References
- PolanczykGde LimaMSHortaBLBiedermanJRohdeLAThe worldwide prevalence of ADHD: A systematic review and metaregression analysisAm J Psychiatry2007164694294817541055
- Lasky-SuJAnneyRJNealeBMGenome-wide association scan of the time to onset of attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2008147B81355135818937294
- ReiffMISteinMTAttention-deficit/hyperactivity disorder evaluation and diagnosis: A practical approach in office practicePediatr Clin North Am20035051019104814558680
- MannuzzaSKleinRGKonigPHGiampinoTLHyperactive boys almost grown up. IV. Criminality and its relationship to psychiatric statusArch Gen Psychiatry19894612107310792589922
- SatterfieldJHFallerKJCrinellaFMSchellAMSwansonJMHomerLDA 30-year prospective follow-up study of hyperactive boys with conduct problems: Adult criminalityJ Am Acad Child Adolesc Psychiatry200746560161017450051
- BarkleyRAFischerMSmallishLFletcherKYoung adult follow-up of hyperactive children: Antisocial activities and drug useJ Child Psychol Psychiatry200445219521114982236
- SwansonJMKinsbourneMNiggJEtiologic subtypes of attention-deficit/hyperactivity disorder: Brain imaging, molecular genetic and environmental factors and the dopamine hypothesisNeuropsychol Rev2007171395917318414
- Sonuga-BarkeEJElgieSHallMMore to ADHD than meets the eye: Observable abnormalities in search behaviour do not account for performance deficits on a discrimination taskBehav Brain Funct2005111016033644
- ArnstenAFLiBMNeurobiology of executive functions: Catecholamine influences on prefrontal cortical functionsBiol Psychiatry200557111377138415950011
- PliszkaSRMcCrackenJTMaasJWCatecholamines in attention-deficit hyperactivity disorder: Current perspectivesJ Am Acad Child Adolesc Psychiatry19963532642728714313
- SchultzWGetting formal with dopamine and rewardNeuron200236224126312383780
- SchultzWMultiple dopamine functions at different time coursesAnnu Rev Neurosci20073025928817600522
- SeemanPMadrasBKAnti-hyperactivity medication: Methylphenidate and amphetamineMol Psychiatry1998353863969774771
- LeesAJHardyJReveszTParkinson’s diseaseLancet200937396802055206619524782
- AultmanJMMoghaddamBDistinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant taskPsychopharmacology (Berl)2001153335336411271408
- FlorescoSBPhillipsAGDelay-dependent modulation of memory retrieval by infusion of a dopamine D1 agonist into the rat medial prefrontal cortexBehav Neurosci2001115493493911508732
- VolkowNDWangGJKollinsSHEvaluating dopamine reward pathway in ADHD: Clinical implicationsJAMA2009302101084109119738093
- HranilovicDBucanMWangYEmotional response in dopamine D2L receptor-deficient miceBehav Brain Res2008195224625018835570
- PezzeMAFeldonJMesolimbic dopaminergic pathways in fear conditioningProg Neurobiol200474530132015582224
- WenderPHA possible monoaminergic basis for minimal brain dysfunctionPsychopharmacol Bull197511336371153658
- GiulianoFAllardJDopamine and sexual functionInt J Impot Res200113Suppl 3S18S2811477488
- HymanSEMalenkaRCNestlerEJNeural mechanisms of addiction: The role of reward-related learning and memoryAnnu Rev Neurosci20062956559816776597
- PecinaSBerridgeKCHedonic hot spot in nucleus accumbens shell: Where do mu-opioids cause increased hedonic impact of sweetness?J Neurosci20052550117771178616354936
- BarbeauAHigh-level levodopa therapy in Parkinson’s disease: Five years laterTrans Am Neurol Assoc1974991601634463526
- MogensonGJJonesDLYimCYFrom motivation to action: Functional interface between the limbic system and the motor systemProg Neurobiol1980142–369976999537
- WiseRADopamine, learning and motivationNat Rev Neurosci20045648349415152198
- WiseRADopamine and food reward: Back to the elementsAm J Physiol Regul Integr Comp Physiol20042861R1314660469
- Ben-JonathanNHnaskoRDopamine as a prolactin (PRL) inhibitorEndocr Rev200122672476311739329
