93
Views
46
CrossRef citations to date
0
Altmetric
Reviews

ABCD of the phosphodiesterase family: interaction and differential activity in COPD

Pages 543-561 | Published online: 05 Dec 2008

References

  • AgostiniCTrentinLAdamiF2003Chronic obstructive pulmonary disease (COPD): new insights on the events leading to pulmonary inflammationSarcoidosis Vasc Diffuse Lung Dis203712737274
  • AgustiAGNogueraASauledaJ2003Systemic effects of chronic obstructive pulmonary diseaseEur Respir J213476012608452
  • AlexanderRPWarrellowGJEatonMA2002CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitorsBioorg Med Chem Lett121451612031318
  • AokiMKobayashiMIshikawaJ2000A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido [2,3-d]pyrimidin-2(1H)-one), with little emetogenic activityJ Pharmacol Exp Ther2952556010991987
  • AravindLKooninEV1998The HD domain defines a new superfamily of metal-dependent phosphohydrolasesTrends Biochem Sci23469729868367
  • AravindLPontingCP1997The GAF domain: an evolutionary link between diverse phototransducing proteinsTrends Biochem Sci2245899433123
  • AsirvathamALGalliganSGSchillaceRV2004A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell linesJ Immunol17348061415470020
  • BaillieGSSoodAMcpheeI2003beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to GiProc Natl Acad Sci U S A100940512552097
  • BarberRBaillieGSBergmannR2004Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokersAm J Physiol Lung Cell Mol Physiol287L3324315047569
  • BarnesAPLiveraGHuangP2005Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epitheliumJ Biol Chem2807997800315611099
  • BarnetteMS1999Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD)Prog Drug Res5319322910616299
  • BarnetteMSChristensenSBEssayanDM1998SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actionsJ Pharmacol Exp Ther28442069435206
  • BaumerWHoppmannJRundfeldtC2007Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasisInflamm Allergy Drug Targets6172617352685
  • BeardMBHustonECampbellL2002In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targetingCell Signal144536511882390
  • BeavoJABruntonLL2002Cyclic nucleotide research – still expanding after half a centuryNat Rev Mol Cell Biol3710812209131
  • BeavoJAContiMHeaslipRJ1994Multiple cyclic nucleotide phosphodiesterasesMol Pharmacol463994057935318
  • BeletaJBouJMiralpeixM1996LAS 31025, a new compound with selective phosphodiesterase IV inhibitory activityThird International Conference on Cyclic Nucleotide Phosphodiesterases: From Genes to TherapiesGlasgow
  • BenderATBeavoJA2006PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyteProc Natl Acad Sci U S A103460516407168
  • BenderATOstensonCLWangEH2005Selective up-regulation of PDE1B2 upon monocyteto-macrophage differentiationProc Natl Acad Sci U S A10249750215625104
  • BillahMMCooperNMinnicozziM2002Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quino line carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitorJ Pharmacol Exp Ther3021273712065709
  • BinghamJSudarsanamSSrinivasanS2006Profiling human phosphodiesterase genes and splice isoformsBiochem Biophys Res Commun350253216987497
  • BloomTJBeavoJA1996Identification and tissue-specific expression of PDE7 phosphodiesterase splice variantsProc Natl Acad Sci U S A9314188928943082
  • BlountMABeasleyAZoraghiR2004Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulationMol Pharmacol661445215213306
  • BolgerGMichaeliTMartinsT1993A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugsMol Cell Biol136558718413254
  • BolgerGB1994Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymesCell Signal685197718405
  • BolgerGBPedenAHSteeleMR2003Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2J Biol Chem278333516312810716
  • BootJDDe HaasSLVan GervenJM2008MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteersPulm Pharmacol Ther In press
  • BorgeatPChavancyGDupontA1972Stimulation of adenosine 3′:5′-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormoneProc Natl Acad Sci U S A692677814341705
  • BosJL2003Epac: a new cAMP target and new avenues in cAMP researchNat Rev Mol Cell Biol4733814506476
  • BourneHRLichtensteinLMMelmonKL1974Modulation of inflammation and immunity by cyclic AMPScience18419284131281
  • BreerH1993Second messenger signalling in olfactionCiba Found Symp17997109 discussion 109–14, 147–98168385
