Association Metabolic Obesity Phenotypes with Cardiometabolic Index, Atherogenic Index of Plasma and Novel Anthropometric Indices: A Link of FTO-rs9939609 Polymorphism

References

• Mazidi M, Banach M, Kengne AP, et al. Prevalence of childhood and adolescent overweight and obesity in Asian countries: a systematic review and meta-analysis. Arch Med Sci. 2018;14(6):1185–1203. doi:10.5114/aoms.2018.79001
   PubMed Web of Science ®Google Scholar
• Oh YS, Bae GD, Baek DJ, Park EY, Jun HS. Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes. Front Endocrinol (Lausanne). 2018;9:384. doi:10.3389/fendo.2018.00384
   PubMed Web of Science ®Google Scholar
• Evia-Viscarra ML, Rodea-Montero ER, Apolinar-Jiménez E, Quintana-Vargas S. Metabolic syndrome and its components among obese (BMI ≥95th) Mexican adolescents. Endocr Connect. 2013;2(4):208–215. doi:10.1530/EC-13-0057
   PubMed Web of Science ®Google Scholar
• Bazyar H, Adibmanesh A, Javid AZ, et al. The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obes Med. 2019;16:100138. doi:10.1016/j.obmed.2019.100138
   Google Scholar
• Bawadi H, Katkhouda R, Tayyem R, Kerkadi A, Raad SB, Subih H. Abdominal fat is directly associated with inflammation in persons with type-2 diabetes regardless of glycemic control – a Jordanian study. Diabetes Metab Syndr Obes. 2019;12:2411–2417. doi:10.2147/DMSO.S214426
   PubMed Web of Science ®Google Scholar
• Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851–863. doi:10.5114/aoms.2016.58928
   PubMed Web of Science ®Google Scholar
• Papaetis GS, Papakyriakou P, Panagioto TN. Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci. 2015;11(3):463–482. doi:10.5114/aoms.2015.52350
   PubMed Web of Science ®Google Scholar
• Phillips CM. Metabolically healthy obesity: definitions, determinants and clinical implications. Rev Endocr Metab Disord. 2013;14(3):219–227. doi:10.1007/s11154-013-9252-x
   PubMed Web of Science ®Google Scholar
• Lin H, Zhang L, Zheng R, Zheng Y. The prevalence, metabolic risk and effects of lifestyle intervention for metabolically healthy obesity: a systematic review and meta-analysis: a PRISMA-compliant article. Medicine (Baltimore). 2017;96(47):e8838. doi:10.1097/MD.0000000000008838
   PubMed Web of Science ®Google Scholar
• Bluher M. Are metabolically healthy obese individuals really healthy? Eur J Endocrinol. 2014;171(6):R209–R219. doi:10.1530/EJE-14-0540
   PubMed Web of Science ®Google Scholar
• Samocha-Bonet D, Dixit VD, Kahn CR, et al. Metabolically healthy and unhealthy obese: the 2013 stock conference report. Obes Rev. 2014;15(9):697–708. doi:10.1111/obr.12199
   PubMed Web of Science ®Google Scholar
• Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis. Ann Intern Med. 2013;159(11):758–769. doi:10.7326/0003-4819-159-11-201312030-00008
   PubMed Web of Science ®Google Scholar
• Karelis AD, Faraj M, Bastard JP, et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab. 2005;90(7):4145–4150. doi:10.1210/jc.2005-0482
   PubMed Web of Science ®Google Scholar
• Zheng R, Zhou D, Zhu Y. The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and meta-analysis. J Epidemiol Community Health. 2016;70(10):1024–1031. doi:10.1136/jech-2015-206948
   PubMed Web of Science ®Google Scholar
• Bell JA, Kivimaki M, Hamer M. Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies. Obes Rev. 2014;15(6):504–515. doi:10.1111/obr.12157
   PubMed Web of Science ®Google Scholar
• Stefan N, Schick F, Häring HU. Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans. Cell Metab. 2017;26(2):292–300. doi:10.1016/j.cmet.2017.07.008
   PubMed Web of Science ®Google Scholar
• Mǎrginean CO, Mǎrginean C, Meliţ LE. New insights regarding genetic aspects of childhood obesity: a minireview. Front Pediatr. 2018;6:271. doi:10.3389/fped.2018.00271
   PubMed Web of Science ®Google Scholar
• Wang K, Li WD, Zhang CK, et al. A genome-wide association study on obesity and obesity-related traits. PLoS One. 2011;6(4):e18939. doi:10.1371/journal.pone.0018939
   PubMed Web of Science ®Google Scholar
