Therapeutic implications of Epstein–Barr virus infection for the treatment of nasopharyngeal carcinoma

References

• ShamJSWeiWIZongYSDetection of subclinical nasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsyLancet199033586863713741968116
   PubMed Web of Science ®Google Scholar
• ShanmugaratnamKSobinLHThe World Health Organization histological classification of tumours of the upper respiratory tract and ear. A commentary on the second editionCancer1993718268926978453591
   PubMed Web of Science ®Google Scholar
• ReddySPRaslanWFGooneratneSKathuriaSMarksJEPrognostic significance of keratinization in nasopharyngeal carcinomaAm J Otolaryngol19951621031087540805
   PubMed Web of Science ®Google Scholar
• ParkinDMWhelanSLFerlayJRaymondLYoungJCancer Incidence in Five Continents. Vol VIIIARC Scientific Publications No 143Lyon1997
   Google Scholar
• YuMCYuanJMEpidemiology of nasopharyngeal carcinomaSemin Cancer Biol200212642142912450728
   PubMed Web of Science ®Google Scholar
• ChenCJYouSLLinLHHsuWLYangYWCancer epidemiology and control in Taiwan: a brief reviewJpn J Clin Oncol200232 SupplS66S8111959880
   PubMedGoogle Scholar
• DeviBCPisaniPTangTSParkinDMHigh incidence of nasopharyngeal carcinoma in native people of Sarawak, Borneo IslandCancer Epidemiol Biomarkers Prev200413348248615006927
   PubMed Web of Science ®Google Scholar
• WeeJTHaTCLoongSLQianCNIs nasopharyngeal cancer really a “Cantonese cancer”?Chin J Cancer201029551752620426903
   PubMedGoogle Scholar
• TrejautJLeeCLYenJCLooJHLinMAncient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinomaChin J Cancer20113029610521272441
   PubMedGoogle Scholar
• LevinePHPocinkiAGMadiganPBaleSFamilial nasopharyngeal carcinoma in patients who are not ChineseCancer1992705102410291515979
   PubMed Web of Science ®Google Scholar
• FriborgJWohlfahrtJMelbyeMFamilial risk and clustering of nasopharyngeal carcinoma in Guangdong, ChinaCancer2005103121115540234
   PubMed Web of Science ®Google Scholar
• UngAChenCJLevinePHFamilial and sporadic cases of nasopharyngeal carcinoma in TaiwanAnticancer Res1999191B66166510216473
   PubMed Web of Science ®Google Scholar
• NgWTChoiCWLeeMCChanSHYauTKLeeAWFamilial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screeningFam Cancer20098210310818726711
   PubMed Web of Science ®Google Scholar
• FengBJHuangWShugartYYGenome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4Nat Genet200231439539912118254
   PubMed Web of Science ®Google Scholar
• XiongWZengZYXiaJHA susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinomaCancer Res20046461972197415026332
   PubMed Web of Science ®Google Scholar
• HuLFQiuQHFuSMA genome-wide scan suggests a susceptibility locus on 5p 13 for nasopharyngeal carcinomaEur J Hum Genet200816334334918197201
   PubMed Web of Science ®Google Scholar
• HildesheimAWangCPGenetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000–2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factorsSemin Cancer Biol201222210711622300735
   PubMed Web of Science ®Google Scholar
• HsuWLTseKPLiangSEvaluation of human leukocyte antigen-A (HLA-A), other non-HLA markers on chromosome 6p21 and risk of nasopharyngeal carcinomaPLoS One201278e4276722880099
   PubMed Web of Science ®Google Scholar
• YuMCHuangTBHendersonBEDiet and nasopharyngeal carcinoma: a case-control study in Guangzhou, ChinaInt J Cancer1989436107710822732001
   PubMed Web of Science ®Google Scholar
• GuoXJohnsonRCDengHEvaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern ChinaInt J Cancer2009124122942294719296536
   PubMed Web of Science ®Google Scholar
• JiaWHLuoXYFengBJTraditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, ChinaBMC Cancer20101044620727127
   PubMed Web of Science ®Google Scholar
• FarrowDCVaughanTLBerwickMLynchCFSwansonGMLyonJLDiet and nasopharyngeal cancer in a low-risk populationInt J Cancer19987866756799833758
   PubMed Web of Science ®Google Scholar
• JeannelDHubertAde VathaireFDiet, living conditions and nasopharyngeal carcinoma in Tunisia – a case-control studyInt J Cancer19904634214252394508
   PubMed Web of Science ®Google Scholar
• XueWQQinHDRuanHLShugartYYJiaWHQuantitative association of tobacco smoking with the risk of nasopharyngeal carcinoma: a comprehensive meta-analysis of studies conducted between 1979 and 2011Am J Epidemiol2013178332533823785114
   PubMed Web of Science ®Google Scholar
• FangCYHuangSYWuCCThe synergistic effect of chemical carcinogens enhances Epstein-Barr virus reactivation and tumor progression of nasopharyngeal carcinoma cellsPLoS One201279e4481023024765
   PubMed Web of Science ®Google Scholar
• HildesheimALevinePHEtiology of nasopharyngeal carcinoma: a reviewEpidemiol Rev19931524664858174667
   PubMed Web of Science ®Google Scholar
• MiddeldorpJMBrinkAAvan den BruleAJMeijerCJPathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disordersCrit Rev Oncol Hematol200345113612482570
   PubMed Web of Science ®Google Scholar
• RickinsonABKieffEEpstein-Barr Virus4th edLippincott Williams & WilkinsPhiladelphia, PA, USA200125752627
   Google Scholar
• KieffEEpstein-Barr virus and its replicationFieldsBNKnipeDMHowleyPMFields VirologyPhiladelphia, PALippincott-Raven199623432396
   Google Scholar
