Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies

References

• AmosAFMcCartyDJZimmetPThe rising global burden of diabetes and its complications: estimates and projections to the year 2010Diabet Med199714Suppl 1S1S859450510
   PubMedGoogle Scholar
• FisherBMGillenGLindopGBDargieHJFrierBMCardiac function and coronary arteriography in asymptomatic type-1 (insulin-dependent) diabetic patients: evidence for a specif ic diabetic heart diseaseDiabetologia1986297067123803744
   PubMed Web of Science ®Google Scholar
• KannelWBHjortlandMCastelliWPRole of diabetes in congestive heart failure: the Framingham StudyAm J Cardiol19763429344835750
   PubMed Web of Science ®Google Scholar
• KannelWBMcGeeDLDiabetes and cardiovascular disease: the Framingham StudyJAMA197924120352038430798
   PubMed Web of Science ®Google Scholar
• RublerSDlugashJYuceogluYZKumralTBranwoodAWGrishmanANew type of cardiomyopathy associated with diabetic glomerulosclerosisAm J Cardiol1972305956024263660
   PubMed Web of Science ®Google Scholar
• ZimmetPAlbertiKGMMSwanJGlobal and social implications of the diabetes epidemicNature200141478278711742409
   PubMed Web of Science ®Google Scholar
• BerensonGSSrinivasanSRBaoWNewmanWPIIITracyREWattigneyWAAssociation between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart StudyN Engl J Med1998338165016569614255
   PubMed Web of Science ®Google Scholar
• KròlewskiASKosinskiEJWarramJHMagnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitusAm J Cardiol1987597507553825934
   PubMed Web of Science ®Google Scholar
• Barrett-ConnorEWingardDLSex differences in ischemic heart disease mortality in diabetics: a prospective population based studyAm J Epidemiol19831184894966637976
   PubMed Web of Science ®Google Scholar
• GaedePVedelPParvingHHPedersenOIntensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the STENO type 2 randomized studyLancet199935361762210030326
   PubMed Web of Science ®Google Scholar
• HaffnerSMLebtoSRoenemaaTPyöräläKLaaksoMMortality from coronary heart disease in subjects with type 2 diabetes and in non diabetic subjects with and without prior myocardial infarctionN Engl J Med19983392292349673301
   PubMed Web of Science ®Google Scholar
• MalmbergKRydenLMyocardial infarction in patients with diabetes mellitusEur Heart J19889256264
   Web of Science ®Google Scholar
• HerlitzJMalmbergKKarlssonBRydénLHjalmarsonAMortality and morbidity during a five year follow up of diabetics with myocardial infarctionActa Med Scand19882431383046232
   PubMedGoogle Scholar
• NorhammarATenerzANilssonGGlucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective studyLancet20023592140214412090978
   PubMed Web of Science ®Google Scholar
• BarzilayJIKronmalRABittnerVEakerEEvansCFosterEDCoronary artery disease and coronary artery bypass grafting in diabetic subjects aged ≥65 yearsAm J Cardiol1994743343398059694
   PubMed Web of Science ®Google Scholar
• Borch-JohnsenKAndersenPKDeckertTThe effect of proteinuria on relative mortality in type-1 (insulin-dependent) diabetes mellitusDiabetologia1985285905964054448
   PubMed Web of Science ®Google Scholar
• BertoniAGTsaiAKasperEKBrancatiFLDiabetes and idiopathic cardiomyopathyDiabetes Care2003262791279514514581
   PubMed Web of Science ®Google Scholar
• ShindlerDMKostisJBYusufSDiabetes Mellitus, a predictor of morbidity and mortality in the studies of the left ventricular dysfunction (SOLVD) trials and registryAm J Cardiol199677101710208644628
   PubMed Web of Science ®Google Scholar
• RydenLArmstrongPWClelandJGEfficacy and safety of highdose lisinopril in chronic heart failure patients at high cardiovascular risk, including those with diabetes mellitus. Results from the ATLAS trialEur Heart J2000211967197811071803
   PubMed Web of Science ®Google Scholar
• CohnJNJohnsonGZiescheSA comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failureN Engl J Med19913253033102057035
   PubMed Web of Science ®Google Scholar
• HayatSAPatelBKhattarRSMalikRADiabetic cardiomyopathy: mechanisms, diagnosis, and treatmentClin Sci200410753955715341511
   PubMed Web of Science ®Google Scholar
• VigoritaVJMorreGWHutchensSMAbsence of correlation between coronary arterial atherosclerosis and severity or duration of diabetes mellitus of adult onsetAm J Cardiol1980465355427416013
   PubMed Web of Science ®Google Scholar
• FactorSMMinaseTSonnenblickEHClinical and morphological features of human hypertensive-diabetic cardiomyopathyAm Heart J1980994464586444776
   PubMed Web of Science ®Google Scholar
• FactorSMBhanRMinaseTWolinskyHSonnenblickEHHypertensive diabetic cardiomyopathy in the rat: an experimental model of human diseaseAm J Pathol19811022192287468768
