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Review

Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management

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Pages 259-271 | Published online: 27 May 2013

References

  • CorsonelloAPedoneCCoricaFIncalziRAPolypharmacy in elderly patients at discharge from the acute care hospitalTher Clin Risk Manag20073119720318360627
  • KohYKuttyFBLiSCDrug-related problems in hospitalized patients on polypharmacy: the influence of age and genderTher Clin Risk Manag200511394818360542
  • DoanJZakrzewski-JakubiakHRoyJTurgeonJTannenbaumCPrevalence and risk of potential cytochrome P450-mediated drug-drug interactions in older hospitalized patients with polypharmacyAnn Pharmacother201347332433223482734
  • Joint Commission InternationalJCI accreditation standards for hospitals [webpage on the Internet]Oak Brook, ILJoint Commission International2010 Available from: http://www.jointcommissioninternational.org/common/pdfs/jcia/IAS400_Standards_Lists_Only.pdfAccessed March 20, 2013
  • MahmoodMMaloneDCSkrepnekGHPotential drug-drug interactions within Veterans Affairs medical centersAm J Health Syst Pharm200764141500150517617500
  • OgawaREchizenHDrug-drug interaction profiles of proton pump inhibitorsClin Pharmacokinet201049850953320608754
  • BlumeHDonathFWarnkeASchugBSPharmacokinetic drug interaction profiles of proton pump inhibitorsDrug Saf200629976978416944963
  • GersonLBTriadafilopoulosGProton pump inhibitors and their drug interactions: an evidence-based approachEur J Gastroenterol Hepatol200113561161611396546
  • GuglerRJensenJCOmeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitroGastroenterology1985896123512413932118
  • ZvyagaTChangSYChenCEvaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450: focus on cytochrome P4502C19Drug Metab Dispos20124091698171122648560
  • CaracoYTateishiTWoodAJInterethnic difference in omeprazole’s inhibition of diazepam metabolismClin Pharmacol Ther199558162727628184
  • GuglerRHartmannMRudiJLack of pharmacokinetic interaction of pantoprazole with diazepam in manBr J Clin Pharmacol19964222492528864328
  • LefebvreRAFlouvatBKarolac-TamisierSMoermanEVan GanseEInfluence of lansoprazole treatment on diazepam plasma concentrationsClin Pharmacol Ther19925254584631424419
  • IshizakiTChibaKManabeKComparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylationClin Pharmacol Ther19955821551647648765
  • NaiduMURShobhaJCDixitVKEffect of multiple dose omeprazole on the pharmacokinetics of carbamazepineDrug Invest199471812
  • DixitRKChawlaABKumarNGargSKEffect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteersMethods Find Exp Clin Pharmacol2001231373911413862
  • BertilssonLTybringGWidénJChangMTomsonTCarbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19Br J Clin Pharmacol19974421861899278208
  • HuberRBliesathHHartmannMPantoprazole does not interact with the pharmacokinetics of carbamazepineInt J Clin Pharmacol Ther199836105215249799054
  • DaltonMJPowellJRMessenheimerJAJrRanitidine does not alter single-dose carbamazepine pharmacokinetics in healthy adultsDrug Intell Clin Pharm198519129419444085354
  • HanXMOuyangDSChenXPInducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2Br J Clin Pharmacol200254554054312445035
  • RostKLBrösickeHHeinemeyerGRootsISpecific and dose-dependent enzyme induction by omeprazole in human beingsHepatology1994205120412127927253
  • FrickAKopitzJBergemannNOmeprazole reduces clozapine plasma concentrations. A case reportPharmacopsychiatry200336312112806570
  • MookhoekEJLoonenAJRetrospective evaluation of the effect of omeprazole on clozapine metabolismPharm World Sci200426318018215230368
  • HartmannMZechKBliesathHPantoprazole lacks induction of CYP1A2 activity in manInt J Clin Pharmacol Ther199937415916410235417
  • BondolfiGMorelFCrettolSRachidFBaumannPEapCBIncreased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patientsTher Drug Monit200527453954316044115
  • FalconRWKakudaTNDrug interactions between HIV protease inhibitors and acid-reducing agentsClin Pharmacokinet2008472758918193914
  • BurgerDMHugenPWKroonFPPharmacokinetic interaction between the proton pump inhibitor omeprazole and the HIV protease inhibitor indinavirAIDS19981215208020829814882
  • FangAFDamleBDLaBadieRRCrownoverPHHewlettDJrGluePWSignificant decrease in nelfinavir systemic exposure after omeprazole coad-ministration in healthy subjectsPharmacotherapy2008281425018154473
  • ZhuLPerssonAMahnkeLEffect of low-dose omeprazole (20 mg daily) on the pharmacokinetics of multiple-dose atazanavir with ritonavir in healthy subjectsJ Clin Pharmacol201151336837720457590
  • SharmaMSaravolatzLDRilpivirine: a new non-nucleoside reverse tran-scriptase inhibitorJ Antimicrob Chemother201368225025623099850
  • TappouniHLRubleinJCDonovanBJEffect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavirAm J Health Syst Pharm200865542242818281734
