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Review

Nanomedicine in pulmonary delivery

, &
Pages 299-319 | Published online: 07 Dec 2009

References

  • YangWPetersJIWilliamsRO3rdInhaled nanoparticles–a current reviewInt J Pharm200835623924718358652
  • PattonJSByronPRInhaling medicines: delivering drugs to the body through the lungsNat Rev Drug Discov20076677417195033
  • SungJCPulliamBLEdwardsDANanoparticles for drug delivery to the lungsTrends Biotechnol20072556357017997181
  • BaileyMMBerklandCJNanoparticle formulations in pulmonary drug deliveryMed Res Rev20092919621218958847
  • ShekunovBNanoparticle technology for drug delivery – From nanoparticles to cutting-edge delivery strategies – Part I – 21–22 March 2005, Philadelphia, PA, USAIdrugs2005839940115883921
  • KreuterJNanoparticle-based drug delivery systemsJ Control Release199116169176
  • BriggerIDubernetCCouvreurPNanoparticles in cancer therapy and diagnosisAdv Drug Deliv Rev20025463165112204596
  • TiwariSBAmijiMMA review of nanocarrier-based CNS delivery systemsCurr Drug Deliv2006321923216611008
  • KaurIPBhandariRBhandariSKakkarVPotential of solid lipid nanoparticles in brain targetingJ Control Release20081279710918313785
  • DriscollDBhargavaHLiLZaimRBabayanVBistrianBPhysicochemical stability of total nutrient admixturesAm J Health Syst Pharm1995526236347606577
  • KosterVSKuksPFMLangeRTalsmaHParticle size in parenteral fat emulsions, what are the true limitations?Int J Pharm1996134235238
  • ZimmerAKreuterJMicrospheres and nanoparticles used in ocular delivery systemsAdv Drug Deliv Rev1995166173
  • ChonoSTaninoTSekiTMorimotoKInfluence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomesJ Drug Target20061455756617043040
  • ParkJHLeeSKimJHParkKKimKKwonICPolymeric nanomedicine for cancer therapyProg Polym Sci200833113137
  • ResnikDBTinkleSSEthical issues in clinical trials involving nanomedicineContemp Clin Trials20072843344117166777
  • AzarmiSRoaWHLobenbergRTargeted delivery of nanoparticles for the treatment of lung diseasesAdv Drug Deliv Rev20086086387518308418
  • CryanSACarrier-based strategies for targeting protein and peptide drugs to the lungsAAPS J20057E20E4116146340
  • JoshiMRMisraALiposomal budesonide for dry powder inhaler: preparation and stabilizationAAPS Pharm Sci Tech2001225
  • KonduriKSNandedkarSDuzgunesNEfficacy of liposomal budesonide in experimental asthmaJ Allergy Clin Immunol200311132132712589352
  • StentonGRUlanovaMDeryREInhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinaseJ Immunol20021691028103612097411
  • JoshiMMisraADisposition kinetics of ketotifen from liposomal dry powder for inhalation in rat lungClin Exp Pharmacol Physiol20033015315612603343
  • SeongJHLeeKMKimSTJinSEKimCKPolyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammationJ Gene Med2006831432316292779
  • ChattopadhyayPShekunovBYYimDCipollaDBoydBFarrSProduction of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx systemAdv Drug Deliv Rev20075944445317582648
  • HajosFStarkBHenslerSPrasslRMosgoellerWInhalable liposomal formulation for vasoactive intestinal peptideInt J Pharm200835728629418328650
  • StarkBDebbagePAndreaeFMosgoellerWPrasslRAssociation of vasoactive intestinal peptide with polymer-grafted liposomes: structural aspects for pulmonary deliveryBiochim Biophys Acta2007176870571417204237
  • WernigKGriesbacherMAndreaeFDepot formulation of vasoactive intestinal peptide by protamine-based biodegradable nanoparticlesJ Control Release200813019219818601963
  • WijagkanalanWKawakamiSTakenagaMIgarashiRYamashitaFHashidaMEfficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in ratsJ Control Release200812512113018037185
  • GongFTangHLinYGuWWangWKangMGene transfer of vascular endothelial growth factor reduces bleomycin-induced pulmonary hypertension in immature rabbitsPediatr Int20054724224715910444
  • KimuraSEgashiraKChenLNanoparticle-mediated delivery of nuclear factor {kappa}B decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertensionHypertension2009
  • ChouguleMBPadhiBKMisraANano-liposomal dry powder inhaler of Amiloride HydrochlorideJ Nanosci Nanotechnol200663001300917048511