  • BuckleyGCooperNDykeHJ20007-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthmaBioorg Med Chem Lett1021374010999488
  • BundschuhDSEltzeMBarsigJ2001In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitorJ Pharmacol Exp Ther2972809011259555
  • BurnoufCAuclairEAvenelN2000Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitorsJ Med Chem4348506711123995
  • CalverleyPMSanchez-TorilFMcIvorA2007Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary diseaseAm J Respir Crit Care Med1761546117463412
  • CharanNB2001Does sildenafil also improve breathing?Chest120305611451855
  • ChenJCChenJQXieQM2004Selective inhibition of purified human phosphodiesterase 4A expressed in yeast cell GL62 by ciclami-last, piclamilast, and rolipramActa Pharmacol Sin251171515339393
  • ChihiroMNagamotoHTakemuraI1995Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: synthesis and structure-activity relationshipsJ Med Chem3835387830278
  • ChristensenSBGuiderAForsterCJ19981,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthmaJ Med Chem41821359526558
  • ClaveauDChenSLO’KeefeS2004Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-[2-(3,4-Bisdifluromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxy propan-2-yl)-phenyl]-ethyl]3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitorJ Pharmacol Exp Ther3107526015082748
  • ComptonCHGubbJNiemanR2001Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging studyLancet3582657011498212
  • ContiMBeavoJ2007Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signalingAnnu Rev Biochem7648151117376027
  • ContiMJinSL1999The molecular biology of cyclic nucleotide phosphodiesterasesProg Nucleic Acid Res Mol Biol6313810506827
  • CorbinJDBlountMAWeeksJL2nd2003[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMPMol Pharmacol6313647212761347
  • CorbinJDFrancisSH1999Cyclic GMP phosphodiesterase-5: target of sildenafilJ Biol Chem274137293210318772
  • CorbinJDTurkoIVBeasleyA2000Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activitiesEur J Biochem2672760710785399
  • De BoerJPhilpottAJVan AmsterdamRG1992Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitorsBr J Pharmacol1061028341393276
  • DegermanEBelfragePManganielloVC1997Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)J Biol Chem272682369102399
  • DentGGiembyczMAEvansPM1994Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterolJ Pharmacol Exp Ther2711167747996422
  • DentGWhiteSRTenorH1998Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitorsPulm Pharmacol Ther1147569802963
  • Dodge-KafkaKLSoughayerJPareGC2005The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathwaysNature437574816177794
  • DodgeKLKhouangsathieneSKapiloffMS2001mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleEMBO J2019213011296225
  • DolciSBelmonteASantoneR2006Subcellular localization and regulation of type-1C and type-5 phosphodiesterasesBiochem Biophys Res Commun3418374616455054
  • DuplantierAJBachertELChengJB2007SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesteraseJ Med Chem50344917228876
  • EneferS2005Inflammation 2005 – Seventh World Congress. Highlights IIDrugs87889016254791
  • EngelsPFichtelKLubbertH1994Expression and regulation of human and rat phosphodiesterase type IV isogenesFEBS Lett35029158070581
  • EngelsPSullivanMMullerT1995Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)FEBS Lett358305107843419
  • EvgenovOVBuschCJEvgenovNV2006Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertensionAm J Physiol Lung Cell Mol Physiol290L723L916284211
  • FidockMMillerMLanfearJ2002Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variantsCell Signal14536011747989
  • FrancisSHLincolnTMCorbinJD1980Characterization of a novel cGMP binding protein from rat lungJ Biol Chem25562066153179
  • FrancisSHTurkoIVCorbinJD2001Cyclic nucleotide phosphodiesterases: relating structure and functionProg Nucleic Acid Res Mol Biol6515211008484
  • FriedmanDLJohnsonRAZeiligCE1976The role of cyclic nucleotides in the cell cycleAdv Cyclic Nucleotide Res769114188318
  • FujimuraMKamioYSaitoM1995Bronchodilator and broncho-protective effects of cilostazol in humans in vivoAm J Respir Crit Care Med15122257812559
