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ORIGINAL RESEARCH

Correlation Between Cardiac Index, Plasma Troponin I, Myocardial Histopathology, CPB and AoX Duration in Glutamine versus No Glutamine Administered Patients with Low Ejection Fraction Undergoing Elective On-Pump CABG Surgery: Secondary Analysis of an RCT

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Pages 93-101 | Received 05 Dec 2022, Accepted 18 Feb 2023, Published online: 28 Feb 2023

References

  • Gupta M, Mishra PK, Shoeb M, Agarwal A, Prasad J. A comparison of clinical outcomes of LVEF ≤35% versus LVEF>35% in off-pump coronary artery bypass graft surgery. Int Surg J. 2017;4(6):1908. doi:10.18203/2349-2902.isj20172011
  • Jongman RM, Zijlstra JG, Kok WF, et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study. Shock. 2014;42(2):121–128. doi:10.1097/SHK.0000000000000190
  • Jones D, Patel J. Therapeutic approaches targeting inflammation in cardiovascular disorders. Biology. 2018;7(4):49. doi:10.3390/biology7040049
  • Ulukan MO, Ugurlucan M, Unal O, Yılmaz MF, Kasifoglu N, Sevin MB. Comparisons of heart-type fatty acid-binding protein (H-FABP) levels in off-pump versus on-pump coronary artery bypass grafting. amsad. 2019;4(1):119–125. doi:10.5114/amsad.2019.85426
  • Warren OJ, Watret AL, de Wit KL, et al. The inflammatory response to cardiopulmonary bypass: part 2—anti-inflammatory therapeutic strategies. J Cardiothorac Vasc Anesth. 2009;23(3):384–393. doi:10.1053/j.jvca.2008.09.007
  • Khan SA, Campbell AM, Lu Y, An L, Alpert JS, Chen QM. N-Acetylcysteine for cardiac protection during coronary artery reperfusion: a systematic review and meta-analysis of randomized controlled trials. Front Cardiovasc Med. 2021;8:752939. doi:10.3389/fcvm.2021.752939
  • Drake KJ, Sidorov VY, McGuinness OP, Wasserman DH, Wikswo JP. Amino acids as metabolic substrates during cardiac ischemia. Exp Biol Med. 2012;237(12):1369–1378. doi:10.1258/ebm.2012.012025
  • Lomivorotov VV, Efremov SM, Shmirev VA, Ponomarev DN, Lomivorotov VN, Karaskov AM. Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass. Heart Surg Forum. 2011;14(6):E384–388. doi:10.1532/HSF98.20111074
  • Preeshagul I, Gharbaran R, Jeong KH, et al. Potential biomarkers for predicting outcomes in CABG cardiothoracic surgeries. J Cardiothorac Surg. 2013;8(1):1–12. doi:10.1186/1749-8090-8-176
  • Palstrøm NB, Matthiesen R, Rasmussen LM, Beck HC. Recent developments in clinical plasma proteomics—applied to cardiovascular research. Biomedicines. 2022;10(1):162. doi:10.3390/biomedicines10010162
  • Sarkisian L, Saaby L, Poulsen TS, et al. Clinical characteristics and outcomes of patients with myocardial infarction, myocardial injury, and nonelevated troponins. Am J Med. 2016;129(4):446.e5–446.e21. doi:10.1016/j.amjmed.2015.11.006
  • Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Circulation. 2018;138(20):e618–51. doi:10.1161/CIR.0000000000000617
  • Wu W, Liu X, Han L. Apoptosis of cardiomyocytes in diabetic cardiomyopathy involves overexpression of glycogen synthase kinase-3β. Biosci Rep. 2019;39(1):BSR20171307. doi:10.1042/BSR20171307
  • Kocak E, Kocak C, Aksoy A, et al. High-sensitivity cardiac troponin T is more helpful in detecting peri-operative myocardial injury and apoptosis during coronary artery bypass graft surgery. CVJA. 2015;26(6):234–241. doi:10.5830/CVJA-2015-052
  • Ibe T, Wada H, Sakakura K, et al. Cardiac index predicts long-term outcomes in patients with heart failure. PLoS One. 2021;16(6):e0252833. doi:10.1371/journal.pone.0252833
  • Parmana IMA, Boom CE, Rachmadi L, et al. Myocardial protecting role of glutamine in patients with low ejection fraction undergoing elective on-pump coronary artery bypass graft surgery. Vasc Health Risk Manag. 2022;18:219–231. doi:10.2147/VHRM.S361298
  • Fishbein MC, Wang T, Matijasevic M, Hong L, Apple FS. Myocardial tissue troponins T and I: an immunohistochemical study in experimental models of myocardial ischemia. Cardiovasc Pathol. 2003;12(2):65–71. doi:10.1016/S1054-8807(02)00188-6
  • Akoglu H. User’s guide to correlation coefficients. Turk J Emerg Med. 2018;18(3):91–93. doi:10.1016/j.tjem.2018.08.001
  • Yan H, Zhang Y, Sjun LV, et al. Effects of glutamine treatment on myocardial damage and cardiac function in rats after severe burn injury. Int J Clin Exp Pathol. 2012;5(7):651–659.
  • Bolotin G, Raman J, Williams U, Bacha E, Kocherginsky M, Jeevanandam V. Glutamine improves myocardial function following ischemia-reperfusion injury. Asian Cardiovasc Thorac Ann. 2007;15(6):463–467. doi:10.1177/021849230701500603
  • Fathi H, Mowafy S, Helmy K. Evaluation of the effectiveness of glutamine in different times of administration in patients undergoing cardiopulmonary bypass during elective cardiac surgeries: randomized controlled study. Egypt J Cardiothorac Anesth. 2018;12(1):4–11. doi:10.4103/ejca.ejca_4_16
  • Engel JM, Mühling J, Kwapisz M, Heidt M. Glutamine administration in patients undergoing cardiac surgery and the influence on blood glutathione levels. Acta Anaesthesiol Scand. 2009;53(10):1317–1323. doi:10.1111/j.1399-6576.2009.02084.x
  • Rajendram R, Preedy VR, Patel VB, eds. Glutamine in Clinical Nutrition. Humana Press; 2015.
  • Fischer UM, Cox CS, Laine GA, Mehlhorn U, Bloch W, Allen SJ. Induction of cardioplegic arrest immediately activates the myocardial apoptosis signal pathway. Am J Physiol Heart Circ Physiol. 2007;292(3):H1630–H1633. doi:10.1152/ajpheart.00006.2005
  • Sufit A, Weitzel LB, Hamiel C, et al. Pharmacologically dosed oral glutamine reduces myocardial injury in patients undergoing cardiac surgery. JPEN J Parenter Enteral Nutr. 2012;36(5):556–561. doi:10.1177/0148607112448823