The osteoporotic male: Overlooked and undermanaged?

References

• AminSZhangYSawinCT2000Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham studyAnn Intern Med1339516311119396
   PubMed Web of Science ®Google Scholar
• AmmanPShenVRobinB2004Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female ratsJ Bone Miner Res1920122015537445
   PubMed Web of Science ®Google Scholar
• AmoryJKWattsNBEasleyKA2004Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosteroneJ Clin Endocrinol Metab895031014764753
   PubMed Web of Science ®Google Scholar
• BaronRTsouderosY2002In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiationEur J Pharmacol45011712176103
   PubMed Web of Science ®Google Scholar
• Barrett-ConnorEMuellerJEvon MuhlenDG2000Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo StudyJ Clin Endocrinol Metab852192310634390
   PubMed Web of Science ®Google Scholar
• BasariaSDobsAS2001Hypogonadism and androgen replacement therapy in elderly menAm J Med1105637211343670
   PubMed Web of Science ®Google Scholar
• BehreHMKlieschSLeifkeE1997Long-term effect of testosterone therapy on bone mineral density in hypogonadal menJ Clin Endocrinol Metab822386909253305
   PubMed Web of Science ®Google Scholar
• BenitoMGombergBWehrliRH2003Deterioration of trabecular architecture in hypogonadal menJ Clin Endocr Metab881497150212679429
   PubMed Web of Science ®Google Scholar
• BenitoMVasilicBWehrliFW2005Effect of testosterone replacement on trabecular architecture in hypogonadal menJ Bone Miner Res2017859116160736
   PubMed Web of Science ®Google Scholar
• BhasinSBagatellCJBremnerWJ1998Issues in testosterone replacement in older menJ Clin Endocrinol Metab833435489768643
   PubMed Web of Science ®Google Scholar
• BilezikianJP1999Osteoporosis in menJ Clin Endocrinol Metab843431410522975
   PubMed Web of Science ®Google Scholar
• BlumJHarrisRH2003Diagnosis and treatment of hypogonadism with emphasis on erectile dysfunction and osteoporosisPrime Care Case Rev697109
   Google Scholar
• BoonenSVanderschuerenD2002Bone loss and osteoporotic fracture occurrence in aging menIn Textbook of Men’s HealthLunenfeldBGoorenLNew York, NYParthenon Publishing Group45562
   Google Scholar
• BouillonRBexMVanderschuerenD2004Estrogens are essential for male pubertal periosteal bone expansionJ Clin Endocrinol Metab896025915579754
   PubMed Web of Science ®Google Scholar
• BurgerHde LaetCEvan DaelePL1998Risk factors for increased bone loss in an elderly population: the Rotterdam StudyAm J Epidemiol14787199583718
   PubMed Web of Science ®Google Scholar
• CanalisEHottMDeloffreP1996The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitroBone18517238805991
   PubMed Web of Science ®Google Scholar
• CaraniCQinKSimoniM1997Effect of testosterone and estradiol in a man with aromatase deficiencyN Eng J Med337915
   PubMed Web of Science ®Google Scholar
• CenterJRNguyenTVSchneiderD1999Mortality after all major types of osteoporotic fracture in men and women: an observational studyLancet3538788210093980
   PubMed Web of Science ®Google Scholar
• ChapuyMCPreziosiPMaamerM1997Prevalence of vitamin D insufficiency in an adult normal populationOsteoporos Int7439439425501
   PubMed Web of Science ®Google Scholar
• CompstonJ2002Local biosynthesis of sex steroids in boneJ Clin Endocrinol Metab87539840012466324
   PubMed Web of Science ®Google Scholar
• Consensus Development Conference1993Diagnosis, prophylaxis, and treatment of osteoporosisAm J Med94646508506892
   PubMed Web of Science ®Google Scholar
• CrawfordBALLiuPYKeanMT2003Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatmentJ Clin Endocrinol Metab8831677612843161
   PubMed Web of Science ®Google Scholar
