Drug Design, Development and Therapy, Volume 2, Issue (2008)

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Drug Design, Development and Therapy, Volume 2, Issue (2008)

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Opinion

Article
Aerosol delivery by an ultrasonic nebulizer during different mechanical ventilation settings in a lung model – a pilot study
Michael Winterhalter, Michael Bund, Nawid Khaladj, Christian Hagl, Andre Simon, Ludwig Hoy, Siegfried Piepenbrock & Niels Rahe-Meyer
Pages: 1-7
Published online: 28 Sep 2022
AbstractforAerosol delivery by an ultrasonic nebulizer during different mechanical ventilation settings in a lung model – a pilot study | Full Text | References | PDF (163.5 KB)
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Open Access

Review

Review Article
Pharmaco-management of inhalation injuries for burn survivors
Anthony C Bartley, Dale W Edgar & Fiona M Wood
Pages: 9-16
Published online: 28 Sep 2022
AbstractforPharmaco-management of inhalation injuries for burn survivors | Full Text | References | PDF (148.5 KB)
  • 77 Views
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Open Access

Original Research

Article
A safety-modified SV40 Tag developed for human cancer immunotherapy
Stephanie S Tseng-Rogenski, Mohamed S Arredouani, June F Escara-Wilke, Yilin C Neeley, Michael J Imperiale & Martin G Sanda
Pages: 17-24
Published online: 28 Sep 2022
AbstractforA safety-modified SV40 Tag developed for human cancer immunotherapy | Full Text | References | PDF (4.1 MB)
  • 25 Views
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Open Access
Article
Outcome of anthroposophic medication therapy in chronic disease: A 12-month prospective cohort study
Harald J Hamre, Claudia M Witt, Anja Glockmann, Renatus Ziegler, Gunver S Kienle, Stefan N Willich & Helmut Kiene
Pages: 25-37
Published online: 28 Sep 2022
AbstractforOutcome of anthroposophic medication therapy in chronic disease: A 12-month prospective cohort study | Full Text | References | PDF (176.6 KB)
  • 63 Views
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Open Access
Article
Optimization of experimental parameters for the production of LMWH-loaded polymeric microspheres
Nusrat Motlekar & Bi-Botti Youan
Pages: 39-47
Published online: 28 Sep 2022
AbstractforOptimization of experimental parameters for the production of LMWH-loaded polymeric microspheres | Full Text | References | PDF (1.1 MB)
  • 71 Views
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Open Access

Review

Review Article
Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent
Mark Welliver, John McDonough, Nicholas Kalynych & Robert Redfern
Pages: 49-59
Published online: 25 Feb 2008
AbstractforDiscovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent | Full Text | References | PDF (3.4 MB)
  • 146 Views
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Open Access

Original Research

Article
Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells
Laurent Brard, Rakesh K Singh, Kyu Kwang Kim, Thilo S Lange & Giselle L Saulier Sholler
Pages: 61-69
Published online: 28 Sep 2022
AbstractforInduction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells | Full Text | References | PDF (3 MB)
  • 43 Views
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Open Access

Review

Review Article
Modafinil in the treatment of excessive sleepiness
Jonathan RL Schwartz
Pages: 71-85
Published online: 20 May 2008
AbstractforModafinil in the treatment of excessive sleepiness | Full Text | References | PDF (132.2 KB)
  • 83 Views
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Open Access

Original Research

Article
Changes in CD4+ T-cells and HIV RNA resulting from combination of anti-TB therapy with Dzherelo in TB/HIV dually infected patients
Lyudmila G Nikolaeva, Tatyana V Maystat, Lilia A Masyuk, Volodymyr S Pylypchuk, Yuri L Volyanskii & Galyna A Kutsyna
Pages: 87-93
Published online: 28 Sep 2022
AbstractforChanges in CD4+ T-cells and HIV RNA resulting from combination of anti-TB therapy with Dzherelo in TB/HIV dually infected patients | Full Text | References | PDF (137.3 KB)
  • 35 Views
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Open Access