  • SaahAJWinchellGANesslyMLSeniukMARhodesRRDeutschPJPharmacokinetic profile and tolerability of indinavir-ritonavir combinations in healthy volunteersAntimicrob Agents Chemother200145102710271511557459
  • ZhouSChanELiXHuangMClinical outcomes and management of mechanism-based inhibition of cytochrome P4503A4Ther Clin Risk Manag20051131318360537
  • BoffitoMCarrieroPTrentiniLPharmacokinetics of saquinavir co-administered with cimetidineJ Antimicrob Chemother20025061081108412461038
  • SaberiPRanatungaDKQuesenberryCPSilverbergMJClinical implications of the nelfinavir-proton pump inhibitor drug interaction in patients with human immunodeficiency virusPharmacotherapy201131325326121361735
  • LuberADBrowerRKimDSilvermanRPeloquinCAFrankISteady-state pharmacokinetics of once-daily fosamprenavir/ritonavir and atazanavir/ritonavir alone and in combination with 20 mg omeprazole in healthy volunteersHIV Med20078745746417760738
  • VanHeeswijk RHoetelmansRKestensDInternational AIDS SocietyThe pharmacokinetic (PK) interaction between famotidine and TMC278, a next generation non-nucleoside reverse transcriptase inhibitor (NNRTI), in HIV-negative volunteersProceedings of the Fourth IAS Conference on HIV Pathogenesis, Treatment, and Prevention2007Sydney, Australia
  • BrownKCPaulSKashubaADDrug interactions with new and investigational antiretroviralsClin Pharmacokinet200948421124119492868
  • BeorleguiBAldazAOrtegaAAquerretaISierrasesúmegaLGiráldezJPotential interaction between methotrexate and omeprazoleAnn Pharmacother20003491024102710981249
  • BezabehSMackeyACKluetzPJapparDKorvickJAccumulating evidence for a drug-drug interaction between methotrexate and proton pump inhibitorsOncologist201217455055422477728
  • BautersTGVerlooyJRobaysHLaureysGInteraction between methotrexate and omeprazole in an adolescent with leukemia: a case reportPharm World Sci200830431631818386155
  • RanchonFVantardNGouraudASuspicion of drug-drug interaction between high-dose methotrexate and proton pump inhibitors: a case report—should the practice be changed?Chemotherapy201157322522921597286
  • ChristiansUSchmidtGBaderAIdentification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomesBr J Clin Pharmacol19964131871908866917
  • MaguireMFranzTHainsDSA clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipientPediatr Transplant2012166E217E22021883747
  • HosohataKMasudaSKatsuraTImpact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patientsDrug Metab Dispos200937482182619139162
  • HosohataKMasudaSOguraYInteraction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5Drug Metab Pharmacokinet200823213413818445994
  • HosohataKMasudaSYonezawaAAbsence of influence of concomitant administration of rabeprazole on the pharmacokinetics of tacrolimus in adult living-donor liver transplant patients: a case-control studyDrug Metab Pharmacokinet200924545846319881258
  • TakahashiKYanoIFukuharaYDistinct effects of omeprazole and rabeprazole on the tacrolimus blood concentration in a kidney transplant recipientDrug Metab Pharmacokinet200722644144418159131
  • LorfTRamadoriGRingeBSchwörerHThe effect of pantoprazole on tacrolimus and cyclosporin A blood concentration in transplant recipientsEur J Clin Pharmacol200056543944011009056
  • DoeschAOMuellerSKonstandinMProton pump inhibitor co-medication reduces active drug exposure in heart transplant recipients receiving mycophenolate mofetilTransplant Proc201042104243424621168674
  • David-NetoETakakiKMAgenaFDiminished mycophenolic acid exposure caused by omeprazole may be clinically relevant in the first week posttransplantationTher Drug Monit201234333133622549498
  • KiberdBAWrobelMDandavinoRKeownPGourishankarSThe role of proton pump inhibitors on early mycophenolic acid exposure in kidney transplantation: evidence from the CLEAR studyTher Drug Monit201133112012321192310
  • KeesMGSteinkeTMoritzSOmeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycophenolate sodium in healthy volunteersJ Clin Pharmacol20125281265127221903891
  • DrepperMDSpahrLFrossardJLClopidogrel and proton pump inhibitors – where do we stand in 2012?World J Gastroenterol201218182161217122611308
  • NorgardNBMathewsKDWallGCDrug-drug interaction between clopidogrel and the proton pump inhibitorsAnn Pharmacother20094371266127419470853
  • BhattDLCryerBLContantCFCOGENT InvestigatorsClopidogrel with or without omeprazole in coronary artery diseaseN Engl J Med2010363201909191720925534
  • BatesERLauWCAngiolilloDJClopidogrel-drug interactionsJ Am Coll Cardiol201157111251126321392639
  • WuJJiaLTShaoLMDrug-drug interaction of rabeprazole and clopidogrel in healthy Chinese volunteersEur J Clin Pharmacol201369217918722706585
  • NeubauerHEngelhardtAKrügerJCPantoprazole does not influence the antiplatelet effect of clopidogrel-a whole blood aggregometry study after coronary stentingJ Cardiovasc Pharmacol2010561919720410834
