Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer–drug conjugate

References

• AchkarCGongQMFrankfaterA1990Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblastsJ Biol Chem2651365042166039
   PubMed Web of Science ®Google Scholar
• AlbainKSCrowleyJJLeblancM1991Survival determinants in extensive-stage non-small-cell lung cancer: the Southwest Oncology Group experienceJ Clin Oncol91618261651993
   PubMed Web of Science ®Google Scholar
• BalaIHariharanSKumarMN2004PLGA nanoparticles in drug delivery: the state of the artCrit Rev Ther Drug Carrier Syst2138742215719481
   PubMed Web of Science ®Google Scholar
• BernareggiAOldhamFBakerB2005XYOTAX™ (paclitaxel poliglumex, PPX): tumor accumulation and prolonged exposure to paclitaxel11th World Congress on Lung CancerBarcelona, Spain
   Google Scholar
• BhallaKN2003Microtubule-targeted anticancer agents and apoptosisOncogene2290758614663486
   PubMed Web of Science ®Google Scholar
• BlackhallFHBhosleJThatcherN2005Chemotherapy for advanced non-small cell lung cancer patients with performance status 2Curr Opin Oncol17135915725918
   PubMed Web of Science ®Google Scholar
• Cavallo-MedvedDMaiJDosescuJ2005Caveolin-1 mediates the expression and localization of cathepsin B, prourokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cellsJ Cell Sci118149350315769846
   PubMed Web of Science ®Google Scholar
• CrinòLMigliorinoM2002A phase III randomized trial comparing three platinum-based doublets in advanced non-small cell lung cancer (NSCLC): impact of PS = 2 vs 0 or 1 and age >70 vs <70 on chemotherapy outcomeProc Am Soc Clin Oncol21315a
   Google Scholar
• DerooBJKorachKS2006Estrogen receptors and human diseaseJ Clin Invest1165617016511588
   PubMed Web of Science ®Google Scholar
• DuncanR1992Drug-polymer conjugates: potential for improved chemotherapyAnticancer Drugs31752101525399
   PubMed Web of Science ®Google Scholar
• DuncanR2003The dawning era of polymer therapeuticsNat Rev Drug Discov23476012750738
   PubMed Web of Science ®Google Scholar
• EdwardsDP2005Regulation of signal transduction pathways by estrogen and progesteroneAnnu Rev Physiol673357615709962
   PubMed Web of Science ®Google Scholar
• FrasorJDanesJMKommB2003Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotypeEndocrinology14445627412959972
   PubMed Web of Science ®Google Scholar
• GelderblomHVerweijJNooterK2001Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulationEur J Cancer371590811527683
   PubMed Web of Science ®Google Scholar
• GerlowskiLEJainRK1986Microvascular permeability of normal and neoplastic tissuesMicrovasc Res312883052423854
   PubMed Web of Science ®Google Scholar
• GreishKFangJInutsukaT2003Macromolecular therapeutics: advantages and prospects with special emphasis on solid tumour targetingClin Pharmacokinet42108910514531722
   PubMed Web of Science ®Google Scholar
• Gueritte-VoegeleinFGuenardDLavelleF1991Relationships between the structure of taxol analogues and their antimitotic activityJ Med Chem3499281672159
   PubMed Web of Science ®Google Scholar
• KosJSekirnikAPremzlA2005Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissuesExp Cell Res3061031315878337
   PubMed Web of Science ®Google Scholar
• KumarGNWalleUKBhallaKN1993Binding of taxol to human plasma, albumin and alpha 1-acid glycoproteinRes Commun Chem Pathol Pharmacol80337448102493
   PubMedGoogle Scholar
• LangerCJSocinskiMARossH2005Paclitaxel poliglumex (PPX)/carboplatin vs paclitaxel/carboplatin for the treatment of PS2 patients with chemotherapy-naïve advanced non-small cell lung cancer (NSCLC): A phase III studyJ Clin Oncol, ASCO Annual Meeting Proceedings237011
   Google Scholar
• LangerR1998Drug delivery and targetingNature3925109579855
   PubMed Web of Science ®Google Scholar
• LinebaughBESameniMDayNA1999Exocytosis of active cathepsin B enzyme activity at pH 7.0, inhibition and molecular massEur J Biochem264100910447678
   PubMedGoogle Scholar
• LiuYInoueMSobueT2005Reproductive factors, hormone use and the risk of lung cancer among middle-aged never-smoking Japanese women: a large-scale population-based cohort studyInt J Cancer117662615929081
   PubMed Web of Science ®Google Scholar
• ManfrediJJParnessJHorwitzSB1982Taxol binds to cellular microtubulesJ Cell Biol94688966127342
   PubMed Web of Science ®Google Scholar
• MarkmanM2003Managing taxane toxicitiesSupport Care Cancer11144712618923
   PubMed Web of Science ®Google Scholar
• MassaroDMassaroGD2004Estrogen regulates pulmonary alveolar formation, loss, and regeneration in miceAm J Physiol Lung Cell Mol Physiol287L1154915298854