• DeSantisABuchmanA2002Current and emerging therapies in osteoporosisExpert Opin Pharmacother38354312083984
   PubMedGoogle Scholar
• DonaldsonLJCookAThomsonRG1990Incidence of fractures in a geographically defined populationJ Epidemiol Community Health4424152273364
   PubMed Web of Science ®Google Scholar
• DuanYBeckTJWangXF2003Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and agingJ Bone Miner Res1817667414584886
   PubMed Web of Science ®Google Scholar
• Faustini-FustiniMRochiraVCaraniC1999Oestrogen deficiency in men: where are we today?Eur J Endocrinol1401112910069654
   PubMed Web of Science ®Google Scholar
• FeldmanHALongcopeCDerbyCA2002Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the massachusetts male aging studyJ Clin Endocrinol Metab875899811836290
   PubMed Web of Science ®Google Scholar
• FinkHAEwingSKEnsrudKE2006Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older menJ Clin Endocrinol Metab9139081516849417
   PubMed Web of Science ®Google Scholar
• FinkelsteinJSNeerRMBillerBM1992Osteopenia in men with a history of delayed pubertyN Engl J Med32660041734250
   PubMed Web of Science ®Google Scholar
• FinkelsteinJSKlibanskiANeerRM1996A longitudinal evaluation of bone mineral density in adult men with histories of delayed pubertyJ Clin Endocrinol Metab81115258772591
   PubMed Web of Science ®Google Scholar
• GanryOBaudoinCPardeloneP2000Effect of alcohol intake on bone mineral density in elderly women. The EPIDOS studyAm J Epidemiol1517738010965974
   PubMed Web of Science ®Google Scholar
• GavalerJSLoveKOrtegaCT1991An international study of the relationship between alcohol consumption and postmenopausal estradiolKhalantJMKhannaJMIsraelY“Advances in biomedical alcohol research: proceedings of the 5th ISBRA/RSA Congress”OxfordPergamon Press32730
   Google Scholar
• GennariLMerlottiDMartiniG2003Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly menJ Clin Endocrinol Metab8853273314602769
   PubMed Web of Science ®Google Scholar
• Goderie-PlompHWvan der KliftMde RondeW2004Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the rotterdam studyJ Clin Endocrinol Metab893261915240601
   PubMed Web of Science ®Google Scholar
• GonnelliSCepollaroCGennariL2005Quantitative ultrasound and dual-energy X-ray absorptiometry in the prediction of fragility fracture in menOsteoporos Int16963815599495
   PubMed Web of Science ®Google Scholar
• GonnelliSCepollaroCMontagnaniA2003Alendronate treatment in men with primary osteoporosis: a three-year longitudinal studyCalcif Tissue Int73133914565594
   PubMed Web of Science ®Google Scholar
• GreendaleGAEdelsteinSBarrett-ConnorE1997Endogenous sex steroids and bone mineral density in older women and men: the rancho bernardo studyJ Bone Miner Res121833439383688
   PubMed Web of Science ®Google Scholar
• GruenewaldDAMatsumotoAM2003Testosterone supplementation therapy for older men: potential benefits and risksJ Am Geriatr Soc511011512534854
   PubMed Web of Science ®Google Scholar
• HarmanSMMetterEJTobinJD2001Longitudinal effects of aging on serum total and free testosterone levels in healthy menJ Clin Endocrinol Metab867243111158037
   PubMed Web of Science ®Google Scholar
• HoneywellMPhillipsSBranchEIII2003Teriparatide for osteoporosis: A clinical reviewP&T Drug Forecast287136
   Google Scholar
• HottMDeloffrePTsouderosY2003S12911-2 reduces bone loss induced by short-term immobilization in ratsBone331152312919706
   PubMed Web of Science ®Google Scholar
• IsidoriAMGiannettaEGrecoEA2005Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysisClin Endocrinol (Oxf)632809316117815
   PubMed Web of Science ®Google Scholar
