Failure to Reach a Consensus in Polypharmacy Definition: An Obstacle to Measuring Risks and Impacts—Results of a Literature Review

References

• WHO Centre for Health Development (Kobe J. A glossary of terms for community health care and services for older persons. 2004 [cité 8 janv 2020].; Disponible sur: https://apps.who.int/iris/handle/10665/68896.
   Google Scholar
• Pieper D, Mathes T, Eikermann M Can AMSTAR also be applied to systematic reviews of non-randomized studies? BMC Res Notes [Internet]. September 6, 2014 [cité janv 6, 2019].;7. Disponible sur: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167129/. Accessed December 12, 2019.
   Google Scholar
• Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE What is polypharmacy? A systematic review of definitions. BMC Geriatr [Internet]. October 10, 2017 [cité juill 9, 2018].;17. Disponible sur: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635569/. Accessed December 12, 2019.
   Google Scholar
• Shea BJ, Grimshaw JM, Wells GA, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10. doi:10.1186/1471-2288-7-10
   PubMed Web of Science ®Google Scholar
• Bushardt RL, Massey EB, Simpson TW, Ariail JC, Simpson KN. Polypharmacy: misleading, but manageable. Clin Interv Aging. 2008;3(2):383–389. doi:10.2147/CIA.S2468
   PubMed Web of Science ®Google Scholar
• Veehof LJG, Meyboom-De Jong B, Haaijer-Ruskamp FM. Polypharmacy in the elderly – a literature review. Eur J Gen Pract. 2000;6(3):98–106. doi:10.3109/13814780009069956
   Google Scholar
• Fulton MM, Allen ER. Polypharmacy in the elderly: a literature review. J Am Acad Nurse Pract. 2005;17(4):123–132. doi:10.1111/jaan.2005.17.issue-4
   PubMedGoogle Scholar
• Monégat M, Sermet C. (IRDES), In collaboration with Perronnin M. (IRDES) and Rococo E. (Institut Gustave Roussy – IGR). Polypharmacy: definitions, measurement and stakes involved. Review of the literature and measurement tests. Questions d’économie de la santé: 2014 (état de santé, protection sociale, enquête, analyses économiques, comparaisons internationales) - IRDES [Internet]. [cité November 29, 2018]. Disponible sur: http://www.bdsp.ehesp.fr/Base/492692/.
   Google Scholar
• Bakaki PM, Horace A, Dawson N, et al. Defining pediatric polypharmacy: a scoping review. PLoS One. 2018;13(11):e0208047. doi:10.1371/journal.pone.0208047
   PubMed Web of Science ®Google Scholar
• Lee RD. Polypharmacy: a case report and new protocol for management. J Am Board Fam Pract. 1998;11(2):140–144. doi:10.3122/15572625-11-2-140
   PubMedGoogle Scholar
• Maggiore RJ, Gross CP, Hurria A. Polypharmacy in older adults with cancer. Oncologist. 2010;15(5):507–522. doi:10.1634/theoncologist.2009-0290
   PubMed Web of Science ®Google Scholar
• Pire V, Fournier A, Schoevaerdts D, Spinewine A, Swine C. Polypharmacy among the elderly. Louvain Med. 2009;128(7):235–240.
