References
- SiegelRLMillerKDJemalACancer statistics, 2017CA Cancer J Clin201767173028055103
- JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
- GanepolaGARutledgeJRSumanPYiengpruksawanAChangDHNovel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancerWorld J Gastrointest Oncol201461223324578785
- KimJBamletWRObergALDetection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markersSci Transl Med20179398pii:eaah5583
- ZhouGLiuXWangXCombination of preoperative CEA and CA19-9 improves prediction outcomes in patients with resectable pancreatic adenocarcinoma: results from a large follow-up cohortOnco Targets Ther2017101199120628280354
- SchmidtCEarly detection tools for pancreatic cancerJ Natl Cancer Inst2012104151117111822851273
- PorukKEGayDZBrownKThe clinical utility of CA 19-9 in pancreatic adenocarcinoma: diagnostic and prognostic updatesCurr Mol Med201313334035123331006
- GalassoMSandhuSKVoliniaSMicroRNA expression signatures in solid malignanciesCancer J201218323824322647360
- IorioMVCroceCMMicroRNAs in cancer: small molecules with a huge impactJ Clin Oncol200927345848585619884536
- LiMMarin-MullerCBharadwajUChowKHYaoQChenCMicroRNAs: control and loss of control in human physiology and diseaseWorld J Surg200933466768419030926
- LingHFabbriMCalinGAMicroRNAs and other non-coding RNAs as targets for anticancer drug developmentNat Rev Drug Discov2013121184786524172333
- BrunettiORussoAScarpaAMicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets?Oncotarget2015627233232334126259238
- MitchellPSParkinRKKrohEMCirculating microRNAs as stable blood-based markers for cancer detectionProc Natl Acad Sci U S A200810530105131051818663219
- EngelsBMHutvagnerGPrinciples and effects of microRNA-mediated post-transcriptional gene regulationOncogene200625466163616917028595
- ZareMBastamiMSolaliSAlivandMRAberrantly miRNA promoter methylation and EMT-involving miRNAs in breast cancer metastasis: diagnosis and therapeutic implicationsJ Cell Physiol Epub201783
- SwitlikWZSzemrajJCirculating miRNAs as non-invasive biomarkers for non-small cell lung cancer diagnosis, prognosis and prediction of treatment responsePostepy Hig Med Dosw (Online)201771064966228791959
- BimonteSBarbieriALeongitoMThe role of miRNAs in the regulation of pancreatic cancer stem cellsStem Cells Int20162016835268427006664
- HawaZHaqueIGhoshABanerjeeSHarrisLBanerjeeSKThe miRacle in pancreatic cancer by miRNAs: tiny angels or devils in disease progressionInt J Mol Sci2016176pii:E809
- KishikawaTOtsukaMOhnoMYoshikawaTTakataAKoikeKCirculating RNAs as new biomarkers for detecting pancreatic cancerWorld J Gastroenterol201521288527854026229396
- WangJRaimondoMGuhaSCirculating microRNAs in pancreatic juice as candidate biomarkers of pancreatic cancerJ Cancer20145869670525258651
- BloomstonMFrankelWLPetroccaFMicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitisJAMA2007297171901190817473300
- SchultzNAWernerJWillenbrockHMicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinomaMod Pathol201225121609162222878649
- Vychytilova-FaltejskovaPKissIKlusovaSMiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinomaDiagn Pathol2015103825908274
- CaponiSFunelNFramptonAEThe good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasmsAnn Oncol201324373474123139258
- SadakariYOhtsukaTOhuchidaKMicroRNA expression analyses in preoperative pancreatic juice samples of pancreatic ductal adenocarcinomaJOP201011658759221068491
- ZhangSHaoJXieFDownregulation of miR-132 by promoter methylation contributes to pancreatic cancer developmentCarcinogenesis20113281183118921665894
- YuSLuZLiuCmiRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancerCancer Res201070146015602520610624
- HalkovaTCuperkovaRMinarikMMicroRNAs in pancreatic cancer: involvement in carcinogenesis and potential use for diagnosis and prognosisGastroenterol Res Pract2015201589290325960741
- LiAYuJKimHMicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with low-stage pancreatic cancer from healthy and disease controlsClin Cancer Res201319133600361023697990
- ZhaoCZhangJZhangSDiagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinomaOncol Rep201330127628423612862
- RyuJKHongSMKarikariCAAberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinomaPancreatology2010101667320332664
- MorimuraRKomatsuSIchikawaDNovel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancerBr J Cancer2011105111733174022045190
- ParkJYHelmJCoppolaDMicroRNAs in pancreatic ductal adenocarcinomaWorld J Gastroenterol201117781782721412491
- WeberJABaxterDHZhangSThe microRNA spectrum in 12 body fluidsClin Chem201056111733174120847327
- PreisMGardnerTBGordonSRMicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinomaClin Cancer Res201117175812582121652542
- CoteGAGoreAJMcElyeaSDA pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bileAm J Gastroenterol2014109121942195225350767
- LiuJGaoJDuYCombination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancerInt J Cancer2012131368369121913185
