Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

References

• Heikkila A, Kaipia A, Venermo M, Kautiainen H, Korhonen P. Relationship of blood pressure and erectile dysfunction in men without previously diagnosed hypertension. J Sex Med. 2017;14(11):1336–1341.
   PubMed Web of Science ®Google Scholar
• Ajeigbe OF, Oboh G, Ademosun AO. Ficus plants in the co-management of hypertension and erectile dysfunction. Phytomedicine Plus. 2021;1(3):100096. doi:10.1016/j.phyplu.2021.100096
   Google Scholar
• Lunelli RP, Irigoyen MC, Goldmeier S. Hypertension as a risk factor for female sexual dysfunction: cross-sectional study. Rev Bras Enferm. 2018;71(5):2477–2482. doi:10.1590/0034-7167-2017-0259
   PubMed Web of Science ®Google Scholar
• Wang XY, Huang W, Zhang Y. Relation between hypertension and erectile dysfunction: a meta-analysis of cross-section studies. Int J Impot Res. 2018;30(3):141–146. doi:10.1038/s41443-018-0020-z
   PubMed Web of Science ®Google Scholar
• Gur O, Gurkan S, Yumun G, Turker P. The comparison of the effects of nebivolol and metoprolol on erectile dysfunction in the cases with coronary artery bypass surgery. Anna Thorac Cardiovasc Surg. 2017;23(2):91–95. doi:10.5761/atcs.oa.16-00242
   PubMed Web of Science ®Google Scholar
• Sharp RP, Gales BJ. Nebivolol versus other beta blockers in patients with hypertension and erectile dysfunction. Ther Adv Urol. 2017;9(2):59–63. doi:10.1177/1756287216685027
   PubMed Web of Science ®Google Scholar
• Salman M, Shehzadi N, Khan MT, et al. Erectile dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention. Trop J Pharm Res. 2016;15(4):869–876. doi:10.4314/tjpr.v15i4.29
   Web of Science ®Google Scholar
• Ravikanth R. Diagnostic categorization of erectile dysfunction using duplex color Doppler ultrasonography and significance of phentolamine redosing in abolishing false diagnosis of venous leak impotence: a single center experience. Indian J Radiol Imag. 2020;30(3):344–353. doi:10.4103/ijri.IJRI_419_19
   PubMed Web of Science ®Google Scholar
• Altamar CMA, Torres OAC, Castillo CHM, Ramos SM, Barreto EI. Prevalence of comorbidities and risk factors associated with erectile dysfunction in hypertension patients in Cartagena HUC in 2013. Urolog Colomb. 2014;23(2):109–112. doi:10.1016/S0120-789X(14)50036-6
   Google Scholar
• Rajfer J, Miner MM. Hypertension: the link between erectile dysfunction and coronary artery disease. J Mens Health. 2013;10(3):81–85. doi:10.1089/jomh.2013.1503
   Web of Science ®Google Scholar
• de Oliveira L, Chiavegato LD, Arakaki JSO, et al. Prevalence of sexual dysfunction in women with pulmonary hypertension and associated factors. Heart Lung. 2021;50(5):714–719. doi:10.1016/j.hrtlng.2021.04.018
   PubMed Web of Science ®Google Scholar
• Vintoniv OR, Popadynets IR, Hrodzinskyy VI, Melnyk SV, Herych PR, Halipchak IM. Algorithm of diagnostics of erectile dysfunction in patients with arterial hypertension and dynamics of arterial blood pressure against the background of androgenic deficiency. Med Perspek. 2021;26(2):119–125. doi:10.26641/2307-0404.2021.2.234638
   Google Scholar
• Santana LM, Perin L, Lunelli R, et al. Sexual dysfunction in women with hypertension: a systematic review and meta-analysis. Curr Hypertens Rep. 2019;21(3). doi:10.1007/s11906-019-0925-z
   PubMed Web of Science ®Google Scholar
• Ates I, Mutlu D, Kaya Z, Okutucu S, Sarier M, Cilingiroglu M. Relationship between masked arterial hypertension and erectile dysfunction. J Mens Health. 2020;16(SpecialIss):e4–12.