  • GibbonsAMMcElvaneyNGTaggartCCCryanSADelivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradationJ Microencapsul2008110
  • BeaulacCSachetelliSLagaceJAerosolization of low phase transition temperature liposomal tobramycin as a dry powder in an animal model of chronic pulmonary infection caused by Pseudomonas aeruginosaJ Drug Target19997334110614813
  • MarierJFBrazierJLLavigneJDucharmeMPLiposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal administrations in ratsJ Antimicrob Chemother20035224725212837733
  • LabanaSPandeyRSharmaSKhullerGKChemotherapeutic activity against murine tuberculosis of once weekly administered drugs (isoniazid and rifampicin) encapsulated in liposomesInt J Antimicrob Agents20022030130412385689
  • VyasSPKannanMEJainSMishraVSinghPDesign of liposomal aerosols for improved delivery of rifampicin to alveolar macrophagesInt J Pharm2004269374914698575
  • ChangsanNChanHKSeparovicFSrichanaTPhysicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalationJ Pharm Sci20099862863918484099
  • JustoORMoraesAMIncorporation of antibiotics in liposomes designed for tuberculosis therapy by inhalationDrug Deliv20031020120712944141
  • PandeyRSharmaAZahoorASharmaSKhullerGKPrasadBPoly(DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosisJ Antimicrob Chemother20035298198614613962
  • ZahoorASharmaSKhullerGKInhalable alginate nanoparticles as antitubercular drug carriers against experimental tuberculosisInt J Antimicrob Agents20052629830316154726
  • EsmaeiliFHosseini-NasrMRad-MalekshahiMSamadiNAtyabiFDinarvandRPreparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticlesNanomedicine2007316116717468055
  • OhashiKKabasawaTOzekiTOkadaHOne-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosisJ Control Release2009135192419121349
  • PandeyRKhullerGKSolid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosisTuberculosis (Edinb)20058522723415922668
  • WongJPYangHBlasettiKLSchnellGConleyJSchofieldLNLiposome delivery of ciprofloxacin against intracellular Francisella tularensis infectionJ Control Release20039226527314568408
  • SweeneyLGWangZLoebenbergRWongJPLangeCFFinlayWHSpray-freeze-dried liposomal ciprofloxacin powder for inhaled aerosol drug deliveryInt J Pharm200530518018516242277
  • ShahSPMisraADevelopment of liposomal amphotericin B dry powder inhaler formulationDrug Deliv20041124725315371106
  • VyasSPQuraishiSGuptaSJaganathanKSAerosolized liposome-based delivery of amphotericin B to alveolar macrophagesInt J Pharm2005296122515885451
  • KhannaCAndersonPMHaszDEKatsanisENevilleMKlausnerJSInterleukin-2 liposome inhalation therapy is safe and effective for dogs with spontaneous pulmonary metastasesCancer199779140914219083164
  • DensmoreCLKleinermanESGautamAGrowth suppression of established human osteosarcoma lung metastases in mice by aerosol gene therapy with PEI-p53 complexesCancer Gene Ther2001861962711593330
  • GautamADensmoreCLWaldrepJCInhibition of experimental lung metastasis by aerosol delivery of PEI-p53 complexesMol Ther2000231832311020346
  • KoshkinaNVAgoulnikIYMeltonSLDensmoreCLKnightVBiodistribution and pharmacokinetics of aerosol and intravenously administered DNA-polyethyleneimine complexes: optimization of pulmonary delivery and retentionMol Ther2003824925412907147
  • GautamADensmoreCLMeltonSGolunskiEWaldrepJCAerosol delivery of PEI-p53 complexes inhibits B16-F10 lung metastases through regulation of angiogenesisCancer Gene Ther20029283611916242
  • VerschraegenCFGilbertBELoyerEClinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignanciesClin Cancer Res2004102319232615073107
  • ShahiwalaAMisraAA preliminary pharmacokinetic study of liposomal leuprolide dry powder inhaler: a technical noteAAPS Pharm Sci Tech20056E482E486
  • AzarmiSTaoXChenHFormulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particlesInt J Pharm200631915516116713150
  • HwangSKJinHKwonJTAerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter miceGene Ther2007141353136117611588
  • JinHKimTHHwangSKAerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null miceMol Cancer Ther200651041104916648576
  • TaetzSNafeeNBeisnerJThe influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2’-O-methyl-RNA directed against telomerase in lung cancer cellsEur J Pharm Biopharm20097235836918703137