  • FrelingerAL3rdLeeRDMulfordDJA randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteersJ Am Coll Cardiol201259141304131122464259
  • TunggalPNgFHLamKFChanFKLauYKEffect of esomeprazole versus famotidine on platelet inhibition by clopidogrel: a double-blind, randomized trialAm Heart J2011162587087422093203
  • NgFHTunggalPChuWMEsomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarctionAm J Gastroenterol2012107338939622108447
  • GurbelPABlidenKPFortJGSpaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrelAm Heart J2013165217618223351820
  • KileyCACraginDJRothBJOmeprazole-associated digoxin toxicitySouth Med J2007100440040217458401
  • GabelloMValenzanoMCBarrMZurbachPMullinJMOmeprazole induces gastric permeability to digoxinDig Dis Sci20105551255126319513837
  • CollettATanianis-HughesJCarlsonGLHarwoodMDWarhurstGComparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo predictionEur J Pharm Sci200526538639316153812
  • Pauli-MagnusCRekersbrinkSKlotzUFrommMFInteraction of omeprazole, lansoprazole and pantoprazole with P-glycoproteinNaunyn Schmiedebergs Arch Pharmacol2001364655155711770010
  • HartmannMHuberRBliesathHLack of interaction between pantoprazole and digoxin at therapeutic doses in manInt J Clin Pharmacol Ther199634Suppl 1S67S718793605
  • JaruratanasirikulSSriwiriyajanSEffect of omeprazole on the pharmacokinetics of itraconazoleEur J Clin Pharmacol19985421591619626921
  • JohnsonMDHamiltonCDDrewRHSandersLLPennickGJPerfectJRA randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solutionJ Antimicrob Chemother200351245345712562722
  • AlffenaarJWvan AssenSvan der WerfTSKosterinkJGUgesDROmeprazole significantly reduces posaconazole serum trough levelClin Infect Dis200948683919220151
  • LangeDPavaoJHWuJKlausnerMEffect of a cola beverage on the bioavailability of itraconazole in the presence of H2 blockersJ Clin Pharmacol19973765355409208361
  • DoltonMJRayJEMarriottDMcLachlanAJPosaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoringAntimicrob Agents Chemother20125662806281322391534
  • RossALSlainDCumpstonABryantAMHamadaniMCraigMEvaluation of an alternative posaconazole prophylaxis regimen in haematological malignancy patients receiving concomitant stress ulcer prophylaxisInt J Antimicrob Agents201240655756123068599
  • AjmeraAVShastriGSGajeraMJJudgeTASuboptimal response to ferrous sulfate in iron-deficient patients taking omeprazoleAm J Ther201219318518921150767
  • KaramWGGoldsteinJALaskerJMGhanayemBIHuman CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymesDrug Metab Dispos19962410108110878894508
  • FaucetteSRZhangTCMooreRRelative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducersJ Pharmacol Exp Ther20073201728017041008
  • ChenYFergusonSSNegishiMGoldsteinJAIdentification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoterMol Pharmacol200364231632412869636
  • MugunduGMHariparsadNDesaiPBImpact of ritonavir, atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytesDrug Metab Lett201041455020201776
  • MichaudVOgburnEThongNInduction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteersClin Pharmacol Ther201291347548222318618
  • WangLSZhouGZhuBSt John’s Wort induces both cytochrome P4503A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazoleClin Pharmacol Ther200475319119715001970
  • XieHGAdditional discussions regarding the altered metabolism and transport of omeprazole after long-term use of St John’s WortClin Pharmacol Ther200578444044116198664
  • ZuoXCZhangBKJiaSJEffects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjectsEur J Clin Pharmacol201066550350920186406
  • LeiHPWangGWangLSLack of effect of Ginkgo biloba on voriconazole pharmacokinetics in Chinese volunteers identified as CYP2C19 poor and extensive metabolizersAnn Pharmacother200943472673119299322
  • ZadoyanGRokittaDKlementSEffect of Ginkgo biloba special extract EGb761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteersEur J Clin Pharmacol201268555356022189672
  • YinOQTomlinsonBWayeMMChowAHChowMSPharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazolePharmacogenetics2004141284185015608563
  • HuangWZhangJMooreDDA traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CARJ Clin Invest2004113113714314702117
  • FanLWangGWangLSHerbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazoleActa Pharmacol Sin200728101685169217883958
  • PaceFPallottaSCasaliniSPorroGBA review of rabeprazole in the treatment of acid-related diseasesTher Clin Risk Manag20073336337918488081
  • MarelliSPaceFRabeprazole for the treatment of acid-related disordersExpert Rev Gastroenterol Hepatol20126442343522928894
  • MoherDLiberatiATetzlaffJAltmanDGPRISMA GroupPreferred reporting items for systematic reviews and meta-analyses:the PRISMA statementBMJ2009339b253519622551