   PubMed Web of Science ®Google Scholar
• KawaguchiMTechigawaraMIshihataTA comparison of ultrastructural changes on endomyocardial biopsy specimens obtained from patients with and without diabetes mellitus with and without hypertensionHeart Vessels1997122672749860193
   PubMed Web of Science ®Google Scholar
• LevyDGarrisonRJSavageDDKannelWBCastelliWPPrognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart StudyN Eng J Med199032215611566
   PubMed Web of Science ®Google Scholar
• PalmieriVBellaJNTracyRPRelationship of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes. The Strong Heart StudyDiabetes Care2003262764276914514577
   PubMed Web of Science ®Google Scholar
• PetrieMCCaruanaLBerryCMcMurrayJJDiastolic heart failure caused by subtle left ventricular systolic dysfunctionHeart200287293111751660
   PubMed Web of Science ®Google Scholar
• BrutsaertDLHousmansPRGoethalsMADual control of relaxation. Its role in the ventricular function in the mammalian heartCirc Res1980476376526106532
   PubMed Web of Science ®Google Scholar
• ZileMRBaicuCFGaaschWHDiastolic heart failure: abnormalities in active relaxation and passive stiffness of the left ventricleN Engl J Med20043501953195915128895
   PubMed Web of Science ®Google Scholar
• RaevDCWhich left ventricular dysfunction is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type 1 diabetic patientsDiabetes Care1994176336397924771
   PubMed Web of Science ®Google Scholar
• RiggsTWTransueDDoppler echocardiographic evaluation of left ventricular diastolic dysfunction in adolescents with diabetes mellitusAm J Cardiol1990658999022321540
   PubMed Web of Science ®Google Scholar
• MargonatoAGerundiniPVicedominiGGilardiMCPozzaGFazioFAbnormal cardiovascular response to exercise in young asymptomatic diabetic patients with retinopathyAm Heart J19861125545603751866
   PubMed Web of Science ®Google Scholar
• MirskyIAssessing diastolic function: suggested methods and future considerationsCirculation1984698368416697466
   PubMed Web of Science ®Google Scholar
• OmmenSRNishimuraRAA clinical approach to the assessment of left ventricular diastolic function by Doppler echocardiography: updateHeart200389182312482783
   PubMed Web of Science ®Google Scholar
• AurigemmaGPGottdienerJSShemanskiLGardinJKitzmanDPredictive value of systolic and diastolic function for incident congestive heart failure in the elderly: the Cardiovascular Health StudyJ Am Coll Cardiol2001371042104811263606
   PubMed Web of Science ®Google Scholar
• VasanRLarsonMGBenjaminEJEvansJCReissCKLevyDCongestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohortJ Am Coll Cardiol1999331948195510362198
   PubMed Web of Science ®Google Scholar
• JudgeKWPawitanYCaldwellJGershBJKennedyJWCongestive heart failure in patients with preserved left ventricular systolic function: analysis of the CASS registryJ Am Coll Cardiol1991183773821856405
   PubMed Web of Science ®Google Scholar
• BroganWCIIIHillisLDFloresEDLangeRAThe natural history of isolated left ventricular diastolic dysfunctionAm J Med1992926276301605144
   PubMed Web of Science ®Google Scholar
• IribarrenCKarterAJGoASGlycaemic control and heart failure among adult patients with diabetesCirculation20011032668267311390335
   PubMed Web of Science ®Google Scholar
• AvendanoGFAgarwalRKBasheyRIEffects of glucose intolerance on myocardial function and collagen-linked glycationDiabetes1999481443144710389851
   PubMed Web of Science ®Google Scholar
• SinghRBardenAMoriTBeilinLAdvanced glycation end products: a reviewDiabetologia20014412914611270668
   PubMed Web of Science ®Google Scholar
• DevereuxRBRomanMJParanicasMImpact of diabetes on cardiac structure and function: The Strong Heart StudyCirculation20001012271227610811594
   PubMed Web of Science ®Google Scholar
• YoungMEMcnultyPTaegtmeyerHAdaptation and maladaptation of the heart in Diabetes: part II Potential mechanismsCirculation20021051861187011956132
   PubMed Web of Science ®Google Scholar
• CandidoRForbesJMThomasMCA breaker of advanced glycation end products attenuates diabetes induced myocardial structural changesCirc Res20039278579212623881
   PubMed Web of Science ®Google Scholar
• GalderisiMAndersonKMWilsonPWFLevyDEchocardiographic evidence for the existence of a distinct diabetic cardiomyopathy. The Framingham Heart StudyAm J Cardiol19916885892058564
   PubMed Web of Science ®Google Scholar
• RodriguesBCamMCMcNeillJHMetabolic disturbances in diabetic cardiomyopathyMol Cell Biochem199818053579546630
   PubMed Web of Science ®Google Scholar
