References
- GatterllariMWorthingtonJZwarNBarriers to the use of anticoagulation for nonvalvular atrial fibrillation: a representative survey of Australian family physiciansStroke20083922723018048861
- Pradaxa (dabigatran etexilate mesylate) capsules [prescribing information]Ridgefield, CTBoehringer Ingelheim Pharmaceuticals, Inc2015
- Eliquis (apixaban) tablets [prescribing information]Princeton NJBristol-Myers Squibb Company2015
- Savaysa (edoxaban) tablets [prescribing information]Parsippany, NJDaiichi Sankyo, Inc2015
- Xarelto (rivaroxaban) tablets [prescribing information]Titusville, NJJanssen Pharmaceuticals, Inc2015
- ZafarMUVorchheimerDAGaztanagaJAntithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamberThromb Haemost200798488388817938815
- FurugohriTIsobeKHondaYDU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profilesJ Thromb Haemost2008691542154918624979
- OgataKMendell-HararyJTachibanaMClinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteersJ Clin Pharmacol201050774375320081065
- YinOQTetsuyaKMillerREdoxaban population pharmacokinetics and exposure-response analysis in patients with non-valvular atrial fibrillationEur J Clin Pharmacol201470111339135125168620
- MatsushimaNLeeFSatoTWeissDMendellJBioavailability and safety of the factor Xa inhibitor edoxaban and the effects of quinidine in healthy subjectsClin Pharm Drug Dev20132358366
- MendellJTachibanaMShiMKunitadaSEffects of food on the pharmacokinetics of edoxaban, an oral direct factor Xa inhibitor, in healthy volunteersJ Clin Pharmacol201151568769420534818
- BathalaMSMasumotoHOgumaTHeLLowrieCMendellJPharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humansDrug Metab Dispos201240122250225522936313
- MendellJLeeFChenSWorlandVShiMSamamaMMThe effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitorJ Cardiovasc Pharmacol201362221222123615159
- MendellJZahirHMatsushimaNDrug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitorAm J Cardiovasc Drugs201313533134223784266
- MendellJNoveckRJShiMPharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combinationJ Cardiovasc Pharmacol201260433534123064240
- MendellJBasavapathruniRSwearingenDDravesAZhangGMorganrothJA thorough electrocardiogram study of edoxaban, a novel factor Xa inhibitorJ Clin Pharmacol20115181241124621209229
- SalazarDEMendellJKastrissiosHModelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillationThromb Haemost2012107592593622398655
- FDA Draft Briefing Document for the Cardiovascular and Renal Drugs Advisory CommitteeENGAGE AF-TIMI 482014 Available from: http://www.fda.gov/downloads/AdvisoryCommittees/Committees-MeetingMaterials/Drugs/CardiovascularandRenalDrugsAdvisoryCommittee/UCM420704.pdfAccessed March 7, 2016
- YamashitaTKoretsuneYYasakaMRandomized, multicenter, warfarin controlled phase II study of edoxaban in Japanese patients with non-valvular atrial fibrillationCirc J20127681840184722664798
- WhiteRHThe epidemiology of venous thromboembolismCirculation2003107Suppl 1I-4I-812814979
- KearonCAklEAComerotaAJAntithrombotic therapy for VTE disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelinesChest2012141Supple419Se494S22315268
- DouketisJDFosterGACrowtherMAPrinsMHGinsbergJSClinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapyArch Intern Med20001603431343611112236
- LinkinsLAChoiPTDouketisJDClinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysisAnn Intern Med200313989390014644891
- Hokusai-VTE InvestigatorsBüllerHRDécoususHEdoxaban versus warfarin for the treatment of symptomatic venous thromboembolismN Engl J Med20133691406141523991658
- SchulmanSKearonCKakkarAKDabigatran versus warfarin in the treatment of acute venous thromboembolismN Engl J Med20093612342235219966341
- EINSTEIN InvestigatorsBauersachsRBerkowitzSDOral rivaroxaban for symptomatic venous thromboembolismN Engl J Med20103632499251021128814
- EINSTEIN-PE InvestigatorsBüllerHRPrinsMHOral rivaroxaban for the treatment of symptomatic pulmonary embolismN Engl J Med20123661287129722449293
- AgnelliGBüllerHRCohenAOral apixaban for the treatment of acute venous thromboembolismN Engl J Med201336979980823808982
- Van der HulleTKooimanJden ExterPLDekkersOMKlokFAHuismanMVEffectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysisJ Thromb Haemost20141232032824330006
- ColillaSCrowAPetkunWSingerDESimonTLiuXEstimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult populationAm J Cardiol20131121142114723831166
- Birman-DeychERadfordMJNilasenaDSGageBFUse and effectiveness of warfarin in Medicare beneficiaries with atrial fibrillationStoke20063710701074
- JanuaryCTWannLSAlpertJS2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm SocietyCirculation20141302071210424682348
- GageBFWatermanADShannonWBoechlerMRichMWRadfordMJValidation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial FibrillationJAMA20012852864287011401607
- GiuglianoRRuffCTBraunwaldEEdoxaban versus warfarin in patients with atrial fibrillationN Engl J Med20133692093210424251359
- ConnollySJEzekowitzMDYusufSDabigatran versus warfarin in patients with atrial fibrillationN Engl J Med2009361121139115119717844
- PatelMRMahaffeyKWGargJRivaroxaban versus warfarin in nonvalvular atrial fibrillationN Engl J Med20113651088389121830957
- GrangerCBAlexanderJHMcmurrayJJApixaban versus warfarin in patients with atrial fibrillationN Engl J Med20113651198199221870978
- RuffCTGiuglianoRPBraunwaldEComparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trialsLancet201438395596224315724
- US Food and Drug AdministrationFDA Drug Safety Communication: FDA study of Medicare patients finds risks lower for stroke and death but higher for gastrointestinal bleeding with Pradaxa (dabigatran) compared to warfarin2014 Available from: www.fda.gov/Drugs/DrugSafety/ucm396470.htmAccessed November 19, 2015
- GoldAMCrowtherMLevyGANNEXA-R: a phase 3 randomized, double-blind, placebo-controlled trial, demonstrating reversal of rivaroxaban-induced anticoagulation in older subjects by andexanet alfa (PRT064445), a universal antidote for factor Xa (FXA) inhibitorsJ Am Coll Cardiol20156510S
- SiegalDMCurnutteJTConnollySJAndexanet alfa for the reversal of factor Xa inhibitor activityN Engl J Med2015373252413242426559317
- AnsellJEBakhruSHLaulichtBEUse of PER977 to reverse the anticoagulant effect of edoxabanN Engl J Med2014371222141214225371966
- ParasrampuriaDAMarburyTMatsushimaNPharmacokinetics, safety, and tolerability of edoxaban in end-stage renal disease subjects undergoing haemodialysisThromb Haemost2015113471972725566930
- ZahirHBrownKSVandellAGEdoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrateCirculation2015131829025403645