   Google Scholar
• Viigimaa M, Vlachopoulos C, Doumas M, et al. Update of the position paper on arterial hypertension and erectile dysfunction. J Hypertens. 2020;38(7):1220–1234. doi:10.1097/HJH.0000000000002382
   PubMed Web of Science ®Google Scholar
• Ceyhan O, Ozen B, Simsek N, Dogan A. Sexuality and marital adjustment in women with hypertension in Turkey: how culture affects sex. J Hum Hypertens. 2019;33(5):378–384. doi:10.1038/s41371-019-0181-3
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG and Tetzlaff J, et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol, 62(10), e1–e34. doi:10.1016/j.jclinepi.2009.06.006
   PubMed Web of Science ®Google Scholar
• Wang TD, Lee CK, Chia YC, et al. Hypertension and erectile dysfunction: the role of endovascular therapy in Asia. J Clin Hypertens. 2021;23(3):481–488. doi:10.1111/jch.14123
   Web of Science ®Google Scholar
• Abolyosr A, ElSagheer GA, Abdel-Kader MS, Hassan AM, Abou-Zeid AMM. Evaluation of the effect of sildenafil and/or doxazosin on Benign prostatic hyperplasia-related lower urinary tract symptoms and erectile dysfunction. Urol Ann. 2013;5(4):237–240. doi:10.4103/0974-7796.120293
   PubMedGoogle Scholar
• Koroglu G, Kaya-Sezginer E, Yilmaz-Oral D, Gur S. Management of erectile dysfunction: an under-recognition of hypertension. Curr Pharm Des. 2018;24(30):3506–3519. doi:10.2174/1381612824666180828104350
   PubMed Web of Science ®Google Scholar
• Ning L, Yang L. Hypertension might be a risk factor for erectile dysfunction: a meta-analysis. Andrologia. 2017;49(4). doi:10.1111/and.12644
   PubMed Web of Science ®Google Scholar
• Babić Z. [The importance of valsartan in the treatment of hypertonic patients with erectile dysfunction]. Važnost valsartana u liječenju hipertoničara s erektilnom disfunkcijom. Cardiol Croat. 2015;10(11–12):290–294. doi:10.15836/ccar2015.290
   Google Scholar
• Shin EY, Park JH, Shin ME, Song JE, Khang G. Formulation of double-layer tadalafil and amlodipine complex tablets to treat erectile dysfunction and hypertension. Polymer-Korea. 2019;43(2):274–281. doi:10.7317/pk.2019.43.2.274
   Web of Science ®Google Scholar
• Choy CL, Sidi H, Koon CS, et al. Systematic review and meta-analysis for sexual dysfunction in women with hypertension. J Sex Med. 2019;16(7):1029–1048. doi:10.1016/j.jsxm.2019.04.007
   PubMed Web of Science ®Google Scholar
• Nascimento ER, Maia ACO, Nardi AE, Silva AC. Sexual dysfunction in arterial hypertension women: the role of depression and anxiety. J Affect Disord. 2015;181:96–100. doi:10.1016/j.jad.2015.03.050
   PubMed Web of Science ®Google Scholar
• Stavropoulos K, Imprialos K, Petidis K, et al. Female sexual dysfunction with diuretics in women with arterial hypertension. J Hypertens. 2018;36(Supplement 1):e196. doi:10.1097/01.hjh.0000539543.01157.f5
   Google Scholar
• Zhong Q, Anderson Y. Management of hypertension with female sexual dysfunction. Medicina. 2022;58:5.
