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Review

Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent

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Pages 49-59 | Published online: 25 Feb 2008

References

  • AdamJMBennettDJBomA2002Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationshipsJ Med Chem4518061611960492
  • Alvarez-GomezJAWattwilMVanackerB2007Reversal of vecuronium-induced shallow neuromuscular blockade is significantly faster with sugammadex compared with neostigmineEur J Anaesthesiol24Suppl 391245
  • AmaoRZornowMHCowanMR2007Sugammadex safely reverses rocuronium-induced blockade in patients with pulmonary diseaseAnesthesiology107A1582
  • AppelboamRMulderRSaddlerJ2003Atracurium associated with post operative residual curarization. CorrespondenceBr J Anaesthesiol905238
  • BaillardCGehanGReboul-MartyJ2000Residual curarization in the recovery room after vecuroniumBr J of Anaesthesiol843945
  • BergHRoedJViby-MogensonJ1997Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomized, and blinded study of postoperative pulmonary complications after atracurium, vecuronium, and pancuroniumActa Anaesthesiol Scand4110951039366929
  • BlobnerMErikssonLScholzJ2007Sugammadex 92.0 mg/kg) significantly faster reverses shallow rocuronium-induced neuromuscular blockade compared with neostigmine (50 mcg/kg)Eur J Anaesthsiol24Suppl 39125
  • BohmR1912Ueber die Verbindung der Lokalanasthesie mit der Narkose, uber hohe Extraduralanasthesie und epidurale Injektion anastesierender Losenungen bei tabischen MagenkrisenBeitrage zur Klinischen Chirurgie8016889
  • BomABradleyMCameronK2002aA novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic hostAgnew Chem Int Ed4126670
  • BomAClarkJKPalinR2002bNew approaches to reversal of neuromuscular blockCurr Opin Drug Discov Develop5793800
  • BomAEpemoluOHopeF2007Selective relaxant binding agent for reversal of neuromuscular blockadeCurr Opin Pharmacol729830217368102
  • BomAHopeF2007Propanolol and isprenaline do not modify the sugammadex-induced fast recovery from neuromuscular blockadeEur J Anaesthesiol2411112
  • BomAMasonRMcIndewarI2002cOrg 25969 causes rapid reversal of rocuronium-induced neuromuscular block, independent of acid-base statusAnesthesiology96A-1009
  • BomAVan EgmondJHopeF2003Rapid reversal of rocuronium-induced neuromuscular block by Org 25969 is independent of renal perfusionAnesthesiology99A-1158
  • ChallaRAhulaAAliJ2005Cyclodextrins in drug delivery: an updated reviewAAPS Pharma Sci Tech632957
  • DebaeneBPlaudBDillyMP2003Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of actionAnesthesiology981042812717123
  • DahlVPendevillePEHollmanMW2007Reversal of rocuronium-induced blockade by sugammadex in cardiac patientsAnesthesiology107A1581
  • de BoerHDriessenJMarcusM2007Reversal of rocuronium-induced (1.2 mg/kg) profound neuromuscular block by sugammadex: a multicenter, dose-finding and safety studyAnesthesiology1072394417667567
  • de BoerHDvan EgmondJvan de PolF2006Reversal of profound neuromuscular blockade by sugammadex in anesthesized rhesus monkeysAnesthesiology1047182316571967
  • DecoopmanMCammuGSuyK2007Reversal of pancuronium-induced block by the selective relaxany binding agent sugammadexEur J Anaesthesiol24Suppl 3911011
  • de KamP-Jvan KuijkJSmeetsJ2007Single IV sugammaedx doses up to 32 mg/kg are not associated with QT/QTc prolongationAnesthesiology107A1580
  • DuvaldestinPKuizengaKKjaerCC2007Sugammadex achieves fast recovery from profound neuromuscular blockade induced by rocuronium or vecuronium: a dose-response studyEur J Anaesthesiol24Suppl 39123
  • EikermanMBlobnerMGroebenH2006Postoperative upper airway obstruction after recovery of the train of four ratio of the adductor pollicis muscle from neuromuscular blockadeAnesth Analg1029374216492855
  • EleveldDJKuizengaKProostJH2007A temporary decrease in twitch response during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadexAnesth Analg104582417312212
  • EpemoluOBomAHopeF2003Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969Anesthesiology99632712960547
  • ErikssonLI1999The effects of residual neuromuscular blockade and volatile anesthestics on the control of ventilationAnesth Analg892435110389813
  • FlocktonEScanniEGomarC2007Sugammadex after rocuronium provides faster recovery from neuromuscular blockade than neostigmine after cisatracuriumEur J Anaesthesiol24Suppl 39123
  • GijsenberghFRamaelSHouwingN2005First human exposure of Org 25969. A novel agent to reverse the action of rocuronium bromideAnesthesiology10369570316192761
  • Glycopyrrolate injection package insert2002American Regent Laboratories, Inc9 2002Shirley NY. USA
  • GriffithHRJohnsonGE1942The use of curare in general anesthesiaAnesthesiology3418
  • HarrisAMWelliverMRedfernR2007Orthopaedic surgery implications of a novel encapsulation process that improves neuromuscular blockade and reversalThe Internet Journal of Orthopedic Surgery72
  • HartmannJSmeetsJMWdeZwartMAH2007In-vitro dialysability of sugammadex, a selective relaxant binding agent for reversal of neuromuscular block induced by rocuroniumAccessed March 10, 2007 Available at: www.euroanesthesia.org/abstractresults/Madrid2006/f-h.php