• ZhouYGrayburnPKarimALipotoxic heart disease in obese rats: implications for human obesityProc Natl Acad Sci U S A20009717941789
   Web of Science ®Google Scholar
• AsifMEganJVasanSAn advanced gylcation end product crosslink breaker can reverse age-related increases in myocardial stiffnessProc Natl Acad Sci U S A2000972809281310706607
   PubMed Web of Science ®Google Scholar
• LiangQCarlsonECDonthiRVOverexpression of metallothionein reduces diabetic cardiomyopathyDiabetes20025117418111756338
   PubMed Web of Science ®Google Scholar
• ZhangFLiGDingWScreening and analysis of early cardiopathology-related gene in type 2 diabetes mellitusZhonghua Nei Ke Za Zhi20024153053312421500
   PubMedGoogle Scholar
• MonkemannHde VrieseASBlomHJEarly molecular events in the development of the diabetic cardiomyopathyAmino Acids20022333133612373555
   PubMed Web of Science ®Google Scholar
• MizushigeKYaoLNomaTAlteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of type II diabetic modelCirculation200010189990710694530
   PubMed Web of Science ®Google Scholar
• RenJSampsonWKSowersJRInsulin-like growth factor 1 as a cardiac hormon: physiological and pathophysiological implications in heart diseaseMoll Cell Cardiol19993120492061
   PubMed Web of Science ®Google Scholar
• AiraksinenKKostinenJAkaheimoMHuikuriHAugmentation of atrial contraction to LV filling in IDDM subjects as assessed by Doppler echocardiographDiabetes Care1989121591612702899
   PubMedGoogle Scholar
• ZieglerDCardiovascular autonomic neuropathy: clinical manifestations and measurementDiabetes Rev19997300315
   Google Scholar
• KahnKZolaBJuniJEVinikAIRadionuclide assessment of LV diastolic filling pressures in diabetes mellitus with and without cardiac autonomic neuropathyJ Am Coll Cardiol19867130313093011872
   PubMed Web of Science ®Google Scholar
• ZolaBKahnJKJuniJEVinikAIAbnormal cardiac function in diabetic patients with autonomic neuropathy in the absence of ischemic heart diseaseJ Clin Endocrinol Metab1986632082143711260
   PubMed Web of Science ®Google Scholar
• UusitupaMMustonenJLaaksoMImpairment of diastolic function in middle aged type 1 and type 2 diabetic patients free of cardiovascular diseaseDiabetologia1988317837913234632
   PubMed Web of Science ®Google Scholar
• RathmannWZieglerDJahnkeMHaastertBGriesFAMortality in diabetic patients with cardiovascular autonomic neuropathyDiabet Med1993108208248281726
   PubMed Web of Science ®Google Scholar
• RoyTMPetersonHRSniderHLAutonomic influence on cardiovascular performance in diabetic subjectsAm J Med1989873823882801728
   PubMed Web of Science ®Google Scholar
• AnnonuAKFattahAAMokhtarMSGhareebSElhendyALV systolic and diastolic functional abnormalities in asymptomatic patients with non-insulin-dependent diabetes mellitusJ Am Soc Echocardiogr20011488589111547274
   PubMed Web of Science ®Google Scholar
• MustonenJMantysaariMKuikkaJDecreased myocardial 123I-metaiodobenzylguanidine uptake is associated with disturbed LV diastolic filling in diabetesAm Heart J19921238048051539538
   PubMed Web of Science ®Google Scholar
• MonteagudoPTMoisesVAKohlmannOJrRibeiroABLimaVCZanellaMTInfluence of autonomic neuropathy upon LV dysfunction in insulin-dependent diabetic patientsClin Cardiol20002337137510803447
   PubMed Web of Science ®Google Scholar
• WillenheimerRBErhardtLRNilssonHLiljaBJuul-MöllerSSundkvistGParasympathetic neuropathy associated with left ventricular diastolic dysfunction in patients with insulin-dependent diabetes mellitusScand Cardiovasc J19983217229536501
   PubMed Web of Science ®Google Scholar
• di CarliMFBianco-BatllesDLandaMEEffects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitusCirculation199910081381910458716
   PubMedGoogle Scholar
• BalkauBJouvenXDucimetiérePEschwègeEDiabetes as a risk factor for sudden deathLancet19993541968196910622302
   PubMed Web of Science ®Google Scholar
• EwingDJBolandONeilsonJMChoCGClarkeBFAutonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patientsDiabetologia1991341821851884890
   PubMed Web of Science ®Google Scholar
• TentolourisNKatsilambrosNPapazachosGCorrected QT interval in relation to the severity of diabetic autonomic neuropathyEur J Clin Invest199727104910549466135
   PubMed Web of Science ®Google Scholar
• PoirierPBogatyPPhilipponFPreclinical diabetic cardiomyopathy: relation of left ventricular diastolic dysfunction to cardiac autonomic neuropathy in men with uncomplicated well-controlled type 2 diabetesMetabolism2003521056106112898473
   PubMed Web of Science ®Google Scholar
• VoulgariCTentolourisNMoyssakisIThe spatial QRS-T angle is increased in patients with type 2 diabetes mellitus and cardiac autonomic neuropathyDiabetologia200951Suppl 1S500S500
