Current research and clinical trials for a vaccine against Chikungunya virus

References

• Simon F, Savini H, Parola P. Chikungunya: a paradigm of emergence and globalisation of vector borne diseases. Med Clin North Am. 2008;92:1323–1343.
   PubMed Web of Science ®Google Scholar
• Sudeep AB, Parashar D. Chikungunya: an overview. JBiosci. 2008;33:443–449.
   Google Scholar
• Chevillon C, Braint L, Renaud F, Devaux C. The Chikungunya threat: an ecological and evolutionary perspective. Trends Microbiol. 2008;16:80–88.
   PubMed Web of Science ®Google Scholar
• Bodenmann P, Genton B. Chikungunya: an epidemic in real time. Lancet. 2006;368:258.
   Web of Science ®Google Scholar
• Benjamin M. Chikungunya is not a Swahii word; it is from the Makonde language! Available from: http://kamusiproject.org/en/node/144. Accessed March 6, 2013.
   Google Scholar
• Muyembe TJ, Peyrefitte CN, Yogolelo R, et al. Epidemic of Chikungunya virus in 1999 and 2000 in the Democratic Republic of the Congo. Med Trop. 2003;63:637–638.
   Google Scholar
• Ng LFP, Ojcius DM. Chikungunya fever - re-emergence of an old disease. Microbes Infect. 2009;11:1163–1164.
   Web of Science ®Google Scholar
• National Vector Borne Disease Control Programme. Directorate General of Health Services, Ministry of Health and family welfare, India. Chikungunya fever. Available from: http://www.nvbdcp.gov.in. Accessed March 6, 2013.
   Google Scholar
• Patrick B, Blaise G. Chikungunya: an epidemic in real time. Lancet Infect Dis. 2006;368:258.
   Google Scholar
• Rezza G, Nicoletti L, Angelini R, et al. Infection with chikungunya virus in Italy: an outbreak in a temperate region. Lancet. 2007;370:1840–1846.
   PubMed Web of Science ®Google Scholar
• Grandadam M, Caro V, Plumet S, et al. Chikungunya virus, Southeastern France. Emerg Infect Dis. 2011;17:910–913.
   PubMed Web of Science ®Google Scholar
• Mari BR, Peydro JR. Current status and eco-epidemiology of mosquito- borne arboviruses in Spain. RevEsp Salud Publica. 2010;84:255–269. Spanish.
   Google Scholar
• Labadie K, Larcher T, Joubert C, et al. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest. 2010;120:894–906.
   PubMed Web of Science ®Google Scholar
• Krishnamoorthy K, Harichandrakumar KT, Kumari AK, Das LK. Burden of Chikungunya in India: estimates of disability adjusted life years (DALY) lost in 2006 epidemic. J Vector Borne Dis. 2009;46:26–35.
   PubMed Web of Science ®Google Scholar
• Karabatsos N. Antigenic relationship of group Arboviruses by plaque reduction neutralization testing. Am J Trop Med Hyg. 1975;24:527.
   Web of Science ®Google Scholar
• Higashi N, Matsumoto A, Tabata K, Nagatomo Y. Electron microscope study of development of Chikungunya virus in green monkey kidney stable (VERO) cells. Virology. 1967;33:55–69.
   Web of Science ®Google Scholar
• Powers AM, Brault AC, Shirako Y, et al. Evolutionary relationships and systematics of the alphaviruses. J Virol. 2001;75:10118–10131.
   PubMed Web of Science ®Google Scholar
• Simizu B, Yamamoto K, Hashimoto K, Ogata T. Structural proteins of chikungunya virus. J Virol. 1984;51:254–258.
   PubMed Web of Science ®Google Scholar
• Strauss JH, Strauss EG. The alphaviruses: gene expression, replication, and evolution. Microbiol Rev. 1994;58:491–562.
   PubMedGoogle Scholar
• Khan AH, Morita K, Parquet MC, Hasebe F, Mathenge EG, Igarashi A. Complete nucleotide sequence of Chikungunya virus and evidence for an internal polyadenylation site. J Gen Virol. 2002;83:3075–3084.