  • HayesAHMirakhurRKBreslinDS2001Postoperative residual block after intermediate-acting neuromuscular blocking drugsAnesthesia5631218
  • JonesRKCaldwellJEBrullSJ2007Faster reversal of profound rocuronium-induced neuromuscular blockade with sugammadex vs neostigmineAnesthesiology107A1577
  • Khunl-BradyKRexCSielenkamperA2005Reversal of high-dose rocuronium with Org 25969Eur J Anaesthesiol22Suppl 34121
  • KirkegaardHHeierTCaldwellJ2002Efficacy of tactile-guided reversal from cisatracurium-induced neuromuscular blockAnesthesiology96455011753000
  • KopmanAF2006Sugammadex: A revolutionary approach to neuromuscular antagonismAnesthesiology104631316571954
  • LemmensHJMEl-OrbanyMIBerryJ2007Sugammadex reverses profound vecuronium blockade more rapidly than neostigmineAnesthesiology107A1578
  • LoftssonTPekkaJMarM2005Cyclodextrins in drug deliveryExpert Opin Drug Deliv211716296731
  • LiuLGuoQ-X2002The driving forces in the inclusion complexation of cyclodextrinsJournal of Inclusion Phenomena and Macrocyclic Chemistry42114
  • MacPhersonRD2001Pharmaceuticals for the anaesthetistAnaesthesia569657911576099
  • MasonRBomA2001Org 25969 causes selective reversal of neuromuscular block induced by steroidal NMBs in anesthetized guinea pigsEur J Anaesthesiol18Suppl 2310011270018
  • McDonaghDLBenedictPEKovacAL2007Efficacy and safety for reversal of rocuronium-induced blockade in elederly patientsAnesthesiology107A1583
  • MolinaALde BoerHDKlimeklM2007Reversal of rocuronium-induced (1.2 mg kg−1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg−1)Br J Anaesth98624717347184
  • MurphyGS2006Residual neuromuscular blockade: incidence, assessment, and relevance in the postoperative periodMinerva Anesthesiol7297109
  • MurphyGSSzokolJWMarymontJH2005Residual paralysis at the time of tracheal extubationAnesth Analg1001840184515920224
  • NaguibM2007Sugammadex: Another milestone in clinical neuromuscular pharmacologyAnesth Analg1045758117312211
  • Neostigmine package insert2002American Regent Laboratories, Inc9 2002Shirley NY. USA
  • PlaudBMeretojaOPohlB2007Reversal of rocuronium-induced neuromuscular blockade with sugammadex in paediatric and adult patientsEur J Anaesthesiol24Suppl 39124
  • PuhringerFBlaszykMCammuG2007Sugammadex achieves fast recovery from shallow neuromuscular blockade induced by rocuronium of vecuronium: dose-response studiesEur J Anaesthesiol24Suppl 39111
  • RexCKhuenl-BradyKSielenkaemper2005Reversal of high-dose rocuronium (1.2 mg/kg) with Org 25969AnesthesiologyA1129
  • Rocuronium Bromide package insert2007Organon InternationalOss NetherlandsAccessed Oct 9, 2007 URL: http://www.zemuron.com/hcp/productsummary/chemistry/index.asp?C=86765393246433101852&svarqvp2=0
  • SacanOWhitePFTufanogullariB2007Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropineAnesth Analg1045697417312210
  • ShahRR2005Drugs, QTc interval prolongation and final ICH E14 guideline: An important milestone with challenges aheadDrug Saf2810092816231954
  • ShieldsMGiovannelliMMirakhurRK2006Org 25069 (sugammadex) a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular blockadeBr J Anaesthesiol963643
  • SinghPDKaurJSidhuGS1982Assessment of postoperative residual paralysis with muscle relaxantsIndian Journal of Anaesthesia304838
  • StaalsLMSnoekMMJFlocktonE2007The efficacy of sugammadex in subjects with impaired renal functionEur J Anaesthesiol24Suppl 39122316938153
  • SorgenfreiIFNorrildKLarsenPB2006Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety studyAnesthesiology1046677416571960
  • SuyKMoriasKCammuG2007Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agentAnesthesiology106283817264722
  • SzenteJSzejtliJ1999Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in developmentAdv Drug Deliv Rev36172810837706
  • SzejtliJozsef2004Past, present, and future of cyclodextrin researchPure Appl Chem76182545
  • TarverGJGroveSJBuchananK20022-O-substituted cyclodextrins as reversal agents for the neuromuscular blocker rocuronium bromideBioorg Med Chem1018192711937340
  • ThompsonDOChaubalMV2002Cyclodextrins (CDS) excipients by definition, drug delivery systems by function (part I: injectable applications)Drug Delivery Technology273438
  • TramerMRFuchs-BuderT1999Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic reviewBr J Anaesthesiol8237986
  • United States Department of Health and Human Services2007Guidance for IndustryE14 clinical evaluation of QT/QTc interval prolongation and proarrythmic potential for non-antiarrythmic drugs10 2005Accessed Sept 10, 2007 URL: http://www.fda.gov/cber/gdlns/iche14qtc.htm
  • VanackerBVermeyenKStruysMRF2005Reversal by Org 25969 is not affected by sevoflurane when compared with propofolEur J Anaesthesiol22Suppl 34119
  • VanackerBFVermeyenKMStruysMMRF2007Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevofluraneAnesth Analg104563817312209
  • WelliverM2006New drug sugammadexAANA J743576317048555
  • WelliverM2007Update for nurse anesthetists. Part 3. Cyclodextrin introduction to anesthesia practice: form, function, and applicationAANA J752899617711159
  • ZhangM-Q2003Drug-specific cyclodextrins: The future of rapid neuromuscular block reversal?Drugs Future2834754