  • FukaoMMasonHSBrittonFC1999Cyclic GMP-dependent protein kinase activates cloned BKCa channels expressed in mammalian cells by direct phosphorylation at serine 1072J Biol Chem274109273510196172
  • FuruieHNakagawaSKawashimaM2003Suppressive effect of novel phosphodiesterase4 (PDE4) inhibitor ONO-6126 on TNF-α release was increased after repeated oral administration in healthy Japanese subjectsEur Respir J22Suppl 45395s
  • GaleDDLandellsLJSpinaD2002Pharmacokinetic and pharmaco-dynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteersBr J Clin Pharmacol544788412445026
  • GambleEGrootendorstDCBrightlingCE2003Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med1689768212816740
  • GardnerCRobasNCawkillD2000Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesteraseBiochem Biophys Res Commun2721869210872825
  • GhofraniHAVoswinckelRReichenbergerF2004Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective studyJ Am Coll Cardiol4414889615464333
  • GiembyczMA2005Phosphodiesterase-4. Selective and dual specificity inhibitors for the therapy of chronic obstructive pulmonary diseaseProc Am Thorac Soc232633316267357
  • GiembyczMACorriganCJSeyboldJ1996Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2Br J Pharmacol1181945588864528
  • GiovannoniMPCesariNGrazianoA2007Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitorsJ Enzyme Inhib Med Chem223091817674813
  • GlavasNAOstensonCSchaeferJB2001T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3Proc Natl Acad Sci U S A9863192411371644
  • Global Initiative for Chronic Obstructive Pulmonary Disease2006Global strategy for the diagnosis, management and prevention of chronicobstructive pulmonary disease, Executive Summary URL: www.goldcopd.com
  • GrashoffWFSontJKSterkPJ1997Chronic obstructive pulmonary disease: role of bronchiolar mast cells and macrophagesAm J Pathol1511785909403729
  • GriswoldDEWebbEFBadgerAM1998SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivoJ Pharmacol Exp Ther287705119808700
  • GrootendorstDCGauwSABenschopN2003Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD)Pulm Pharmacol Ther16341714580925
  • GutkeHJGuseJHKhobzaouiM2005AWD-12-281 (inhaled) (elbion/GlaxoSmithKline)Curr Opin Investig Drugs6114958
  • HabenerJFDegrooLJJamesonJL2001The cyclic AMP second messenger signaling pathwayEndocrinologyPhiladelphiaWB Saunders
  • HalpinDMG2007Systemic Effects of COPDExpert Rev Resp Med17584
  • HambletonRKrallJTikishviliE2005Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardiumJ Biol Chem280391687416172121
  • HanPFletcherCFCopelandNG1998Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13Genomics4827569521885
  • HanPSonatiPRubinC2006PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with CJ Biol Chem28115050716556600
  • HanPZhuXMichaeliT1997/Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heartJ Biol Chem2721615279195912
  • HatzelmannASchudtC2001Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitroJ Pharmacol Exp Ther2972677911259554
  • HeaslipRJLombardoLJGolankiewiczJM1994Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641J Pharmacol Exp Ther268888968114002
  • HetmanJMSoderlingSHGlavasNA2000Cloning and characterization of PDE7B, a cAMP-specific phosphodiesteraseProc Natl Acad Sci U S A97472610618442
  • HoggJCChuFUtokaparchS2004The nature of small-airway obstruction in chronic obstructive pulmonary diseaseN Engl J Med35026455315215480
  • HorowskiRSastre-Y-HernandezM1985Clinical effects of the neurotropic selective cAMP phosphodiesterase inhibitor rolipram in depressed patients: global evaluation of the preliminary reportsCurr Ther Res38239
  • HortonYMSullivanMHouslayMD1995Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2–q12 region of human chromosome 19 [corrected]Biochem J308683917772058
  • HouslayMDSchaferPZhangKY2005Keynote review: phosphodiesterase-4 as a therapeutic targetDrug Discov Today1015031916257373
  • HuangZLiuSZhangL2006Preferential inhibition of human phosphodiesterase 4 by ibudilastLife Sci782663816313925
  • JefferyPK2001aLymphocytes, chronic bronchitis and chronic obstructive pulmonary diseaseNovartis Found Symp23414961 discussion 161–811199094
  • JefferyPK2001bRemodeling in asthma and chronic obstructive lung diseaseAm J Respir Crit Care Med164S283811734464
  • JeonYHHeoYSKimCM2005Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug developmentCell Mol Life Sci62119822015798894