• CrawfordDHMacsweenKFHigginsCDA cohort study among university students: identification of risk factors for Epstein-Barr virus seroconversion and infectious mononucleosisClin Infect Dis200643327628216804839
   PubMed Web of Science ®Google Scholar
• KutokJLWangFSpectrum of Epstein-Barr virus-associated diseasesAnnu Rev Pathol2006137540418039120
   PubMed Web of Science ®Google Scholar
• OkanoMGrossTGAcute or chronic life-threatening diseases associated with Epstein-Barr virus infectionAm J Med Sci2012343648348922104426
   PubMed Web of Science ®Google Scholar
• LossiusAJohansenJNTorkildsenØVartdalFHolmøyTEpstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis – association and causationViruses20124123701373023342374
   PubMed Web of Science ®Google Scholar
• NiedobitekGThe Epstein-Barr virus: a group 1 carcinogen?Virchows Arch19994352798610599304
   PubMed Web of Science ®Google Scholar
• BabcockGJDeckerLLVolkMThorley-LawsonDAEBV persistence in memory B cells in vivoImmunity1998933954049768759
   PubMed Web of Science ®Google Scholar
• PegtelDMMiddeldorpJThorley-LawsonDAEpstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriersJ Virol20047822126131262415507648
   PubMed Web of Science ®Google Scholar
• TaoQYoungLSWoodmanCBMurrayPGEpstein-Barr virus (EBV) and its associated human cancers – genetics, epigenetics, pathobiology and novel therapeuticsFront Biosci2006112672271316720343
   PubMed Web of Science ®Google Scholar
• Thorley-LawsonDAHawkinsJBTracySIShapiroMThe pathogenesis of Epstein-Barr virus persistent infectionCurr Opin Virol20133322723223683686
   PubMed Web of Science ®Google Scholar
• MenonMPPittalugaSJaffeESThe histological and biological spectrum of diffuse large B-cell lymphoma in the World Health Organization classificationCancer J201218541142023006945
   PubMed Web of Science ®Google Scholar
• HadinotoVShapiroMSunCCThorley-LawsonDAThe dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral outputPLoS Pathog200957e100049619578433
   PubMed Web of Science ®Google Scholar
• HislopADTaylorGSSauceDRickinsonABCellular responses to viral infection in humans: lessons from Epstein-Barr virusAnnu Rev Immunol20072558761717378764
   PubMed Web of Science ®Google Scholar
• HochbergDMiddeldorpJMCatalinaMSullivanJLLuzuriagaKThorley-LawsonDADemonstration of the Burkitt’s lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivoProc Natl Acad Sci U S A2004101123924414688409
   PubMed Web of Science ®Google Scholar
• LaichalkLLThorley-LawsonDATerminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivoJ Virol20057921296130715613356
   PubMed Web of Science ®Google Scholar
• LaichalkLLHochbergDBabcockGJFreemanRBThorley-LawsonDAThe dispersal of mucosal memory B cells: evidence from persistent EBV infectionImmunity200216574575412049725
   PubMed Web of Science ®Google Scholar
• RoughanJETorgborCThorley-LawsonDAGerminal center B cells latently infected with Epstein-Barr virus proliferate extensively but do not increase in numberJ Virol20108421158116819889783
   PubMed Web of Science ®Google Scholar
• KisLLSalamonDPerssonEKIL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoterProc Natl Acad Sci U S A2010107287287720080768
   PubMed Web of Science ®Google Scholar
• Raab-TraubNEBV-induced oncogenesisArvinACampadelli-FiumeGMocarskiEHuman Herpesviruses: Biology, Therapy, and ImmunoprophylaxisCambridgeCambridge University Press20079861006 Chapter 55
   Google Scholar
• PathmanathanRPrasadUChandrikaGSadlerRFlynnKRaab-TraubNUndifferentiated, nonkeratinizing, and squamous cell carcinoma of the nasopharynx. Variants of Epstein-Barr virus-infected neoplasiaAm J Pathol19951466135513677778675
   PubMed Web of Science ®Google Scholar
• PathmanathanRPrasadUSadlerRFlynnKRaab-TraubNClonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinomaN Engl J Med1995333116936987637746
   PubMed Web of Science ®Google Scholar
• Raab-TraubNFlynnKThe structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferationCell19864768838893022942
   PubMed Web of Science ®Google Scholar
• TaoQSrivastavaGChanACChungLPLokeSLHoFCEvidence for lytic infection by Epstein-Barr virus in mucosal lymphocytes instead of nasopharyngeal epithelial cells in normal individualsJ Med Virol199545171777714494
   PubMed Web of Science ®Google Scholar
• SamCKBrooksLANiedobitekGYoungLSPrasadURickinsonABAnalysis of Epstein-Barr virus infection in nasopharyngeal biopsies from a group at high risk of nasopharyngeal carcinomaInt J Cancer19935369579628386141
   PubMed Web of Science ®Google Scholar
• FrappierLContributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survivalViruses2012491537154723170171
   PubMed Web of Science ®Google Scholar
• FrappierLEBNA1 and host factors in Epstein-Barr virus latent DNA replicationCurr Opin Virol20122673373923031715
   PubMed Web of Science ®Google Scholar
• DawsonCWPortRJYoungLSThe role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC)Semin Cancer Biol201222214415322249143
   PubMed Web of Science ®Google Scholar
• SetoEYangLMiddeldorpJEpstein-Barr virus (EBV)-encoded BARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expressionJ Med Virol2005761828815778977
   PubMed Web of Science ®Google Scholar
• HoebeEKLe LargeTYGreijerAEMiddeldorpJMBamHI-A rightward frame 1, an Epstein-Barr virus-encoded oncogene and immune modulatorRev Med Virol201323636738323996634