- AlexanderGECrutcherMDFunctional architecture of basal ganglia circuits: Neural substrates of parallel processingTrends Neurosci19901372662711695401
- Bar-GadIBergmanHStepping out of the box: Information processing in the neural networks of the basal gangliaCurr Opin Neurobiol200111668969511741019
- HaberSNThe primate basal ganglia: Parallel and integrative networksJ Chem Neuroanat200326431733014729134
- MiddletonFAStrickPLBasal-ganglia ‘projections’ to the prefrontal cortex of the primateCereb Cortex200212992693512183392
- TakadaMTokunoHNambuAInaseMCorticostriatal projections from the somatic motor areas of the frontal cortex in the macaque monkey: Segregation versus overlap of input zones from the primary motor cortex, the supplementary motor area, and the premotor cortexExp Brain Res199812011141289628410
- Sonuga-BarkeEJDalenLDaleyDRemingtonBAre planning, working memory, and inhibition associated with individual differences in preschool ADHD symptoms?Dev Neuropsychol200221325527212233938
- KolomietsBPDeniauJMMaillyPMenetreyAGlowinskiJThierryAMSegregation and convergence of information flow through the cortico-subthalamic pathwaysJ Neurosci200121155764577211466448
- McFarlandNRHaberSNThalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areasJ Neurosci200222188117813212223566
- HaberSNCalzavaraRThe cortico-basal ganglia integrative network: The role of the thalamusBrain Res Bull2009782–3697418950692
- CallierSSnapyanMLe CromSProuDVincentJDVernierPEvolution and cell biology of dopamine receptors in vertebratesBiol Cell200395748950214597267
- AltarCABoyarWCOeiEWoodPLDopamine autoreceptors modulate the in vivo release of dopamine in the frontal, cingulate and entorhinal corticesJ Pharmacol Exp Ther198724211151203612520
- MarinelliMRudickCNHuXTWhiteFJExcitability of dopamine neurons: modulation and physiological consequencesCNS Neurol Disord Drug Targets200651799716613555
- HuotariMSanthaMLucasLRKarayiorgouMGogosJAMannistoPTEffect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted miceJ Pharmacol Exp Ther200230331309131612438556
- ZametkinAJLiottaWThe neurobiology of attention-deficit/hyperactivity disorderJ Clin Psychiatry199859Suppl 717239680049
- GizerIRFicksCWaldmanIDCandidate gene studies of ADHD: A meta-analytic reviewHum Genet20091261519019506906
- VolkowNDWangGJFowlerJSDingYSImaging the effects of methylphenidate on brain dopamine: New model on its therapeutic actions for attention-deficit/hyperactivity disorderBiol Psychiatry200557111410141515950015
- VolkowNDWangGJFowlerJSEvidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brainAm J Psychiatry200416171173118015229048
- PatrickKSCaldwellRWFerrisRMBreeseGRPharmacology of the enantiomers of threo-methylphenidateJ Pharmacol Exp Ther198724111521583572779
- SeemanPMadrasBMethylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: A hypothesisBehav Brain Res20021301–2798311864721
- FanXXuMHessEJD2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHDNeurobiol Dis20103722823619840852
- KuczenskiRSegalDSDifferential effects of D- and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesisEur J Pharmacol19753022442511126362
- KuczenskiRSegalDSEffects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamineJ Neurochem1997685203220379109529
- AcciliDFishburnCSDragoJA targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in miceProc Natl Acad Sci U S A1996935194519498700864
- GirosBJaberMJonesSRWightmanRMCaronMGHyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporterNature199637965666066128628395
- GranonSPassettiFThomasKLDalleyJWEverittBJRobbinsTWEnhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortexJ Neurosci20002031208121510648725
- LeoDSorrentinoEVolpicelliFAltered midbrain dopaminergic neurotransmission during development in an animal model of ADHDNeurosci Biobehav Rev200327766166914624810
- XuMMoratallaRGoldLHDopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responsesCell19947947297427954836
- ShaywitzBAYagerRDKlopperJHSelective brain dopamine depletion in developing rats: An experimental model of minimal brain dysfunctionScience19761914224305308942800
- MookDMJeffreyJNeuringerASpontaneously hypertensive rats (SHR) readily learn to vary but not repeat instrumental responsesBehav Neural Biol19935921261358476380
- SagvoldenTBehavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD)Neurosci Biobehav Rev2000241313910654658
- WongAHBuckleCEVan TolHHPolymorphisms in dopamine receptors: What do they tell us?Eur J Pharmacol20004102–318320311134669
- WyssJMFiskGvan GroenTImpaired learning and memory in mature spontaneously hypertensive ratsBrain Res19925921–21351401450905
- BoixFQiaoSWKolpusTSagvoldenTChronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of attention-deficit/hyperactivity disorderBehav Brain Res19989411531629708846
- MyersMMMustyREHendleyEDAttenuation of hyperactivity in the spontaneously hypertensive rat by amphetamineBehav Neural Biol198234142547073635
- Gonzalez-LimaFSadileAGNetwork operations revealed by brain metabolic mapping in a genetic model of hyperactivity and attention deficit: The Naples high- and low-excitability ratsNeurosci Biobehav Rev200024115716010654673
- PapaMSellittiSSadileAGRemodeling of neural networks in the anterior forebrain of an animal model of hyperactivity and attention deficits as monitored by molecular imaging probesNeurosci Biobehav Rev200024114915610654672
- SadileAGLambertiCSiegfriedBWelzlHCircadian activity, nociceptive thresholds, nigrostriatal and mesolimbic dopaminergic activity in the Naples high- and low-excitability rat linesBehav Brain Res199355117278101085
- SadileAGPellicanoMPSagvoldenTSergeantJANMDA and non-NMDA sensitive [L-3H] glutamate receptor binding in the brain of the Naples high- and low-excitability rats: An autoradiographic studyBehav Brain Res19967821631748864048
- HessEJCollinsKAWilsonMCMouse model of hyperkinesis implicates SNAP-25 in behavioral regulationJ Neurosci1996169310431118622140
- SteffensenSCHenriksenSJWilsonMCTransgenic rescue of SNAP-25 restores dopamine-modulated synaptic transmission in the coloboma mutantBrain Res1999847218619510575087
- GononFThe dopaminergic hypothesis of attention-deficit/hyperactivity disorder needs re-examiningTrends Neurosci20093212818986716
- CheonKARyuYHKimYKNamkoongKKimCHLeeJDDopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorderEur J Nucl Med Mol Imaging200330230631112552351
- DoughertyDDBonabAASpencerTJRauchSLMadrasBKFischmanAJDopamine transporter density in patients with attention deficit hyperactivity disorderLancet199935491962132213310609822
- KrauseKHDreselSHKrauseJKungHFTatschKIncreased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomographyNeurosci Lett2000285210711010793238
- LarischRSitteWAntkeCStriatal dopamine transporter density in drug naive patients with attention-deficit/hyperactivity disorderNucl Med Commun200627326727016479247
- van DyckCHQuinlanDMCretellaLMUnaltered dopamine transporter availability in adult attention deficit hyperactivity disorderAm J Psychiatry2002159230931211823278
- HesseSBallaschkeOBarthelHSabriODopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorderPsychiatry Res2009171212012819176281
- MadrasBKMillerGMFischmanAJThe dopamine transporter: Relevance to attention deficit hyperactivity disorder (ADHD)Behav Brain Res20021301–2576311864718
- BiedermanJFaraoneSVAttention-deficit hyperactivity disorderLancet2005366948123724816023516
- StevensonJEvidence for a genetic etiology in hyperactivity in childrenBehav Genet19922233373441616463
- SwansonJMSergeantJATaylorESonuga-BarkeEJJensenPSCantwellDPAttention-deficit hyperactivity disorder and hyperkinetic disorderLancet199835191004294339482319