- KomatsuSIchikawaDTakeshitaHCirculating miR-18a: a sensitive cancer screening biomarker in human cancerIn Vivo201428329329724815829
- LiuRChenXDuYSerum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancerClin Chem201258361061822194634
- WangJChenJChangPMicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of diseaseCancer Prev Res (Phila)20092980781319723895
- WangWSLiuLXLiGPCombined serum CA19-9 and miR-27-a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancerCancer Prev Res (Phila)20136433133823430754
- LuYHuJSunWMiR-29c inhibits cell growth, invasion, and migration of pancreatic cancer by targeting ITGB1Onco Targets Ther201699910926766915
- LongLMZhanJKWangHQThe clinical significance of miR-34a in pancreatic ductal carcinoma and associated molecular and cellular mechanismsPathobiology2017841384827458977
- RoldoCMissiagliaEHaganJPMicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behaviorJ Clin Oncol200624294677468416966691
- ParkJKHenryJCJiangJmiR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressorBiochem Biophys Res Commun2011406451852321329664
- SzafranskaAEDavisonTSJohnJMicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinomaOncogene200726304442445217237814
- HanounNDelpuYSuriawinataAAThe silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesisClin Chem20105671107111820431052
- RenYGaoJLiuJQDifferential signature of fecal microRNAs in patients with pancreatic cancerMol Med Rep20126120120922504911
- ZhangJZhaoCYZhangSHUpregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinomaOncol Rep20143131157116424398877
- SlaterEPStrauchKRospleszczSMicroRNA-196a and -196b as potential biomarkers for the early detection of familial pancreatic cancerTransl Oncol20147446447124956938
- YuJLiAHongSMMicroRNA alterations of pancreatic intraepithelial neoplasiasClin Cancer Res201218498199222114139
- LiAOmuraNHongSMPancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levelsCancer Res201070135226523720551052
- IkenagaNOhuchidaKMizumotoKMicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinomaAnn Surg Oncol201017123120312820652642
- YabushitaSFukamachiKTanakaHCirculating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomasPancreas20124171013101822513294
- HoASHuangXCaoHCirculating miR-210 as a novel hypoxia marker in pancreatic cancerTransl Oncol20103210911320360935
- LeeEJGusevYJiangJExpression profiling identifies microRNA signature in pancreatic cancerInt J Cancer200712051046105417149698
- HuaYChenHWangLLow serum miR-373 predicts poor prognosis in patients with pancreatic cancerCancer Biomark20172019510028759959
- LinMSChenWCHuangJXAberrant expression of microRNAs in serum may identify individuals with pancreatic cancerInt J Clin Exp Med20147125226523425664025
- MadhavanBYueSGalliUCombined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificityInt J Cancer2015136112616262725388097
- GongJMunozARPingaliSDownregulation of STAT3/NF-kappaB potentiates gemcitabine activity in pancreatic cancer cellsMol Carcinog201756240241127208550
- CostelloEGreenhalfWNeoptolemosJPNew biomarkers and targets in pancreatic cancer and their application to treatmentNat Rev Gastroenterol Hepatol20129843544422733351
- GiovannettiEErozenciASmitJMolecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practiceCrit Rev Oncol Hematol201281210312221546262
- WangZLiYAhmadAPancreatic cancer: understanding and overcoming chemoresistanceNat Rev Gastroenterol Hepatol201181273321102532
- XiaQSIshigakiYSunLEffect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cellsZhonghua Yi Xue Za Zhi201090212312720356498
- ParkJKLeeEJEsauCAntisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinomaPancreas2009387e190e19919730150
- JiQHaoXZhangMMicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cellsPLoS One200948e681619714243
- HamadaSMasamuneAMiuraSMiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAXCell Signal201426217918524216611
- HasegawaSEguchiHNaganoHMicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancerBr J Cancer201411181572158025117811
- WellnerUSchubertJBurkUCThe EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAsNat Cell Biol200911121487149519935649
- LiYVandenBoomTG2ndKongDUp-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsCancer Res200969166704671219654291
- SetoyamaTZhangXNatsugoeSmicroRNA-10b: a new marker or the marker of pancreatic ductal adenocarcinoma?Clin Cancer Res201117175527552921816909
- ZhaoYZhaoLIschenkoIAntisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancerTarget Oncol201510453554825639539
- HwangJHVoortmanJGiovannettiEIdentification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancerPLoS One201055e1063020498843
- MoriyamaTOhuchidaKMizumotoKMicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistanceMol Cancer Ther2009851067107419435867
- ZhangLYaoJLiWMicro-RNA-21 regulates cancer-associated fibroblast-mediated frug resistance in pancreatic cancerOncol Res Epub201755
- WangPZhuangLZhangJThe serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasLMol Oncol20137333434523177026
- WeiXWangWWangLMicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4Cancer Med20165469370226864640
- NaganoHTomimaruYEguchiHMicroRNA-29a induces resistance to gemcitabine through the Wnt/beta-catenin signaling pathway in pancreatic cancer cellsInt J Oncol20134341066107223900458
- WeiFLiuYGuoYmiR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancerMol Cancer2013128123886294
- FanPLiuLYinYMicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancerCancer Lett2016373113013726828016
- BeraAVenkataSubbaRaoKManoharanMSA miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancerPLoS One201499e10634325184537
- OhuchidaKMizumotoKKayashimaTMicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancerAnn Surg Oncol20111882381238721347785
- XiaQSIshigakiYZhaoXHuman SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer PANC-1 cellsPancreas2011401556020871480
- MikamoriMYamadaDEguchiHMicroRNA-155 Controls exosome synthesis and promotes gemcitabine resistance in pancreatic ductal adenocarcinomaSci Rep201774233928198398
- TakiuchiDEguchiHNaganoHInvolvement of microRNA-181b in the gemcitabine resistance of pancreatic cancer cellsPancreatology201313551752324075517
- AmponsahPSFanPBauerNmicroRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancerCancer Lett201738810711727940128
- ZhangXJYeHZengCWDysregulation of miR-15a and miR-214 in human pancreatic cancerJ Hematol Oncol201034621106054
- WangWZhaoLWeiXMicroRNA-320a promotes 5-FU resistance in human pancreatic cancer cellsSci Rep201662764127279541
- IwagamiYEguchiHNaganoHmiR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1Br J Cancer2013109250251123799850
- SchreiberRMezencevRMatyuninaLVEvidence for the role of microRNA 374b in acquired cisplatin resistance in pancreatic cancer cellsCancer Gene Ther201623824124527229158
- CaoFLiJSunHHES 1 is essential for chemoresistance induced by stellate cells and is associated with poor prognosis in pancreatic cancerOncol Rep20153341883188925672829
- FramptonAEKrellJJamiesonNBmicroRNAs with prognostic significance in pancreatic ductal adenocarcinoma: a meta-analysisEur J Cancer201551111389140426002251
- LiBSLiuHYangWLReduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosisGenet Mol Res2015144163721637826662432
- XuJWangTCaoZMiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosisOncotarget20145166983699325149530
- ZouYLiJChenZmiR-29c suppresses pancreatic cancer liver metastasis in an orthotopic implantation model in nude mice and affects survival in pancreatic cancer patientsCarcinogenesis201536667668425863127
- KongXDuYWangGDetection of differentially expressed microRNAs in serum of pancreatic ductal adenocarcinoma patients: miR-196a could be a potential marker for poor prognosisDig Dis Sci201156260260920614181
- SchultzNAAndersenKKRoslindAWillenbrockHWøjdemannMJohansenJSPrognostic microRNAs in cancer tissue from patients operated for pancreatic cancer–five microRNAs in a prognostic indexWorld J Surg201236112699270722851141
- SinghSChitkaraDKumarVBehrmanSWMahatoRImiRNA profiling in pancreatic cancer and restoration of chemosensitivityCancer Lett2013334221122023073476
- NakataKOhuchidaKMizumotoKMicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosisSurgery2011150591692222018284
- YuJOhuchidaKMizumotoKFujitaHNakataKTanakaMMicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasionCancer Biol Ther201010874875720703102
- JamiesonNBMorranDCMortonJPMicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinomaClin Cancer Res201218253454522114136
- WangSZhaoYLiDZhuLShenZIdentification of biomarkers for the prognosis of pancreatic ductal adenocarcinoma with miRNA microarray dataInt J Biol Markers2015302e226e23325791160
- ZhaoGZhangJGShiYMiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3PLoS One201389e7380324040078
- Di LevaGCroceCMmiRNA profiling of cancerCurr Opin Genet Dev201323131123465882
- TavanoFdi MolaFFPiepoliAChanges in miR-143 and miR-21 expression and clinicopathological correlations in pancreatic cancersPancreas20124181280128422836856
- GreitherTGrocholaLFUdelnowAElevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survivalInt J Cancer20101261738019551852
- ZhangZLBaiZHWangXBmiR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cellsPLoS One2015103e011881425742499
- FramptonAEKrellJJacobJmicroRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinomaExpert Rev Anticancer Ther201111121837184222117151
- PapaconstantinouIGMantaAGazouliMExpression of microRNAs in patients with pancreatic cancer and its prognostic significancePancreas2013421677122850622
- LeeCHeHJiangYElevated expression of tumor miR-222 in pancreatic cancer is associated with Ki67 and poor prognosisMed Oncol201330470024026657
- KomatsuSIchikawaDMiyamaeMMalignant potential in pancreatic neoplasm; new insights provided by circulating miR-223 in plasmaExpert Opin Biol Ther201515677378525819175
- ShiSLuYQinYmiR-1247 is correlated with prognosis of pancreatic cancer and inhibits cell proliferation by targeting neuropilinsCurr Mol Med201414331632724588767