   PubMed Web of Science ®Google Scholar
• TakadaKRole of EBER and BARF1 in nasopharyngeal carcinoma (NPC) tumorigenesisSemin Cancer Biol201222216216522210180
   PubMed Web of Science ®Google Scholar
• MarquitzARRaab-TraubNThe role of miRNAs and EBV BARTs in NPCSemin Cancer Biol201222216617222178394
   PubMed Web of Science ®Google Scholar
• YoungLSRickinsonABEpstein-Barr virus: 40 years onNat Rev Cancer200441075776815510157
   PubMed Web of Science ®Google Scholar
• YoshizakiTKondoSWakisakaNPathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinomaCancer Lett201333711723689138
   PubMed Web of Science ®Google Scholar
• KieffERickinsonABEpstein-Barr virus and its replicationKnipeDMHowleyPMFields Virology5th ed2Philadelphia, PALippincott Williams and Wilkins200726032654
   Google Scholar
• YoshizakiTSatoHFurukawaMPaganoJSThe expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1Proc Natl Acad Sci U S A1998957362136269520415
   PubMed Web of Science ®Google Scholar
• EndoKKondoSShacklefordJPhosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migrationOncogene200928141725173519234486
   PubMed Web of Science ®Google Scholar
• ShairKHSchneggCIRaab-TraubNEpstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switchCancer Res200969145734574219584275
   PubMed Web of Science ®Google Scholar
• SchoreyJSBhatnagarSExosome function: from tumor immunology to pathogen biologyTraffic20089687188118331451
   PubMed Web of Science ®Google Scholar
• SimonsMRaposoGExosomes – vesicular carriers for intercellular communicationCurr Opin Cell Biol200921457558119442504
   PubMed Web of Science ®Google Scholar
• PegtelDMCosmopoulosKThorley-LawsonDAFunctional delivery of viral miRNAs via exosomesProc Natl Acad Sci U S A2010107146328633320304794
   PubMed Web of Science ®Google Scholar
• DukersDFMeijPVervoortMBDirect immunosuppressive effects of EBV-encoded latent membrane protein 1J Immunol2000165266367010878338
   PubMed Web of Science ®Google Scholar
• FlanaganJMiddeldorpJSculleyTLocalization of the Epstein-Barr virus protein LMP 1 to exosomesJ Gen Virol200384Pt 71871187912810882
   PubMed Web of Science ®Google Scholar
• MiddeldorpJMPegtelDMMultiple roles of LMP1 in Epstein-Barr virus induced immune escapeSemin Cancer Biol200818638839619013244
   PubMed Web of Science ®Google Scholar
• VerweijFJvan EijndhovenMAHopmansESLMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activationEMBO J201130112115212921527913
   PubMed Web of Science ®Google Scholar
• MillerWEEarpHSRaab-TraubNThe Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptorJ Virol1995697439043987769701
   PubMed Web of Science ®Google Scholar
• HuLFMinarovitsJCaoSLVariable expression of latent membrane protein in nasopharyngeal carcinoma can be related to methylation status of the Epstein-Barr virus BNLF-1 5′-flanking regionJ Virol1991653155815671847471
   PubMed Web of Science ®Google Scholar
• KhabirAKarrayHRodriguezSEBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomasVirol J200523915842731
   PubMed Web of Science ®Google Scholar
• TaoQHoFCLokeSLSrivastavaGEpstein-Barr virus is localized in the tumour cells of nasal lymphomas of NK, T or B cell typeInt J Cancer19956033153207829236
   PubMed Web of Science ®Google Scholar
• ChiangAKTaoQSrivastavaGHoFCNasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin’s diseaseInt J Cancer19966832852908903467
   PubMed Web of Science ®Google Scholar
• DecaussinGSbih-LammaliFde Turenne-TessierMBouguermouhAOokaTExpression of BARF1 gene encoded by Epstein-Barr virus in nasopharyngeal carcinoma biopsiesCancer Res200060195584558811034107
   PubMed Web of Science ®Google Scholar
• StevensSJVerkuijlenSAHariwiyantoBNoninvasive diagnosis of nasopharyngeal carcinoma: nasopharyngeal brushings reveal high Epstein-Barr virus DNA load and carcinoma-specific viral BARF1 mRNAInt J Cancer2006119360861416572427
   PubMed Web of Science ®Google Scholar
• CosmopoulosKPegtelMHawkinsJComprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinomaJ Virol20098352357236719091858
   PubMed Web of Science ®Google Scholar
• BarthSPfuhlTMamianiAEpstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5Nucleic Acids Res200836266667518073197
   PubMed Web of Science ®Google Scholar
• LoAKToKFLoKWModulation of LMP1 protein expression by EBV-encoded microRNAsProc Natl Acad Sci U S A200710441161641616917911266
   PubMed Web of Science ®Google Scholar
• ChoyEYSiuKLKokKHAn Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survivalJ Exp Med2008205112551256018838543
   PubMed Web of Science ®Google Scholar
• BarthSMeisterGGrässerFAEBV-encoded miRNAsBiochim Biophys Acta2011180911–1263164021640213
   PubMed Web of Science ®Google Scholar
• IsraelBFKenneySCEBV lytic infectionRobertsonESEpstein-Barr VirusPhiladelphia, PACaister Academic Press2011571611
   Google Scholar
• KenneySCMertzJERegulation of the latent-lytic switch in Epstein-Barr virusSemin Cancer Biol Epub1202014
   PubMed Web of Science ®Google Scholar
• StevensSJZwaanCMVerkuijlenSAMiddeldorpJMEpstein-Barr virus (EBV) serology for predicting distant metastases in a white juvenile patient with nasopharyngeal carcinoma and no clinical response to EBV lytic induction therapyHead Neck200628111040104516933315