   Google Scholar
• ChappetODosquetCWautierMPAdvanced glycation end products, oxidant stress and vascular lesionsEur J Clin Invest199727971089061302
   PubMed Web of Science ®Google Scholar
• BrownleeMAdvanced protein glycation in diabetes and agingAnn Rev Med1995462232347598459
   PubMed Web of Science ®Google Scholar
• BanCRTwiggSMFibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markersVasc Health Risk Manag2008457559618827908
   PubMedGoogle Scholar
• Effect of intensive management on macrovascular events and risk factors in Diabetes Control and Complications TrialAm J Cardiol1995758949037732997
   PubMed Web of Science ®Google Scholar
• StrattonIMAdlerAINeilHAAssociation of glycaemia with macrovascular and microvascular complications in type 2 diabetes (UKPDS 35): prospective observational studyBMJ200032140541210938048
   PubMed Web of Science ®Google Scholar
• HaffnerSMImpaired glucose tolerance, insulin resistance, and cardiovascular diseaseDiabet Med199714Suppl 3S12S189272608
   PubMedGoogle Scholar
• DespresJPLamarcheBMauriegePHyperinsulinemia as an independent risk factor for ischemic heart diseaseN Engl J Med19963349529578596596
   PubMed Web of Science ®Google Scholar
• ZavaroniIBonoraEPagliaraMRisk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose toleranceN Engl J Med19893207027062646537
   PubMed Web of Science ®Google Scholar
• ReavenGMBanting lecture 1988. Role of insulin resistance in human diseaseDiabetes198837159516073056758
   PubMed Web of Science ®Google Scholar
• HaffnerSMMykkanenLFestaAInsulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic stageCirculation200010197598010704163
   PubMed Web of Science ®Google Scholar
• KoivistoVAStevensLKMattockMCardiovascular disease and its risk factors in IDDM in Europe. EURODIAB IDDM Complications Study GroupDiabetes Care1996196896978799621
   PubMedGoogle Scholar
• KohlerHPGrantPJMechanisms of disease: plasminogen activator inhibitor-1 and coronary artery diseaseN Engl J Med20003421792180110853003
   PubMed Web of Science ®Google Scholar
• Juhan-VagueIAlessiMCVaguePIncreased plasma plasminogen activator inhibitor 1 levels: a possible link between insulin resistance and atherothrombosisDiabetologia1991344574621916049
   PubMed Web of Science ®Google Scholar
• MansfieldMWHeywoodDGrantPJCirculating levels of factor VII, fibrinogen, and non Willebrand factor and features of insulin resistance in first degree relatives of patients with NIDDMCirculation199694217121768901668
   PubMed Web of Science ®Google Scholar
• HeywoodDMMansfieldMWGrantPJFactor VII gene polymorphisms, factor VII: C levels and features of insulin resistance in non-insulin-dependent diabetes mellitusThromb Haemost1996754014068701397
   PubMed Web of Science ®Google Scholar
• KohlerHPCarterAMSticklandMHGrantPJLevels of activated FXII in survivors of myocardial infarction: association with circulating risk factors and extent of coronary artery diseaseThromb Haemost19987914189459314
   PubMed Web of Science ®Google Scholar
• FestaAD’AgostinoRJHowardGMykkänenLTracyRPHaffnerSMChronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)Circulation2000102424710880413
   PubMed Web of Science ®Google Scholar
• SchlkwijkCGPolandDCvan DijkWPlasma concentrations of C-reactive protein are increased in type 1 diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammationDiabetologia19994235135710096789
   PubMed Web of Science ®Google Scholar
• KoenigWSundMFrohlichMC-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992Circulation1999992372429892589
   PubMed Web of Science ®Google Scholar
• RidkerPMHennekensCHBuringJERifaiNC-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in womenN Engl J Med200034283684310733371
   PubMed Web of Science ®Google Scholar
• VoulgariCTentolourisNPapadogiannisDIncreased left ventricular arrhythmogenicity in metabolic syndrome and relationship with myocardial performance, risk factors for atherosclerosis, and low-grade inflammationMetabolism20105915916519766273
   PubMed Web of Science ®Google Scholar
• FeenerEPKingGLVascular dysfunction in diabetes mellitusLancet1997350S19113
   Web of Science ®Google Scholar
• ZavaroniIDall’AglioEBonoraEAlpiOPasseriMReavenGMEvidence that multiple risk factors for coronary artery disease exist in persons with abnormal glucose toleranceAm J Med1987836096123674049
   PubMed Web of Science ®Google Scholar
• HaffnerSMD’AgostinoRJrMykkanenLInsulin sensitivity in subjects with type 2 diabetes: relationship to cardiovascular risk factors. The insulin Resistance Atherosclerosis StudyDiabetes Care19992256256810189532
