Immune-mediated keratoconjunctivitis sicca in dogs: current perspectives on management

References

• BerdoulayAEnglishRVNadelsteinBEffect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis siccaVet Ophthalmol20058422523216008701
   PubMed Web of Science ®Google Scholar
• KaswanRLSalisburyMAA new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporineVet Clin North Am Small Anim Pract1990205836132194349
   PubMed Web of Science ®Google Scholar
• KaswanRLSalisburyMALothrupCDInteraction of age and gender on occurrence of canine keratoconjunctivitis siccaProg Vet Comp Ophthalmol199119397
   Google Scholar
• HelperLCThe tear film in the dog. Causes and treatment of diseases associated with overproduction and underproduction of tearsAnim Eye Res199615511
   Google Scholar
• MooreCPDiseases and surgery of the lacrimal secretory systemGelattKNVeterinary Ophthalmology3rd edPhiladelphia, PALippincott Williams & Wilkins1999583607
   Google Scholar
• WilliamsDLImmunopathogenesis of keratoconjunctivitis sicca in the dogVet Clin North Am Small Anim Pract200838225126818299006
   PubMed Web of Science ®Google Scholar
• de AlmeidaDERoverattiCBritoFLConjunctival effects of canine distemper virus-induced keratoconjunctivitis siccaVet Ophthalmol200912421121519604335
   PubMed Web of Science ®Google Scholar
• AguirreGDRubinLFHarveyCEKeratoconjunctivitis sicca in dogsJ Am Vet Med Assoc19711589156615795104964
   PubMed Web of Science ®Google Scholar
• DodiPLZanottiCRossiSAloeLTear level of nerve growth factor in normal dogsActa Ophthalmol200987s2440 Special Issue: Abstracts from the 2009 European Association for Vision and Eye Research Conference
   Google Scholar
• HartleyCWilliamsDLAdamsVAEffect of age, gender, weight, and time of day on tear production in normal dogsVet Ophthalmol200691535716409246
   PubMed Web of Science ®Google Scholar
• OfriRLambrouGNAllgoewerIClinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: a comparison with cyclosporine AVet J2009179707717950639
   PubMed Web of Science ®Google Scholar
• GipsonIKYankauckasMSpurr-MichaudSJTisdaleASRinehartWCharacteristics of a glycoprotein in the ocular surface glycocalyxInvest Ophthalmol Vis Sci1992332182271370440
   PubMed Web of Science ®Google Scholar
• HerreraHDWeichslerNGómezJRde JalónJASevere, unilateral, unresponsive keratoconjunctivitis sicca in 16 juvenile Yorkshire terriersVet Ophthalmol200710528528817760706
   PubMed Web of Science ®Google Scholar
• WestermeyerHDWardDAAbramsKBreed predisposition to congenital alacrima in dogsVet Ophthalmol200912115
   PubMed Web of Science ®Google Scholar
• SanchezRFInnocentGMouldJBillsonFMCanine keratoconjunctivitis sicca: disease trends in a review of 229 casesJ Small Anim Pract200748421121717381766
   PubMed Web of Science ®Google Scholar
• BarnettKCCongenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the Cavalier King Charles spanielJ Small Anim Pract200647952452816961470
   PubMed Web of Science ®Google Scholar
• HartleyCDonaldsonDSmithKCCongenital keratoconjunctivitis sicca and ichthyosiform dermatosis in 25 Cavalier King Charles spaniel dogs. Part I: clinical signs, histopathology, and inheritanceVet Ophthalmol201215531532622212237
   PubMed Web of Science ®Google Scholar
• HartleyCBarnettKCPettittLFormanOPBlottSMellershCSCongenital keratoconjunctivitis sicca and ichthyosiform dermatosis in Cavalier King Charles spaniel dogs. Part II: candidate gene studyVet Ophthalmol201215532733222339941
   PubMed Web of Science ®Google Scholar
• MillerPEPancieraDLEffects of experimentally induced hypothyroidism on the eye and ocular adnexa of dogsAm J Vet Res19945556926978067619
   PubMed Web of Science ®Google Scholar
• CullenCLIhleSLWebbAAMcCarvilleCKeratoconjunctival effects if diabetes mellitus in dogsVet Ophthalmol20058421522416008700
   PubMed Web of Science ®Google Scholar
• CiaramellaPOlivaGLunaRDA retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantumVet Rec1997141215395439413121
   PubMed Web of Science ®Google Scholar