• Witka BZ, Oktaviani DJ, Marcellino M, Barliana MI, Abdulah R. Type 2 diabetes-associated genetic polymorphisms as potential disease predictors. Diabetes Metab Syndr Obes. 2019;12:2689–2706. doi:10.2147/DMSO.S230061
   PubMed Web of Science ®Google Scholar
• Duicu C, Mărginean CO, Voidăzan S, Tripon F, Bănescu C. FTO rs 9939609 SNP is associated with adiponectin and leptin levels and the risk of obesity in a cohort of romanian children population. Medicine (Baltimore). 2016;95(20):e3709. doi:10.1097/MD.0000000000003709
   PubMed Web of Science ®Google Scholar
• Freathy RM, Timpson NJ, Lawlor DA, et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes. 2008;57(5):1419–1426. doi:10.2337/db07-1466
   PubMed Web of Science ®Google Scholar
• Kring SI, Holst C, Zimmermann E, et al. FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness. PLoS One. 2008;3(8):e2958. doi:10.1371/journal.pone.0002958
   PubMed Web of Science ®Google Scholar
• Barber TM, Bennett AJ, Groves CJ, et al. Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia. 2008;51(7):1153–1158. doi:10.1007/s00125-008-1028-6
   PubMed Web of Science ®Google Scholar
• Ashtary-Larky D, Daneghian S, Alipour M, et al. Waist circumference to height ratio: better correlation with fat mass than other anthropometric indices during dietary weight loss in different rates. Int J Endocrinol Metab. 2018;16(4):e55023. doi:10.5812/ijem.55023
   PubMed Web of Science ®Google Scholar
• Park Y, Kim NH, Kwon TY, Kim SG. A novel adiposity index as an integrated predictor of cardiometabolic disease morbidity and mortality. Sci Rep. 2018;8(1):16753. doi:10.1038/s41598-018-35073-4
   PubMedGoogle Scholar
• Yoo HK, Choi EY, Park EW, Cheong YS, Bae RA. Comparison of metabolic characteristics of metabolically healthy but obese (MHO) middle-aged men according to different criteria. Korean J Fam Med. 2013;34(1):19–26. doi:10.4082/kjfm.2013.34.1.19
   PubMedGoogle Scholar
• Cherqaoui R, Kassim TA, Kwagyan J, et al. The metabolically healthy but obese phenotype in African Americans. J Clin Hypertens (Greenwich). 2012;14(2):92–96. doi:10.1111/j.1751-7176.2011.00565.x
   PubMed Web of Science ®Google Scholar
• Rhee EJ, Seo MH, Kim JD, et al. Metabolic health is more closely associated with coronary artery calcification than obesity. PLoS One. 2013;8(9):e74564. doi:10.1371/journal.pone.0074564
   PubMed Web of Science ®Google Scholar
• Messier V, Karelis AD, Robillard ME, et al. Metabolically healthy but obese individuals: relationship with hepatic enzymes. Metabolism. 2010;59(1):20–24. doi:10.1016/j.metabol.2009.06.020
   PubMed Web of Science ®Google Scholar
• Zeng Q, Dong SY, Sun XN, Xie J, Cui Y. Percent body fat is a better predictor of cardiovascular risk factors than body mass index. Braz J Med Biol Res. 2012;45(7):591–600. doi:10.1590/S0100-879X2012007500059
   PubMed Web of Science ®Google Scholar
• Madeira FB, Silva AA, Veloso HF, et al. Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country. PLoS One. 2013;8(3):e60673. doi:10.1371/journal.pone.0060673
   PubMed Web of Science ®Google Scholar
• Iglesias Molli AE, Penas Steinhardt A, López AP, et al. Metabolically healthy obese individuals present similar chronic inflammation level but less insulin-resistance than obese individuals with metabolic syndrome. PLoS One. 2017;12(12):e0190528. doi:10.1371/journal.pone.0190528
   PubMed Web of Science ®Google Scholar
• Velho S, Paccaud F, Waeber G, Vollenweider P, Marques-Vidal P. Metabolically healthy obesity: different prevalences using different criteria. Eur J Clin Nutr. 2010;64(10):1043–1051. doi:10.1038/ejcn.2010.114
   PubMed Web of Science ®Google Scholar
• Bradshaw PT, Reynolds KR, Wagenknecht LE, Ndumele CE, Stevens J. Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: the atherosclerosis risk in communities study. Int J Obes (Lond). 2018;42(3):295–301. doi:10.1038/ijo.2017.249
   PubMed Web of Science ®Google Scholar
• Sedaghati-Khayat B, Barzin M, Akbarzadeh M, et al. Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran cardio-metabolic genetic study (TCGS). Eat Weight Disord. 2020;25(1):25–35. doi:10.1007/s40519-018-0493-2
   PubMed Web of Science ®Google Scholar