  • JiangXLiJPaskindMEpsteinPM1996Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cellsProc Natl Acad Sci U S A9311236418855339
  • JinSLContiM2002Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responsesProc Natl Acad Sci U S A9976283312032334
  • KakiuchiSYamazakiR1970Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain studies on cyclic 3′,5′-nucleotide phosphodiesterase (3)Biochem Biophys Res Commun411104104320714
  • KakkarRRajuRVRajputAH1996Inhibition of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes by deprenylLife Sci5933741
  • KakkarRRajuRVRajputAH1997Amantadine: an antiparkinsonian agent inhibits bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozymeBrain Res74929049138729
  • KakkarRRajuRVSharmaRK1999Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)Cell Mol Life Sci5511648610442095
  • KammerGM1988The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune responseImmunol Today922292855581
  • KandaNWatanabeS2001Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cellsBiochem Pharmacol6249550711448460
  • KasuyaJLiangSJGokoH2000Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B geneBiochem Biophys Res Commun2688273410679291
  • KirsteinMRivet-BastideMHatemS1995Nitric oxide regulates the calcium current in isolated human atrial myocytesJ Clin Invest957948027860763
  • KitamuraTKitamuraYKurodaS1999Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase AktMol Cell Biol1962869610454575
  • KoteraJFujishigeKAkatsukaH1998Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesteraseJ Biol Chem27326982909756948
  • KovalaTSanwalBDBallEH1997Recombinant expression of a type IV, cAMP-specific phosphodiesterase: characterization and structure-function studies of deletion mutantsBiochemistry362968769062127
  • KoyamaHBornfeldtKEFukumotoS2001Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferationJ Cell Physiol18611011147803
  • KucharekovaMHornixMAshikagaT2003The effect of the PDE-4 inhibitor (cipamfylline) in two human models of irritant contact dermatitisArch Dermatol Res295293212709818
  • LedbetterJAParsonsMMartinPJ1986Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppressionJ Immunol13732993053021852
  • LeeCGHomerRJZhuZ2001Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)J Exp Med1948092111560996
  • LeemanMLejeunePMelotC1987Reduction in pulmonary hypertension and in airway resistances by enoximone (MDL 17,043) in decompensated COPDChest9166262952467
  • LenhardJMKasselDBRocqueWJ1996Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinaseBiochem J31675188670148
  • LewDBNebigilCMalikKU1992Dual regulation by cAMP of beta-hexosaminidase-induced mitogenesis in bovine tracheal myocytesAm J Respir Cell Mol Biol761491333245
  • LiLYeeCBeavoJA1999CD3- and CD28-dependent induction of PDE7 required for T cell activationScience283848519933169
  • LinCSLauATuR2000Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosumBiochem Biophys Res Commun2686283510679255
  • LincolnTMHallCLParkCR1976Guanosine 3′,5′-cyclic mono-phosphate binding proteins in rat tissuesProc Natl Acad Sci U S A732559638775
  • LipworthBJ2005Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary diseaseLancet3651677515639300
  • LoherFSchmallKFreytagP2003The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in miceJ Pharmacol Exp Ther3055495612606674
  • LoscoPEEvansEWBaratSA2004The toxicity of SCH 351591, a novel phosphodiesterase-4 inhibitor, in Cynomolgus monkeysToxicol Pathol3229530815204971
  • LoughneyKHillTRFlorioVA1998Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesteraseGene216139479714779
  • MacdonaldEVan Der LeeHPocockD2007A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemiaNeurorehabil Neural Repair214869617823313
  • MackenzieSJBaillieGSMcPheeI2000ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regionsJ Biol Chem275166091710828059
  • MackenzieSJBaillieGSMcPheeI2002Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)Br J Pharmacol1364213312023945
  • MackintoshC2004Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processesBiochem J3813294215167810
  • ManningCDBurmanMChristensenSB1999Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4BBr J Pharmacol1281393810602317
  • McAllister-LucasLMHaikTLColbranJL1995An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesteraseJ Biol Chem2703067198530505