   PubMed Web of Science ®Google Scholar
• FachirohJSchoutenTHariwiyantoBMolecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjectsJ Infect Dis20041901536215195243
   PubMed Web of Science ®Google Scholar
• JiMFWangDKYuYLSustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinomaBr J Cancer200796462363017285127
   PubMed Web of Science ®Google Scholar
• CaoSMLiuZJiaWHFluctuations of Epstein-Barr virus serological antibodies and risk for nasopharyngeal carcinoma: a prospective screening study with a 20-year follow-upPLoS One201164e1910021544243
   PubMed Web of Science ®Google Scholar
• GanYJChodoshJMorganASixbeyJWEpithelial cell polarization is a determinant in the infectious outcome of immunoglobulin A-mediated entry by Epstein-Barr virusJ Virol19977115195268985380
   PubMed Web of Science ®Google Scholar
• BoseSYapLFFungMThe ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinomaJ Pathol2009217334535219142888
   PubMed Web of Science ®Google Scholar
• SivachandranNCaoJYFrappierLEpstein-Barr virus nuclear antigen 1 hijacks the host kinase CK2 to disrupt PML nuclear bodiesJ Virol20108421111131112320719947
   PubMed Web of Science ®Google Scholar
• HuangSYFangCYTsaiCHN-methyl-N′-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cellsChem Biol Interact2010188362363420869957
   PubMed Web of Science ®Google Scholar
• de SanjoséSBoschRSchoutenTEpstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controlsInt J Cancer200712181806181217557295
   PubMed Web of Science ®Google Scholar
• RessingMEHorstDGriffinBDEpstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene productsSemin Cancer Biol200818639740818977445
   PubMed Web of Science ®Google Scholar
• MerloATurriniRDolcettiRThe interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disordersHaematologica201095101769177720421267
   PubMed Web of Science ®Google Scholar
• MiddeldorpJMHerbrinkPEpstein-Barr virus specific marker molecules for early diagnosis of infectious mononucleosisJ Virol Methods1988211–41331462846609
   PubMed Web of Science ®Google Scholar
• CallanMFStevenNKrausaPLarge clonal expansions of CD8+ T cells in acute infectious mononucleosisNat Med1996289069118705861
   PubMed Web of Science ®Google Scholar
• CallanMFTanLAnnelsNDirect visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivoJ Exp Med19981879139514029565632
   PubMed Web of Science ®Google Scholar
• YatesJLWarrenNSugdenBStable replication of plasmids derived from Epstein-Barr virus in various mammalian cellsNature198531360058128152983224
   PubMed Web of Science ®Google Scholar
• TellamJConnollyGGreenKJEndogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1J Exp Med2004199101421143115148340
   PubMed Web of Science ®Google Scholar
• VooKSFuTWangHYEvidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytesJ Exp Med2004199445947014769850
   PubMed Web of Science ®Google Scholar
• LevitskayaJSharipoALeonchiksACiechanoverAMasucciMGInhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1Proc Natl Acad Sci U S A1997942312616126219356498
   PubMed Web of Science ®Google Scholar
• KlibiJNikiTRiedelABlood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cellsBlood200911391957196619005181
   PubMed Web of Science ®Google Scholar
• Keryer-BibensCPioche-DurieuCVillemantCExosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9BMC Cancer2006628317156439
   PubMed Web of Science ®Google Scholar
• CohenJILekstromKEpstein-Barr virus BARF1 protein is dispensable for B-cell transformation and inhibits alpha interferon secretion from mononuclear cellsJ Virol19997397627763210438853
   PubMed Web of Science ®Google Scholar
• HuangYTSheenTSChenCLProfile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin 1 in tumor and CD4+ T cellsCancer Res19995971599160510197635
   PubMed Web of Science ®Google Scholar
• MacphersonAJMcCoyKDJohansenFEBrandtzaegPThe immune geography of IgA induction and functionMucosal Immunol200811112219079156
   PubMed Web of Science ®Google Scholar
• ChanKHGuYLNgFEBV specific antibody-based and DNA-based assays in serologic diagnosis of nasopharyngeal carcinomaInt J Cancer2003105570670912740922
   PubMed Web of Science ®Google Scholar
• FachirohJParamitaDKHariwiyantoBSingle-assay combination of Epstein-Barr Virus (EBV) EBNA1- and viral capsid antigen-p18-derived synthetic peptides for measuring anti-EBV immunoglobulin G (IgG) and IgA antibody levels in sera from nasopharyngeal carcinoma patients: options for field screeningJ Clin Microbiol20064441459146716597877
   PubMed Web of Science ®Google Scholar
• HutajuluSHNgNJatiBRSeroreactivity against Epstein-Barr virus (EBV) among first-degree relatives of sporadic EBV-associated nasopharyngeal carcinoma in IndonesiaJ Med Virol201284576877622431025
   PubMed Web of Science ®Google Scholar
• LiuZJiMFHuangQHTwo Epstein-Barr virus-related serologic antibody tests in nasopharyngeal carcinoma screening: results from the initial phase of a cluster randomized controlled trial in Southern ChinaAm J Epidemiol2013177324225023255783
   PubMed Web of Science ®Google Scholar
• MeijPVervoortMBBloemenaEAntibody responses to Epstein-Barr virus-encoded latent membrane protein-1 (LMP1) and expression of LMP1 in juvenile Hodgkin’s diseaseJ Med Virol200268337037712226824