  • JereDXuCXAroteRYunCHChoMHChoCSPoly(betaamino ester) as a carrier for si/shRNA delivery in lung cancer cellsBiomaterials2008292535254718316120
  • XuCXJereDJinHPoly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesisAm J Respir Crit Care Med2008178607318310482
  • TomodaKOhkoshiTHirotaKPreparation and properties of inhalable nanocomposite particles for treatment of lung cancerColloids Surf B Biointerfaces20097117718219264458
  • de SemirDPetrizJAvinyoANon-viral vector-mediated uptake, distribution, and stability of chimeraplasts in human airway epithelial cellsJ Gene Med2002430832212112648
  • GilbertBEKnightCAlvarezFGTolerance of volunteers to cyclosporine A-dilauroylphosphatidylcholine liposome aerosolAm J Respir Crit Care Med1997156178917939412556
  • ChouguleMPadhiBMisraANano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokineticsInt J Nanomedicine2007267568818203434
  • Bivas-BenitaMvan MeijgaardenKEFrankenKLPulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosisVaccine2004221609161515068842
  • Bivas-BenitaMOudshoornMRomeijnSCationic submicron emulsions for pulmonary DNA immunizationJ Control Release200410014515515491818
  • KaipelMWagnerAWassermannEIncreased biological half-life of aerosolized liposomal recombinant human Cu/Zn superoxide dismutase in pigsJ Aerosol Med Pulm Drug Deliv20082128129018578594
  • CarpenterMEpperlyMWAgarwalAInhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damageGene Ther20051268569315750616
  • EpperlyMWGuoHLJeffersonMCell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapyGene Ther20031016317112571645
  • YamamotoHKunoYSugimotoSTakeuchiHKawashimaYSurfacemodified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctionsJ Control Release200510237338115653158
  • ZhangQShenZNagaiTProlonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal ratsInt J Pharm2001218758011337151
  • HuangYYWangCHPulmonary delivery of insulin by liposomal carriersJ Control Release200611391416730838
  • BiRShaoWWangQZhangNSpray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary deliveryJ Drug Target20081663964818982512
  • LiuJGongTFuHSolid lipid nanoparticles for pulmonary delivery of insulinInt J Pharm200835633334418281169
  • BaiSThomasCAhsanFDendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparinJ Pharm Sci2007962090210617286291
  • BaiSAhsanFSynthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparinPharm Res20092653954819034631
  • PirasAMChielliniFFiumiCA new biocompatible nanoparticle delivery system for the release of fibrinolytic drugsInt J Pharm200835726027118313868
  • PlumleyCGormanEMEl-GendyNBybeeCRMunsonEJBerklandCNifedipine nanoparticle agglomeration as a dry powder aerosol formulation strategyInt J Pharm200936913614319015016
  • AlmeidaAJSoutoESolid lipid nanoparticles as a drug delivery system for peptides and proteinsAdv Drug Deliv Rev20075947849017543416
  • Koping-HoggardMVarumKMIssaMImproved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomersGene Ther2004111441145215269712
  • HowardKARahbekULLiuXRNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle systemMol Ther20061447648416829204
  • GrenhaASeijoBRemunan-LopezCMicroencapsulated chitosan nanoparticles for lung protein deliveryEur J Pharm Sci20052542743715893461
  • IssaMMKoping-HoggardMTommeraasKTargeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivoJ Control Release200611510311216901570
  • BrzoskaMLangerKCoesterCLoitschSWagnerTOMallinckrodtCIncorporation of biodegradable nanoparticles into human airway epithelium cells-in vitro study of the suitability as a vehicle for drug or gene delivery in pulmonary diseasesBiochem Biophys Res Commun200431856257015120637
  • ShamJOZhangYFinlayWHRoaWHLobenbergRFormulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lungInt J Pharm200426945746714706257
  • KaulGAmijiMTumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studiesPharm Res20052295196115948039
  • ElyLRoaWFinlayWHLobenbergREffervescent dry powder for respiratory drug deliveryEur J Pharm Biopharm20076534635317156987
  • Beck-BroichsitterMGaussJPackhaeuserCBPulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung modelInt J Pharm200936716917818848609