  • McAllister-LucasLMSonnenburgWKKadlecekA1993The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA cloneJ Biol Chem26822863738226796
  • McConnachieGLangebergLKScottJD2006AKAP signaling complexes: getting to the heart of the matterTrends Mol Med123172316809066
  • McLaughlinMMCieslinskiLBBurmanM1993A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNAJ Biol Chem268647068384210
  • MichaeliTBloomTJMartinsT1993Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiaeJ Biol Chem26812925328389765
  • MichibataHYanakaNKanohY2001Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localizationBiochim Biophys Acta15172788711342109
  • MikiTTairaMHockmanS1996Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase familyGenomics36476858884271
  • MilatovichABolgerGMichaeliT1994Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouseSomat Cell Mol Genet207586
  • MongilloMMcSorleyTEvellinS2004Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterasesCirc Res95677515178638
  • MooreARWilloughbyDA1995The role of cAMP regulation in controlling inflammationClin Exp Immunol10138797664483
  • MullerTEngelsPFozardJR1996Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibitionTrends Pharmacol Sci1729488810876
  • MullershausenFRusswurmMThompsonWJLiu2001Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzymeJ Cell Biol155271811604422
  • MurthyKS2001Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscleBiochem J36019920811696008
  • MyouSFujimuraMKamioY1999Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patientsAm J Respir Crit Care Med1608172010471602
  • National Institute for Clinical Excellence (Nice)2004Chronic obstructive pulmonary disease. National clinical guideline for management of chronic obstructive pulmonary disease in adults in primary and secondary careThorax59Suppl 11232
  • NemozGZhangRSetteCContiM1996Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cellsFEBS Lett384971028797812
  • NewmanSPRiveroXLuriaXHooperGPitcairnGR1997A scintigraphic study to evaluate the deposition patterns of a novel anti-asthma drug inhaled from the Cyclohaler dry powder inhalerAdv Drug Deliv Rev26596710837533
  • NielsonCPVestalRESturmRJ1990Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burstJ Allergy Clin Immunol8680181977788
  • NovackJPCharbonneauHBentleyJK1991Sequence comparison of the 63-, 61-, and 59-kDa calmodulin-dependent cyclic nucleotide phosphodiesterasesBiochemistry30794071651112
  • O’connellJCMccallumJFMcPheeI1996The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)Biochem J318255618761480
  • O’ShaughnessyTCAnsariTWBarnesNC1997Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1Am J Respir Crit Care Med15585279117016
  • OkadaDAsakawaS2002Allosteric activation of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) by cGMPBiochemistry419672912135389
  • OuaguedMMartin-ChoulyCABrinchaultG2005The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patientsPulm Pharmacol Ther18495415607127
  • PastanIHJohnsonGSAndersonWB1975Role of cyclic nucleotides in growth controlAnnu Rev Biochem44491522166606
  • PauvertOSalvailDRousseauE2002Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary arteryBiochem Pharmacol6317637212007579
  • PeachellPTUndemBJSchleimerRP1992Preliminary identification and role of phosphodiesterase isozymes in human basophilsJ Immunol1482503101373172
  • PooleyLShakurYRenaG1997Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell linesBiochem J321177859003417
  • Pozuelo RubioMCampbellDGMorriceNA2005Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428Biochem J3921637216153182
  • Pozuelo RubioMGeraghtyKMWongBH200414-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and traffickingBiochem J37939540814744259
  • ProfitaMChiapparaGMirabellaF2003Effect of cilomilast (Ariflo) on TNF-alpha, IL-8, and GM-CSF release by airway cells of patients with COPDThorax58573912832668
  • RabeKFBatemanEDO’DonnellD2005Roflumilast – an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trialLancet3665637116099292
  • RabeKFTenorHDentG1993Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterizationAm J Physiol264L458647684572
  • RasconADegermanETairaM1994Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesteraseJ Biol Chem2691196268163498