   PubMed Web of Science ®Google Scholar
• Porterfield JH. Antigenic characteristic and classification of Togaviridae. In: Schlesinger RW, editor. The Togaviruses. New York, NY: Academic Press; 1980.
   Google Scholar
• Van Regenmortel MHV, Fauquet CM, Bishop DHL, et al. Virus Taxonomy: Seventh Report of the International Committee on Taxonomy of Viruses. San Diego, CA: Academic Press; 2000.
   Google Scholar
• Weaver SC, Frey TK, Huang HV et al. Togaviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA, editors. Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses. Amsterdam, The Netherlands: Elsevier Academic Press; 2005.
   Google Scholar
• Jeandal P, Josse R, Durand JP. Exotic viral arthritis: role of alphavirus. Med Trop. 2004;64:81–88.
   Google Scholar
• Zeller HG. Dengue, arbovirus and migration in the Indian Ocean. Bull Soc Pathol Exot. 1998;91:56–60. French.
   PubMed Web of Science ®Google Scholar
• Lam SK, Chua KB, Hooi PS, et al. Chikungunya infection - an emerging disease in Malaysia. South East Asian J Trop Med Public Health. 2001;32:447–451.
   PubMedGoogle Scholar
• Jupp PG, McIntosh BM. Aedes furcifer and other mosquitoes as vectors of chikungunya virus at Mica, northeastern Transvaal, South Africa. JAm Mosq Control Assoc. 1990;6:415–420.
   PubMed Web of Science ®Google Scholar
• Lahariya C, Pradhan SK. Emergence of chikungunya virus in Indian Subcontinent after 32 years: a review. J Vect Borne Dis. 2006;43:151–160.
   PubMedGoogle Scholar
• Mohan A, Kiran DHN, Manohar IC, Kumar DP. Epidemiology, clinical manifestation and diagnosis of chikungunya fever: lesson learned from the reemerging epidemic. Indian J Dermatol. 2010;55:54–64.
   PubMedGoogle Scholar
• Singh P, Mittal V, Rizvi MMA, et al. The first dominant co-circulation of both dengue and Chikungunya viruses during the post-monsoon period of 2010 in Delhi, India. Epidemiol Infect. 2012;140:1337–1342.
   Web of Science ®Google Scholar
• Chahar HS, Bharaj P, Dar L, Broor S. Co-infections with Chikungunya virus and dengue virus in Delhi, India. Emerg Infect Dis. 2009;15:1077–1080.
   Web of Science ®Google Scholar
• Neogi DK, Bhattacharya N, Mukherjee KK, et al. Serosurvey of Chikungunya antibody in Calcutta metropolis. J Commun Dis. 1995;27:19–22.
   Google Scholar
• Thonnon J, Spiegel A, Diallo M, Diallo A, Fontenille D. Chikungunya virus outbreak in Senegal in 1996 and 1997. Bull Soc Pathol Exot. 1999;92:79–82. French.
   Google Scholar
• Yergolkar PN, Tandale BV, Arankalle VA, et al. Chikungunya outbreaks caused by African genotype, India. EmergInfect Dis. 2006;12:1580–1583.
   PubMed Web of Science ®Google Scholar
• Licia B, Silvia M, Marina S, et al. The re-emergence of an old disease: Chikungunya fever. In: Rodriguez-Morales, editor. Current Topics in Tropical Medicine. New York, NY: InTech; 2012.
   Google Scholar
• Knudsen AB. Global distribution and continuing spread of Aedes albopictus. Parassitologia. 1995;37:91–97.
   PubMedGoogle Scholar
• Diallo M, Thonnon J, Traore LM, Fontenille D. Vectors of Chikungunya virus in Senegal: current data and transmission cycles. Am J Trop Med Hyg. 1999;60:281–286.
