The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

References

• Rodick TC, Seibels DR, Babu JR, et al. Potential role of coenzyme Q10 in health and disease conditions. Nutri Dietary Suppl. 2018;(10):1–11. doi:10.2147/NDS.S112119
   Web of Science ®Google Scholar
• Garrido-Maraver J, Cordero MD, Oropesa-Avila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3–4):187–197. doi:10.1159/00036010125126052
   PubMedGoogle Scholar
• Pinto L, Sloan A, Persaud I, Narain NR. Normalization of Bcl-2 family members in breast cancer by coenzyme Q10. Ethnicity Dis. 2009;19.
   Web of Science ®Google Scholar
• FARHOOD B, GERAILY G, ALIZADEH A. Incidence and mortality of various cancers in iran and compare to other countries: a review article. Iran J Public Health. 2018;47(3):309–316.29845017
   PubMed Web of Science ®Google Scholar
• Farhood B, Raei B, Malekzadeh R, Shirvani M, Najafi M, Mortezazadeh T. A review of incidence and mortality of colorectal, lung, liver, thyroid, and bladder cancers in Iran and compared to other countries. Contemp Oncol (Pozn). 2019;23(1):7–15. doi:10.5114/wo.2019.8411231061631
   PubMed Web of Science ®Google Scholar
• Kumar RV, Panwar D, Amirtham U, et al. Estrogen receptor, Progesterone receptor, and human epidermal growth factor receptor-2 status in breast cancer: a retrospective study of 5436 women from a regional cancer center in South India. South Asian J Cancer. 2018;7(1):7–10. doi:10.4103/sajc.sajc_211_1729600224
   PubMed Web of Science ®Google Scholar
• Hayes EL, Lewis-Wambi JS. Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA. Breast Cancer Res. 2015;17:40.25849966
   PubMed Web of Science ®Google Scholar
• Heer K, Kumar H, Read JR, Fox JN, Monson JR, Kerin MJ. Serum vascular endothelial growth factor in breast cancer: its relation with cancer type and estrogen receptor status. Clin Cancer Res. 2001;7(11):3491–3494.11705867
   PubMed Web of Science ®Google Scholar
• Lopes CM, Dourado A, Oliveira R. Phytotherapy and nutritional supplements on breast cancer. Biomed Res Int. 2017;2017:7207983. doi:10.1155/2017/720798328845434
   PubMed Web of Science ®Google Scholar
• Tawara K, Scott H, Emathinger J, et al. Co-expression of VEGF and IL-6 family cytokines is associated with decreased survival in HER2 negative breast cancer patients: subtype-specific IL-6 family cytokine-mediated VEGF secretion. Transl Oncol. 2019;12(2):245–255. doi:10.1016/j.tranon.2018.10.00430439625
   PubMed Web of Science ®Google Scholar
• Zhai J, Yacong B, Yan L, Liu C, Zhang L. Effects of coenzyme Q10 on markers of inflammation: a systematic review and meta-analysis. PLoS ONE. 2017;12(1):e0170172. doi:10.1371/journal.pone.017017228125601
   PubMed Web of Science ®Google Scholar
• Schmelzer C, Kitano M, Rimbach G, et al. Effects of Ubiquinol-10 on microrna-146a expression in vitro and in vivo. Mediator Inflammation. 2009.