   PubMed Web of Science ®Google Scholar
• LennetteETWinbergGYadavMEnbladGKleinGAntibodies to LMP2A/2B in EBV-carrying malignanciesEur J Cancer199531A11187518788541116
   PubMed Web of Science ®Google Scholar
• TannerJEWeiMXAlfieriCAntibody and antibody-dependent cellular cytotoxicity responses against the BamHI A rightward open-reading frame-1 protein of Epstein-Barr virus (EBV) in EBV-associated disordersJ Infect Dis1997175138468985194
   PubMed Web of Science ®Google Scholar
• HoebeEKHutajuluSHvan BeekJPurified hexameric Epstein-Barr virus-encoded BARF1 protein for measuring anti-BARF1 antibody responses in nasopharyngeal carcinoma patientsClin Vaccine Immunol201118229830421123521
   PubMedGoogle Scholar
• CroftNPShannon-LoweCBellAIStage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cyclePLoS Pathog200956e100049019557156
   PubMed Web of Science ®Google Scholar
• RoweMGlaunsingerBvan LeeuwenDHost shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasionProc Natl Acad Sci U S A200710493366337117360652
   PubMed Web of Science ®Google Scholar
• ZuoJQuinnLLTamblynJThe Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic pathwaysJ Virol20118541604161421123379
   PubMed Web of Science ®Google Scholar
• VicariAPTrinchieriGInterleukin-10 in viral diseases and cancer: exiting the labyrinth?Immunol Rev200420222323615546396
   PubMed Web of Science ®Google Scholar
• LiJZengXHMoHYFunctional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapyPLoS One2007211e112217987110
   PubMed Web of Science ®Google Scholar
• OudejansJJHarijadiHKummerJAHigh numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intentJ Pathol2002198446847512434416
   PubMed Web of Science ®Google Scholar
• OudejansJJHarijadiACillessenSAAbsence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcomeMod Pathol200518787788515803189
   PubMed Web of Science ®Google Scholar
• OginoTMoriaiSIshidaYAssociation of immunoescape mechanisms with Epstein-Barr virus infection in nasopharyngeal carcinomaInt J Cancer2007120112401241017315195
   PubMed Web of Science ®Google Scholar
• BaylinSBHermanJGGraffJRVertinoPMIssaJPAlterations in DNA methylation: a fundamental aspect of neoplasiaAdv Cancer Res1998721411969338076
   PubMed Web of Science ®Google Scholar
• TakacsMBanatiFKoroknaiAEpigenetic regulation of latent Epstein-Barr virus promotersBiochim Biophys Acta201017993–422823519853674
   PubMed Web of Science ®Google Scholar
• TaoQChanATNasopharyngeal carcinoma: molecular pathogenesis and therapeutic developmentsExpert Rev Mol Med200791212417477889
   PubMedGoogle Scholar
• WoisetschlaegerMYandavaCNFurmanskiLAStromingerJLSpeckSHPromoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytesProc Natl Acad Sci U S A1990875172517292155423
   PubMed Web of Science ®Google Scholar
• RufIKMoghaddamAWangFSampleJMechanisms that regulate Epstein-Barr virus EBNA-1 gene transcription during restricted latency are conserved among lymphocryptoviruses of Old World primatesJ Virol1999733198019899971778
   PubMed Web of Science ®Google Scholar
• TaoQRobertsonKDStealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detectionClin Immunol20031091536314585276
   PubMed Web of Science ®Google Scholar
• SpruckCHTsaiYCHuangDPAbsence of p53 gene mutations in primary nasopharyngeal carcinomasCancer Res19925217478747901511442
   PubMed Web of Science ®Google Scholar
• SunYHegamyerGColburnNHNasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterationsOncogene1993837917958437863
   PubMed Web of Science ®Google Scholar
• FriesKLMillerWERaab-TraubNEpstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 geneJ Virol19967012865386598970991
   PubMed Web of Science ®Google Scholar
• LoKWHuangDPLauKMp16 gene alterations in nasopharyngeal carcinomaCancer Res19955510203920437743498
   PubMed Web of Science ®Google Scholar
• LoKWHuangDPGenetic and epigenetic changes in nasopharyngeal carcinomaSemin Cancer Biol200212645146212450731
   PubMed Web of Science ®Google Scholar
• LiLLShuXSWangZHCaoYTaoQEpigenetic disruption of cell signaling in nasopharyngeal carcinomaChin J Cancer201130423123921439244
   PubMedGoogle Scholar
• NillerHHWolfHMinarovitsJEpigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasiaSemin Cancer Biol200919315816419429479
   PubMed Web of Science ®Google Scholar
• KwongJLoKWToKFTeoPMJohnsonPJHuangDPPromoter hypermethylation of multiple genes in nasopharyngeal carcinomaClin Cancer Res20028113113711801549
   PubMed Web of Science ®Google Scholar
• ZhouLJiangWRenCFrequent hypermethylation of RASSF1A and TSLC1, and high viral load of Epstein-Barr Virus DNA in nasopharyngeal carcinoma and matched tumor-adjacent tissuesNeoplasia20057980981516229803
   PubMed Web of Science ®Google Scholar
• HutajuluSHIndrasariSRIndrawatiLPEpigenetic markers for early detection of nasopharyngeal carcinoma in a high risk populationMol Cancer2011104821535891
   PubMed Web of Science ®Google Scholar
• LiHPLeuYWChangYSEpigenetic changes in virus-associated human cancersCell Res200515426227115857581
   PubMed Web of Science ®Google Scholar
• TsaiCLLiHPLuYJActivation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signalingCancer Res20066624116681167617178861
