Optimal Use of Perampanel in Elderly Asian Patients with Epilepsy: Expert Opinion

References

• Trinka E, Kwan P, Lee B, Dash A. Epilepsy in Asia: disease burden, management barriers, and challenges. Epilepsia. 2019;60(Suppl 1):7–21.
   PubMedGoogle Scholar
• Huang C, Feng L, Li Y, et al. Clinical features and prognosis of epilepsy in the elderly in western China. Seizure. 2016;38:26–31.
   PubMed Web of Science ®Google Scholar
• Chen CC, Chen LS, Yen MF, Chen HH, Liou HH. Geographic variation in the age- and gender-specific prevalence and incidence of epilepsy: analysis of Taiwanese National Health Insurance-based data. Epilepsia. 2012;53(2):283–290.
   PubMed Web of Science ®Google Scholar
• Phabphal K, Geater A, Limapichat K, Sathirapanya P, Setthawatcharawanich S. Risk factors of recurrent seizure, co-morbidities, and mortality in new onset seizure in elderly. Seizure. 2013;22(7):577–580.
   PubMed Web of Science ®Google Scholar
• Brodie MJ, Elder AT, Kwan P. Epilepsy in later life. Lancet Neurol. 2009;8(11):1019–1030.
   PubMed Web of Science ®Google Scholar
• Lezaic N, Roussy J, Masson H, Jetté N, Keezer MR. Epilepsy in the elderly: unique challenges in an increasingly prevalent population. Epilepsy Behav. 2020;102:106724.
   PubMed Web of Science ®Google Scholar
• Sen A, Jette N, Husain M, Sander JW. Epilepsy in older people. Lancet. 2020;395(10225):735–748.
   PubMed Web of Science ®Google Scholar
• Gaitatzis A, Carroll K, Majeed A, Sander WJ. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia. 2004;45(12):1613–1622.
   PubMed Web of Science ®Google Scholar
• Johnston A, Smith PE. Epilepsy in the elderly. Expert Rev Neurother. 2010;10(12):1899–1910.
   PubMed Web of Science ®Google Scholar
• Rohracher A, Kalss G, Kuchukhidze G, et al. New anti-seizure medication for elderly epilepsy patients – a critical narrative review. Expert Opin Pharmacother. 2021;22(5):621–634.
   PubMed Web of Science ®Google Scholar
• Organization WH. Ageing and health in the South-East Asia Region. Available from: https://www.who.int/southeastasia/health-topics/ageing. Accessed August 3, 2022. Accessed December 9, 2021.
   Google Scholar
• Lattanzi S, Trinka E, Zaccara G, et al. Third-generation antiseizure medications for adjunctive treatment of focal-onset seizures in adults: a systematic review and network meta-analysis. Drugs. 2022;82(2):199–218.
   PubMed Web of Science ®Google Scholar
• Ferlazzo E, Sueri C, Gasparini S, Aguglia U. Challenges in the pharmacological management of epilepsy and its causes in the elderly. Pharmacol Res. 2016;106:21–26.
   PubMed Web of Science ®Google Scholar
• Trinka E, Steinhoff BJ, Nikanorova M, Brodie MJ. Perampanel for focal epilepsy: insights from early clinical experience. Acta Neurol Scand. 2016;133(3):160–172.
   PubMed Web of Science ®Google Scholar
• Vu LC, Piccenna L, Kwan P, O’Brien TJ. New-onset epilepsy in the elderly. Br J Clin Pharmacol. 2018;84(10):2208–2217.
   PubMed Web of Science ®Google Scholar
• Chinvarun Y, Huang CW, Wu Y, et al. Optimal use of perampanel in Asian patients with epilepsy: expert opinion. Ther Clin Risk Manag. 2021;17:739–746.
   PubMed Web of Science ®Google Scholar
• Leppik IE, Wechsler RT, Williams B, Yang H, Zhou S, Laurenza A. Efficacy and safety of perampanel in the subgroup of elderly patients included in the phase III epilepsy clinical trials. Epilepsy Res. 2015;110:216–220.