   Google Scholar
• Hersh LR, Beldowski K, Hajjar ER. Polypharmacy in the geriatric oncology population. Curr Oncol Rep. 2017;19(11):73. doi:10.1007/s11912-017-0632-3
   PubMed Web of Science ®Google Scholar
• Barnett K, McCowan C, Evans JMM, Gillespie ND, Davey PG, Fahey T. Prevalence and outcomes of use of potentially inappropriate medicines in older people: cohort study stratified by residence in nursing home or in the community. BMJ Qual Saf. 2011;20(3):275–281. doi:10.1136/bmjqs.2009.039818
   PubMed Web of Science ®Google Scholar
• Gillette C, Prunty L, Wolcott J, Broedel-Zaugg K. A new lexicon for polypharmacy: implications for research, practice, and education. Res Soc Adm Pharm. 2015;11(3):468–471. doi:10.1016/j.sapharm.2014.08.010
   PubMed Web of Science ®Google Scholar
• Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med. 1997;157(14):1531–1536. doi:10.1001/archinte.1997.00440350031003
   PubMed Web of Science ®Google Scholar
• Aparasu RR, Sitzman SJ. Inappropriate prescribing for elderly outpatients. Am J Health Syst Pharm. 1999;56(5):433–439. doi:10.1093/ajhp/56.5.433
   PubMed Web of Science ®Google Scholar
• Gallagher LP. The potential for adverse drug reactions in elderly patients. Appl Nurs Res. 2001;14(4):220–224. doi:10.1053/apnr.2001.26788
   PubMed Web of Science ®Google Scholar
• Golden AG, Preston RA, Barnett SD, Llorente M, Hamdan K, Silverman MA. Inappropriate medication prescribing in homebound older adults. J Am Geriatr Soc. 1999;47(8):948–953. doi:10.1111/jgs.1999.47.issue-8
   PubMed Web of Science ®Google Scholar
• Hanlon JT, Fillenbaum GG, Kuchibhatla M, et al. Impact of inappropriate drug use on mortality and functional status in representative community dwelling elders. Med Care. 2002;40(2):166–176. doi:10.1097/00005650-200202000-00011
   PubMed Web of Science ®Google Scholar
• Polypharmacy in the elderly: clinical challenges in emergency practice | 2002- 06-03| AHC media: continuing medical education publishing [Internet]. [cité mars17, 2019]. Disponible sur: https://www.reliasmedia.com/articles/120095-polypharmacy-in-the-elderly-clinical-challenges-in-emergency-practice. Accessed December 12, 2019.
   Google Scholar
• Managing polypharmacy: walking the fine line between help and harm | mDedge Psychiatry [Internet]. [cité mars 17, 2019]. Disponible sur: https://www.mdedge.com/psychiatry/article/59699/practice-management/managing-polypharmacy-walking-fine-line-between-help. Accessed December 12, 2019.
   Google Scholar
• Carlson JE. Perils of polypharmacy: 10 steps to prudent prescribing. Geriatrics. 1996;51(7):26–30, 35.
   PubMed Web of Science ®Google Scholar
• Rapp MS, Kaplan A. Polypsychopharmacy revisited. Can J Psychiatry. 1981;26(8):569–573. doi:10.1177/070674378102600811
   PubMed Web of Science ®Google Scholar
• Polypharmacy and medicines optimisation [Internet]. The King’s Fund. 2013 [cité 8 janv 2020]. Disponible sur: https://www.kingsfund.org.uk/publications/polypharmacy-and-medicines-optimisation.
   Google Scholar
• Santé M des S et de la, Santé M des S et de la. Le dispositif Paerpa [Internet]. Ministère des Solidarités et de la Santé. 2020 [cité 8 Janv 2020]. Disponible sur: https://solidarites-sante.gouv.fr/systeme-de-sante-et-medico-social/parcours-des-patients-et-des-usagers/le-parcours-sante-des-aines-paerpa/article/le-dispositif-paerpa.