   PubMed Web of Science ®Google Scholar
• SeoSYKimEOJangKLEpstein-Barr virus latent membrane protein 1 suppresses the growth-inhibitory effect of retinoic acid by inhibiting retinoic acid receptor-beta2 expression via DNA methylationCancer Lett20082701667618539384
   PubMed Web of Science ®Google Scholar
• LeeHSeoSYTiwariIJangKLEpstein-Barr Virus latent membrane protein 1 overcomes all-trans retinoic acid-induced apoptosis by inhibiting retinoic acid receptor-β2 expressionBiochem Biophys Res Commun2012423231331822659417
   PubMed Web of Science ®Google Scholar
• MohammadHPBaylinSBLinking cell signaling and the epigenetic machineryNat Biotechnol201028101033103820944593
   PubMed Web of Science ®Google Scholar
• SongLBLiJLiaoWTThe polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cellsJ Clin Invest2009119123626363619884659
   PubMed Web of Science ®Google Scholar
• RotteySMadaniIDeronPVan BelleSModern treatment for nasopharyngeal carcinoma: current status and prospectsCurr Opin Oncol201123325425821330921
   PubMed Web of Science ®Google Scholar
• Al-SarrafMLeBlancMGiriPGChemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099J Clin Oncol1998164131013179552031
   PubMed Web of Science ®Google Scholar
• WeeJTanEHTaiBCRandomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic varietyJ Clin Oncol200523276730673816170180
   PubMed Web of Science ®Google Scholar
• LeeAWLinJCNgWTCurrent management of nasopharyngeal cancerSemin Radiat Oncol201222323324422687948
   PubMed Web of Science ®Google Scholar
• LeeAWSzeWMAuJSTreatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experienceInt J Radiat Oncol Biol Phys20056141107111615752890
   PubMed Web of Science ®Google Scholar
• BakstRLLeeNPfisterDGHypofractionated dose-painting intensity modulated radiation therapy with chemotherapy for nasopharyngeal carcinoma: a prospective trialInt J Radiat Oncol Biol Phys201180114815320605352
   PubMed Web of Science ®Google Scholar
• ThamIWHeeSWYeoRMTreatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy-the national cancer centre singapore experienceInt J Radiat Oncol Biol Phys20097551481148619386431
   PubMed Web of Science ®Google Scholar
• SprattDELeeNCurrent and emerging treatment options for nasopharyngeal carcinomaOnco Targets Ther2012529730823118544
   PubMed Web of Science ®Google Scholar
• LeungTWTungSYSzeWKSzeWMWongVYOSKSalvage brachytherapy for patients with locally persistent nasopharyngeal carcinomaInt J Radiat Oncol Biol Phys200047240541210802367
   PubMed Web of Science ®Google Scholar
• WildemanMANystHJKarakullukcuBTanBIPhotodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancerHead Neck Oncol200914020017928
   PubMedGoogle Scholar
• LeungTWWongVYTungSYStereotactic radiotherapy for locally recurrent nasopharyngeal carcinomaInt J Radiat Oncol Biol Phys200975373474119327912
   PubMedGoogle Scholar
• WeiWIChanJYNgRWHoWKSurgical salvage of persistent or recurrent nasopharyngeal carcinoma with maxillary swing approach – Critical appraisal after 2 decadesHead Neck201133796997520967865
   PubMed Web of Science ®Google Scholar
• ZhangLZhuYXWangYHuangCPWuYJiQHSalvage surgery for neck residue or recurrence of nasopharyngeal carcinoma: a 10-year experienceAnn Surg Oncol201118123323820737217
   PubMed Web of Science ®Google Scholar
• ZhangLChenQYLiuHTangLQMaiHQEmerging treatment options for nasopharyngeal carcinomaDrug Des Devel Ther201373752
   PubMed Web of Science ®Google Scholar
• XuTTangJGuMLiuLWeiWYangHRecurrent nasopharyngeal carcinoma: a clinical dilemma and challengeCurr Oncol2013205e406e41924155638
   PubMed Web of Science ®Google Scholar
• AliHal-SarrafMChemotherapy in advanced nasopharyngeal cancerOncology (Williston Park)200014812231230 discussion 1232–1227, 1239–124210989829
   PubMed Web of Science ®Google Scholar
• ChenMYJiangRGuoLLocoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosisChin J Cancer2013321160461324206918
   PubMedGoogle Scholar
• BensoudaYKaikaniWAhbeddouNTreatment for metastatic nasopharyngeal carcinomaEur Ann Otorhinolaryngol Head Neck Dis20111282798521177151
   PubMed Web of Science ®Google Scholar
• LeongSSWeeJTayMHPaclitaxel, carboplatin, and gemcitabine in metastatic nasopharyngeal carcinoma: a Phase II trial using a triplet combinationCancer2005103356957515611975
   PubMed Web of Science ®Google Scholar
• ChuaDTWeiWIWongMPShamJSNichollsJAuGKPhase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinomaHead Neck200830786386718213730
   PubMed Web of Science ®Google Scholar
• MaBHuiEPKingAA phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacyCancer Chemother Pharmacol2008621596417762933
   PubMed Web of Science ®Google Scholar
• LeeNYZhangQPfisterDGAddition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trialLancet Oncol201213217218022178121
   PubMed Web of Science ®Google Scholar
• MaBBLuiVWHuiEPThe activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell linesInvest New Drugs201028441342019471857
   PubMed Web of Science ®Google Scholar
• HongBLuiVWHashiguchiMHuiEPChanATTargeting tumor hypoxia in nasopharyngeal carcinomaHead Neck201335113314522106024
   PubMed Web of Science ®Google Scholar
• ChuaDTNichollsJMShamJSAuGKPrognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapyInt J Radiat Oncol Biol Phys2004591112015093894