Review

Review Article
Pharmacological control of neutrophil-mediated inflammation: Strategies targeting calcium handling by activated polymorphonuclear leukocytes
Gregory R Tintinger, Helen C Steel, Annette J Theron & Ronald Anderson
Pages: 95-104
Published online: 28 Sep 2022
AbstractforPharmacological control of neutrophil-mediated inflammation: Strategies targeting calcium handling by activated polymorphonuclear leukocytes | Full Text | References | PDF (168.6 KB)
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Open Access

Original Research

Article
A phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck
Glen C MacDonald, Michèle Rasamoelisolo, Joycelyn Entwistle, Jeannick Cizeau, Denis Bosc, Wendy Cuthbert, Mark Kowalski, Maureen Spearman & Nick Glover
Pages: 105-114
Published online: 25 Jun 2008
AbstractforA phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck | Full Text | References | PDF (1,004.2 KB)
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Open Access

Review

Review Article
Gene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China
Guangyu Ma, Hideaki Shimada, Kenzo Hiroshima, Yuji Tada, Nobuo Suzuki & Masatoshi Tagawa
Pages: 115-122
Published online: 11 Aug 2008
AbstractforGene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China | Full Text | References | PDF (85.2 KB)
  • 52 Views
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Open Access

Original Research

Article
Structure-based design of anticancer prodrug PABA/NO
Xinhua Ji, Ajai Pal, Ravi Kalathur, Xun Hu, Yijun Gu, Joseph E Saavedra, Gregory S Buzard, Aloka Srinivasan, Larry K Keefer & Shivendra V Singh
Pages: 123-130
Published online: 11 Aug 2008
AbstractforStructure-based design of anticancer prodrug PABA/NO | Full Text | References | PDF (5.6 MB)
  • 42 Views
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Open Access

Review

Review Article
Submucosal injection solution for gastrointestinal tract endoscopic mucosal resection and endoscopic submucosal dissection
Toshio Uraoka, Yutaka Saito, Kazuhide Yamamoto & Takahiro Fujii
Pages: 131-138
Published online: 28 Sep 2022
AbstractforSubmucosal injection solution for gastrointestinal tract endoscopic mucosal resection and endoscopic submucosal dissection | Full Text | References | PDF (1.6 MB)
  • 121 Views
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Open Access

Expert Opinion

Article
Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulations
Akira Fujii, Norio Yasui-Furukori, Taku Nakagami, Takenori Niioka, Manabu Saito, Yasushi Sato & Sunao Kaneko
Pages: 139-144
Published online: 11 Aug 2008
AbstractforComparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulations | Full Text | References | PDF (243 KB)
  • 114 Views
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Open Access

Original Research

Article
Surface activity of surfactant spiked with vitamin A
Vadim Bronshtein, Vugranam Venkatesh, Jas Aulakh & Philippe Chessex
Pages: 145-150
Published online: 14 Aug 2008
AbstractforSurface activity of surfactant spiked with vitamin A | Full Text | References | PDF (151.1 KB)
  • 40 Views
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Open Access

Review

Review Article
Maraviroc in the treatment of HIV infection
Neelanjana Ray
Pages: 151-161
Published online: 20 Aug 2008
AbstractforMaraviroc in the treatment of HIV infection | Full Text | References | PDF (19.4 MB)
  • 128 Views
  • 7 CrossRef citations
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Free Access
Review Article
Polyethylenimine-mediated gene delivery to the lung and therapeutic applications
Sante Di Gioia & Massimo Conese
Pages: 163-188
Published online: 19 Sep 2008
AbstractforPolyethylenimine-mediated gene delivery to the lung and therapeutic applications | Full Text | References | PDF (980.9 KB)
  • 98 Views
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Open Access
Review Article
Next-generation anthracycline for the management of small cell lung cancer: focus on amrubicin
Michiko Yamamoto, Akira Takakura & Noriyuki Masuda
Pages: 189-192
Published online: 28 Sep 2008
AbstractforNext-generation anthracycline for the management of small cell lung cancer: focus on amrubicin | Full Text | References | PDF (108.3 KB)
  • 32 Views
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Free Access
Review Article
Transdermal hormone therapy in postmenopausal women: A review of metabolic effects and drug delivery technologies
Nathan W Kopper, Jennifer Gudeman & Daniel J Thompson
Pages: 193-202
Published online: 10 Oct 2008
AbstractforTransdermal hormone therapy in postmenopausal women: A review of metabolic effects and drug delivery technologies | Full Text | References | PDF (190.2 KB)
  • 221 Views
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Open Access
Review Article
Review of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes
Gina Ryan, Tim A Briscoe & Lynette Jobe
Pages: 203-214
Published online: 16 Oct 2008
AbstractforReview of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes | Full Text | References | PDF (327 KB)
  • 130 Views
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Free Access