   PubMed Web of Science ®Google Scholar
• McCrae AWR, Henderson BG, Kirya BG, Sempala SDK. Chikungunya virus in the Entebbe areas Uganda: isolations and epidemiology. Trans R Soc Trop Med Hyg. 1971;65:152–168.
   PubMed Web of Science ®Google Scholar
• Guilherme JM, Christine Gonella-Legall, Legalla F, Nakoume E, Vincent J. Seroprevalence of five arboviruses in zebu cattle in the central African Republic. Trans R Soc Trop MedHyg. 1996;90:31–33.
   PubMed Web of Science ®Google Scholar
• Padbidri VS, Gnaneswar TT. Epidemiological investigations of chikungunya epidemic at Barsi, Maharashtra state, India. J Hyg Epidemiol Microbiol Immunol. 1979;23:445–4451.
   PubMedGoogle Scholar
• Robinson MC. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–1953. I Trans R Soc Trop Med Hyg. 1955;49:28–32.
   Google Scholar
• Lumsden WH. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–1953. II. General description and epidemiology. Trans R Soc Trop Med Hyg. 1955;49:33–57.
   PubMedGoogle Scholar
• Cavrini F, Gaibani P, Pierro AM, Rossini G, Landini MP, Sambri V. Chikungunya: an emerging and spreading arthropod borne viral disease. J Infect Dev Ctries. 2009;3:744–752.
   PubMed Web of Science ®Google Scholar
• Rao TR. Recent epidemics caused by chikungunya virus in India 1963–1965. Sci Cult. 1966;32:215–220.
   Google Scholar
• Rao TR, Carey DE, Pavri KM. Preliminary isolation and identification of chikungunya virus from cases of dengue-like illness in Madras city. Indian J Med Res. 1965;53:689–693.
   Web of Science ®Google Scholar
• Shah KV, Gibbs CJ, Jr, Banerjee G. Virological investigation of the epidemic of haemorrhagic fever in Calcutta: isolation of three strains of chikungunya virus. Indian J Med Res. 1964;52:676–693.
   PubMed Web of Science ®Google Scholar
• Thiruvengadam KV, Kalyanasundaram V, Rajgopal J. Clinical and pathological studies on Chikungunya fever in Madras City. Indian J Med Res. 1965;53:729–744.
   Web of Science ®Google Scholar
• Jadhav M, Namboodripad M, Carman RH, Carey DE, Myers RM. Chikungunya disease in infants and children in Vellore: a report of clinical and haematological features of virologically proved cases. Indian J Med Res. 1965;53:764–776.
   PubMed Web of Science ®Google Scholar
• Rodrigues FM, Patankar MR, Banerjee K, et al. Etiology of the 1965 epidemic of febrile illness in Nagpur city, Maharashtra state, India. Bull World Health Organ. 1972;46:173–179.
   PubMed Web of Science ®Google Scholar
• Mourya DT. Absence of transovarial transmission of chikungunya virus in Ae. Aegypti and Ae. albopictus. Indian J Med Res. 1987;85:593–595.
   Web of Science ®Google Scholar
• Chhabra M, Mittal V, Bhattacharya D, Rana UVS, Lal S. Chikungunya fever: a reemerging viral infection. Indian J Med Microbiol. 2008;26:5–12.
   Web of Science ®Google Scholar
• Bessaud M, Peyrefitte CN, Pastorino BAM, et al. Chikungunya virus strains, Reunion Island outbreak. Emerg Infect Dis. 2006;12:1604–1606.
   Web of Science ®Google Scholar
• Schuffenecker I, Iteman I, Michault A, et al. Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Med. 2006;3:e263.
   PubMed Web of Science ®Google Scholar
• Kowalzik S, Xuan NV, Weissbrich B, et al. Characterisation of a chikungunya virus from a German patient returning from Mauritius and development of a serological test. Med Microbiol Immunol. 2008;197:381–386.
   Web of Science ®Google Scholar
• Kariuki Njenga M, Nderitu L, Ledermann JP, et al. Tracking epidemic Chikungunya virus into the Indian Ocean from East Africa. J Gen Virol. 2008;89:2754–2760.
