Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study

References

• ChristianJBBourgeoisNSnipesRLoweKAPrevalence of severe (500 to 2,000 mg/dL) hypertriglyceridemia in United States adultsAm J Cardiol201110789189721247544
   PubMed Web of Science ®Google Scholar
• ReinerZCatapanoALDe BackerGEuropean Association for Cardiovascular Prevention and Rehabilitation. ESC Committee for Practice Guidelines (CPG) 2008–2010 and 2010–2012 Committees ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)Eur Heart J2011321769181821712404
   PubMed Web of Science ®Google Scholar
• National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final ReportCirculation20021063143342112485966
   PubMed Web of Science ®Google Scholar
• DavidsonMHJohnsonJRooneyMWKyleMLKlingDFA novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: The ECLIPSE (Epanova compared to Lovaza in a pharmacokinetic single-dose evaluation) studyJ Clin Lipidol2012657358423312053
   PubMed Web of Science ®Google Scholar
• IkedaISasakiEYasunamiHDigestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in ratsBiochim Biophys Acta199512592973048541338
   PubMedGoogle Scholar
• SmallDMThe effects of glyceride structure on absorption and metabolismAnnu Rev Nutr1991114134341892708
   PubMed Web of Science ®Google Scholar
• El BoustaniSColetteCMonnierLDescompsBCrastes de PauletAMendyFEnteral absorption in man of eicosapentaenoic acid in different chemical formsLipids1987227117142828810
   PubMed Web of Science ®Google Scholar
• HazraATripathiSKGhoshAPharmacology and therapeutic potential of the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fish oilsIndian J Pharmacol199931247264
   Google Scholar
• LawsonLDHughesBGHuman absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl estersBiochem Biophys Res Commun19881523283353358766
   PubMed Web of Science ®Google Scholar
• LawsonLDHughesBGAbsorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat mealBiochem Biophys Res Commun19881569609632847723
   PubMed Web of Science ®Google Scholar
• BeckermannBBenekeMSeitzIComparative bioavailability of eicosapentaenoic acid and docosahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteersArzneimittelforschung1990407007042144420
   PubMed Web of Science ®Google Scholar
• HansenJBGrimsgaardSNilsenHNordøyABønaaKHEffects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemiaLipids1998331311389507234
   PubMed Web of Science ®Google Scholar
• GuraKStrijboschRArnoldSMcPhersonCPuderMThe role of an intravenous fat emulsion composed of fish oil in a parenteral nutrition-dependent patient with hypertriglyceridemiaNutr Clin Pract20072266467218042955
   PubMed Web of Science ®Google Scholar
• Australian Government: Department of Health and AgeingTherapeutic Goods Administration. Australian Public Assessment Report (AusPAR) for omega-3-acid ethyl esters 902010 Available from: http://www.tga.gov.au/pdf/auspar/auspar-omacor.pdfAccessed March 22, 2013
   Google Scholar
• ChanDCWattsGFMoriTABarrettPHRedgraveTGBeilinLJRandomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesityAm J Clin Nutr20037730030712540386
   PubMed Web of Science ®Google Scholar
• YahagiNShimanoHHastyAHA crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acidsJ Biol Chem1999274358403584410585468
   PubMed Web of Science ®Google Scholar
• DavidsonMHMechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acidsAm J Cardiol20069827i33i
   PubMed Web of Science ®Google Scholar
• SteffenBTSteffenLMTracyREthnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation bio-markers in the Multi-Ethnic Study of Atherosclerosis (MESA)Eur J Clin Nutr20126660060522215136
   PubMed Web of Science ®Google Scholar
• LemaitreRNTanakaTTangWGenetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE ConsortiumPLoS Genet20117e100219321829377
   PubMed Web of Science ®Google Scholar
• KasteleinJJPMakiKCSusekovADose response of a novel free-fatty acid formulation of omega-3 for the management of dyslipidemia in patients with severe hypertriglyceridemia EpanoVa fOr Lowering Very High TriglycErides (The EVOLVE Trial)Abstract APS20204 presented at the American Heart Association Scientific SessionsLos Angeles, CANovember 6, 2012
   Google Scholar
• MakiKCOrloffDGNichollsSJA highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk statin-treated patients with residual hypertriglyceridemia (the ESPRIT Trial)Clin Ther2013 2013 Aug 30. pii:S0149-2918(13)00807-210.1016/j.clinthera.2013.07.420 [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• YokoyamaMOrigasaHMatsuzakiMEffects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysisLancet20073691090109817398308
   PubMed Web of Science ®Google Scholar