   PubMed Web of Science ®Google Scholar
• MassaroDMassaroGD2006Estrogen receptor regulation of pulmonary alveolar dimensions: alveolar sexual dimorphism in miceAm J Physiol Lung Cell Mol Physiol290L8667016361355
   PubMed Web of Science ®Google Scholar
• MassaroGDMortolaJPMassaroD1996Estrogen modulates the dimensions of the lung’s gas-exchange surface area and alveoli in female ratsAm J Physiol270L11048772533
   PubMed Web of Science ®Google Scholar
• MatsumuraYMaedaH1986A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancsCancer Res466387922946403
   PubMed Web of Science ®Google Scholar
• O’ByrneKJ2005aPaclitaxel poliglumex vs. gemcitabine or vinorelbine for the treatment of performance status (PS) 2 patients with chemotherapy-naïve advanced non-small cell lung cancer (NSCLC): the STELLAR 4 phase III studyEur J Cancer Suppl3324
   Google Scholar
• O’ByrneKJ2005Paclitaxel poliglumex vs. docetaxel for the second-line treatment of non-small cell lung cancer (NSCLC): the STELLAR 2 phase III studyEur J Cancer Suppl35
   Google Scholar
• PatelJD2005Lung cancer in womenJ Clin Oncol233212815886308
   PubMed Web of Science ®Google Scholar
• PatroneCCasselTNPetterssonK2003Regulation of postnatal lung development and homeostasis by estrogen receptor betaMol Cell Biol2385425214612399
   PubMed Web of Science ®Google Scholar
• PhielKLHendersonRAAdelmanSJ2005Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populationsImmunol Lett971071315626482
   PubMed Web of Science ®Google Scholar
• PooleARTiltmanKJReckliesAD1978Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomasNature2735457661963
   PubMed Web of Science ®Google Scholar
• PremzlAZavasnik-BergantVTurkV2003Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitroExp Cell Res2832061412581740
   PubMed Web of Science ®Google Scholar
• RobertsWGPaladeGE1997Neovasculature induced by vascular endothelial growth factor is fenestratedCancer Res57765729044858
   PubMed Web of Science ®Google Scholar
• RoshySSloaneBFMoinK2003Pericellular cathepsin B and malignant progressionCancer Metastasis Rev222718612785001
   PubMed Web of Science ®Google Scholar
• RossHBonomiPLangerC2006Effect of gender on outcome in two randomized phase III trials of paclitaxel poliglumex (PPX) in chemonaïve pts with advanced NSCLC and poor performance status (PS2)J Clin Oncol, ASCO Annual Meeting Proceedings247039
   Web of Science ®Google Scholar
• RowinskyEKDonehowerRC1995Paclitaxel (taxol)N Engl J Med3321004147885406
   PubMed Web of Science ®Google Scholar
• SameniMElliottEZieglerG1995Cathepsin B and D are localized at the surface of human breast cancer cellsPathol Oncol Res1435311173567
   PubMedGoogle Scholar
• SeidmanAD2005“Will weekly work”? Seems to be so”J Clin Oncol235873416087954
   PubMed Web of Science ®Google Scholar
• ShafferSALee-BakerCKennedyK2007In vitro and in vivo metabolism of paclitaxel poliglumex: Identification of metabolites and active proteasesCancer Chemother PharmacolIn press.
   Web of Science ®Google Scholar
• SingerJWShafferSBakerB2005Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxaneAnticancer Drugs162435415711176
   PubMed Web of Science ®Google Scholar
• SloaneBFMoinKSameniM1994Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Haras oncogeneJ Cell Sci107373848207069
   PubMed Web of Science ®Google Scholar
• SonnichsenDSRellingMV1994Clinical pharmacokinetics of paclitaxelClin Pharmacokinet27256697834963
   PubMed Web of Science ®Google Scholar
• SpiessEBruningAGackS1994Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular levelJ Histochem Cytochem42917298014475
   PubMed Web of Science ®Google Scholar
• SweeneyCJZhuJSandler2001Outcome of patients with a performance status of 2 in Eastern Cooperative Oncology Group Study E1594: a Phase II trial in patients with metastatic nonsmall cell lung carcinomaCancer9226394711745199
   PubMed Web of Science ®Google Scholar
• SzpaderskaAMFrankfaterA2001An intracellular form of cathepsin B contributes to invasiveness in cancerCancer Res61349350011309313
   PubMed Web of Science ®Google Scholar
• ThomasLDoyleLAEdelmanMJ2005Lung cancer in women: emerging differences in epidemiology, biology, and therapyChest1283708116002959
   PubMed Web of Science ®Google Scholar
• WuCTChangYLShihJY2005The significance of estrogen receptor beta in 301 surgically treated non-small cell lung cancersJ Thorac Cardiovasc Surg1309798616214508
   PubMed Web of Science ®Google Scholar
• YanSSloaneBF2003Molecular regulation of human cathepsin B: implication in pathologiesBiol Chem3848455412887051
   PubMed Web of Science ®Google Scholar