genetics of bone loss: challenges and prospectsJ Clin Endocrinol Metab2011961258126821346070
  • EstradaKStyrkarsdottirUEvangelouEGenome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fractureNat Genet20124449150122504420
  • RichardsJBZhengHFSpectorTDGenetics of osteoporosis from genome-wide association studies: advances and challengesNat Rev Genet20121357658822805710
  • GongYSleeRBFukaiNOsteoporosis-Pseudoglioma Syndrome Collaborative GroupLDL receptor-related protein 5 (LRP5) affects bone accrual and eye developmentCell200110751352311719191
  • ClarkeBNormal bone anatomy and physiologyClin J Am Soc Nephrol20083Suppl 3S131S13918988698
  • GuoYTanLJLeiSFGenome-wide association study identifies ALDH7a1 as a novel susceptibility gene for osteoporosisPLoS Genet20106e100080620072603
  • GiulianiNGirasoleGVescoviPPPasseriGPedrazzoniMEthanol and acetaldehyde inhibit the formation of early osteoblast progenitors in murine and human bone marrow culturesAlcohol Clin Exp Res19992338138510069572
  • RalstonSHUitterlindenAGGenetics of osteoporosisEndocr Rev20103162966220431112
  • LiWFHouSXYuBLiMMFérecCChenJMGenetics of osteoporosis: accelerating pace in gene identification and validationHum Genet201012724928520101412
  • FarberCRLusisAJFuture of osteoporosis genetics: enhancing genome-wide association studiesJ Bone Miner Res2009241937194219888896
  • DuncanELBrownMAGenetic determinants of bone density and fracture risk – state of the art and future directionsJ Clin Endocrinol Metab2010952576258720375209
  • HopkinsRBGoereeRPullenayegumEThe relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal womenBMC Musculoskelet Disord20111220921943363
  • WainwrightSAMarshallLMEnsrudKEStudy of Osteoporotic Fractures Research GroupHip fracture in women without osteoporosisJ Clin Endocrinol Metab2005902787279315728213
  • NguyenNDFrostSACenterJREismanJANguyenTVDevelopment of a nomogram for individualizing hip fracture risk in men and womenOsteoporos Int2007181109111717370100
  • NguyenNDFrostSACenterJREismanJANguyenTVDevelopment of prognostic nomograms for individualizing 5-year and 10-year fracture risksOsteoporos Int2008191431144418324342
  • TranBNNguyenNDCenterJREismanJANguyenTVEnhancement of absolute fracture risk prognosis with genetic marker: the collagen 1 alpha 1 geneCalcif Tissue Int20098537938819789904
  • NguyenTVEismanJAGenetics and the individualized prediction of fractureCurr Osteoporos Rep20121023624422851044
  • HsuYHZillikensMCWilsonSGAn integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis-related traitsPLoS Genet20106e100097720548944
  • LuiJCNilssonOChanYSynthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate heightHum Mol Genet2012215193520122914739
  • BoneHFuture directions in osteoporosis therapeuticsEndocrinol Metab Clin North Am20124165566122877435
  • Delgado-CalleJGarmillaPRianchoJADo epigenetic marks govern bone mass and homeostasis?Curr Genomics20121325226323115526
  • Delgado-CalleJSañudoCFernándezAFGarcía-RenedoRFragaMFRianchoJARole of DNA methylation in the regulation of the RANKL-OPG system in human boneEpigenetics20127839122207352
  • La ThangueNBHistone deacetylase inhibitors and cancer therapyJ Chemother200416Suppl 4646715688613
  • SantosFPKantarjianHGarcia-ManeroGIssaJPRavandiFDecitabine in the treatment of myelodysplastic syndromesExpert Rev Anticancer Ther20101092220014881