  • LynchJBehanNBirkinshawCFactors controlling particle size during nebulization of DNA-polycation complexesJ Aerosol Med20072025726817894533
  • ChenJGaoXHuKGalactose-poly(ethylene glycol)-poly-ethylenimine for improved lung gene transferBiochem Biophys Res Commun200837537838318694731
  • NguyenJXieXNeuMEffects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungsJ Gene Med2008101236124618780309
  • ZiadyAGGedeonCRMuhammadOMinimal toxicity of stabilized compacted DNA nanoparticles in the murine lungMol Ther2003894895614664797
  • ZiadyAGGedeonCRMillerTTransfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivoMol Ther2003893694714664796
  • Kukowska-LatalloJFRaczkaEQuintanaAChenCRymaszewskiMBakerJRJrIntravascular and endobronchial DNA delivery to murine lung tissue using a novel, nonviral vectorHum Gene Ther2000111385139510910136
  • de FougerollesARDelivery vehicles for small interfering RNA in vivoHum Gene Ther20081912513218257677
  • DensmoreCLAdvances in noninvasive pulmonary gene therapyCurr Drug Deliv20063556316472094
  • De SmedtSCDemeesterJHenninkWECationic polymer based gene delivery systemsPharm Res20001711312610751024
  • WightmanLKircheisRRosslerVDifferent behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivoJ Gene Med2001336237211529666
  • KichlerALeborgneCCoeytauxEDanosOPolyethylenimine-mediated gene delivery: a mechanistic studyJ Gene Med2001313514411318112
  • CholletPFavrotMCHurbinACollJLSide-effects of a systemic injection of linear polyethylenimine-DNA complexesJ Gene Med20024849111828391
  • TangMXSzokaFCThe influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexesGene Ther199748238329338011
  • OgrisMWagnerETumor-targeted gene transfer with DNA polyplexesSomat Cell Mol Genet200227859512774943
  • RudolphCSchillingerUPlankCNonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimineBiochim Biophys Acta20021573758312383945
  • LiSDHuangLSurface-modified LPD nanoparticles for tumor targetingAnn N Y Acad Sci200610821817145918
  • EliyahuHJosephASchillemansJPAzzamTDombAJBarenholzYCharacterization and in vivo performance of dextranspermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemicallyBiomaterials2007282339234917298842
  • ChonoSLiSDConwellCCHuangLAn efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumorJ Control Release2008131646918674578
  • ParkMRKimHWHwangCSHighly efficient gene transfer with degradable poly(ester amine) based on poly(ethylene glycol) diacrylate and polyethylenimine in vitro and in vivoJ Gene Med20081019820718064729
  • KoYTKaleAHartnerWCPapahadjopoulos-SternbergBTorchilinVPSelf-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene deliveryJ Control Release200913313213818929605
  • ZengXMMartinGPMarriottCThe controlled delivery of drugs to the lungInt J Pharm1995124149164
  • MullerRHMaderKGohlaSSolid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the artEur J Pharm Biopharm20005016117710840199
  • SchreierHGonzalez-RothiRJStecenkoAAPulmonary delivery of liposomesJ Control Release199324209223
  • TaylorKMGTaylorGKellawayIWStevensJThe stability of liposomes to nebulisationInt J Pharm1990585761
  • JoshiMMisraANPulmonary disposition of budesonide from liposomal dry powder inhalerMethods Find Exp Clin Pharmacol20012353153611957743
  • ShahSPMisraALiposomal amphotericin B dry powder inhaler: effect of fines on in vitro performancePharmazie20045981281315544064
  • WhiteSBennettDBCheuSEXUBERA: pharmaceutical development of a novel product for pulmonary delivery of insulinDiabetes Technol Ther2005789690616386095
  • StriblingRBrunetteELiggittDGaenslerKDebsRAerosol gene delivery in vivoProc Natl Acad Sci U S A19928911277112811454808
  • AltonEWMiddletonPGCaplenNJNon-invasive liposomemediated gene delivery can correct the ion transport defect in cystic fibrosis mutant miceNat Genet199351351427504552
  • ChadwickSLKingstonHDSternMSafety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteersGene Ther199749379429349430
  • OudrhiriNVigneronJPPeuchmaurMLeclercTLehnJMLehnPGene transfer by guanidinium-cholesterol cationic lipids into airway epithelial cells in vitro and in vivoProc Natl Acad Sci U S A199794165116569050833