   PubMed Web of Science ®Google Scholar
• GrundySMHypertriglyceridemia, atherogenic dyslipidemia and the metabolic syndromeAm J Cardiol19888118B25B
   Google Scholar
• AustinMAEdwardsKLSmall dense low density lipoproteins, the insulin resistance syndrome, and non-insulin dependent diabetesCurr Opin Lipidol199671671718818515
   PubMed Web of Science ®Google Scholar
• LamarcheBTchernofAMauriegePSmall, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular StudyCirculation19979569758994419
   PubMed Web of Science ®Google Scholar
• LamarcheBTchernofAMoorjaniSFasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart diseaseJAMA1998279195519619643858
   PubMed Web of Science ®Google Scholar
• VoulgariCHTentolourisNMoyssakisISpatial QRS-T angle: association with diabetes and left ventricular performanceEur J Clin Invest20063660861316919042
   PubMed Web of Science ®Google Scholar
• HiragaTKobayashiTOkuboMProspective study of lipoprotein (a) as a risk factor for atherosclerotic cardiovascular disease in patients with diabetesDiabetes Care1995182412447729305
   PubMed Web of Science ®Google Scholar
• ForsblomCMSaneTGroopPHRisk factors for mortality in type II (non-insulin-dependent) diabetes: evidence for a role for neuropathy and a protective effect of HLA-DR4Diabetologia199841125312629833930
   PubMed Web of Science ®Google Scholar
• StamlerJVaccaroONeatonJDDiabetes, other risk factors and 12 year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention TrialDiabetes Care1993164344448432214
   PubMed Web of Science ®Google Scholar
• LichtensteinMJShipleyMJRoseGSystolic and diastolic blood pressures as predictors of coronary heart disease mortality in the Whitehall studyBMJ19852912432453926137
   PubMed Web of Science ®Google Scholar
• TurnerRCMillinsHNeilHAWRisk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS)BMJ19983468238289549452
   PubMedGoogle Scholar
• deFronzoRFerranniniEInsulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic diseaseDiabetes Care1991141731942044434
   PubMed Web of Science ®Google Scholar
• deFronzoRAGoldbergMAgusZSThe effects of glucose and insulin on renal electrolyte transportJ Clin Invest1976588390932211
   PubMed Web of Science ®Google Scholar
• HallJESummersRLBrandsMWKeenHAlonso-GaliciaMResistance to metabolic actions of insulin and its role in hypertensionAm J Hypertens199477727887986471
   PubMed Web of Science ®Google Scholar
• CapronLJarnetJKazandjianSHoussetEGrowth-promoting effects of diabetes and insulin on arteries: an in vivo study of rat aortaDiabetes1986359739783527827
   PubMed Web of Science ®Google Scholar
• AndersonEABalonTWHoffmanRPSinkeyCAMarkALInsulin increases sympathetic activity but not blood pressure in borderline hypertensive humansHypertension1992196216271592458
   PubMed Web of Science ®Google Scholar
• GoodeGKMillerJPHeagertyAMHyperlipidemia, hypertension and coronary heart diseaseLancet19953453623647845119
   PubMed Web of Science ®Google Scholar
• Comitte of Prinicipal InvestigatorsA co-operative trial in the primary prevention of ischaemic heart disease using clofibrateBr Heart J19784010691118361054
   PubMedGoogle Scholar
• CalleEEThunMJPetrelliJMRodriguezCHeathCWJrBody mass index and mortality in a prospective cohort of US adultsN Engl J Med19993411097110510511607
   PubMed Web of Science ®Google Scholar
• Barret-ConnerELObesity, atherosclerosis, and coronary heart diseaseAnn Intern Med1985103101010193904565
   PubMed Web of Science ®Google Scholar
• YamauchiTKamonJWakiHThe fat-derived hormone adiponectin reverses insulin resistance associated both lipoatrophy and obesityNat Med2001794194611479627
   PubMed Web of Science ®Google Scholar
• VoulgariCMoyssakisIPapazafiropoulouAThe impact of metabolic syndrome on left ventricular myocardial performanceDiabetes Metab Res Rev20102612112720131336
   PubMed Web of Science ®Google Scholar
• MogensenCEMicroalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetesN Engl J Med19843103563606690964
   PubMed Web of Science ®Google Scholar
• ManskeCLWilsonRFWangYThomasWPrevalence of, and risk factors for, angiographically determined coronary artery disease in type 1 diabetic patients with nephropathyArch Intern Med19921522450024505
   Google Scholar
• YudkinJSForrestRDJacksonCAMicroalbuminuria as a predictor of vascular disease in non-diabetic subjectsLancet198825305332900920
   PubMed Web of Science ®Google Scholar
• DeckertTYokoyamaHMathiesenECohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetesBMJ19963128718748611873
   PubMed Web of Science ®Google Scholar