  • ReinhardtRRChinEZhouJ1995Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterasesJ Clin Invest951528387706458
  • RennardSISchachterNStrekM2006Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4Chest129566616424413
  • RichterWContiM2004The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterasesJ Biol Chem279303384815131123
  • RichterWDayPAgrawalR2008Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4Embo J273849318188154
  • RobichaudAStamatiouPBJinSL2002Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisJ Clin Invest11010455212370283
  • RobicsekSABlanchardDKDjeuJY1991Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytesBiochem Pharmacol42869771651080
  • RondinoneCMCarvalhoERahnT2000Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptorJ Biol Chem27510093810744689
  • RybalkinSDBornfeldtKESonnenburgWK1997Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotypeJ Clin Invest1002611219366577
  • RybalkinSDRybalkinaIBeavoJA2002aCyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferationCirc Res90151711834707
  • RybalkinSDRybalkinaIGFeilR2002bRegulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cellsJ Biol Chem2773310711723116
  • RybalkinSDRybalkinaIGShimizu-AlbergineM2003PDE5 is converted to an activated state upon cGMP binding to the GAF A domainEmbo J224697812554648
  • SaettaMBaraldoSCorbinoL1999CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med160711710430750
  • SaettaMDi StefanoAMaestrelliP1994Airway eosinophilia in chronic bronchitis during exacerbationsAm J Respir Crit Care Med1501646527952628
  • SaettaMTuratoGMaestrelliP2001Cellular and structural bases of chronic obstructive pulmonary diseaseAm J Respir Crit Care Med1631304911371392
  • SasakiTKoteraJYuasaK2000Identification of human PDE7B, a cAMP-specific phosphodiesteraseBiochem Biophys Res Commun2715758310814504
  • SastryBKNarasimhanCReddyNK2004Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover studyJ Am Coll Cardiol4311495315063421
  • SchillaceRVAndrewsSFLibertyGA2002Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytesJ Immunol16815909
  • SchlossmannJAmmendolaAAshmanK2000Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase IbetaNature40419720110724174
  • SchlossmannJFeilRHofmannF2003Signaling through NO and cGMP-dependent protein kinasesAnn Med3521712693609
  • SchudtCTenorHHatzelmannA1995PDE isoenzymes as targets for anti-asthma drugsEur Respir J81179837589403
  • SebkhiAStrangeJWPhillipsSC2003Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertensionCirculation1073230512796132
  • SeldonPMBarnesPJMejaK1995Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclaseMol Pharmacol48747577476903
  • SetteCContiM1996Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activationJ Biol Chem27116526348663227
  • ShakurYPrydeJGHouslayMD1993Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipramBiochem J292677867686364
  • ShakurYWilsonMPooleyL1995Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellumBiochem J30680197702577
  • SharmaRK1991Phosphorylation and characterization of bovine heart calmodulin-dependent phosphodiesteraseBiochemistry30596381646004
  • SharmaRKDasSBLakshmikuttyammaA2006Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): reviewInt J Mol Med189510516786160
  • SharmaRKKalraJ1993Ginsenosides are potent and selective inhibitors of some calmodulin-dependent phosphodiesterase isozymesBiochemistry32497588388250
  • SharmaRKSeitzDPSinghB2002Localization and regulation of bovine eye calmodulin-dependent cyclic nucleotide phosphodiesterase by cyclic AMP-dependent protein kinaseInt J Mol Med10172312060846
  • SharmaRKWangJH1985Differential regulation of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphataseProc Natl Acad Sci U S A82260372986124
  • SharmaRKWangJH1986Calmodulin and Ca2+-dependent phosphorylation and dephosphorylation of 63-kDa subunit-containing bovine brain calmodulin-stimulated cyclic nucleotide phosphodiesterase isozymeJ Biol Chem261132283944089
  • SharmaRKWangJHWuZ1997Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonistsJ Neurochem69845509231746
  • ShepherdMCBaillieGSStirlingDI2004Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cellsBr J Pharmacol1423395115066910
  • SmithCJKrallJManganielloVC1993Cytosolic and sarcoplasmic reticulum-associated low Km, cGMP-inhibited cAMP phosphodiesterase in mammalian myocardiumBiochem Biophys Res Commun190516218381278