  • PillaiRPetrakKBlezingerPUltrasonic nebulization of cationic lipid-based gene delivery systems for airway administrationPharm Res199815174317479833997
  • DensmoreCLGiddingsTHWaldrepJCKinseyBMKnightVGene transfer by guanidinium-cholesterol: dioleoylphosphatidyl-ethanolamine liposome-DNA complexes in aerosolJ Gene Med1999125126410738558
  • GautamADensmoreCLWaldrepJCPulmonary cytokine responses associated with PEI-DNA aerosol gene therapyGene Ther2001825425711313798
  • PitardBOudrhiriNLambertOSterically stabilized BGTC-based lipoplexes: structural features and gene transfection into the mouse airways in vivoJ Gene Med2001347848711601761
  • DeshpandeDSBlanchardJDSchusterJGamma scintigraphic evaluation of a miniaturized AERx pulmonary delivery system for aerosol delivery to anesthetized animals using a positive pressure ventilation systemJ Aerosol Med200518344415741772
  • TempletonNSNonviral delivery for genomic therapy of cancerWorld J Surg20093368569719023615
  • MorilleMPassiraniCVonarbourgAClavreulABenoitJPProgress in developing cationic vectors for non-viral systemic gene therapy against cancerBiomaterials2008293477349618499247
  • CryanSADevocelleMMoranPJHickeyAJKellyJGIncreased intracellular targeting to airway cells using octaarginine-coated liposomes: In vitro assessment of their suitability for inhalationMol Pharm2006310411216579639
  • MehnertWMaderKSolid lipid nanoparticles: production, characterization and applicationsAdv Drug Deliv Rev20014716519611311991
  • SchwarzCMehnertWLucksJSM?lerRHSolid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilizationJ Control Release1994308396
  • WestesenKNovel lipid-based colloidal dispersions as potential drug administration systems – expectations and realityColloid Polym Sci2000278608618
  • MullerRHRuhlDRungeSSchulze-ForsterKMehnertWCytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactantPharm Res1997144584629144731
  • HeydenreichAVWestmeierRPedersenNPoulsenHSKristensenHGPreparation and purification of cationic solid lipid nanospheres–effects on particle size, physical stability and cell toxicityInt J Pharm2003254838712615415
  • RudolphCSchillingerUOrtizAApplication of novel solid lipid nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivoPharm Res2004211662166915497694
  • VideiraMAGanoLSantosCNevesMAlmeidaAJLymphatic uptake of lipid nanoparticles following endotracheal administrationJ Microencapsul20062385586217390627
  • VideiraMABotelhoMFSantosACGouveiaLFde LimaJJAlmeidaAJLymphatic uptake of pulmonary delivered radiolabelled solid lipid nanoparticlesJ Drug Target20021060761312683665
  • LiuFYangJHuangLLiuDEffect of non-ionic surfactants on the formation of DNA/emulsion complexes and emulsion-mediated gene transferPharm Res199613164216468956328
  • YiSWYuneTYKimTWA cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery systemPharm Res20001731432010801220
  • KimTWChungHKwonICSungHCJeongSYIn vivo gene transfer to the mouse nasal cavity mucosa using a stable cationic lipid emulsionMol Cells20001014214710850654
  • BoasUHeegaardPMDendrimers in drug researchChem Soc Rev200433436314737508
  • RudolphCLausierJNaundorfSMullerRHRoseneckerJIn vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimersJ Gene Med2000226927810953918
  • HickeyAJLung deposition and clearance of pharmaceutical aerosols: what can be learned from inhalation toxicology and industrial hygieneAerosol Sci Technol199318290304
  • HickeyAJMansourHMDelivery of drugs by the pulmonary routeFlorenceATSiepmannJModern PharmaceuticsNew York, NYTaylor and Francis, Inc2008191219
  • Merisko-LiversidgeEMcGurkSLLiversidgeGGInsulin nanoparticles: a novel formulation approach for poorly water soluble ZninsulinPharm Res2004211545155315497677
  • RabinowBENanosuspensions in drug deliveryNat Rev Drug Discov2004378579615340388
  • MosénKBáckstromKThalbergKParticle formation and capture during spray drying of inhalable particlesPharm Dev Technol2004940941815581077
  • DudduSPSiskSAWalterYHImproved lung delivery from a passive dry powder inhaler using an Engineered PulmoSphere powderPharm Res20021968969512069174
  • MaaYFNguyenPASitKHsuCCSpray-drying performance of a bench-top spray dryer for protein aerosol powder preparationBiotechnol Bioeng19986030130910099432