   PubMed Web of Science ®Google Scholar
• Renault P, Solet JL, Sissoko D, et al. A major epidemic of chikungunya virus infection on Reunion Island, France, 2005–2006. Am J Trop Med Hyg. 2007;77:727–731.
   PubMed Web of Science ®Google Scholar
• Laras K, Sukri NC, Larasati RP, et al. Tracking the re-emergence of epidemic chikungunya virus in Indonesia. Trans R Soc Trop Med Hyg. 2005;99:128–141.
   PubMed Web of Science ®Google Scholar
• Yusof MP, Kuen LS, Adnan N, et al. Epidemiology and molecular characterization of chikungunya virus involved in the 2008 to 2009 outbreak in Malaysia. J Gen Mol Virol. 2011;3:35–42.
   Google Scholar
• Theamboonlers A, Rianthavorn P, Praiantathavorn K, Wuttirattanakowit N, Poovorawan Y. Clinical and molecular characterization of chikungunya virus in South Thailand. Jpn J Infect Dis. 2009;62:303–305.
   PubMed Web of Science ®Google Scholar
• Hapuarachchi HC, Bandara KB, Sumanadasa SD, et al. Re-emergence of chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore. J Gen Virol. 2010;91(Pt 4):1067–1076.
   Google Scholar
• Pfeffer M, Loscher T. Cases of chikungunya imported into Europe. Euro Surveill. 2006;11:e060316.2.
   Google Scholar
• Ligon BL. Re-emergence of an unusual disease: the chikungunya epidemic. Semin Pediatr Infect Dis. 2006;17:99–104.
   PubMedGoogle Scholar
• Centre for Disease Control. Chikungunya fever among US Peace Corps volunteers - Republic of the Philippines. MMWR Morb Mortal Wkly Rep. 1986;35:573–574.
   Google Scholar
• Qiaoli Z, Jianfeng H, De W. Maiden outbreak of Chikungunya in Dong- guan City, Guangdong Province, China: epidemiology characteristics. PloS One. 2012;7(8):e42830.
   Web of Science ®Google Scholar
• Sebastian MR, Lodha R, Kabra SK. Chikungunya infection in children. Indian J Pediatr. 2009;76:185–189.
   Web of Science ®Google Scholar
• Deller JJ Jr, Russell PK. An analysis of fevers of unknown origin in American soldiers in Vietnam. Ann Intern Med. 1967;66:1129–1143.
   PubMed Web of Science ®Google Scholar
• McGill PE. Viral infections: alpha-viral arthropathy. Baillieres Clin Rheumatol. 1995;9:145–150.
   PubMedGoogle Scholar
• Adebajo AO. Rheumatic manifestations of tropical diseases. Curr Opin Rheumatol. 1996;8:85–89.
   Google Scholar
• Chhabra M, Mittal V. Chikungunya fever. Tropical and emerging disease infection. In: Magill AJ, Hill DR, Solomon T, Ryan ET, editors. Tropical Medicine and Emerging Infectious Diseases. Philadelphia, PA: Elsevier; 2013.
   Google Scholar
• Deller JJ Jr, Russell PK. Chikungunya disease. Am J Trop Med Hyg. 1968;17:107–111.
   PubMed Web of Science ®Google Scholar
• Fourie ED, Morrison JG. Rheumatoid arthritic syndrome after chikungunya fever. S Afr Med J. 1979;56:130–132.
   PubMed Web of Science ®Google Scholar
• Brighton SW, Prozesky OW, de la Harpe AL. Chikungunya virus infection. A retrospective study of 107 cases. S Afr Med J. 1983;63:313–315.
   PubMed Web of Science ®Google Scholar
• Brighton SW, Simson IW. A destructive arthropathy following Chikungunya virus arthritis - a possible association. Clin Rheumatol. 1984;3:253–258.
