Development and Validation of a Clinical and Laboratory-Based Nomogram for Predicting Coronary Microvascular Obstruction in NSTEMI Patients After Primary PCI

References

• Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289–1367. doi:10.1093/eurheartj/ehaa575
   PubMed Web of Science ®Google Scholar
• Balzi D, Di Bari M, Barchielli A, et al. Should we improve the management of NSTEMI? Results from the population-based “acute myocardial infarction in Florence 2” (AMI-Florence 2) registry. Intern Emerg Med. 2013;8(8):725–733. doi:10.1007/s11739-012-0817-6
   PubMed Web of Science ®Google Scholar
• Crea F. Coronary microvascular obstruction–a puzzle with many pieces. N Engl J Med. 2015;372(15):1464–1465. doi:10.1056/NEJMe1501882
   PubMed Web of Science ®Google Scholar
• Heusch G. Coronary microvascular obstruction: the new frontier in cardioprotection. Basic Res Cardiol. 2019;114(6):45. doi:10.1007/s00395-019-0756-8
   PubMed Web of Science ®Google Scholar
• Heusch G. The coronary circulation as a target of cardioprotection. Circ Res. 2016;118(10):1643–1658. doi:10.1161/CIRCRESAHA.116.308640
   PubMed Web of Science ®Google Scholar
• Kleinbongard P, Heusch G. A fresh look at coronary microembolization. Nat Rev Cardiol. 2021;18:1–16. doi:10.1038/s41569-020-00473-5
   PubMed Web of Science ®Google Scholar
• Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol. 2020;17(12):773–789. doi:10.1038/s41569-020-0403-y
   PubMed Web of Science ®Google Scholar
• Niccoli G, Montone RA, Ibanez B, et al. Optimized treatment of ST-elevation myocardial infarction. Circ Res. 2019;125(2):245–258. doi:10.1161/CIRCRESAHA.119.315344
   PubMed Web of Science ®Google Scholar
• Heusch G. Treatment of myocardial ischemia/reperfusion injury by ischemic and pharmacological postconditioning. Compr Physiol. 2015;5(3):1123–1145.
   PubMed Web of Science ®Google Scholar
• Kofler T, Hess S, Moccetti F, et al. Efficacy of ranolazine for treatment of coronary microvascular dysfunction-A systematic review and meta-analysis of randomized trials. CJC Open. 2021;3(1):101–108. doi:10.1016/j.cjco.2020.09.005
   PubMedGoogle Scholar
• Kim JS, Ko YG, Yoon SJ, et al. Correlation of serial cardiac magnetic resonance imaging parameters with early resolution of ST-segment elevation after primary percutaneous coronary intervention. Circ j. 2008;72(10):1621–1626. doi:10.1253/circj.CJ-08-0232
   PubMed Web of Science ®Google Scholar
• Jesel L, Morel O, Ohlmann P, et al. Role of pre-infarction angina and inflammatory status in the extent of microvascular obstruction detected by MRI in myocardial infarction patients treated by PCI. Int J Cardiol. 2007;121(2):139–147. doi:10.1016/j.ijcard.2006.10.022
   PubMed Web of Science ®Google Scholar
• Rogers WJ Jr., Kramer CM, Geskin G, et al. Early contrast-enhanced MRI predicts late functional recovery after reperfused myocardial infarction. Circulation. 1999;99(6):744–750. doi:10.1161/01.CIR.99.6.744
   PubMed Web of Science ®Google Scholar
• Vicente J, Mewton N, Croisille P, et al. Comparison of the angiographic myocardial blush grade with delayed-enhanced cardiac magnetic resonance for the assessment of microvascular obstruction in acute myocardial infarctions. Catheter Cardiovasc Interv. 2009;74(7):1000–1007. doi:10.1002/ccd.22157
   PubMed Web of Science ®Google Scholar
• Wu KC, Zerhouni EA, Judd RM, et al. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 1998;97(8):765–772. doi:10.1161/01.CIR.97.8.765
   PubMed Web of Science ®Google Scholar
• Judd RM, Lugo-Olivieri CH, Arai M, et al. Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation. 1995;92(7):1902–1910. doi:10.1161/01.CIR.92.7.1902
   PubMed Web of Science ®Google Scholar
• Park SY. Nomogram: an analogue tool to deliver digital knowledge. J Thorac Cardiovasc Surg. 2018;155(4):1793. doi:10.1016/j.jtcvs.2017.12.107
   PubMed Web of Science ®Google Scholar
• Louvard Y, Thomas M, Dzavik V, et al. Classification of coronary artery bifurcation lesions and treatments: time for a consensus! Catheter Cardiovasc Interv. 2008;71(2):175–183. doi:10.1002/ccd.21314
   PubMed Web of Science ®Google Scholar
• Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol. 2009;54(4):281–292. doi:10.1016/j.jacc.2009.03.054
   PubMed Web of Science ®Google Scholar
• Ndrepepa G, Tiroch K, Keta D, et al. Predictive factors and impact of no reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction. Circ Cardiovasc Interv. 2010;3(1):27–33. doi:10.1161/CIRCINTERVENTIONS.109.896225
   PubMed Web of Science ®Google Scholar
• Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005;112(14):2143–2148. doi:10.1161/CIRCULATIONAHA.105.558122
   PubMed Web of Science ®Google Scholar