Case Report

Case Report
Severe toxicity of skin rash, fever and diarrhea associated with imatinib: case report and review of skin toxicities associated with tyrosine kinase inhibitors
Xuan Huang, Samir Patel, Nasir Ahmed, Karen Seiter & Delong Liu
Pages: 215-219
Published online: 27 Oct 2008
AbstractforSevere toxicity of skin rash, fever and diarrhea associated with imatinib: case report and review of skin toxicities associated with tyrosine kinase inhibitors | Full Text | References | PDF (1,016.3 KB)
  • 53 Views
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Open Access

Original Research

Article
Antidiabetic Bis-Maltolato-OxoVanadium(IV): Conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B
Thomas Scior, Hans-Georg Mack, José Antonio Guevara García & Wolfhard Koch
Pages: 221-231
Published online: 28 Sep 2022
AbstractforAntidiabetic Bis-Maltolato-OxoVanadium(IV): Conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B | Full Text | References | PDF (2.8 MB)
  • 54 Views
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Open Access

Review

Review Article
Development and targeted use of nilotinib in chronic myeloid leukemia
Carmen Fava, Hagop Kantarjian, Jorge Cortes & Elias Jabbour
Pages: 233-243
Published online: 10 Nov 2008
AbstractforDevelopment and targeted use of nilotinib in chronic myeloid leukemia | Full Text | References | PDF (100.8 KB)
  • 52 Views
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Free Access
Review Article
Once-daily transdermal rivastigmine in the treatment of Alzheimer’s disease
Andreas Wentrup, Wolfgang H Oertel & Richard Dodel
Pages: 245-254
Published online: 28 Sep 2022
AbstractforOnce-daily transdermal rivastigmine in the treatment of Alzheimer’s disease | Full Text | References | PDF (180.6 KB)
  • 65 Views
  • 2 CrossRef citations
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Free Access
Review Article
Drug design with Cdc7 kinase: a potential novel cancer therapy target
Masaaki Sawa & Hisao Masai
Pages: 255-264
Published online: 18 Nov 2008
AbstractforDrug design with Cdc7 kinase: a potential novel cancer therapy target | Full Text | References | PDF (4.6 MB)
  • 60 Views
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Open Access
Review Article
Ambrisentan for the treatment of pulmonary arterial hypertension
Brian Casserly & James R Klinger
Pages: 265-280
Published online: 04 Dec 2008
AbstractforAmbrisentan for the treatment of pulmonary arterial hypertension | Full Text | References | PDF (236.7 KB)
  • 60 Views
  • 7 CrossRef citations
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Free Access
Review Article
Raltegravir in the management of HIV-infected patients
Hans-Jürgen Stellbrink
Pages: 281-288
Published online: 23 Dec 2008
AbstractforRaltegravir in the management of HIV-infected patients | Full Text | References | PDF (170.2 KB)
  • 26 Views
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Free Access

Original Research

Article
Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry
Klaus Braun, Manfred Wiessler, Volker Ehemann, Ruediger Pipkorn, Herbert Spring, Juergen Debus, Bernd Didinger, Mario Koch, Gabriele Muller & Waldemar Waldeck
Pages: 289-301
Published online: 04 Jan 2009
AbstractforTreatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry | Full Text | References | PDF (3.9 MB)
  • 45 Views
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Open Access

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