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Review

Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension

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Pages 73-83 | Published online: 24 May 2010

References

  • VijayaLGeorgeRPaulPGPrevalence of open-angle glaucoma in a rural South India populationInvest Ophthalmol Vis Sci2005464461446716303934
  • IwaseASuzukiYAraieMTajimi Study Group, Japan Glaucoma SocietyThe Prevalence of Primary Open-Angle Glaucoma in Japanese: The Tajimi StudyOphthalmology20041111641164815350316
  • LeskeCMOpen-angle glaucoma – an epidemiologic overviewOphthalmic Epidemiol20071416617217896292
  • SakataKSakataLMSakataVMPrevalence of glaucoma in a South Brazilian population: Projeto GlaucomaInvest Ophthalmol Vis Sci2007484974497917962447
  • The Eye Diseases Prevalence Research GroupCauses and prevalence of visual impairment among adults in the United StatesArch Ophthalmol200412247748515078664
  • AstromSStenlundHLindenCIncidence and prevalence of pseudoexfoliations and open-angle glaucoma in northern Sweden: Results after 21 years of follow-upActa Opthalmol Scand200785832837
  • AntonAAndradaMTMujicaVCalleMAPortelaJMayoAPrevalence of primary open-angle glaucoma in a spanish population: The Segovia StudyJ Glaucoma20041337137615354074
  • QuigleyHBromanATThe number of people with glaucoma worldwide in 2010 and 2020Br J Ophthalmol20069026226716488940
  • SchwartzKBudenzDCurrent management of glaucomaCurr Opin Ophthalmol20041511912615021223
  • The Royal College of OphthalmologistsGuidelines for the management of open angle glaucoma and ocular hypertension http://www.rcophth.ac.uk. Accessed Dec 10, 2009
  • MarquisREWhitsonJTManagement of glaucoma: focus on pharmacological therapyDrugs Aging20052212115663346
  • HoyngPFJvan BeekLMPharmacological therapy for glaucoma: a reviewDrugs20005941143410776828
  • HigginbothamEJHansenJDavisEJWaltJGGuckianAGlaucoma medication persistence with a fixed combination versus multiple bottlesCurr Med Res Opin2009252543254719731993
  • YehJKravitzDFrancisBRational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucomaClin Ophthalmol2008238939919668730
  • BalfourJAWildeMIDorzolamide: a review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertensionDrugs Aging1997103844039143858
  • HeelRCBrogdenRNSpeightTMTimolol: a review of its therapeutic efficacy in the topical treatment of glaucomaDrugs1979173855369807
  • SugrueMFPharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitorsProg Retinal Eye Res20001987112
  • CoakesRLBrubakerRFThe mechanism of timolol in lowering intraocular pressure in the normal eyeArch Ophthalmol19789620452048363105
  • SonntagJRBrindleyGOShieldsMBEffect of timolol therapy on outflow facilityInvest Ophthalmol Vis Sci197817293296627467
  • ZimmermanTJHarbinRPettMTimolol and facility of outflowInvest Ophthalmol Vis Sci197716623624873723
  • PhylactosACTimolol inhibits adenylate cyclase activity in the iris-ciliary body and trabecular meshwork of the eye and blocks activation of the enzyme by salbutamolActa Ophthalmol (Copenh)1986646136223028033
  • OrmrodDMcClellanKTopical dorzolamide 2%/timolol 0.5%: a review of its use in the treatment of open-angle glaucomaDrugs Aging20001747749611200308
  • ShellJWPharmacokinetics of topically applied ophthalmic drugsSurv Ophthalmol1982262072187041308
  • HasegawaTHaraKHataSBinding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitroDrug Metab Dispos1994223773828070313
  • WongBKBruhinPJBarrishANonlinear dorzolamide pharmacokinetics in rats: concentration-dependent erythrocyte distribution and drug-metabolite displacement interactionDrug Metab Dispos1996246596638781782
  • MarenTHConroyCWWynnsGCOcular absorption, blood levels, and excretion of dorzolamide, a topically active carbonic anhydrase inhibitorJ Ocul Pharmacol Ther19971323309029437
  • WilkersonMCyrlinMLippaEAFour-week safety and efficacy study of dorzolamide, a novel, active topical carbonic anhydrase inhibitorArch Ophthalmol1993111134313508216014