  • SmithSJBrookes-FazakerleySDonnellyLE2003Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cellsAm J Physiol Lung Cell Mol Physiol284L2798912388353
  • SmithSJCieslinskiLBNewtonR2004Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytesMol Pharmacol6616798915371556
  • SoderlingSHBeavoJA2000Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functionsCurr Opin Cell Biol12174910712916
  • SonnenburgWKSegerDKwakKS1995Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterasesJ Biol Chem2703098910008537356
  • SturtonGFitzgeraldM2002Phosphodiesterase 4 inhibitors for the treatment of COPDChest121192S6S12010850
  • SungBJHwangKYJeonYH2003Structure of the catalytic domain of human phosphodiesterase 5 with bound drug moleculesNature4259810212955149
  • SurksHKMochizukiNKasaiY1999Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase IalphaScience2861583710567269
  • SutherlandEW1970On the biological role of cyclic AMPJAMA214128184320556
  • SzpirerCSzpirerJRiviereM1995Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4Cytogenet Cell Genet691147835077
  • TenorHStaniciuLSchudtC1995Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytesClin Exp Allergy25616248521180
  • TeoTSWangJH1973Mechanism of activation of a cyclic adenosine 3′,5′-monophosphate phosphodiesterase from bovine heart by calcium ions. Identification of the protein activator as a Ca2+ binding proteinJ Biol Chem248595054353626
  • ThomasMKFrancisSHCorbinJD1990aCharacterization of a purified bovine lung cGMP-binding cGMP phosphodiesteraseJ Biol Chem26514964701697584
  • ThomasMKFrancisSHCorbinJD1990bSubstrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMPJ Biol Chem2651497182168396
  • ThompsonWJ1991Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and functionPharmacol Ther5113331663250
  • ThompsonWJApplemanMM1971Characterization of cyclic nucleotide phosphodiesterases of rat tissuesJ Biol Chem2463145504324892
  • ThompsonWJAshikagaTKellyJJ2002Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4)Biochem Pharmacol6379780711992650
  • TomlinsonPRWilsonJWStewart1995Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levelsBiochem Pharmacol491809197598743
  • TorphyTJ1998Phosphodiesterase isozymes: molecular targets for novel antiasthma agentsAm J Respir Crit Care Med157351709476844
  • TorphyTJBarnetteMSUnderwoodDC1999Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinicPulm Pharmacol Ther12131510373396
  • TorphyTJUndemBJCieslinskiLB1993Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscleJ Pharmacol Exp Ther2651213238389856
  • TowardTJSmithNBroadleyKJ2004Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways diseaseAm J Respir Crit Care Med1692273414597480
  • TsoumakidouMDemedtsIKBrusselleGG2008Dendritic cells in COPD: new players in an old gameAm J Respir Crit Care Med In press
  • UkitaTSugaharaMTerakawaY1999Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivativesJ Med Chem4210889910090791
  • VerdeIPahlkeGSalanovaM2001Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesteraseJ Biol Chem276111899811134006
  • WoutersEF2002Chronic obstructive pulmonary disease. 5: systemic effects of COPDThorax5710677012454303
  • WrightKFTurnerCRJayasinghe-BeckR1997Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitorCan J Physiol Pharmacol75100189360015
  • WyattTANaftilanAJFrancisSH1998ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cellsAm J Physiol274H448559486247
  • XuRXHassellAMVanderwallD2000Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificityScience2881822510846163
  • YanCZhaoAZBentleyJK1996The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific mannerJ Biol Chem271256997068810348
  • YanakaNKoteraJOhtsukaA1998Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A geneEur J Biochem25539199716380
  • YangGMcintyreKWTownsendRM2003Phosphodiesterase 7A-deficient mice have functional T cellsJ Immunol17164142014662840
  • ZhangKYCardGLSuzukiY2004A glutamine switch mechanism for nucleotide selectivity by phosphodiesterasesMol Cell152798615260978
  • ZhaoLMasonNAMorrellNW2001Sildenafil inhibits hypoxia-induced pulmonary hypertensionCirculation104424811468204
  • ZhouGBaoZQDixonJE1995Components of a new human protein kinase signal transduction pathwayJ Biol Chem2701266597759517