   PubMed Web of Science ®Google Scholar
• Marawar R, Leppik IE, Wechsler RT, Patten A, Ngo LY, Malhotra M. Long-term efficacy and safety of perampanel in a subgroup of elderly patients aged ≥60 years from phase III open-label extension (OLEx) studies. Paper presented at: Annual Meeting of the American Epilepsy Society; December 4-8, 2020; Seattle, WA, USA.
   Google Scholar
• Villanueva V, Garcés M, López-González FJ, et al. Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: the FYDATA study. Epilepsy Res. 2016;126:201–210.
   PubMed Web of Science ®Google Scholar
• Lattanzi S, Cagnetti C, Foschi N, et al. Adjunctive perampanel in older patients with epilepsy: a multicenter study of clinical practice. Drugs Aging. 2021;38(7):603–610.
   PubMed Web of Science ®Google Scholar
• Rohracher A, Zimmermann G, Villanueva V, et al. Perampanel in routine clinical use across Europe: pooled, multicenter, observational data. Epilepsia. 2018;59(9):1727–1739.
   PubMed Web of Science ®Google Scholar
• Ho CJ, Lin CH, Lu YT, et al. Perampanel treatment for refractory status epilepticus in a neurological intensive care unit. Neurocrit Care. 2019;31(1):24–29.
   PubMed Web of Science ®Google Scholar
• Cheng M-Y, Lim S-N, Wu T. Perampanel as an adjunctive therapy in elderly patients with epilepsy. Paper presented at: International Epilepsy Congress; June 22-26, 2019; Bangkok, Thailand.
   Google Scholar
• Inoue Y, Sumitomo K, Matsutani K, Ishii M. Evaluation of real-world effectiveness of perampanel in Japanese adults and older adults with epilepsy. Epileptic Disord. 2022;24(1):123–132.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Osugi S, Aiba T. Usefulness of long-term administration of perampanel in the treatment of elderly-onset epilepsy secondary to Alzheimer dementia. J New Rem & Clin. 2019;68(8):990–1003.
   Google Scholar
• Chen Y-S, Chen T-S, Huang C-W. Dementia with non-convulsive seizures: a case report. J Int Medical Res. 2021;49(12):03000605211062453.
   PubMed Web of Science ®Google Scholar
• Lee SK. Epilepsy in the elderly: treatment and consideration of comorbid diseases. J Epilepsy Res. 2019;9(1):27–35.
   PubMedGoogle Scholar
• Eisai Inc. Fycompa prescribing information. Available from: https://www.fycompa.com/hcp/-/media/Files/Fycompa/Fycompa_Prescribing_Information.pdf?v=20201020&la=en. Accessed December 16, 2021.
   Google Scholar
• Tabuchi H, Shiba S, Yasuda S, Ohnishi A, Shin JG. Pharmacokinetics of perampanel in healthy Korean, White, and Japanese adult subjects. Clin Pharmacol Drug Dev. 2018;7(6):613–620.
   PubMed Web of Science ®Google Scholar
• Tsai JJ, Ikeda A, Hong SB, Likasitwattanakul S, Dash A. Efficacy, safety, and tolerability of perampanel in Asian and non-Asian patients with epilepsy. Epilepsia. 2019;60(Suppl 1):37–46.
   PubMedGoogle Scholar
• Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. Lancet Neurol. 2017;16(4):311–322.
   PubMed Web of Science ®Google Scholar
• da Costa Miranda D, Dozzi Brucki SM. Epilepsy in patients with Alzheimer’s disease: a systematic review. Dement Neuropsychol. 2014;8(1):66–71.
   PubMedGoogle Scholar
• Palop JJ, Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol. 2009;66(4):435–440.
   PubMedGoogle Scholar
• Galovic M, Ferreira-Atuesta C, Abraira L, et al. Seizures and epilepsy after stroke: epidemiology, biomarkers and management. Drugs Aging. 2021;38(4):285–299.