• NaranjoCFondevilaDLeivaMRouraXPeñaTCharacterization of lacrimal gland lesions and possible pathogenic mechanisms of keratoconjunctivitis sicca in dogs with leishmaniosisVet Parasitol20051331374716023786
   PubMed Web of Science ®Google Scholar
• SoontornvipartKRauserPKecovHLexmaulováLEffect of anaesthetic premedication with medetomidine-buprenorphine on the aqueous tear production in dogsActa Vet Brno200372267272
   Web of Science ®Google Scholar
• BergerSScagliottiRLundEA quantitative study of the effects of Tribrissen on canine tear productionJ Am Anim Hosp Assoc19953132362417634058
   PubMed Web of Science ®Google Scholar
• TrepanierLAIdiosyncratic toxicity associated with potentiated sulfonamides in the dogJ Vet Pharmacol Ther200427312913815189298
   PubMed Web of Science ®Google Scholar
• KlaussGGiulianoEAMooreCPKeratoconjunctivitis sicca associated with administration of etodolac in dogs: 211 cases (1992–2002)J Am Vet Med Assoc2007230454154717302553
   PubMed Web of Science ®Google Scholar
• RuehlmannDPodellMMarchPTreatment of partial seizures and seizure-like activity with felbamate in six dogsJ Small Anim Pract200142840340811518421
   PubMed Web of Science ®Google Scholar
• MatheisFLWalser-ReinhardtLSpiessBMCanine neurogenic keratoconjunctivitis sicca: 11 cases (2006–2010)Vet Ophthalmol201215428829022051024
   PubMed Web of Science ®Google Scholar
• MillerPELacrimal systemMaggsDJMillerPEOfriRSlatter’s Fundamentals of Veterinary Ophthalmology4th edSt LouisSaunders Elsevier2008166171
   Google Scholar
• SaitoAIzumisawaYYamashitaKKotaniTThe effect of third eyelid gland removal on the ocular surface of dogsVet Ophthalmol200141131811397314
   PubMed Web of Science ®Google Scholar
• DuganSJSeverinGAHungerfordLLWhiteleyHERobertsSMClinical and histological evaluation of the prolapsed third eyelid gland in dogsJ Am Vet Med Assoc199220112186118671483903
   PubMed Web of Science ®Google Scholar
• MorganRVDuddyJMMcClurgKProlapse of the gland of the third eyelid in dogs: a retrospective study of 89 cases (1980 to 1990)J Am Anim Hosp Assoc1993295660
   Web of Science ®Google Scholar
• DehghanMMPedramMSAzariOMehrjerdiHKAzadEClinical evaluation of the pocket technique for replacement of prolapsed gland of the third eyelid in dogsTurk J Vet Anim Sci2012364352356
   Web of Science ®Google Scholar
• GelattKNPeifferRLJrEricksonJLGumGGEvaluation of tear formation in the dog, using a modification of the Schirmer tear testJ Am Vet Med Assoc19751663683701116954
   PubMed Web of Science ®Google Scholar
• KaswanRLKeratoconjunctivitis sicca: immunological evaluation of 62 casesAm J Vet Res1985463763833888007
   PubMed Web of Science ®Google Scholar
• KaswanRLMartinCLChapmanWLKeratoconjunctivitis sicca: histopathologic study of nictitating membrane and lacrimal glands from 28 dogsAm J Vet Res19844511121186703444
   PubMed Web of Science ®Google Scholar
• BounousDICarmichaelKPKaswanRLEffects of ophthalmic cyclosporine on lacrimal gland pathology and function in dogs with keratoconjunctivitis siccaVet Ophthalmol19965512
   Google Scholar
• MorganRVAbramsKLTopical administration of cyclosporine for treatment of keratoconjunctivitis sicca in dogsJ Am Vet Med Assoc19911998104310461748607
   PubMed Web of Science ®Google Scholar
• GilgerBCAllenJBCyclosporine A in veterinary ophthalmologyVet Ophthalmol19981418118711397229
   PubMedGoogle Scholar
• SansomJBarnettKCKeratoconjunctivitis sicca in the dog: a review of two hundred casesJ Small Anim Pract198526121131
   Web of Science ®Google Scholar
• SchirmerOStudien zur physiologie und pathologie der traneabsonderung und tranenabfuhr [Studies on physiology and pathology of tears secretion and removal]Graefes Arch Klin Exp Ophthalmol190356197291 German
   Google Scholar
• WilliamsDLAnalysis of tear uptake by the Schirmer tear test strip in the canine eyeVet Ophthalmol20058532533016178843
   PubMed Web of Science ®Google Scholar