   PubMed Web of Science ®Google Scholar
• Brighton SW. Chikungunya virus infections. S Afr Med J. 1981;59:552.
   Web of Science ®Google Scholar
• Pialoux G, Gauzere BA, Jaureguiberry S, Strobel M. Chikungunya an epidemic arbovirosis. Lancet Infect Dis. 2007;7:319–327.
   PubMed Web of Science ®Google Scholar
• Myers RM, Carey DE. Concurrent isolation from patient of two arboviruses, Chikungunya and dengue type 2. Science. 1967;157:1307–1308.
   Web of Science ®Google Scholar
• Vanlandingham DL, Hong C, Klingler K, et al. Differential infectivities of o’nyongnyong and chikungunya virus isolates in Anopheles gam- biae and Aedes aegypti mosquitoes. Am J Trop Med Hyg. 2005;72:616–621.
   PubMed Web of Science ®Google Scholar
• Saxena SK. Re-emergence of the knotty chikungunya virus: facts, fear or fiction. Future Virol. 2007;2:121–126.
   Web of Science ®Google Scholar
• Staples JE, Breiman RF, Powers AM. Chikungunya fever: an epidemiological review of a reemerging infectious disease. Clin Infect Dis. 2009;49:942–948.
   PubMed Web of Science ®Google Scholar
• Panning M, Hess M, Fischer W, Grywna K, Pfeffer M, Drosten C. Performance of the real star Chikungunya virus real-time reverse transcription-PCR kit. J Clin Microbiol. 2009;47:3014–3016.
   Web of Science ®Google Scholar
• Joseph AY, Babu VS, Dev SS, et al. Rapid detection and characterization of chikungunya virus by RT-PCR in febrile patients from Kerala, India. Indian J Exp Biol. 2006;46:573–578.
   Web of Science ®Google Scholar
• Parida MM, Santhosh SR, Dash PK, et al. Rapid and real-time detection of chikungunya virus by reverse transcription loop-mediated isothermal amplification assay. JClin Microbiol. 2007;45:351–357.
   PubMed Web of Science ®Google Scholar
• Ng LF, Chow A, Sun YJ, et al. IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity. PLoS One. 2009;4:e4261.
   PubMed Web of Science ®Google Scholar
• Couderc T, Chrétien F, Schilte C, et al. A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PloSPath. 2008;e29.
   Google Scholar
• Chow A, Her Z, Ong EKS, et al. Persistent arthralgia induced by chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony stimulating factor. J Infect Dis. 2011;203:149–157.
   Web of Science ®Google Scholar
• Powers AM, Brault AC, Tesh RB, Weaver SC. Re-emergence of Chikungunya and O’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. J Gen Virol. 2000;81:471–479.
   PubMed Web of Science ®Google Scholar
• Pastorino B, Muyembe-Tamfum JJ, Bessaud M, Tock H, Durand JP, Pey- refitte CN. Epidemic resurgence of chikungunya virus in Democratic Republic of the Congo: identification of a new central African strain. J Med Virol. 2004;74:277–282.
   PubMed Web of Science ®Google Scholar
• Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S. A single mutation in chikungunya virus affects vector specificity and epidemic potential. PloS Path. 2007;3:e201.
   PubMed Web of Science ®Google Scholar
• Vazeille M, Moutailler S, Coudrier D, et al. Two chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus. Plos One. 2007;2:1–9.
   Web of Science ®Google Scholar
• Singh P Mittal V Rizvi MA, et al. Northward movement of East Central South African Genotype of Chikungunya virus causing an epidemic between 2006–2010 in India. J Infect Dev Ctries. 2012;6:563–571.
   Web of Science ®Google Scholar
• Arankalle VA, Shrivastava S, Cherian S, et al. Genetic divergence of chikungunya viruses in India (1963–2006) with special reference to the 2005-2006 explosive epidemic. J Gen Virol. 2007;88:1967–1976.
   Google Scholar
• Nareshkumar CVM, SaiGopal DVR. Re-emergence of chikungunya virus in Indian subcontinent. Indian J Virol. 2010;21:8–17.
