441
Views
0
CrossRef citations to date
0
Altmetric
REVIEW

Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

, , ORCID Icon &
Pages 691-705 | Received 08 Sep 2023, Accepted 27 Oct 2023, Published online: 02 Nov 2023

References

  • Heikkila A, Kaipia A, Venermo M, Kautiainen H, Korhonen P. Relationship of blood pressure and erectile dysfunction in men without previously diagnosed hypertension. J Sex Med. 2017;14(11):1336–1341.
  • Ajeigbe OF, Oboh G, Ademosun AO. Ficus plants in the co-management of hypertension and erectile dysfunction. Phytomedicine Plus. 2021;1(3):100096. doi:10.1016/j.phyplu.2021.100096
  • Lunelli RP, Irigoyen MC, Goldmeier S. Hypertension as a risk factor for female sexual dysfunction: cross-sectional study. Rev Bras Enferm. 2018;71(5):2477–2482. doi:10.1590/0034-7167-2017-0259
  • Wang XY, Huang W, Zhang Y. Relation between hypertension and erectile dysfunction: a meta-analysis of cross-section studies. Int J Impot Res. 2018;30(3):141–146. doi:10.1038/s41443-018-0020-z
  • Gur O, Gurkan S, Yumun G, Turker P. The comparison of the effects of nebivolol and metoprolol on erectile dysfunction in the cases with coronary artery bypass surgery. Anna Thorac Cardiovasc Surg. 2017;23(2):91–95. doi:10.5761/atcs.oa.16-00242
  • Sharp RP, Gales BJ. Nebivolol versus other beta blockers in patients with hypertension and erectile dysfunction. Ther Adv Urol. 2017;9(2):59–63. doi:10.1177/1756287216685027
  • Salman M, Shehzadi N, Khan MT, et al. Erectile dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention. Trop J Pharm Res. 2016;15(4):869–876. doi:10.4314/tjpr.v15i4.29
  • Ravikanth R. Diagnostic categorization of erectile dysfunction using duplex color Doppler ultrasonography and significance of phentolamine redosing in abolishing false diagnosis of venous leak impotence: a single center experience. Indian J Radiol Imag. 2020;30(3):344–353. doi:10.4103/ijri.IJRI_419_19
  • Altamar CMA, Torres OAC, Castillo CHM, Ramos SM, Barreto EI. Prevalence of comorbidities and risk factors associated with erectile dysfunction in hypertension patients in Cartagena HUC in 2013. Urolog Colomb. 2014;23(2):109–112. doi:10.1016/S0120-789X(14)50036-6
  • Rajfer J, Miner MM. Hypertension: the link between erectile dysfunction and coronary artery disease. J Mens Health. 2013;10(3):81–85. doi:10.1089/jomh.2013.1503
  • de Oliveira L, Chiavegato LD, Arakaki JSO, et al. Prevalence of sexual dysfunction in women with pulmonary hypertension and associated factors. Heart Lung. 2021;50(5):714–719. doi:10.1016/j.hrtlng.2021.04.018
  • Vintoniv OR, Popadynets IR, Hrodzinskyy VI, Melnyk SV, Herych PR, Halipchak IM. Algorithm of diagnostics of erectile dysfunction in patients with arterial hypertension and dynamics of arterial blood pressure against the background of androgenic deficiency. Med Perspek. 2021;26(2):119–125. doi:10.26641/2307-0404.2021.2.234638
  • Santana LM, Perin L, Lunelli R, et al. Sexual dysfunction in women with hypertension: a systematic review and meta-analysis. Curr Hypertens Rep. 2019;21(3). doi:10.1007/s11906-019-0925-z
  • Ates I, Mutlu D, Kaya Z, Okutucu S, Sarier M, Cilingiroglu M. Relationship between masked arterial hypertension and erectile dysfunction. J Mens Health. 2020;16(SpecialIss):e4–12.