   Google Scholar
• Magfira N. 4-1 sexual dysfunction in women with hypertension: a cross-sectional study. J Hypertens. 2020;38(Supplement 1):e7. doi:10.1097/01.hjh.0000689184.98116.c2
   Google Scholar
• Koutsampasopoulos K, Imprialos K, Stavropoulos K, et al. The relation of hypertension with female sexual dysfunction: the heart failure paradigm. J Hypertens. 2019;37(29). doi:10.1097/01.hjh.0000573072.90280.a7
   Google Scholar
• De Franciscis P, Mainini G, Messalli EM, et al. Arterial hypertension and female sexual dysfunction in postmenopausal women. Clin Exp Obstet Gynecol. 2013;40:1.
   Web of Science ®Google Scholar
• Imprialos K, Stavropoulos K, Boutari C, et al. Prevalence of sexual dysfunction in females with resistant hypertension. J Hypertens. 2016;34:E174–E174. doi:10.1097/01.hjh.0000491819.57465.35
   Web of Science ®Google Scholar
• Yildirim U, Karakayali M, Uslu M, et al. Association between international index of erectile function-5 scores and circadian patterns of newly diagnosed hypertension in erectile dysfunction patients. Andrologia. 2022;54(11). doi:10.1111/and.14622
   Web of Science ®Google Scholar
• Alekseeva T, Mova EE, Starostin I, Gamidov S, Litvin A. Relationship between obstructive sleep apnoea and erectile dysfunction in patients with arterial hypertension. J Hypertens. 2018;36:28.
   Web of Science ®Google Scholar
• Arcila JFU. Prevalence of comorbidities and risk factors in hypertension patients associated with erectile dysfunction in Cartagena HUC in 2013 | prevalencia de comorbilidades y factores de riesgo asociados a disfuncion erectil en pacientes hipertensos del Hospital U. Urolog Colomb. 2014;23:2.
   Google Scholar
• Kim SW, Jung J, Kim Y, et al. Efficacy and safety of fixed dose combination of amlodipine and tadalafil in both erectile dysfunction and hypertension patients being treated with amlodipine. J Sex Med. 2017;14(1):S29–30. doi:10.1016/j.jsxm.2016.11.065
   Web of Science ®Google Scholar
• Busari OA, Opadijo OG, Olarewaju TO, Oladosu YO. Male erectile dysfunction and microalbuminuria in adult Nigerians with essential hypertension. N Am J Med Sci. 2013;5(1):32–36. doi:10.4103/1947-2714.106191
   PubMedGoogle Scholar
• Al Khaja KAJ, Sequeira RP, Alkhaja AK, Damanhori AHH. Antihypertensive drugs and male sexual dysfunction: a review of adult hypertension guideline recommendations. J Cardiovasc Pharmacol Ther. 2016;21(3):233–234. doi:10.1177/1074248415598321
   PubMed Web of Science ®Google Scholar
• Kakkavas A, Tsioufis C, Tsiachris D, et al. Erectile dysfunction and target organ damage in the early stages of hypertension. J Clin Hypertens. 2013;15(9):644–649. doi:10.1111/jch.12159
   Web of Science ®Google Scholar
• Boutari C, Imprialos KP, Stavropoulos K, et al. Prevalence and severity of erectile dysfunction in patients with resistant hypertension. J Hypertens. 2016;34:E259–E259. doi:10.1097/01.hjh.0000492091.81271.cf
   Web of Science ®Google Scholar
• Bouhanick B, Blacher J, Huyghe E, et al. Sexual dysfunction and antihypertensive treatment: involvement of the different therapeutic classes and what to do about the treatment of hypertension. Pres Med. 2019;48(11):1222–1228. doi:10.1016/j.lpm.2019.05.029
   PubMed Web of Science ®Google Scholar
• Boutari C, Doumas M, Manolis AJ. Approach to erectile dysfunction in patients with hypertension and coronary artery disease. Hypert Cardiovasc Dis. 2016;2016:309–327.
   Google Scholar
• Satti RRUH, Rasheed SA, Gul R, Athar MH. Erectile dysfunction among patients with hypertension and associated socio-demographic factors. Pakistan Armed Forces Med J. 2022;72:S182–5.