   PubMed Web of Science ®Google Scholar
• Premkumar VG, Yuvaraj S, Vijayasarathy K, Sachdanandam P, Govindaswamy S, Gangadaran D. Serum cytokine levels of interleukin-1β, −6, −8, tumour necrosis factor-α and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q 10, Riboflavin and Niacin. Nord Pharmacol Soc Basic Clin Pharmacol Toxicol. 2007;100:387–391. doi:10.1111/j.1742-7843.2007.00065.x
   PubMed Web of Science ®Google Scholar
• Hathcock JN, Shao A. Risk assessment for coenzyme Q10 (Ubiquinone). Regul Toxicol Pharmacol. 2006;45(3):282–288. doi:10.1016/j.yrtph.2006.05.00616814438
   PubMed Web of Science ®Google Scholar
• Ikematsu H, Nakamura K, Harashima S, Fujii K, Fukutomi N. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006;44(3):212–218. doi:10.1016/j.yrtph.2005.12.00216431002
   PubMed Web of Science ®Google Scholar
• Kwon Y. Effect of soy isoflavones on the growth of human breast tumors: findings from preclinical studies. Food Sci Nutri. 2014;2(6):613–622. doi:10.1002/fsn3.2014.2.issue-6
   PubMedGoogle Scholar
• Cooney RV, Dai Q, Gao YT, et al. Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev. 2011;20(6):1124–1130. doi:10.1158/1055-9965.EPI-10-126121467235
   PubMed Web of Science ®Google Scholar
• Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol. 2012 11(1):31. doi:10.1016/j.suponc.2012.03.003
   Google Scholar
• Abdollahzad H, Aghdashi MA, Asghari Jafarabadi M, Alipour B. Effects of coenzyme Q10 supplementation on inflammatory cytokines (TNF-alpha, IL-6) and oxidative stress in rheumatoid arthritis patients: a randomized controlled trial. Arch Med Res. 2015;46(7):527–533. doi:10.1016/j.arcmed.2015.08.00626342738
   PubMed Web of Science ®Google Scholar
• Liu HT, Huang YC, Cheng SB, Huang YT, Lin PT. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutr J. 2016;15(1):85. doi:10.1186/s12937-016-0205-627716246
   PubMed Web of Science ®Google Scholar
• Farsi F, Mohammadshahi M, Alavinejad P, Rezazadeh A, Zarei M, Ahmadi-Engali K. Functions of Coenzyme Q10 supplementation on liver enzymes, markers of systemic inflammation, and adipokines in patients affected by nonalcoholic fatty liver disease: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr. 2016;35(4):346–353. doi:10.1080/07315724.2015.102105726156412
   PubMed Web of Science ®Google Scholar
• Sanoobar M, Eghtesadi S, Azimi A, et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized. Nutr Neurosci. 2015;18:169–176. doi:10.1179/1476830513Y.000000010624621064
   PubMed Web of Science ®Google Scholar
• Mohseni M, Vafa MR, Hajimiresmail SJ, Zarrati M, Shidfar F, Rahimi-Forushani A. Beneficial effects of coenzyme q10 supplementation on lipid profile and interleukin‑6 and intercellular adhesion molecule‑1 reduction, preliminary results of a double‑blind trial in acute myocardial infarction. Int J Prev Med. 2015;6(1):73. doi:10.4103/2008-7802.16246126330989
   PubMedGoogle Scholar
• Donnino MW, Cocchi MN, Salciccioli JD, et al. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care. 2011;15(4):R189. doi:10.1186/cc1034321827677
   PubMed Web of Science ®Google Scholar
• Fan L, Feng Y, Chen G-C, Qin L-Q, Fu C-L, Chen L-H. Effects of coenzyme Q10 supplementation on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017;119:128–136. doi:10.1016/j.phrs.2017.01.03228179205
   PubMed Web of Science ®Google Scholar
• Rahmani EJM, Samimi M, Zarezade-Mehrizi M, et al. The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2017:1–6.
   Web of Science ®Google Scholar
• Donnino MW, Mortensen SJ, Andersen LW, et al. Ubiquinol (Reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial. Crit Care. 2015;19:275. doi:10.1186/s13054-015-0989-326130237
   PubMed Web of Science ®Google Scholar
• Alam A, Rahman M. Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. J Diabetes Metabol Disord. 2014;13:60. doi:10.1186/2251-6581-13-60
   PubMedGoogle Scholar
• Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol. 2013;48(3):833–903.
   Web of Science ®Google Scholar
• Schmelzer C, Lorenz G, Rimbach G, Doring F. In vitro effects of the reduced form of coenzyme Q10 on secretion levels of TNF-α and chemokines in response to LPS in the human monocytic cell line THP-1. J Clin Biochem Nutr. 2009;44:62–66. doi:10.3164/jcbn.08-18219177190
   PubMed Web of Science ®Google Scholar
• Taganov KD, Boldin MP, Chang K-J, Baltimore D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006;103(33):12481–12486. doi:10.1073/pnas.060529810316885212
   PubMed Web of Science ®Google Scholar
• Choi JS, Park SY, Yi EY, Kim YJ, JW J. Coenzyme Q10 decreases basic fibroblast growth factor (bFGF)-induced angiogenesis by blocking ERK activation. Oncol Res. 2011;19(10–11):455–461. doi:10.3727/096504012X1328536594425622715588
   PubMed Web of Science ®Google Scholar