  • FreitasSMerkleHPGanderBUltrasonic atomisation into reduced pressure atmosphere – envisaging aseptic spray-drying for microencapsulationJ Control Release20049518519514980767
  • StahlKClaessonMLilliehornPLindenHBackstromKThe effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalationInt J Pharm200223322723711897427
  • GilaniKNajafabadiARBarghiMRafiee-TehraniMThe effect of water to ethanol feed ratio on physical properties and aerosolization behavior of spray dried cromolyn sodium particlesJ Pharm Sci2005941048105915793812
  • VidgrenMTVidgrenPAParonenTPComparison of physical and inhalation properties of spray-dried and mechanically micronized disodium cromoglycateInt J Pharm198735139144
  • US Food and Drug AdministrationGuidance for industry: metered dose inhaler (MDI) and dry powder inhaler (DPI) drug products –chemistry, manufacturing, and controls documentationRockville, INUS Department of Health and Human Services1998
  • KawashimaYSeriganoTHinoTYamamotoHTakeuchiHEffect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrateInt J Pharm1998172179188
  • VanderbistFWeryBPavonIMMoesAJOptimization of a dry powder inhaler formulation of nacystelyn, a new mucoactive agentJ Pharm Pharmacol1999511229123410632079
  • SteckelHBolzenNAlternative sugars as potential carriers for dry powder inhalationsInt J Pharm200427029730614726144
  • HarjunenPLankinenTSalonenHLehtoVPJarvinenKEffects of carriers and storage of formulation on the lung deposition of a hydrophobic and hydrophilic drug from a DPIInt J Pharm200326315116312954190
  • RogersTJohnstonKWilliamsRSolution-based particle formation of pharmaceutical powders by supercritical or compressed Fluid CO2 and cryogenic spray-freezing technologiesDrug Dev Ind Pharm2001271003101611794803
  • MaaYFPrestrelskiSJBiopharmaceutical powders: particle formation and formulation considerationsCurr Pharm Biotechnol2000128330211469385
  • MaaYFNguyenPASweeneyTShireSJHsuCCProtein inhalation powders: spray drying vs spray freeze dryingPharm Res19991624925410100310
  • YuZGarciaASJohnstonKPWilliamsRO3rdSpray freezing into liquid nitrogen for highly stable protein nanostructured microparticlesEur J Pharm Biopharm20045852953715451527
  • KuoJHHwangRPreparation of DNA dry powder for non-viral gene delivery by spray-freeze drying: effect of protective agents (polyethyleneimine and sugars) on the stability of DNAJ Pharm Pharmacol200456273314979998
  • TomJWDebenedettiPGParticle formation with supercritical fluids-a reviewJ Aerosol Sci199122555584
  • RehmanMShekunovBYYorkPOptimisation of powders for pulmonary delivery using supercritical fluid technologyEur J Pharm Sci20042211715113578
  • SteckelHThiesJMullerBWMicronizing of steroids for pulmonary delivery by supercritical carbon dioxideInt J Pharm199715299110
  • SteckelHMullerBWMetered-dose inhaler formulation of fluticasone-17-propionate micronized with supercritical carbon dioxide using the alternative propellant HFA-227Int J Pharm19981732533
  • ShekunovBYChattopadhyayPSeitzingerJHuffRNanoparticles of poorly water-soluble drugs prepared by supercritical fluid extraction of emulsionsPharm Res20062319620416307386
  • ChattopadhyayPHuffRShekunovBYDrug encapsulation using supercritical fluid extraction of emulsionsJ Pharm Sci20069566767916447174
  • El-BaseirMMPhippsMAKellawayIWPreparation and subsequent degradation of poly(l-lactic acid) microspheres suitable for aerosolisation: a physico-chemical studyInt J Pharm1997151145153
  • RasenackNSteckelHMullerBWMicronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization processJ Pharm Sci200392354412486680
  • ChowAHLTongHHYChattopadhyayPShekunovBYParticle engineering for pulmonary drug deliveryPharm Res20072441143717245651
  • GrattonSEAPohlhausPDLeeJGuoJChoMJDeSimoneJMNanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINT™ nanoparticlesJ Control Release2007121101817643544
  • GrattonSERoppPAPohlhausPDThe effect of particle design on cellular internalization pathwaysProc Natl Acad Sci U S A2008105116131161818697944
  • GrattonSENapierMERoppPATianSDeSimoneJMMicrofabricated particles for engineered drug therapies: elucidation into the mechanisms of cellular internalization of PRINT particlesPharm Res2008252845285218592353