  • Viigimaa M, Vlachopoulos C, Doumas M, et al. Update of the position paper on arterial hypertension and erectile dysfunction. J Hypertens. 2020;38(7):1220–1234. doi:10.1097/HJH.0000000000002382
  • Ceyhan O, Ozen B, Simsek N, Dogan A. Sexuality and marital adjustment in women with hypertension in Turkey: how culture affects sex. J Hum Hypertens. 2019;33(5):378–384. doi:10.1038/s41371-019-0181-3
  • Liberati A, Altman DG and Tetzlaff J, et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol, 62(10), e1–e34. doi:10.1016/j.jclinepi.2009.06.006
  • Wang TD, Lee CK, Chia YC, et al. Hypertension and erectile dysfunction: the role of endovascular therapy in Asia. J Clin Hypertens. 2021;23(3):481–488. doi:10.1111/jch.14123
  • Abolyosr A, ElSagheer GA, Abdel-Kader MS, Hassan AM, Abou-Zeid AMM. Evaluation of the effect of sildenafil and/or doxazosin on Benign prostatic hyperplasia-related lower urinary tract symptoms and erectile dysfunction. Urol Ann. 2013;5(4):237–240. doi:10.4103/0974-7796.120293
  • Koroglu G, Kaya-Sezginer E, Yilmaz-Oral D, Gur S. Management of erectile dysfunction: an under-recognition of hypertension. Curr Pharm Des. 2018;24(30):3506–3519. doi:10.2174/1381612824666180828104350
  • Ning L, Yang L. Hypertension might be a risk factor for erectile dysfunction: a meta-analysis. Andrologia. 2017;49(4). doi:10.1111/and.12644
  • Babić Z. [The importance of valsartan in the treatment of hypertonic patients with erectile dysfunction]. Važnost valsartana u liječenju hipertoničara s erektilnom disfunkcijom. Cardiol Croat. 2015;10(11–12):290–294. doi:10.15836/ccar2015.290
  • Shin EY, Park JH, Shin ME, Song JE, Khang G. Formulation of double-layer tadalafil and amlodipine complex tablets to treat erectile dysfunction and hypertension. Polymer-Korea. 2019;43(2):274–281. doi:10.7317/pk.2019.43.2.274
  • Choy CL, Sidi H, Koon CS, et al. Systematic review and meta-analysis for sexual dysfunction in women with hypertension. J Sex Med. 2019;16(7):1029–1048. doi:10.1016/j.jsxm.2019.04.007
  • Nascimento ER, Maia ACO, Nardi AE, Silva AC. Sexual dysfunction in arterial hypertension women: the role of depression and anxiety. J Affect Disord. 2015;181:96–100. doi:10.1016/j.jad.2015.03.050
  • Stavropoulos K, Imprialos K, Petidis K, et al. Female sexual dysfunction with diuretics in women with arterial hypertension. J Hypertens. 2018;36(Supplement 1):e196. doi:10.1097/01.hjh.0000539543.01157.f5
  • Zhong Q, Anderson Y. Management of hypertension with female sexual dysfunction. Medicina. 2022;58:5.
  • Magfira N. 4-1 sexual dysfunction in women with hypertension: a cross-sectional study. J Hypertens. 2020;38(Supplement 1):e7. doi:10.1097/01.hjh.0000689184.98116.c2
  • Koutsampasopoulos K, Imprialos K, Stavropoulos K, et al. The relation of hypertension with female sexual dysfunction: the heart failure paradigm. J Hypertens. 2019;37(29). doi:10.1097/01.hjh.0000573072.90280.a7
  • De Franciscis P, Mainini G, Messalli EM, et al. Arterial hypertension and female sexual dysfunction in postmenopausal women. Clin Exp Obstet Gynecol. 2013;40:1.
  • Imprialos K, Stavropoulos K, Boutari C, et al. Prevalence of sexual dysfunction in females with resistant hypertension. J Hypertens. 2016;34:E174–E174. doi:10.1097/01.hjh.0000491819.57465.35
  • Yildirim U, Karakayali M, Uslu M, et al. Association between international index of erectile function-5 scores and circadian patterns of newly diagnosed hypertension in erectile dysfunction patients. Andrologia. 2022;54(11). doi:10.1111/and.14622
  • Alekseeva T, Mova EE, Starostin I, Gamidov S, Litvin A. Relationship between obstructive sleep apnoea and erectile dysfunction in patients with arterial hypertension. J Hypertens. 2018;36:28.
  • Arcila JFU. Prevalence of comorbidities and risk factors in hypertension patients associated with erectile dysfunction in Cartagena HUC in 2013 | prevalencia de comorbilidades y factores de riesgo asociados a disfuncion erectil en pacientes hipertensos del Hospital U. Urolog Colomb. 2014;23:2.