  • StrahlmanETippingRVogelRA six-week dose-response study of the ocular hypotensive effect of dorzolamide with a one-year extension. Dorzolamide Dose-Response Study GroupAm J Ophthalmol1996122183194 Erratum: Am J Ophthalmol. 1996; 122:928.8694086
  • BiollazJMunafoABuclinTWhole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamideEur J Clin Pharmacol199547453460
  • Martens-LobenhofferJBandittPClinical pharmacokinetics of dorzolamideClin Pharmacokinet20024119720511929320
  • SieskyBHarrisABrizendineELiterature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flowSurv Ophthalmol200954334619171209
  • JanulevicieneIHarrisAKagemannLA comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patientsActa Ophthalmol Scand20048273073715606472
  • ManniGCentofantiMGregoriDThe pulsatile ocular blood flow behaviour in open angle glaucoma patients after replacing timolol therapy with timolol and dorzolamide fixed combination: preliminary studyActa Ophthalmol Scand20022365556
  • MartinezASanchezMA comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patientsCurr Med Res Opin200622677316393432
  • HarrisAJonescu-CuypersCPKagemannLEffect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucomaAm J Ophthalmol200113249049511589868
  • RolleTTofaniFBrogliattiBGrignoloFMThe effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patientsEye (Lond)2008221172117918202708
  • Fuchsjager-MayrlGWallyBRainerGEffect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertensionBr J Ophthalmol2005891293129716170119
  • GalassiFSodiARenieriGEffects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucomaOphthalmologica200221612312811919438
  • ClineschmidtCMWilliamsRDSnyderEA randomized trial in patients inadequately controlled with timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Dorzolamide-Timolol Combination Study GroupOphthalmology199810519529599787369
  • BoyleJEGhoshKGieserDKA randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol and dorzolamide. Dorzo lamide-Timolol Study GroupOphthalmology1998105194519519787368
  • FechtnerRDAiraksinenPJGetsonAJEfficacy and tolerability of the dorzolamide 2%/timolol 0.5% combination (COSOPT) versus 0.005% (XALATAN) in the treatment of ocular hypertension or glaucoma: results from two randomized clinical trialsActa Ophthalmol Scand200482424814982045
  • SusannaRJrSheuWPComparison of latanoprost with fixed combination dorzolamide and timolol in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label, parallel-group, multicenter study in Latin AmericaClin Ther20042675576815220019
  • HonrubiaFMLarssonLISpiegelDA comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucomaActa Ophthalmol Scand20028063564112485286
  • KonstasAGPapapanosPTersisITwenty-four-hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combinationOphthalmology20031101357136012867391
  • OrzalesiNRissettiLBottoliAThe effect of latanoprost, brimonidinee and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertensionArch Ophthalmol200312145345712695241
  • OzturkFErmisSInanUComparison of ocular hypotensive effects of bimatoprost and timolol-dorzolamide combination in patients with elevated intraocular pressure: a 6 month studyActa Ophthalmol Scand200785808317244215
  • ChiselitaDAntohiIMedvichiRComparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, ran-domized, masked, cross-over design studyOftalmologia200549394516408674
  • ParmaksizSYukselNKarabasVLA comparison of travoprost, latanoprost, and the fixed combination of dorzolamide and timolol in patients with pseudoexfoliation glaucomaEur J Ophthalmol200616738016496249
  • ColemanALLernerFBernsteinPA 3-month randomized controlled trial of bimatoprost (LUMIGAN) versus combined timolol and dorzolamide (Cosopt) in patients with glaucoma or ocular hypertensionOphthalmology20031102362236814644719
  • DayDGSharpeEDBeischelCJSafety and efficacy of bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% fixed combinationEur J Ophthalmol20051533634215945001