• Borch-JohnsenKKreinerSProteinuria: value as predictor of cardiovascular mortality in insulin-dependent diabetes mellitusBMJ1989294165116543113569
   PubMedGoogle Scholar
• DinneenSFGersteinHCThe association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus: a systematic overview of the literatureArch Intern Med1997157141314189224218
   PubMed Web of Science ®Google Scholar
• FullerJHStevensLKWangSLWHO Multinational Study GroupRisk Factors for cardiovascular mortality and morbidity: the WHO multinational study of vascular disease in diabetesDiabetologia200144Suppl 2S54S6411587051
   PubMedGoogle Scholar
• GrudenGCavallo-PerinPBazzanMStellaSVuoloAPaganoGPAI-1 and factor VII activity are higher in IDDM patients with microalbuminuriaDiabetes1994434264298314015
   PubMed Web of Science ®Google Scholar
• BrunoGCavallo-PerinPBargeroGBorraMD’ErricoNPaganoGAssociation of fibrinogen with glycemic control and albumin excretion rate in patients with non-insulin-dependent diabetes mellitusAnn Intern Med19961256536578849150
   PubMed Web of Science ®Google Scholar
• EarleKSWalkerJHillCVibertiGFamilial clustering of cardiovascular disease in patients with insulin-dependent diabetes and nephropathyN Engl J Med19923256736771736105
   PubMedGoogle Scholar
• LeeMGardinJMLynchJCDiabetes mellitus and echocardiographic left ventricular function in free-living elderly men and women: The Cardiovascular Health StudyAm Heart J199713336439006288
   PubMed Web of Science ®Google Scholar
• PalmieriVBellaJNArnettDKEffect of Type 2 Diabetes Mellitus on Left Ventricular Geometry and Systolic Function in Hypertensive Subjects: Hypertension Genetic Epidemiology Network (HyperGEN) StudyCirculation200110310210711136693
   PubMed Web of Science ®Google Scholar
• IlercilADevereuxRBRomanMJRelationship of impaired glucose tolerance to left ventricular structure and function: the Strong Heart StudyAm Heart J200114199299811376315
   PubMed Web of Science ®Google Scholar
• StruthersADMorrisADScreening for and treating left ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deathsLancet20023591430143211978359
   PubMed Web of Science ®Google Scholar
• KimballTRDanielsSRKhouryPRMagnottiRATurnerAMDolanLMCardiovascular status in young patients with insulin dependent diabetes mellitusCirculation1994903573618026019
   PubMed Web of Science ®Google Scholar
• DumesnilJGGaudreaultGHonosGNKingmaJGJrUse of Valsalva maneuver to unmask left ventricular diastolic function abnormalities by Doppler echocardiography in patients with coronary artery disease or systemic hypertensionAm J Cardiol1991685155191872280
   PubMed Web of Science ®Google Scholar
• GarneauCDiastolic dysfunction in normotensive men with well controlled type 2 diabetes mellitus. Importance of manoeuvres in echocardiographic screening for preclinical diabetic cardiomyopathyDiabetes Care20012451011194240
   PubMed Web of Science ®Google Scholar
• TeiCNew non-invasive index for combined systolic and diastolic ventricular functionJ Cardiol1995261351367674144
   PubMedGoogle Scholar
• TeiCLingLHHodgeDONew index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function: a study in normal and dilated cardiomyopathyJ Cardiol1995263573668558414
   PubMedGoogle Scholar
• PoulsenSHNielsenJCAndersenHRThe influence of heart rate on the Doppler-derived myocardial performance indexJ Am Soc Echocardiogr20001337938410804435
   PubMed Web of Science ®Google Scholar
• VinereanuDNicolaidesETweddelACSubclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated haemoglobinClin Sci200310559159912831396
   PubMed Web of Science ®Google Scholar
• GillebertTCvan de VeireNde BuyzereMLde SutterJTime intervals and global cardiac function. Use and limitationsEur Heart J2004252185218615589634
   PubMed Web of Science ®Google Scholar
• BruchCSchmermundAMarinDTei-Index in patients with mild-to-moderate congestive heart failureEur Heart J2000211888189511052862
   PubMed Web of Science ®Google Scholar
• ArnlövJLindLAndrénBRisérusUBerglundLLithellHA Doppler-derived index of combined left ventricular systolic and diastolic function is an independent predictor of cardiovascular mortality in elderly menAm Heart J200514990290715894975
   PubMed Web of Science ®Google Scholar
• SzczepaniakLSVictorRGOrciLUngerRHForgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in AmericaCirc Res200710175976717932333
   PubMed Web of Science ®Google Scholar
• FangZYYudaSAndersonVShortLCaseCMarwickTHEchocardiographic detection of early diabetic myocardial diseaseJ Am Coll Cardiol20034161161712598073
   PubMed Web of Science ®Google Scholar