   Google Scholar
• De Oliveira AA, Nunes KP. Hypertension and erectile dysfunction: breaking down the challenges. Am J Hypertens. 2021;34(2):134–142. doi:10.1093/ajh/hpaa143
   PubMed Web of Science ®Google Scholar
• Ejike CECC, Eze KC, Okpan CE. Erectile dysfunction and hypertension among adult males in Umudike, Nigeria: a study of prevalence and relationships. Asian J Sci Res. 2015;8(3):315–323. doi:10.3923/ajsr.2015.315.323
   Google Scholar
• Karakurt D, Ede H, Turan Y, Gurel A, Ardahanli I, Sarak T. Evaluation of the relationship between erectile dysfunction and epicardial fat tissue thickness and carotid intima-media thickness in patients with newly diagnosed hypertension. Turk Kardiyol Dernegi Arsivi Archiv Turkish Soc Cardiol. 2020;48:8.
   Web of Science ®Google Scholar
• Labudová M, Beňačka J, Zambojová I. Incidence and severity of erectile dysfunction in patients with hypertension. Cardiology Letters. 2021;30(1):37–41. doi:10.4149/Cardiol_2021_1_7
   Google Scholar
• Ioakeimidis N, Vlachopoulos C, Angelis A, et al. Arterial function and structure parameters are significantly impaired in pre-diabetic men with arterial hypertension and erectile dysfunction. Eur Heart J. 2018;39. doi:10.1093/eurheartj/ehy565.1158
   Web of Science ®Google Scholar
• Koutsampasopoulos K, Imprialos K, Stavropoulos K, et al. Hypertension and erectile dysfunction: new insights in heart failure patients. J Hypertens. 2019;37(29):e118. doi:10.1097/01.hjh.0000571536.94186.73
   Google Scholar
• Viigimaa M, Vlachopoulos C, Lazaridis A, Doumas M. Management of erectile dysfunction in hypertension: tips and tricks. World J Cardiol. 2014;6(9):908–915. doi:10.4330/wjc.v6.i9.908
   PubMedGoogle Scholar
• de Simone G, Mancusi C. Erectile dysfunction and arterial hypertension: still looking for a scapegoat. Eur J Intern Med. 2020;81:22–23. doi:10.1016/j.ejim.2020.09.004
   PubMed Web of Science ®Google Scholar
• Woznicka-Leskiewicz L, Posadzy-Malaczynska A. Sexual dysfunction in women with hypertension depending on the kind of antihypertensive therapy. J Hypertens. 2017;35:E60–1. doi:10.1097/01.hjh.0000523134.92900.53
   Web of Science ®Google Scholar
• Salobir B, Brguljan-Hitij J, Dolenc P, et al. Impact of valsartan and combination of valsartan and hydrochlorothiazide on erectile dysfunction in patients with mild to moderate hypertension. J Hypertens. 2016;34:E275–E275. doi:10.1097/01.hjh.0000492137.63346.75
   Web of Science ®Google Scholar
• Gungor G, Perk H, Soyupek S, Baykal B, Demir M, Sezer MT. Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: a prospective, randomized, cross-over, clinical trial. Eur J Intern Med. 2022;103:69–75. doi:10.1016/j.ejim.2022.06.013
   PubMed Web of Science ®Google Scholar
• Persu A. Sexuality and antihypertensive drugs. Louv Med. 2016;135(8):493–496.
   Google Scholar
• Yangyun W, Xilong W, Guowei S, Jiayang H, Jun Z, Yanbin Z. Comparison of solifenacin monotherapy with solifenacin and doxazosin combination therapy for the treatment of severe overactive bladder with sexual dysfunction among youthful and middle-aged females. Chin J Androl. 2014;28(2):26–31.