  • Kim SW, Jung J, Kim Y, et al. Efficacy and safety of fixed dose combination of amlodipine and tadalafil in both erectile dysfunction and hypertension patients being treated with amlodipine. J Sex Med. 2017;14(1):S29–30. doi:10.1016/j.jsxm.2016.11.065
  • Busari OA, Opadijo OG, Olarewaju TO, Oladosu YO. Male erectile dysfunction and microalbuminuria in adult Nigerians with essential hypertension. N Am J Med Sci. 2013;5(1):32–36. doi:10.4103/1947-2714.106191
  • Al Khaja KAJ, Sequeira RP, Alkhaja AK, Damanhori AHH. Antihypertensive drugs and male sexual dysfunction: a review of adult hypertension guideline recommendations. J Cardiovasc Pharmacol Ther. 2016;21(3):233–234. doi:10.1177/1074248415598321
  • Kakkavas A, Tsioufis C, Tsiachris D, et al. Erectile dysfunction and target organ damage in the early stages of hypertension. J Clin Hypertens. 2013;15(9):644–649. doi:10.1111/jch.12159
  • Boutari C, Imprialos KP, Stavropoulos K, et al. Prevalence and severity of erectile dysfunction in patients with resistant hypertension. J Hypertens. 2016;34:E259–E259. doi:10.1097/01.hjh.0000492091.81271.cf
  • Bouhanick B, Blacher J, Huyghe E, et al. Sexual dysfunction and antihypertensive treatment: involvement of the different therapeutic classes and what to do about the treatment of hypertension. Pres Med. 2019;48(11):1222–1228. doi:10.1016/j.lpm.2019.05.029
  • Boutari C, Doumas M, Manolis AJ. Approach to erectile dysfunction in patients with hypertension and coronary artery disease. Hypert Cardiovasc Dis. 2016;2016:309–327.
  • Satti RRUH, Rasheed SA, Gul R, Athar MH. Erectile dysfunction among patients with hypertension and associated socio-demographic factors. Pakistan Armed Forces Med J. 2022;72:S182–5.
  • De Oliveira AA, Nunes KP. Hypertension and erectile dysfunction: breaking down the challenges. Am J Hypertens. 2021;34(2):134–142. doi:10.1093/ajh/hpaa143
  • Ejike CECC, Eze KC, Okpan CE. Erectile dysfunction and hypertension among adult males in Umudike, Nigeria: a study of prevalence and relationships. Asian J Sci Res. 2015;8(3):315–323. doi:10.3923/ajsr.2015.315.323
  • Karakurt D, Ede H, Turan Y, Gurel A, Ardahanli I, Sarak T. Evaluation of the relationship between erectile dysfunction and epicardial fat tissue thickness and carotid intima-media thickness in patients with newly diagnosed hypertension. Turk Kardiyol Dernegi Arsivi Archiv Turkish Soc Cardiol. 2020;48:8.
  • Labudová M, Beňačka J, Zambojová I. Incidence and severity of erectile dysfunction in patients with hypertension. Cardiology Letters. 2021;30(1):37–41. doi:10.4149/Cardiol_2021_1_7
  • Ioakeimidis N, Vlachopoulos C, Angelis A, et al. Arterial function and structure parameters are significantly impaired in pre-diabetic men with arterial hypertension and erectile dysfunction. Eur Heart J. 2018;39. doi:10.1093/eurheartj/ehy565.1158
  • Koutsampasopoulos K, Imprialos K, Stavropoulos K, et al. Hypertension and erectile dysfunction: new insights in heart failure patients. J Hypertens. 2019;37(29):e118. doi:10.1097/01.hjh.0000571536.94186.73
  • Viigimaa M, Vlachopoulos C, Lazaridis A, Doumas M. Management of erectile dysfunction in hypertension: tips and tricks. World J Cardiol. 2014;6(9):908–915. doi:10.4330/wjc.v6.i9.908
  • de Simone G, Mancusi C. Erectile dysfunction and arterial hypertension: still looking for a scapegoat. Eur J Intern Med. 2020;81:22–23. doi:10.1016/j.ejim.2020.09.004
  • Woznicka-Leskiewicz L, Posadzy-Malaczynska A. Sexual dysfunction in women with hypertension depending on the kind of antihypertensive therapy. J Hypertens. 2017;35:E60–1. doi:10.1097/01.hjh.0000523134.92900.53
  • Salobir B, Brguljan-Hitij J, Dolenc P, et al. Impact of valsartan and combination of valsartan and hydrochlorothiazide on erectile dysfunction in patients with mild to moderate hypertension. J Hypertens. 2016;34:E275–E275. doi:10.1097/01.hjh.0000492137.63346.75
  • Gungor G, Perk H, Soyupek S, Baykal B, Demir M, Sezer MT. Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: a prospective, randomized, cross-over, clinical trial. Eur J Intern Med. 2022;103:69–75. doi:10.1016/j.ejim.2022.06.013
  • Persu A. Sexuality and antihypertensive drugs. Louv Med. 2016;135(8):493–496.