   PubMed Web of Science ®Google Scholar
• ChanATHsuMMGohBCMulticenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinomaJ Clin Oncol200523153568357615809453
   PubMed Web of Science ®Google Scholar
• ChanSLMaBBNovel systemic therapeutic for nasopharyngeal carcinomaExpert Opin Ther Targets201216Suppl 1S63S6822313344
   PubMedGoogle Scholar
• Guang-WuHSunagawaMJie-EnLThe relationship between microvessel density, the expression of vascular endothelial growth factor (VEGF), and the extension of nasopharyngeal carcinomaLaryngoscope2000110122066206911129022
   PubMed Web of Science ®Google Scholar
• HuiEPMaBBKingADHemorrhagic complications in a phase II study of sunitinib in patients of nasopharyngeal carcinoma who has previously received high-dose radiationAnn Oncol20112261280128721317222
   PubMed Web of Science ®Google Scholar
• ElserCSiuLLWinquistEPhase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinomaJ Clin Oncol200725243766377317704426
   PubMed Web of Science ®Google Scholar
• ShahKMYoungLSEpstein-Barr virus and carcinogenesis: beyond Burkitt’s lymphomaClin Microbiol Infect2009151198298819874382
   PubMed Web of Science ®Google Scholar
• CaponigroFLongoFIonnaFPerriFTreatment approaches to nasopharyngeal carcinoma: a reviewAnticancer Drugs201021547147720124988
   PubMed Web of Science ®Google Scholar
• TsangJLeeVHKwongDLNovel therapy for nasopharyngeal carcinoma – Where are weOral Oncol Epub1222014
   Google Scholar
• KhannaRBussonPBurrowsSRMolecular characterization of antigen-processing function in nasopharyngeal carcinoma (NPC): evidence for efficient presentation of Epstein-Barr virus cytotoxic T-cell epitopes by NPC cellsCancer Res19985823103149443410
   PubMed Web of Science ®Google Scholar
• KhannaRMossDGandhiMTechnology insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignanciesNat Clin Pract Oncol20052313814916264907
   PubMedGoogle Scholar
• YaoYMinterHAChenXReynoldsGMBromleyMArrandJRHeterogeneity of HLA and EBER expression in Epstein-Barr virus-associated nasopharyngeal carcinomaInt J Cancer200088694995511093820
   PubMed Web of Science ®Google Scholar
• ZhenYLiuZYangHTumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinomaCell Death Dis20134e87224157866
   PubMed Web of Science ®Google Scholar
• KontosCKFendriAKhabirAMokdad-GargouriRScorilasAQuantitative expression analysis and prognostic significance of the BCL2-associated X gene in nasopharyngeal carcinoma: a retrospective cohort studyBMC Cancer20131329323777485
   PubMed Web of Science ®Google Scholar
• De PaoliPNovel virally targeted therapies of EBV-associated tumorsCurr Cancer Drug Targets20088759159618991568
   PubMed Web of Science ®Google Scholar
• ChuaDHuangJZhengBAdoptive transfer of autologous Epstein-Barr virus-specific cytotoxic T cells for nasopharyngeal carcinomaInt J Cancer2001941738011668481
   PubMed Web of Science ®Google Scholar
• ComoliPPedrazzoliPMaccarioRCell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytesJ Clin Oncol200523358942894916204009
   PubMed Web of Science ®Google Scholar
• StraathofKCBollardCMPopatUTreatment of nasopharyngeal carcinoma with Epstein-Barr virus – specific T lymphocytesBlood200510551898190415542583
   PubMed Web of Science ®Google Scholar
• SecondinoSZeccaMLicitraLT-cell therapy for EBV-associated nasopharyngeal carcinoma: preparative lymphodepleting chemotherapy does not improve clinical resultsAnn Oncol201223243544121586688
   PubMed Web of Science ®Google Scholar
• MerloATurriniRDolcettiRZanovelloPRosatoAImmunotherapy for EBV-associated malignanciesInt J Hematol201193328129321336546
   PubMed Web of Science ®Google Scholar
• SmithCTsangJBeagleyLEffective treatment of metastatic forms of Epstein-Barr virus-associated nasopharyngeal carcinoma with a novel adenovirus-based adoptive immunotherapyCancer Res20127251116112522282657
   PubMed Web of Science ®Google Scholar
• LutzkyVPCrooksPMorrisonLCytotoxic T cell adoptive immunotherapy as a treatment for nasopharyngeal carcinomaClin Vaccine Immunol201421225625924351754
   PubMed Web of Science ®Google Scholar
• ChiaWKTeoMWangWWAdoptive T-cell transfer and chemotherapy in the first-line treatment of metastatic and/or locally recurrent nasopharyngeal carcinomaMol Ther201422113213924297049
   PubMed Web of Science ®Google Scholar
• LinCLLoWFLeeTHImmunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinomaCancer Res200262236952695812460912
   PubMed Web of Science ®Google Scholar
• ChiaWKWangWWTeoMA phase II study evaluating the safety and efficacy of an adenovirus-ΔLMP1-LMP2 transduced dendritic cell vaccine in patients with advanced metastatic nasopharyngeal carcinomaAnn Oncol2012234997100521821548
   PubMed Web of Science ®Google Scholar
• LiFSongDLuYZhuHChenZHeXDelayed-type hypersensitivity (DTH) immune response related with EBV-DNA in nasopharyngeal carcinoma treated with autologous dendritic cell vaccination after radiotherapyJ Immunother201336320821423502768
   PubMed Web of Science ®Google Scholar
• DuraiswamyJSherrittMThomsonSTherapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinomaBlood200310183150315612468425
   PubMed Web of Science ®Google Scholar
• LutzkyVPCorbanMHeslopLNovel approach to the formulation of an Epstein-Barr virus antigen-based nasopharyngeal carcinoma vaccineJ Virol201084140741719846527