  • LiXBlondinoFEHindleMSoineWHByronPRStability and characterization of perphenazine aerosols generated using the capillary aerosol generatorInt J Pharm200530311312416139453
  • AvramMJHenthornTKSpykerDARecirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogsDrug Metab Dispos20073526226717079359
  • RabinowitzJDWensleyMLloydPFast onset medications through thermally generated aerosolsJ Pharmacol Exp Ther200430976977514752061
  • HongJNHindleMByronPRControl of particle size by coagulation of novel condensation aerosols in reservoir chambersJ Aerosol Med20021535936812581502
  • GuptaRHindleMByronPRCoxKAMcRaeDDInvestigation of a novel condensation aerosol generator: solute and solvent effectsAerosol Sci Technol200337672681
  • RabinowitzJDLloydPMMunzarPUltra-fast absorption of amorphous pure drug aerosols via deep lung inhalationJ Pharm Sci2006952438245116886198
  • MyersDJTimmonsRDLuATThe effect of film thickness on thermal aerosol generationPharm Res20072433634217180726
  • HickeyAJMansourHMTelkoMJPhysical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristicsJ Pharm Sci2007961282130117455324
  • WilliamsRO3rdBrownJLiuJInfluence of micronization method on the performance of a suspension triamcinolone acetonide pressurized metered-dose inhaler formulationPharm Dev Technol1999416717910231878
  • BarryPWO’CallaghanCAn in vitro analysis of the output of budesonide from different nebulizersJ Allergy Clin Immunol19991041168117310588997
  • SchauerJJChristensenCGKittelsonDBJohnsonJPWattsWFImpact of ambient temperatures and driving conditions on the chemical composition of particulate matter emissions from nonsmoking gasoline-powered motor vehiclesAerosol Sci Technol200842210223
  • MiguelAEiguren-FernandezASioutasCFinePGellerMMayoPObservations of twelve USEPA priority polycyclic aromatic hydrocarbons in the aitken size range (10–32 nm Dp)Aerosol Sci Technol200539415418
  • ParkKCaoFKittelsonDBMcMurryPHRelationship between particle mass and mobility for diesel exhaust particlesEnviron Sci Technol20033757758312630475
  • SardarSBFinePMMayoPRSioutasCSize-fractionated measurements of ambient ultrafine particle chemical composition in Los Angeles using the NanoMOUDIEnviron Sci Technol20053993294415773464
  • LinCCChenSJHuangKLCharacteristics of metals in nano/ultrafine/fine/coarse particles collected beside a heavily trafficked roadEnviron Sci Technol2005398113812216294844
  • GellerMDKimSMisraCSioutasCOlsonBAMarpleVAA methodology for measuring size-dependent chemical composition of ultrafine particlesAerosol Sci Technol200236748762
  • VenkatachariPHopkePKBruneWHCharacterization of wintertime reactive oxygen species concentrations in Flushing, New YorkAerosol Sci Technol20074197111
  • FujitaniYHasegawaSFushimiACollection characteristics of low-pressure impactors with various impaction substrate materialsAtmos Environ20064032213229
  • BatesSZografiGEngersDMorrisKCrowleyKNewmanAAnalysis of amorphous and nanocrystalline solids from their X-ray diffraction patternsPharm Res2006232333234917021963
  • LarhribHZengXMMartinGPMarriottCPritchardJThe use of different grades of lactose as a carrier for aerosolised salbutamol sulphateInt J Pharm199919111410556735
  • TrainiDYoungPMThielmannFAcharyaMThe influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulationsDrug Dev Ind Pharm200834992100118800259
  • NewmanAWByrnSRSolid-state analysis of the active pharmaceutical ingredient in drug productsDrug Discov Today2003889890514554018
  • Saleki-GerhardtAAhlneckCZografiGAssessment of disorder in crystalline solidsInt J Pharm1994101237247
  • BunkerMDaviesMRobertsCTowards screening of inhalation formulations: measuring interactions with atomic force microscopyExpert Opin Drug Deliv2005261362416296789
  • SethuramanVVHickeyAJPowder properties and their influence on dry powder inhaler delivery of an antitubercular drugAAPS Pharm Sci Tech20023E28
  • MansourHMZografiGThe relationship between water vapor absorption and desorption by phospholipids and bilayer phase transitionsJ Pharm Sci20079637739617080427
  • AguRUUgwokeMIArmandMKingetRVerbekeNThe lung as a route for systemic delivery of therapeutic proteins and peptidesRespir Res2001219820911686885