  • Yangyun W, Xilong W, Guowei S, Jiayang H, Jun Z, Yanbin Z. Comparison of solifenacin monotherapy with solifenacin and doxazosin combination therapy for the treatment of severe overactive bladder with sexual dysfunction among youthful and middle-aged females. Chin J Androl. 2014;28(2):26–31.
  • Ala M, Mohammad Jafari R, Dehpour AR. Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: thinking about new indications. Fundam Clin Pharmacol. 2021;35(2):235–259. doi:10.1111/fcp.12633
  • Gur S, Kadowitz PJ, Gokce A, Sikka SC, Lokman U, Hellstrom WJG. Update on drug interactions with phosphodiesterase-5 inhibitors prescribed as first-line therapy for patients with erectile dysfunction or pulmonary hypertension. Curr Drug Metab. 2013;14(2):265–269.
  • Shkolyar E, Li SF, Tang J, Eisenberg ML. Risk of melanoma with phosphodiesterase type 5 inhibitor use among patients with erectile dysfunction, pulmonary hypertension, and lower urinary tract symptoms. J Sex Med. 2018;15(7):982–989. doi:10.1016/j.jsxm.2018.05.002
  • Diosdado-Figueiredo M, Balboa-Barreiro V, Pértega-Diaz S, Seoane-Pillado T, Pita-Fernández S, Chantada-Abal V. Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life. Med Clin. 2019;152(6):209–215. doi:10.1016/j.medcli.2018.05.022
  • Skeldon SC, Detsky AS, Goldenberg SL, Law MR. Erectile dysfunction and undiagnosed diabetes, hypertension, and hypercholesterolemia. Ann Fam Med. 2015;13(4):331–335. doi:10.1370/afm.1816
  • Paternostro R, Heinisch BB, Reiberger T, et al. Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension. Liver Internat. 2018;38(8):1427–1436. doi:10.1111/liv.13704
  • Kratiras Z, Ioakeimidis N, Rokkas K, et al. Testosterone levels in erectile dysfunction patients with arterial hypertension and vascular organ damage. J Sex Med. 2016;13(5):S76–S76. doi:10.1016/j.jsxm.2016.03.007
  • Alekseeva TA, Shariya MA, Gamidov SI, et al. Interrelation of erectile dysfunction with obesity in patients with arterial hypertension. Ter Arkh. 2018;90(12):84–89. doi:10.26442/00403660.2018.12.000013
  • Alekseeva T, Litvin A, Gamidov S, Shariya M, Chazova I. Pericardial fat and erectile dysfunction in patients with obesity, obstructive sleep apnea and arterial hypertension. J Hypertens. 2019;37(29):e205–e206. doi:10.1097/01.hjh.0000572648.60915.37
  • Romano L, Zagari RM, Arcaniolo D, et al. Sexual dysfunction in gastroenterological patients: do gastroenterologists care enough? A nationwide survey from the Italian Society of Gastroenterology (SIGE). Dig Liver Dis. 2023;54(11):1494–1501. doi:10.1016/j.dld.2022.05.016
  • Romano L, Pellegrino R, Sciorio C, et al. Erectile and sexual dysfunction in male and female patients with celiac disease: a cross-sectional observational study. Andrology. 2023;10(5):910–918. doi:10.1111/andr.13186
  • Cantone E, Massanova M, Crocetto F, et al. The relationship between obstructive sleep apnoea and erectile dysfunction: an underdiagnosed link? A prospective cross-sectional study. Andrologia. 2023;54:9.
  • Leuci S, Coppola N, Adamo D, et al. Sexual desire, mood disorders and sleep disturbances in female BMS patients: a controlled study. J Oral Pathol Med. 2023;52(3):276–282. doi:10.1111/jop.13362
  • Veenstra G. Race, gender, class, sexuality (RGCS) and hypertension. Soc Sci Med. 2013;89:16–24. doi:10.1016/j.socscimed.2013.04.014