• JacksonRDLaCroixAZGassM2006Calcium plus Vitamin D Supplementation and the Risk of FracturesN Engl J Med3546698316481635
   PubMed Web of Science ®Google Scholar
• JockenhovelF2004Testosterone therapy – what, when and to whom?Aging Male73192415799128
   PubMedGoogle Scholar
• KennyAMPrestwoodKMMarcelloKMDeterminants of bone density in healthy older men with low testosterone levelsJ Gerontol A Biol Sci Med Sci554927
   Web of Science ®Google Scholar
• KhoslaSMeltonLJ3rdAtkinsonEJ1998Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogenJ Clin Endocrinol Metab832266749661593
   PubMed Web of Science ®Google Scholar
• KhoslaSMeltonLJ3rdRiggsBL2001aEstrogens and bone health in menCalcif Tissue Int691899211730247
   PubMed Web of Science ®Google Scholar
• KhoslaSMeltonLJ3rdAtkinsonEJ2001bRelationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly menJ Clin Endocrinol Metab8635556111502778
   PubMed Web of Science ®Google Scholar
• LeeJSEttingerBStanczykFZ2006Comparison of methods to measure low serum estradiol levels in postmenopausal womenJ Clin Endocrinol Metab913791716882749
   PubMed Web of Science ®Google Scholar
• LegrandEHeddeCGalloisY2001Osteoporosis in men: a potential role for the sex hormone binding globulinBone2990511472897
   PubMed Web of Science ®Google Scholar
• LipsP2001Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implicationsEndocr Rev2247750111493580
   PubMed Web of Science ®Google Scholar
• McClungMR2003The menopause and HRT. Prevention and management of osteoporosisBest Pract Clin Endocrinol Metab175371
   Web of Science ®Google Scholar
• MeierCLiuPYLyLP2004Recombinant human chorionic gonadotropin but not dihydrotestosterone alone stimulates osteoblastic collagen synthesis in older men with partial age-related androgen deficiencyJ Clin Endocrinol Metab8930334115181095
   PubMed Web of Science ®Google Scholar
• MeunierPJRouxCSeemanE2004The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosisN Engl J Med3504596814749454
   PubMed Web of Science ®Google Scholar
• NieschlagEBehreHM2004Testosterone: action, deficiency, substitution3rd edSpringer-VerlagBerlin
   Google Scholar
• NieschlagESwerdloffRBehreHM2005Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendationsInt J Androl28125715910536
   PubMed Web of Science ®Google Scholar
• OrwollESKleinRF1995Osteoporosis in menEndocr Rev16871167758434
   PubMed Web of Science ®Google Scholar
• OrwollESEttingerMWeissS2000Alendronate for the treatment of osteoporosis in menN Engl J Med3436041010979796
   PubMed Web of Science ®Google Scholar
• OrwollESScheeleWHPaulS2003The effect of teriparatide [Human Parathyroid Hormone (1–34)] therapy on bone density in men with osteoporosisJ Bone Miner Res1891712510800
   PubMed Web of Science ®Google Scholar
• PattanaungkulSRiggsBLYergeyAL2000Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D[1,25(OH)2D] levels in young versus elderly women: evidence for age-related intestinal restitance to 1,25(OH)2D actionJ Clin Endocrinol Metab854023711095427
   PubMed Web of Science ®Google Scholar
• ReginsterJYSeemanEDe VernejoulMC2005Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) studyJ Clin Endocrinol Metab9028162215728210
   PubMed Web of Science ®Google Scholar
• RingeJDFaberHDorstA2001Alendronate treatment of established primary osteoporosis in men: results of a 2-year prospective studyJ Clin Endocrinol Metab865252511701687
   PubMed Web of Science ®Google Scholar
• RiggsBLKhoslaSMeltonLJ3rd1998A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging menJ Bone Miner Res13763739610739
   PubMed Web of Science ®Google Scholar
• RiggsBLMeltonJIIIRobbRA2004Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sitesJ Bone Miner Res1919455415537436