   Google Scholar
• Kumar NP, Joseph R, Kamaraj T, Jambulingam P. A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India. J Gen Virol. 2008;89:1945–1948.
   PubMed Web of Science ®Google Scholar
• Santhosh SR, Dash PK, Parida MM, Khan M, Tiwari M, Rao PVL. Comparative full genome analysis revealed E1:A226V shift in 2007 Indian chikungunya virus isolates. Virus Res. 2008;135:36–41.
   Web of Science ®Google Scholar
• Santhosh SR, Dash PK, Parida MM, Khan M, Rao PVL. Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak. Virol J. 2009;6:e172.
   Web of Science ®Google Scholar
• Das B, Sahu A, Das M, et al. Molecular investigations of chikungunya virus during outbreaks in Orrisa, Eastern India in 2010. Infect Genet Evol. 2012;12:1094–1101.
   Google Scholar
• Sumathy K, Ella KM. Genetic diversity of chikungunya virus, India, 2006-2010, evolutionary dynamics and serotype analysis. J Med Virol. 2012;84:462–470.
   Web of Science ®Google Scholar
• Shrinet J, Jain S, Sharma A, et al. Genetic characterization of chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates. Virol J. 2012;9:e100.
   Web of Science ®Google Scholar
• Rianthavorn P, Prianantathavorn K, Wuttirattanakowit N, Theamboonlers A. Poovorawan An outbreak of chikungunya in Southern Thailand from 2008 to 2009 caused by African strains with A226V mutation. Int J InfectDis. 2010;145:e161–165.
   Google Scholar
• Ho K, Ang LW, Tan BH, et al. Epidemiology and control of chikungunya fever in Singapore. J Infect. 2011;62:263–270.
   Web of Science ®Google Scholar
• Jain M, Rai S, Chakravarti A. Chikungunya: a review. Trop Doc. 2008;38:70–72.
   Web of Science ®Google Scholar
• Brighton SW. Chloroquine phosphate treatment of chronic chikungunya arthritis. S Afr Med J. 1984;66:217–218.
   PubMed Web of Science ®Google Scholar
• De Lamballerie X, Boisson V, Reynier JC, et al. On chikungunya acute infection and chloroquine treatment. Vector Borne Zoonotic Dis. 2008;8:837–839.
   PubMed Web of Science ®Google Scholar
• Khan M, Santhosh SR, Tiwari M, Rao PVL, Parida M. Assessment of invitro prophylactic and therapeutic efficacy of chloroquine against chikungunya virus in Vero cells. J Med Virol. 2010;82:817–824.
   PubMed Web of Science ®Google Scholar
• Ravichandran R, Manian M. Ribavirin therapy for chikungunya arthritis. J Infect Dev Ctries. 2008;2:140–142.
   PubMed Web of Science ®Google Scholar
• Briolant S, Garin D, Scaramozzino N, Jouan A, Crance JM. In vitro inhibition of chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination. Antiviral Res. 2004;61:111–117.
   PubMed Web of Science ®Google Scholar
• Reiter P, Fontenille D, Paupy C. Aedes albopictus as an epidemic vector of chikungunya virus: another emerging problem? Lancet Infect Dis. 2006;6:463–464.
   PubMed Web of Science ®Google Scholar
• Cui F, Raymond M, Qiao CL. Insecticide resistance in vector mosquitoes in China. Pest Manag Sci. 2006;62:1013–1022.
   PubMed Web of Science ®Google Scholar
• Jaffar-Bandjee MC, Ramful D, Gauere BA, et al. Emergence and clinical insights into the pathology of Chikungunya infection. Expert Rev Anti Infect Ther. 2010;8:897–996.
   Web of Science ®Google Scholar
• Ng LC, Hapuarachchi HC. Tracing the path of chikungunya virusevolution and adaption. Infect Genet Evol. 2010;10:876–885.