• FangZYNajos-ValenciaOLeanoRMarwickTHPatients with early diabetic heart disease demonstrate a normal myocardial response to dobutamineJ Am Coll Cardiol20034244645312906970
   PubMed Web of Science ®Google Scholar
• KosmalaWKucharskiWPrzewlocka-KosmalaMMazurekWComparison of left ventricular function by tissue doppler imaging in patients with diabetes mellitus without systemic hypertension vs diabetes mellitus with systemic hypertensionAm J Cardiol20049439539915276118
   PubMed Web of Science ®Google Scholar
• Guang-weiLYing-huaHWen-yingYEffects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes complications: the Da Qing IGT and diabetes studyDiabetes Res Clin Pract20025819320012413779
   PubMed Web of Science ®Google Scholar
• TuomilehtoJLindstrőmJErikssonJGfor the Finnish Diabetes Prevention Study GroupPrevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose toleranceN Engl J Med20013441343135011333990
   PubMed Web of Science ®Google Scholar
• HuGTuomilehtoJSilventoinenKBarengoNJousilahtiPJoint effects of physical activity, body mass index, waist circumference, and waist-to-hip ratio with the risk of cardiovascular disease among middle-aged Finnish men and womenEur Heart J2004252212221915589638
   PubMed Web of Science ®Google Scholar
• KemplerPLearning from large cardiovascular clinical trials: classical cardiovascular risk factorsDiabetes Res Clin Pract200568Suppl 1S43S4715955374
   PubMed Web of Science ®Google Scholar
• HaddenDRPattersonCCAtkinsonABMacrovascular disease and hyperglycemia: 10-year survival analysis in type 2 diabetes mellitus: the Belfast Diet StudyDiabet Med1997146636729272593
   PubMed Web of Science ®Google Scholar
• HanefeldMFischerSJuliusUfor the DIS groupRisk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes Intervention Study, 11-year follow-upDiabetologia199639157715838960845
   PubMed Web of Science ®Google Scholar
• MeierMHummelMCardiovascular disease and intensive glucose control in type 2 diabetes mellitus: moving practice toward evidence-based strategiesVasc Health Risk Manag2009585987119898642
   PubMedGoogle Scholar
• UK Prospective Diabetes Study GroupAssociation of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational studyBMJ200032140541210938048
   PubMedGoogle Scholar
• HaffnerSMThe Scandinavian Simvastatin Survival Study (4S) subgroup analysis of diabetic subjects: implications for the prevention of coronary heart diseaseDiabetes Care1997204694719096961
   PubMed Web of Science ®Google Scholar
• RobinsSJCollinsDWittesJTfor the VA-HIT groupRelation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trialJAMA20012851585159111268266
   PubMed Web of Science ®Google Scholar
• RubinsHBRobinsSJCollinsDfor the VA-HIT study groupDiabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs High-density lipoprotein intervention Trial (VA-HIT)Arch Intern Med20021622597260412456232
   PubMed Web of Science ®Google Scholar
• RobinsSJCollinsDMcNamaraJRBloomfieldHEBody weight, plasma insulin, and coronary events with gemfibrozil in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)Atherosclerosis2008196284985517335828
   PubMed Web of Science ®Google Scholar
• JonesPHExpert perspective: reducing cardiovascular risk in metabolic syndrome and type 2 diabetes mellitus beyond low-density lipoprotein cholesterol loweringAm J Cardiol200810212A41L47L
   PubMed Web of Science ®Google Scholar
• The ALLHAT officers and coordinators for the ALLHAT collaborative research studyMajor outcomes in high-risk hypertensive patients randomized to ACE inhibitors or calcium channel blocker vs diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack trial (ALLHAT)JAMA20022882981299712479763
   PubMed Web of Science ®Google Scholar
• The Heart Outcomes Prevention Evaluation Study InvestigatorsEffects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patientsN Engl J Med200034214515310639539
   PubMed Web of Science ®Google Scholar
• HanssonLZachettiACarruthersSGfor the HOT study groupEffects of intensive blood-pressure lowering and lowdose aspirin in patients with hypertension; principal results of the Hypertension Optimal Treatment (HOT) randomized trialLancet1998351175517629635947
   PubMed Web of Science ®Google Scholar
• LindholmLHIbsenHDalhofBfor the LIFE Study groupCardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomized trial against atenololLancet20023591004101011937179
   PubMed Web of Science ®Google Scholar
• UK Prospective Diabetes Study GroupTight blood pressure control and risk of macrovascular complications in type 2 diabetes: UKPDS 38BMJ19983177037119732337
   PubMed Web of Science ®Google Scholar