   Google Scholar
• Gnjidic D, Tinetti M, Allore HG. Assessing medication burden and polypharmacy: finding the perfect measure. Expert Rev Clin Pharmacol. 2017;10(4):345–347. doi:10.1080/17512433.2017.1301206
   PubMed Web of Science ®Google Scholar
• Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85(1):86–88. doi:10.1038/clpt.2008.224
   PubMed Web of Science ®Google Scholar
• Burt J, Elmore N, Campbell SM, Rodgers S, Avery AJ, Payne RA. Developing a measure of polypharmacy appropriateness in primary care: systematic review and expert consensus study. BMC Med. 2018;16(1):91. doi:10.1186/s12916-018-1078-7
   PubMed Web of Science ®Google Scholar
• Dhalwani NN, Fahami R, Sathanapally H, Seidu S, Davies MJ, Khunti K. Association between polypharmacy and falls in older adults: a longitudinal study from England. BMJ Open. 2017;7(10):e016358. doi:10.1136/bmjopen-2017-016358
   PubMed Web of Science ®Google Scholar
• Fornaro M, De Berardis D, Koshy AS, et al. Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review. Neuropsychiatr Dis Treat. 2016;12:719–735. doi:10.2147/NDT.S100846
   PubMed Web of Science ®Google Scholar
• Prescription cost analysis - England, 2015 [Internet]. NHS Digital. [cité déc 2, 2018]. Disponible sur: https://digital.nhs.uk/data-and-information/publications/statistical/prescription-cost-analysis/prescription-cost-analysis-england-2015. Accessed December 12, 2019.
   Google Scholar
• Falls Awareness. Programmes and innovation. Age UK [Internet]. [cité déc 2, 2018]. Disponible sur: https://www.ageuk.org.uk/our-impact/programmes/falls-prevention-resources/. Accessed December 12, 2019.
   Google Scholar
• Stevens JA, Corso PS, Finkelstein EA, Miller TR. The costs of fatal and non-fatal falls among older adults. Inj Prev J Int Soc Child Adolesc. 2006;12(5):290–295. doi:10.1136/ip.2005.011015
   PubMed Web of Science ®Google Scholar
• Kojima T, Akishita M, Nakamura T, et al. Association of polypharmacy with fall risk among geriatric outpatients. Geriatr Gerontol Int. 2011;11(4):438–444. doi:10.1111/j.1447-0594.2011.00703.x
   PubMed Web of Science ®Google Scholar
• Wong H, Heuberger R, Logomarsino J, Hewlings S. Associations between alcohol use, polypharmacy and falls in older adults. Nurs Older People. 2016;28(1):30–36. doi:10.7748/nop.28.1.30.s22
   PubMedGoogle Scholar
• Baranzini F, Diurni M, Ceccon F, et al. Fall-related injuries in a nursing home setting: is polypharmacy a risk factor? BMC Health Serv Res. 2009;9:228. doi:10.1186/1472-6963-9-228
   PubMed Web of Science ®Google Scholar
• Helgadóttir B, Laflamme L, Monárrez-Espino J, Möller J. Medication and fall injury in the elderly population; do individual demographics, health status and lifestyle matter? BMC Geriatr. 2014;14:92. doi:10.1186/1471-2318-14-92
   PubMed Web of Science ®Google Scholar
• Zia A, Kamaruzzaman SB, Tan MP. Polypharmacy and falls in older people: balancing evidence-based medicine against falls risk. Postgrad Med. 2015;127(3):330–337. doi:10.1080/00325481.2014.996112
   PubMed Web of Science ®Google Scholar
• Ziere G, Dieleman JP, Hofman A, Pols HAP, van der Cammen TJM, Stricker BHC. Polypharmacy and falls in the middle age and elderly population. Br J Clin Pharmacol. 2006;61(2):218–223. doi:10.1111/bcp.2006.61.issue-2
   PubMed Web of Science ®Google Scholar
• Kojima T, Akishita M, Nakamura T, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12(3):425–430. doi:10.1111/j.1447-0594.2011.00783.x
   PubMed Web of Science ®Google Scholar
• Kadam UT, Roberts I, White S, et al. Conceptualizing multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. J Clin Epidemiol. 2019;106:98–107. doi:10.1016/j.jclinepi.2018.10.014
   PubMed Web of Science ®Google Scholar
• Aronson JK. In defence of polypharmacy. Br J Clin Pharmacol. 2004;57(2):119–120. doi:10.1111/bcp.2004.57.issue-2
   PubMed Web of Science ®Google Scholar