   PubMed Web of Science ®Google Scholar
• Harrison VR, Eckels KH, Bartelloni PJ, Hampton C. Production and evaluation of a. a formalin-killed Chikungunya vaccine. J Immunol. 1971;107:643–647.
   PubMed Web of Science ®Google Scholar
• Eckels KH, Harrison VR, Hetrick FM. Chikungunya virus vaccine prepared by a. Tween-ether extraction. Appl Microbiol. 1970;19:321–325.
   PubMedGoogle Scholar
• Tiwari M, Parida M, Santhosh SR, Khan M, Dash PK, Rao PV Assessment of immunogenic potential of Vero adapted formalin inactivated vaccine derived from novel ECSA genotype of Chikungunya virus. Vaccine. 2009;27:2513–2522.
   Web of Science ®Google Scholar
• Levitt NH, Ramsburg HH, Hasty SE, Repik PM, Cole FE Jr, Lupton HW. Development of an attenuated strain of chikungunya virus for use in vaccine production. Vaccine. 1986;4:157–162.
   PubMed Web of Science ®Google Scholar
• Turell MJ, Malinoski FJ. Limited potential for mosquito transmission of a live, attenuated chikungunya virus vaccine. Am J Trop Med Hyg. 1992;47:98–103.
   Web of Science ®Google Scholar
• Edelman R, Tacket CO, Wasserman SS, Bodison SA, Perry JG, Mangiafico JA. Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218. Am JTrop MedHyg. 2000;62:681–685.
   PubMed Web of Science ®Google Scholar
• Wang E, Volkova E, Adams AP, et al. Chimeric alphavirus vaccine candidates for chikungunya. Vaccine. 2008;26:5030–5039.
   PubMed Web of Science ®Google Scholar
• Kenney JL, Volk SM, Pandya J, et al. Stability of RNA virus attenuation approaches. Vaccine. 2011;29:2230–2234.
   PubMed Web of Science ®Google Scholar
• Pedersen CE, Robinson DM, Cole FE. Isolation of the vaccine strain of Venezuelan equine encephalomyelitis virus from mosquitoes in Louisiana. Am J Epidemiol. 1972;95:490–496.
   PubMed Web of Science ®Google Scholar
• Wang E, Kim DY, Weaver SC, Frolov I. Chimeric chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response. J Virol. 2011;85:9249–9252.
   Web of Science ®Google Scholar
• Plante K, Wang E, Partidos CS, et al. Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism. PLoS Pathog. 2011;7:e1002142.
   Web of Science ®Google Scholar
• Muthumani K, Lankaraman KM, Laddy DJ, et al. Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus. Vaccine. 2008;26:5128–5134.
   PubMed Web of Science ®Google Scholar
• Mallilankaraman K, Shedlock DJ, Bao H, et al. A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates. PLoSNegl Trop Dis. 2011;5:e928.
   PubMed Web of Science ®Google Scholar
• Akahata W, Yang ZY, Andersen H, et al. A virus like particle vaccine for epidemic chikungunya virus protects nonhuman primates against infection. Nat Med. 2010;16:334–338.
   PubMed Web of Science ®Google Scholar
• ClinicalTrials.gov. VRC 311: a Phase 1 open label, dose-escalation clinical trial to evaluate the safety and immunogenicity of a virus-like particle (VLP) Chikungunya vaccine, VRC-CHKVLP059–000-VP in healthy adults. Available from: http://clinicaltrials.gov/ct2/show/NCT01489358. Accessed March 6, 2013.
   Google Scholar
• Couderc T, Khandoudi N, Grandadam M, et al. Prophylaxis and therapy for Chikungunya virus infection. J Infect Dis. 2009;200:516–523.
   PubMed Web of Science ®Google Scholar
• Dash PK, Tiwari M, Santhosh SR, Parida M, Rao PVL. RNA interference mediated inhibition of Chikungunya virus replication in mammalian cells. Biochem Biophys Res Commun. 2008;376:718–722.
   PubMed Web of Science ®Google Scholar