   PubMed Web of Science ®Google Scholar
• Delgado RT, Morillo L, Vlasov P, Trinka E, Goldman S, Villanueva V. Real-world evidence on the use of perampanel for the treatment of epilepsy patients with vascular etiology. Paper presented at: Annual Meeting of the American Epilepsy Society; December 3-7, 2021; Chicago, IL, USA.
   Google Scholar
• Suda S, Kimura K. Therapeutic potential of AMPA receptor antagonist perampanel against cerebral ischemia: beyond epileptic disorder. Neural Regen Res. 2019;14(9):1525–1526.
   PubMed Web of Science ®Google Scholar
• Yang L, Wang Y, Zhang C, Cheng H. Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation. Mol Med Rep. 2021;24(2):544.
   PubMed Web of Science ®Google Scholar
• Perucca E, Berlowitz D, Birnbaum A, et al. Pharmacological and clinical aspects of antiepileptic drug use in the elderly. Epilepsy Res. 2006;68:49–63.
   PubMed Web of Science ®Google Scholar
• Johannessen SI, Landmark CJ. Antiepileptic drug interactions - principles and clinical implications. Curr Neuropharmacol. 2010;8(3):254–267.
   PubMed Web of Science ®Google Scholar
• Di Bonaventura C, Labate A, Maschio M, Meletti S, Russo E. AMPA receptors and perampanel behind selected epilepsies: current evidence and future perspectives. Expert Opin Pharmacother. 2017;18(16):1751–1764.
   PubMed Web of Science ®Google Scholar
• Majid O, Laurenza A, Ferry J, Hussein Z. Impact of perampanel on pharmacokinetics of concomitant antiepileptics in patients with partial-onset seizures: pooled analysis of clinical trials. Br J Clin Pharmacol. 2016;82(2):422–430.
   PubMed Web of Science ®Google Scholar
• Eatock J, Baker GA. Managing patient adherence and quality of life in epilepsy. Neuropsychiatr Dis Treat. 2007;3(1):117–131.
   PubMedGoogle Scholar
• Schulze-Bonhage A. Perampanel for epilepsy with partial-onset seizures: a pharmacokinetic and pharmacodynamic evaluation. Expert Opin Drug Metab Toxicol. 2015;11(8):1329–1337.
   PubMed Web of Science ®Google Scholar
• Ko D, Yang H, Williams B, Xing D, Laurenza A. Perampanel in the treatment of partial seizures: time to onset and duration of most common adverse events from pooled Phase III and extension studies. Epilepsy Behav. 2015;48:45–52.
   PubMed Web of Science ®Google Scholar
• Rocamora R, Álvarez I, Chavarría B, Principe A. Perampanel effect on sleep architecture in patients with epilepsy. Seizure. 2020;76:137–142.
   PubMed Web of Science ®Google Scholar
• Quigg M, Gharai S, Ruland J, et al. Insomnia in epilepsy is associated with continuing seizures and worse quality of life. Epilepsy Res. 2016;122:91–96.
   PubMed Web of Science ®Google Scholar
• Giovagnoli AR, Parente A, Tarallo A, Casazza M, Franceschetti S, Avanzini G. Self-rated and assessed cognitive functions in epilepsy: impact on quality of life. Epilepsy Res. 2014;108(8):1461–1468.
   PubMed Web of Science ®Google Scholar
• Bonanni P, Gambardella A, Tinuper P, Acone B, Perucca E, Coppola G. Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements. BMC Neurol. 2021;21(1):410.
   PubMed Web of Science ®Google Scholar
• Meador KJ, Yang H, Piña-Garza JE, Laurenza A, Kumar D, Wesnes KA. Cognitive effects of adjunctive perampanel for partial-onset seizures: a randomized trial. Epilepsia. 2016;57(2):243–251.
   PubMed Web of Science ®Google Scholar
• Ahn SJ, Kim TJ, Cha KS, et al. Effects of perampanel on cognition and quantitative electroencephalography in patients with epilepsy. Epilepsy Behav. 2021;115:107514.
   PubMed Web of Science ®Google Scholar