• HamorRERobertsSMSeverinGAChavkinMJEvaluation of results for Schirmer tear tests conducted with and without application of a topical anesthetic in clinically normal dogs of 5 breedsAm J Vet Res200061111422142511108191
   PubMed Web of Science ®Google Scholar
• BergerSLKingVLThe fluctuation of tear production in the dogJ Am Anim Hosp Assoc199834179839527434
   PubMed Web of Science ®Google Scholar
• BiondiFDornbuschPTSampaioMMontiani-FerreiraFInfrared ocular thermography in dogs with and without keratoconjunctivitis siccaVet Ophthalmol2015181283423905697
   PubMed Web of Science ®Google Scholar
• CrispinSNotes on Veterinary Ophthalmology1st edOxfordBlackwell Publishing20059799
   Google Scholar
• SchreiberSLCrabtreeRRThe mechanism of action of cyclosporin A and FK506Immunol Today19921341361421374612
   PubMedGoogle Scholar
• MatsudaSKoyasuSMechanisms of action of cyclosporineImmunopharmacology2000472–311912510878286
   PubMed Web of Science ®Google Scholar
• SalisburyMAKaswanRLWardDATopical application of cyclosporine in the management of keratoconjunctivitis sicca in dogsJ Am Anim Hosp Assoc199026269274
   Web of Science ®Google Scholar
• DodiPLBianchiEQuintavallaFCyclosporine A topical administration in dogs affected by immune-mediated keratoconjunctivitis siccaActa Ophthal Scand Suppl201088s2460 Special Issue: Abstracts from the 2010 European Association for Vision and Eye Research Conference
   Google Scholar
• KinoTHatanakaHHashimotoMFK506, a novel immuno-suppressant isolated from Streptomyces. I. Fermentation, isolation, and physio-chemical and biological characteristicsJ Antibiot (Tokyo)1987601249
   Google Scholar
• Levi-MontalciniRThe nerve growth factor 35 years laterScience1987237115411623306916
   PubMed Web of Science ®Google Scholar
• KangSSHaSJKimESShinJAKimJYTchahHEffect of nerve growth factor on the in vitro induction of apoptosis of human conjunc-tival epithelial cells by hyperosmolar stressInvest Ophthalmol Vis Sci201455153554124327613
   PubMed Web of Science ®Google Scholar
• CoassinMLambiaseACostaNEfficacy of topical nerve growth factor treatment in dogs affected by dry eyeGraefes Arch Clin Exp Ophthalmol2005243215115515650854
   PubMed Web of Science ®Google Scholar
• LambiaseARamaPBoniniSCaprioglioGAloeLTopical treatment with nerve growth factor for corneal neurotrophic ulcersN Engl J Med199833817117411809554857
   PubMed Web of Science ®Google Scholar
• LambiaseABoniniSMiceraARamaPBoniniSAloeLExpression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseasesInvest Ophthalmol Vis Sci1998397127212759620090
   PubMed Web of Science ®Google Scholar
• LambiaseAManniLBoniniSRamaPMiceraAAloeLNerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneasInvest Ophthalmol Vis Sci20004151063106910752942
   PubMed Web of Science ®Google Scholar
• DodiPLZanottiCCostaNAloeLNGF topical administration in dogs affected by spontaneous keratoconjunctivitis siccaActa Ophthalmol Scand Suppl200785s2400 Special Issue: Abstracts from the 2007 European Association for Vision and Eye Research Conference
   Google Scholar
• DodiPLZanottiCCostaNAloeLTopical use of nerve growth factor on ocular flora and cytology in dogs eye surfaceActa Ophthal Scand Suppl200886s2430 Special Issue: Abstracts from the 2008 European Association for Vision and Eye Research Conference
   Google Scholar
• RhodesMHeinrichCFeatherstoneHParotid duct transposition in dogs: a retrospective review of 92 eyes from 1999 to 2009Vet Ophthalmol201215421322222117571
   PubMed Web of Science ®Google Scholar
• LewinAKeratoconjunctivitis sicca in dogs: causes, diagnosis and treatmentVet Times2014620141617
   Google Scholar
• GelattKNMacKayEOWidenhouseCWidenhouseTSStopekJBEffect of lacrimal punctal occlusion on tear production and tear fluorescein dilution in normal dogsVet Ophthalmol200691232716409241
   PubMed Web of Science ®Google Scholar
• GiulianoEAMooreCPDiseases and surgery of the lacrimal secretory systemGelattKNVeterinary Ophthalmology4th edIowaWiley-Blackwell2007633661
   Google Scholar