   PubMed Web of Science ®Google Scholar
• TaylorGSHaighTAGudgeonNHDual stimulation of Epstein-Barr Virus (EBV)-specific CD4+- and CD8+-T-cell responses by a chimeric antigen construct: potential therapeutic vaccine for EBV-positive nasopharyngeal carcinomaJ Virol200478276877814694109
   PubMed Web of Science ®Google Scholar
• HuiEPTaylorGSJiaHPhase I trial of recombinant modified vaccinia ankara encoding Epstein-Barr viral tumor antigens in nasopharyngeal carcinoma patientsCancer Res20137361676168823348421
   PubMed Web of Science ®Google Scholar
• ParamitaDKFatmawatiCJuwanaHHumoral immune responses to Epstein-Barr virus encoded tumor associated proteins and their putative extracellular domains in nasopharyngeal carcinoma patients and regional controlsJ Med Virol201183466567821328382
   PubMed Web of Science ®Google Scholar
• MiddeldorpJMLegion [webpage on Internet]. Epstein Barr Virus (EBV) tumor-associated latent membrane extracellular domain peptides Available from: https://www.Legionpatent.com/patents/7811581/Accessed July 30, 2014
   Google Scholar
• ChenRZhangDMaoYA human Fab-based immunoconjugate specific for the LMP1 extracellular domain inhibits nasopharyngeal carcinoma growth in vitro and in vivoMol Cancer Ther201211359460322169768
   PubMed Web of Science ®Google Scholar
• DelbendeCVerwaerdeCMougelATranchand BunelDInduction of therapeutic antibodies by vaccination against external loops of tumor-associated viral latent membrane proteinJ Virol20098322117341174519726497
   PubMed Web of Science ®Google Scholar
• SuzukiHGabrielsonEChenWA genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancerNat Genet200231214114911992124
   PubMed Web of Science ®Google Scholar
• DokmanovicMClarkeCMarksPAHistone deacetylase inhibitors: overview and perspectivesMol Cancer Res200751098198917951399
   PubMed Web of Science ®Google Scholar
• ChengJCYooCBWeisenbergerDJPreferential response of cancer cells to zebularineCancer Cell20046215115815324698
   PubMed Web of Science ®Google Scholar
• AbeleRClavelMDodionPThe EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomasEur J Cancer Clin Oncol19872312192119242449354
   PubMedGoogle Scholar
• van GroeningenCJLeyvaAO’BrienAMGallHEPinedoHMPhase I and pharmacokinetic study of 5-aza-2′-deoxycytidine (NSC 127716) in cancer patientsCancer Res1986469483148362425959
   PubMed Web of Science ®Google Scholar
• ChanATTaoQRobertsonKDAzacitidine induces demethylation of the Epstein-Barr virus genome in tumorsJ Clin Oncol20042281373138115007085
   PubMed Web of Science ®Google Scholar
• LeeSPChanATCheungSTCTL control of EBV in nasopharyngeal carcinoma (NPC): EBV-specific CTL responses in the blood and tumors of NPC patients and the antigen-processing function of the tumor cellsJ Immunol2000165157358210861098
   PubMed Web of Science ®Google Scholar
• FengWHIsraelBRaab-TraubNBussonPKenneySCChemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumorsCancer Res20026261920192611912175
   PubMed Web of Science ®Google Scholar
• FengWHHongGDelecluseHJKenneySCLytic induction therapy for Epstein-Barr virus-positive B-cell lymphomasJ Virol20047841893190214747554
   PubMed Web of Science ®Google Scholar
• FengWHKenneySCValproic acid enhances the efficacy of chemotherapy in EBV-positive tumors by increasing lytic viral gene expressionCancer Res200666178762876916951192
   PubMed Web of Science ®Google Scholar
• HuiKFHoDNTsangCMMiddeldorpJMTsaoGSChiangAKActivation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinomaInt J Cancer201213181930194022261816
   PubMed Web of Science ®Google Scholar
• Ben-SassonSAKleinGActivation of the Epstein-Barr virus genome by 5-aza-cytidine in latently infected human lymphoid linesInt J Cancer19812821311356172387
   PubMed Web of Science ®Google Scholar
• DattaAKColbyBMShawJEPaganoJSAcyclovir inhibition of Epstein-Barr virus replicationProc Natl Acad Sci U S A1980779516351666254061
   PubMed Web of Science ®Google Scholar
• MeerbachAHolýAWutzlerPDe ClercqENeytsJInhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replicationAntivir Chem Chemother1998932752829875407
   PubMed Web of Science ®Google Scholar
• MooreSMCannonJSTanhehcoYCHamzehFMAmbinderRFInduction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analoguesAntimicrob Agents Chemother20014572082209111408227
   PubMed Web of Science ®Google Scholar
• KenneySTheodoreEWoodward Award: development of novel, EBV-targeted therapies for EBV-positive tumorsTrans Am Clin Climatol Assoc20061175573 discussion 73–7418528464
   PubMedGoogle Scholar
• MentzerSJFingerothJReillyJJPerrineSPFallerDVArginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr-virus-associated lymphomaBlood Cells Mol Dis19982421141239628848
   PubMedGoogle Scholar
• JonesKNourseJCorbettGGandhiMKSodium valproate in combination with ganciclovir induces lysis of EBV-infected lymphoma cells without impairing EBV-specific T-cell immunityInt J Lab Hematol2010321 Pt 1e169e17419196381
   PubMed Web of Science ®Google Scholar
• WildemanMANovalicZVerkuijlenSACytolytic virus activation therapy for Epstein-Barr virus-driven tumorsClin Cancer Res201218185061507022761471
   PubMed Web of Science ®Google Scholar