   Google Scholar
• Ala M, Mohammad Jafari R, Dehpour AR. Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: thinking about new indications. Fundam Clin Pharmacol. 2021;35(2):235–259. doi:10.1111/fcp.12633
   PubMed Web of Science ®Google Scholar
• Gur S, Kadowitz PJ, Gokce A, Sikka SC, Lokman U, Hellstrom WJG. Update on drug interactions with phosphodiesterase-5 inhibitors prescribed as first-line therapy for patients with erectile dysfunction or pulmonary hypertension. Curr Drug Metab. 2013;14(2):265–269.
   PubMed Web of Science ®Google Scholar
• Shkolyar E, Li SF, Tang J, Eisenberg ML. Risk of melanoma with phosphodiesterase type 5 inhibitor use among patients with erectile dysfunction, pulmonary hypertension, and lower urinary tract symptoms. J Sex Med. 2018;15(7):982–989. doi:10.1016/j.jsxm.2018.05.002
   PubMed Web of Science ®Google Scholar
• Diosdado-Figueiredo M, Balboa-Barreiro V, Pértega-Diaz S, Seoane-Pillado T, Pita-Fernández S, Chantada-Abal V. Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life. Med Clin. 2019;152(6):209–215. doi:10.1016/j.medcli.2018.05.022
   PubMed Web of Science ®Google Scholar
• Skeldon SC, Detsky AS, Goldenberg SL, Law MR. Erectile dysfunction and undiagnosed diabetes, hypertension, and hypercholesterolemia. Ann Fam Med. 2015;13(4):331–335. doi:10.1370/afm.1816
   PubMed Web of Science ®Google Scholar
• Paternostro R, Heinisch BB, Reiberger T, et al. Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension. Liver Internat. 2018;38(8):1427–1436. doi:10.1111/liv.13704
   PubMed Web of Science ®Google Scholar
• Kratiras Z, Ioakeimidis N, Rokkas K, et al. Testosterone levels in erectile dysfunction patients with arterial hypertension and vascular organ damage. J Sex Med. 2016;13(5):S76–S76. doi:10.1016/j.jsxm.2016.03.007
   Google Scholar
• Alekseeva TA, Shariya MA, Gamidov SI, et al. Interrelation of erectile dysfunction with obesity in patients with arterial hypertension. Ter Arkh. 2018;90(12):84–89. doi:10.26442/00403660.2018.12.000013
   PubMed Web of Science ®Google Scholar
• Alekseeva T, Litvin A, Gamidov S, Shariya M, Chazova I. Pericardial fat and erectile dysfunction in patients with obesity, obstructive sleep apnea and arterial hypertension. J Hypertens. 2019;37(29):e205–e206. doi:10.1097/01.hjh.0000572648.60915.37
   Google Scholar
• Romano L, Zagari RM, Arcaniolo D, et al. Sexual dysfunction in gastroenterological patients: do gastroenterologists care enough? A nationwide survey from the Italian Society of Gastroenterology (SIGE). Dig Liver Dis. 2023;54(11):1494–1501. doi:10.1016/j.dld.2022.05.016
   Google Scholar
• Romano L, Pellegrino R, Sciorio C, et al. Erectile and sexual dysfunction in male and female patients with celiac disease: a cross-sectional observational study. Andrology. 2023;10(5):910–918. doi:10.1111/andr.13186
   Web of Science ®Google Scholar
• Cantone E, Massanova M, Crocetto F, et al. The relationship between obstructive sleep apnoea and erectile dysfunction: an underdiagnosed link? A prospective cross-sectional study. Andrologia. 2023;54:9.
   Google Scholar
• Leuci S, Coppola N, Adamo D, et al. Sexual desire, mood disorders and sleep disturbances in female BMS patients: a controlled study. J Oral Pathol Med. 2023;52(3):276–282. doi:10.1111/jop.13362
   PubMed Web of Science ®Google Scholar
• Veenstra G. Race, gender, class, sexuality (RGCS) and hypertension. Soc Sci Med. 2013;89:16–24. doi:10.1016/j.socscimed.2013.04.014
   PubMed Web of Science ®Google Scholar