• Piek JJ. Beyond epicardial reperfusion. N Engl J Med. 2007;356(18):1880–1882. doi:10.1056/NEJMe078024
   PubMed Web of Science ®Google Scholar
• Xiao Y, Fu X, Wang Y, Wu Y, Wang W, Zhang Q. Development and validation of risk nomogram model predicting coronary microvascular obstruction in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous catheterization. Med Sci Monitor. 2019;25:5864–5877. doi:10.12659/MSM.915960
   PubMed Web of Science ®Google Scholar
• Scarabelli T, Stephanou A, Rayment N, et al. Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury. Circulation. 2001;104(3):253–256. doi:10.1161/01.CIR.104.3.253
   PubMed Web of Science ®Google Scholar
• Stakos DA, Kambas K, Konstantinidis T, et al. Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction. Eur Heart J. 2015;36(22):1405–1414. doi:10.1093/eurheartj/ehv007
   PubMed Web of Science ®Google Scholar
• Lee CH, Tse HF. Microvascular obstruction after percutaneous coronary intervention. Catheter Cardiovasc Interv. 2010;75(3):369–377. doi:10.1002/ccd.22234
   PubMed Web of Science ®Google Scholar
• Mehta JL, Nichols WW, Mehta P. Neutrophils as potential participants in acute myocardial ischemia: relevance to reperfusion. J Am Coll Cardiol. 1988;11(6):1309–1316. doi:10.1016/0735-1097(88)90297-5
   PubMed Web of Science ®Google Scholar
• Meegan JE, Yang X, Coleman DC, Jannaway M, Yuan SY. Neutrophil-mediated vascular barrier injury: role of neutrophil extracellular traps. Microcirculation. 2017;24(3):e12352. doi:10.1111/micc.12352
   Web of Science ®Google Scholar
• Dart AM, Chin-Dusting JP. Lipids and the endothelium. Cardiovasc Res. 1999;43(2):308–322. doi:10.1016/S0008-6363(99)00150-9
   PubMed Web of Science ®Google Scholar
• Yang S, Yuan HQ, Hao YM, et al. Macrophage polarization in atherosclerosis. Clin Chim Acta. 2020;501:142–146. doi:10.1016/j.cca.2019.10.034
   PubMed Web of Science ®Google Scholar
• Canali E, Masci P, Bogaert J, et al. Impact of gender differences on myocardial salvage and post-ischaemic left ventricular remodelling after primary coronary angioplasty: new insights from cardiovascular magnetic resonance. Eur Heart J Cardiovasc Imaging. 2012;13(11):948–953. doi:10.1093/ehjci/jes087
   PubMed Web of Science ®Google Scholar
• Jang JH, Lee MJ, Ko KY, et al. Mechanical and pharmacological revascularization strategies for prevention of microvascular dysfunction in ST-segment elevation myocardial infarction: analysis from index of microcirculatory resistance registry data. J Interv Cardiol. 2020;2020:5036396. doi:10.1155/2020/5036396
   PubMed Web of Science ®Google Scholar
• De Luca G, Gibson CM, Huber K, et al. Association between advanced Killip class at presentation and impaired myocardial perfusion among patients with ST-segment elevation myocardial infarction treated with primary angioplasty and adjunctive glycoprotein IIb-IIIa inhibitors. Am Heart J. 2009;158(3):416–421. doi:10.1016/j.ahj.2009.06.029
   PubMed Web of Science ®Google Scholar
• Li P, Ruan JW, Liu M, Li SY, Wang ZD, Xie WC. Thrombus aspiration catheter improve the myocardial reperfusion of STEMI patients with high thrombus load during the emergency PCI operation. J Cardiothorac Surg. 2019;14(1):172. doi:10.1186/s13019-019-0974-z
   PubMed Web of Science ®Google Scholar
• Kloner RA. The importance of no-reflow/microvascular obstruction in the STEMI patient. Eur Heart J. 2017;38(47):3511–3513. doi:10.1093/eurheartj/ehx288
   PubMed Web of Science ®Google Scholar
• Engstrøm T, Kelbæk H, Helqvist S, et al. Effect of ischemic postconditioning during primary percutaneous coronary intervention for patients with ST-segment elevation myocardial infarction: a randomized clinical trial. JAMA cardiol. 2017;2(5):490–497. doi:10.1001/jamacardio.2017.0022
   PubMed Web of Science ®Google Scholar
• Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003;285(2):H579–H588. doi:10.1152/ajpheart.01064.2002
   PubMed Web of Science ®Google Scholar
• Heusch G, Gersh BJ. The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J. 2017;38(11):774–784. doi:10.1093/eurheartj/ehw224
   PubMed Web of Science ®Google Scholar
• Jia G, Aroor AR, Jia C, Sowers JR. Endothelial cell senescence in aging-related vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2019;1865(7):1802–1809. doi:10.1016/j.bbadis.2018.08.008
   PubMed Web of Science ®Google Scholar
• Herrmann J, Lerman A. The endothelium: dysfunction and beyond. J Nuclear Cardiol. 2001;8(2):197–206. doi:10.1067/mnc.2001.114148
   PubMed Web of Science ®Google Scholar
• Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med. 2007;356(8):830–840. doi:10.1056/NEJMra061889
   PubMed Web of Science ®Google Scholar