   PubMed Web of Science ®Google Scholar
• RochiraVFaustini-FustiniMBalestrieriA2000Estrogen replacement therapy in a man with congenital aromatase deficiency: effects of different doses of transdermal estradiol on bone mineral density and hormonal parametersJ Clin Endocrinol Metab851841510843162
   PubMed Web of Science ®Google Scholar
• RochiraVBalestrieriAFaustini-FustiniM2001Role of estrogen on bone in the human male: insights from the natural models of congenital estrogen deficiencyMol Cell Endocrinol1782152011403912
   PubMed Web of Science ®Google Scholar
• RochiraVBalestrieriAMadeoB2002Congenital estrogen deficiency in men: a new syndrome with different phenotypes; clinical and therapeutic implications in menMol Cell Endocrinol193192812160998
   PubMed Web of Science ®Google Scholar
• RochiraVGranataARMadeoB2005Estrogens in males: what have we learned in the last 10 years?Asian J Androl732015685347
   PubMed Web of Science ®Google Scholar
• RochiraVBalestrieriAMadeoB2006Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiologyEur J Endocrinol1541758516452530
   PubMed Web of Science ®Google Scholar
• ScopacasaFHorowitzMWishartJM2000The relation between bone density, free androgen index, and estradiol in men 60 to 70 years oldBone27145910865222
   PubMed Web of Science ®Google Scholar
• SeemanE2002Pathogenesis of bone fragility in women and menLancet35918415012044392
   PubMed Web of Science ®Google Scholar
• SeemanEDelmasPD2006Bone quality – the material and structural basis of bone strength and fragilityN Engl J Med35422506116723616
   PubMed Web of Science ®Google Scholar
• SheaBWellsGCranneyA2002VII. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosisEndocr Rev23552912202470
   PubMed Web of Science ®Google Scholar
• SlemendaCWLongcopeCZhouL1997Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgensJ Clin Invest100175599312174
   PubMed Web of Science ®Google Scholar
• SnyderPJPeacheyHBerlinJA2000Effects of testosterone replacement in hypogonadal menJ Clin Endocrinol Metab852670710946864
   PubMed Web of Science ®Google Scholar
• SteidleCSchwartzSJacobyK2003AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual functionJ Clin Endocrinol Metab8826738112788872
   PubMed Web of Science ®Google Scholar
• SwerdloffRSWangC2002Androgens and the aging maleIn textbook of men’s healthLunenfeldBGoorenLNew York, NYParthenon Publishing Group148157
   Google Scholar
• SzulcPMunozFClaustratB2001Bioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS studyJ Clin Endocrinol Metab86192911232000
   PubMed Web of Science ®Google Scholar
• TakahashiNSasakiTTsouderosY2003S12911-2 inhibits osteoclastic bone resorption in vitroJ Bone Miner Res181082712817762
   PubMed Web of Science ®Google Scholar
• TenoverJS1999Testosterone replacement therapy in older adult menInt J Androl22300610509230
   PubMed Web of Science ®Google Scholar
• TollinSRRosenHNZurowskiK1996Finasteride therapy does not alter bone turnover in men with benign prostatic hyperplasia – a Clinical Research Center studyJ Clin Endocrinol Metab81103148772571
   PubMed Web of Science ®Google Scholar
• TurnerRTKidderLSKennedyAEvansGLSibongaJD2001Moderate alcohol suppresses bone turnover in adult female ratsJ Bone Min Res1658994
   PubMed Web of Science ®Google Scholar
• ValimakiMJKarkkainenMLamberg-AllardtC1994Exercise, smoking, and calcium intake during adolescence and early adulthood as determinants of peak bone mass. Cardiovascular risk in young finns study groupBMJ30923058069139
   PubMed Web of Science ®Google Scholar
• VanderschuerenDVandenputLBoonenS2004Androgens and boneEndocr Rev2538942515180950
   PubMed Web of Science ®Google Scholar