  • GronebergDAWittCWagnerUChungKFFischerAFundamentals of pulmonary drug deliveryRespir Med20039738238712693798
  • MathiasNRYamashitaFLeeVHLRespiratory epithelial cell culture models for evaluation of ion and drug transportAdv Drug Deliv Rev199622215249
  • ForbesBEhrhardtCHuman respiratory epithelial cell culture for drug delivery applicationsEur J Pharm Biopharm20056019320515939233
  • SakagamiMIn vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic deliveryAdv Drug Deliv Rev2006581030106017010473
  • MobleyCHochhausGMethods used to assess pulmonary deposition and absorption of drugsDrug Discov Today2001636737511267923
  • SteimerAHaltnerELehrCMCell culture models of the respiratory tract relevant to pulmonary drug deliveryJ Aerosol Med20051813718215966771
  • BorchardGCassaráMLRoemeléPEHFloreaBIJungingerHETransport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3)J Pharm Sci2002911561156712115854
  • EhrhardtCFiegelJFuchsSDrug absorption by the respiratory mucosa: cell culture models and particulate drug carriersJ Aerosol Med20021513113912184863
  • FosterKAAveryMLYazdanianMAudusKLCharacterization of the Calu-3 cell line as a tool to screen pulmonary drug deliveryInt J Pharm200020811111064206
  • FosterKAOsterCGMayerMMAveryMLAudusKLCharacterization of the A549 cell line as a type ii pulmonary epithelial cell model for drug metabolismExp Cell Res19982433593669743595
  • ManfordFTrondeAJeppssonABPatelNJohanssonFForbesBDrug permeability in 16HBE14o-airway cell layers correlates with absorption from the isolated perfused rat lungEur J Pharm Sci20052641442016153810
  • LinHLiHChoHJAir-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studiesJ Pharm Sci20079634135017080426
  • VaughnJMMcConvilleJTBurgessDSingle dose and multiple dose studies of itraconazole nanoparticlesEur J Pharm Biopharm2006639510216516450
  • YangWTamJMillerDAHigh bioavailability from nebulized itraconazole nanoparticle dispersions with biocompatible stabilizersInt J Pharm200836117718818556158
  • McConvilleJTOverhoffKASinswatPTargeted high lung concentrations of itraconazole using nebulized dispersions in a murine modelPharm Res20062390191116715380
  • MizunoTMohriKNasuSDanjoKOkamotoHDual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescenceJ Control Release200913414915419100298
  • OberdorsterGSharpZAtudoreiVExtrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of ratsJ Toxicol Environ Health A2002651531154312396867
  • HeckelKKiefmannRDorgerMStoeckelhuberMGoetzAEColloidal gold particles as a new in vivo marker of early acute lung injuryAm J Physiol Lung Cell Mol Physiol2004287L867L87815194564
  • KatoTYashiroTMurataYEvidence that exogenous substances can be phagocytized by alveolar epithelial cells and transported into blood capillariesCell Tissue Res2003311475112483283
  • OberdorsterGSharpZAtudoreiVTranslocation of inhaled ultrafine particles to the brainInhal Toxicol20041643744515204759
  • OberdorsterGToxicology of ultrafine particles: in vivo studiesPhilos Trans R Soc Lond A200035827192740
  • BallouBLagerholmBCErnstLABruchezMPWaggonerASNoninvasive imaging of quantum dots in miceBioconjug Chem200415798614733586
  • OberdorsterGOberdorsterEOberdorsterJNanotoxicology: an emerging discipline evolving from studies of ultrafine particlesEnviron Health Perspect200511382383916002369
  • KreylingWGSemmlerMErbeFTranslocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very lowJ Toxicol Environ Health A2002651513153012396866
  • OberdorsterGFerinJMorrowPEVolumetric loading of alveolar macrophages (AM): a possible basis for diminished AM-mediated particle clearanceExp Lung Res199218871041572327
  • OberdorsterGFinkelsteinJNJohnstonCAcute pulmonary effects of ultrafine particles in rats and miceRes Rep Health Eff Inst2000574; disc 75–86.11205815
  • FerinJOberdorsterGSoderholmSCGeleinRPulmonary tissue access of ultrafine particlesJ Aerosol Med199145768
  • HickeyAJMansourHMFormulation challenges of powders for the delivery of small molecular weight molecules as aerosolsRathboneMJHadgraftJRobertsMSLaneMEModifiedrelease Drug Delivery TechnologyNew York, NYInforma Healthcare2008573601