• HolmanRTurnerRStrattonIUK Prospective Diabetes Study GroupEfficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39BMJ19983177137209732338
   PubMed Web of Science ®Google Scholar
• LewisEJHunsickerLGClarkeWRfor the collaborative study groupRenoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesN Engl J Med200134585186011565517
   PubMed Web of Science ®Google Scholar
• BristowMRBeta-adrenergic receptor blockade in chronic heart failureCirculation200010155856910662755
   PubMed Web of Science ®Google Scholar
• The CURE Study InvestigatorsThe Clopidogrel in Unstable Angina to prevent Recurrent Events Study. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial InvestigatorsN Engl J Med200134549450211519503
   PubMedGoogle Scholar
• Falcão-PiresIGonçalvesNGavinaCCorrelation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatmentExpert Opin Ther Targets20101423124120055692
   PubMed Web of Science ®Google Scholar
• SavvatisKWestermannDSchultheissHPTschöpeCKinins in cardiac inflammation and regeneration: insights from ischemic and diabetic cardiomyopathyNeuropeptides201044211912520036002
   PubMed Web of Science ®Google Scholar
• SulaimanMMattaMJSundaresanNRResveratrol, an activator of SIRT1 up-regulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathyAm J Physiol Heart Circ Physiol2010298H83384320008278
   PubMed Web of Science ®Google Scholar
• KohdaYKanematsuMKonoTTerasakiFTanakaTProtein O-glycosylation induces collagen expression and contributes to diabetic cardiomyopathy in rat cardiac fibroblastsJ Pharmacol Sci200911144645019966509
   PubMed Web of Science ®Google Scholar
• Aydemir-KoksoyABilginogluASariahmetogluMSchulzRTuranBAntioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stressJ Nutr Biochem200910.1016/j.jnutbio.2009.06.006
   PubMed Web of Science ®Google Scholar
• LiCJZhangQMLiMZZhangJYYuPYuDMAttenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathyChin Med J (Engl)20091222580258619951573
   PubMed Web of Science ®Google Scholar
• HottaHMiuraTMikiTAngiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardio-protective signaling in diabetic heartsCirc Res201010612923219910577
   PubMed Web of Science ®Google Scholar
• WangMZhangWBZhuJHFuGSZhouBQBreviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca(2+)-cycling proteins in streptozotocin-induced diabetic ratsActa Diabetol200910.1007/s00592-009-0164-x
   Web of Science ®Google Scholar
• WangMZhangWBZhuJHFuGSZhouBQBreviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathwayActa Pharmacol Sin20093081081109119597526
   PubMed Web of Science ®Google Scholar
• ConnellyKAKellyDJZhangYInhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathyCirc Heart Fail2009212913719808328
   PubMed Web of Science ®Google Scholar
• ChaoPCHsuCCYinMCAnti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic miceNutr Metab (Lond)200963319678956
   PubMed Web of Science ®Google Scholar
• XiSZhouGZhangXZhangWCaiLZhaoCProtective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanismsExp Mol Med20094153854719381071
   PubMed Web of Science ®Google Scholar
• SchneiderRWeltKAustWLösterHFitzlGCardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: II. Interstitium and microvasculatureHistol Histopathol20092458759819283667
   PubMed Web of Science ®Google Scholar
• SchneiderRWeltKAustWLösterHFitzlGCardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: I. cardiomyocytesHistol Histopathol20082380781718437679
   PubMed Web of Science ®Google Scholar
• ChengMGaoHQXuLLiBYZhangHLiXHCardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic ratsJ Cardiovasc Pharmacol20075050350918030059
   PubMed Web of Science ®Google Scholar
• ShushakovaNParkJKMenneJFliserDChronic erythropoietin treatment affects different molecular pathways of diabetic cardiomyopathy in mouseEur J Clin Invest20093975576019614950
   PubMed Web of Science ®Google Scholar
• ChachquesJCCellular cardiac regenerative therapy in which patientsExpert Rev Cardiovasc Ther2009791191919673669
   PubMedGoogle Scholar
• BoudinaSAbelEDDiabetic cardiomyopathy revisitedCirculation20071153213322317592090
   PubMed Web of Science ®Google Scholar
• AnejaATangWHBansilalSGarciaMJFarkouhMEDiabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic optionsAm J Med200812174875718724960
   PubMed Web of Science ®Google Scholar
• KhavandiKKhavandiAAsgharODiabetic cardiomyopathy – a distinct diseaseBest Pract Res Clin Endocrinol Metab20092334736019520308
   PubMed Web of Science ®Google Scholar
• AsgharOAl-SunniAKhavandiKDiabetic cardiomyopathyClin Sci (Lond)200911674176019364331
   PubMed Web of Science ®Google Scholar