  • SuzukiERJFranklinLMda SilvaLJComparison of the efficacy and safety of travoprost with a fixed-combination of dorzolamide and timolol in patients with open-angle glaucoma or ocular hypertensionCurr Med Res Opin2006221799180516968583
  • DayDGSchacknowCJWandMTimolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open angle glaucoma or ocular hypertensionAm J Ophthalmol200313513814312566015
  • HutzelmannJOwensSSheddenAComparison of the safety and efficacy of the fixed combination of dorzolamide/timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study. International Clinical Equivalence Study GroupBr J Ophthalmol199882124912539924327
  • StrohmaierKSnyderEDuBinerHThe efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components. Dorzolamide-Timolol Study GroupOphthalmology1998105193619449787367
  • SallKNGreffLJJohnson-PrattLRDorzolamide/timolol combination versus concomitant administration of brimonidinee and timolol: six-month comparison of efficacy and tolerabilityOphthalmology200311061562412623832
  • SolishAMDeLuccaPTCasselDADorzolamide/timolol fixed combination versus concomitant administration of brimonidinee and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measuresJ Glaucoma20041314915715097262
  • NixonDRYanDBChartrandJPPiemontesiRLSimonyiSHollanderDAThree-month, randomized, parallel-group comparison of brimonidinee-timolol versus dorzolamide-timolol fixed-combination therapyCurr Med Res Opin20092516451653
  • ArcieriESPereiraACAAndreoEGVFixed combination brimonidinee-timolol (Combigan) versus fixed combination dorzolamide-timolol (Cosopt) each given twice daily to reduce intraocular pressure in subjects with glaucoma or ocular hypertension [abstract no. E434–169]Invest Ophthalmol Vis Sci200647
  • ZabriskieNNetlandPAComparison of brimonidinee/latanoprost and timolol/dorzolamide: two randomized, double masked, parallel clinical trialsAdv Ther2003209210012836809
  • SverrissonTGrossRPearsonJThe dorzolamide/timolol combination versus timolol plus pilocarpine: patient preference and impact on daily life. United States Patient Preference Study Group. International Patient Preference Study GroupJ Glaucoma1999831532410529932
  • KalzunyJSzaflikJCzechowicz-JanickaKTimolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open angle glaucoma or ocular hypertensive patientsActa Ophthalmol Scand20038134935412859261
  • ShinDHFeldmanRMSheuWPEfficacy and safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressureOphthalmology200411127628215019375
  • KonstasAGKozobolisVPLallosNDaytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%Eye2004181264126915218522
  • CvenkelBStewartJANelsonLAStewartWCDorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertensionCurr Eye Res20083316316818293187
  • ManniGDenisPChewPThe safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertensionJ Glaucoma20091829330019365194
  • MundorfTKRauchmanSHWilliamsRDNotivolRBrinzolamide/Timolol Preference Study Group. A patient preference comparison of Azarga (brinzolamide/timolol fixed combination) vs Cosopt (dorzolamide/timolol fixed combination) in patients with open-angle glaucoma or ocular hypertensionClin Ophthalmol2008262362819668763
  • TeusMAMigliorSLaganovskaGEfficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertensionClin Ophthalmol2009362963619997566
  • HatanakaMReisASanoMESusannaRJrAdditive Intraocular pressure reduction effect of fixed combination of maleate timolol 0.5%/dorzolamide 2% (Cosopt) on monotherapy with latanoprost (Xalatan) in patients with elevated intraocular pressure: a prospective, 4-week, open-label, randomized, controlled clinical trialJ Glaucoma200992 [Epub ahead of print]
  • FechtnerRDMcCarrollKALinesCREfficacy of the dorzolamide/timolol fixed combination versus latanoprost in the treatment of ocular hypertension or glaucoma: combined analysis of pooled data from two large randomized observer and patient-masked studiesJ Ocul Pharmacol Ther20052124224915969642
  • TsaiJCMcClureCARamosSECompliance barriers in glaucoma: a systematic classificationJ Glaucoma20031239339814520147