- NadderTSSilbergJLEavesLJMaesHHMeyerJMGenetic effects on ADHD symptomatology in 7- to 13-year-old twins: Results from a telephone surveyBehav Genet199828283999583234
- SaudinoKJRonaldAPlominRThe etiology of behavior problems in 7-year-old twins: Substantial genetic influence and negligible shared environmental influence for parent ratings and ratings by same and different teachersJ Abnorm Child Psychol200533111313015759595
- LarssonJOLarssonHLichtensteinPGenetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 years of age: A longitudinal twin studyJ Am Acad Child Adolesc Psychiatry200443101267127515381894
- ThaparAHarringtonRMcGuffinPExamining the comorbidity of ADHD-related behaviours and conduct problems using a twin study designBr J Psychiatry200117922422911532799
- PoldermanTJde GeusEJHoekstraRAAttention problems, inhibitory control, and intelligence index overlapping genetic factors: A study in 9-, 12-, and 18-year-old twinsNeuropsychology200923338139119413451
- PurcellSStatistical methods in behavioral geneticsPlominRDeFriesJMcClearnGMcGuffinPBehavioral GeneticsNew York, NYWorth2001
- RutterMGene-environment interdependenceDev Sci2007101121817181693
- SpielmanRSMcGinnisREEwensWJTransmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)Am J Hum Genet19935235065168447318
- SpielmanRSEwensWJThe TDT and other family-based tests for linkage disequilibrium and associationAm J Hum Genet19965959839898900224
- ClaytonDA generalization of the transmission/disequilibrium test for uncertain-haplotype transmissionAm J Hum Genet19996541170117710486336
- WeinbergCRAllowing for missing parents in genetic studies of case-parent triadsAm J Hum Genet19996441186119310090904
- MortonNECollinsATests and estimates of allelic association in complex inheritanceProc Natl Acad Sci U S A1998951911389113939736746
- MitchellAACutlerDJChakravartiAUndetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium testAm J Hum Genet200372359861012587097
- RischNMerikangasKThe future of genetic studies of complex human diseasesScience19962735281151615178801636
- LanderESSchorkNJGenetic dissection of complex traitsScience19942655181203720488091226
- ClarkAGLiJConjuring SNPs to detect associationsNat Genet200739781581617597769
- FisherRThe correlation between relatives on the supposition of Mendelian inheritanceTrans Roy Soc Edin191852399433
- HirschhornJNLettreGProgress in genome-wide association studies of human heightHorm Res200971Suppl 251319407491
- GoldsteinDBCommon genetic variation and human traitsN Engl J Med2009360171696169819369660
- BurnsGLWalshJAOwenSMSnellJInternal validity of attention deficit hyperactivity disorder, oppositional defiant disorder, and overt conduct disorder symptoms in young children: Implications from teacher ratings for a dimensional approach to symptom validityJ Clin Child Psychol19972632662759292384
- PintoLPTryonWWActivity measurements support dimensional assessmentBehav Modif19962032432588768507
- HudziakJJAchenbachTMAlthoffRRPineDSA dimensional approach to developmental psychopathologyInt J Methods Psychiatr Res200716Suppl 1S16S2317623391
- SwansonJMWigalTLakesKDSM-V and the future diagnosis of attention-deficit/hyperactivity disorderCurr Psychiatry Rep200911539940619785982
- AshersonPAttention-deficit hyperactivity disorder in the post-genomic eraEur Child Adolesc Psychiatry200413Suppl 1I50I7015322957
- SpenceJPLiangTLiuLFrom QTL to candidate gene: A genetic approach to alcoholism researchCurr Drug Abuse Rev20092212713419630743
- CornishKMManlyTSavageRAssociation of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sampleMol Psychiatry200510768669815809660
- FisherSEFrancksCMcCrackenJTA genomewide scan for loci involved in attention-deficit/hyperactivity disorderAm J Hum Genet20027051183119611923911
- Arcos-BurgosMCastellanosFXPinedaDAttention-deficit/hyperactivity disorder in a population isolate: Linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11Am J Hum Genet2004756998101415497111
- AminNAulchenkoYSDekkerMCSuggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch populationEur J Hum Genet200917795896619156173
- ZhouKDempfleAArcos-BurgosMMeta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2008147B81392139818988193
- AshersonPZhouKAnneyRJA high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16Mol Psychiatry200813551452118180756
- BakkerSCvan der MeulenEMBuitelaarJKA whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: Suggestive evidence for linkage on chromosomes 7p and 15qAm J Hum Genet20037251251126012679898
- FaraoneSVDoyleAELasky-SuJLinkage analysis of attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2008147B81387139118081027
- HebebrandJDempfleASaarKA genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairsMol Psychiatry200611219620516222334
- OgdieMNMacphieILMinassianSLA genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: Suggestive linkage on 17p11Am J Hum Genet20037251268127912687500
- RomanosMFreitagCJacobCGenome-wide linkage analysis of ADHD using high-density SNP arrays: Novel loci at 5q13.1 and 14q12Mol Psychiatry200813552253018301393
- DoyleAEFerreiraMASklarPBMultivariate genome-wide linkage scan of neurocognitive traits and ADHD symptoms: Suggestive linkage to 3q13Am J Med Genet B Neuropsychiatr Genet2008147B81399141118973233
- NealeBMLasky-SuJAnneyRGenome-wide association scan of attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2008147B81337134418980221
- CookEHJrSteinMAKrasowskiMDAssociation of attention-deficit disorder and the dopamine transporter geneAm J Hum Genet19955649939987717410
- PaytonAHolmesJBarrettJHExamining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: A family-based studyAm J Med Genet2001105546447011449400
- HawiZDringMKirleyASerotonergic system and attention deficit hyperactivity disorder (ADHD): A potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sampleMol Psychiatry20027771872512192616
- TuricDLangleyKWilliamsHA family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorderBiol Psychiatry200557111461146615950021
- FaraoneSVPerlisRHDoyleAEMolecular genetics of attention-deficit/hyperactivity disorderBiol Psychiatry200557111313132315950004
- Purper-OuakilDWohlMMourenMCVerpillatPAdesJGorwoodPMeta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorderPsychiatr Genet2005151535915722958
- YangBChanRCJingJLiTShamPChenRYA meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3’-UTR of dopamine transporter gene and attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2007144B454155017440978
- JaberMRobinsonSWMissaleCCaronMGDopamine receptors and brain functionNeuropharmacology19963511150315199025098
- NeveKASeamansJKTrantham-DavidsonHDopamine receptor signalingJ Recept Signal Transduct Res200424316520515521361
- OakJNOldenhofJVan TolHHThe dopamine D(4) receptor: One decade of researchEur J Pharmacol20004051–330332711033337
- TaraziFIZhangKBaldessariniRJDopamine D4 receptors: Beyond schizophreniaJ Recept Signal Transduct Res200424313114715521359
- Van TolHHBunzowJRGuanHCCloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapineNature199135063196106141840645
- ArianoMAWangJNoblettKLLarsonERSibleyDRCellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antiseraBrain Res19977521–226349106437
- GanLFalzoneTLZhangKRubinsteinMBaldessariniRJTaraziFIEnhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout miceJ Mol Neurosci200422316717814997010
- MrzljakLBergsonCPappyMHuffRLevensonRGoldman-RakicPSLocalization of dopamine D4 receptors in GABAergic neurons of the primate brainNature199638165792452488622768
- NoainDAvaleMEWedemeyerCCalvoDPeperMRubinsteinMIdentification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic miceEur J Neurosci20062492429243817100831
- Van TolHHWuCMGuanHCMultiple dopamine D4 receptor variants in the human populationNature199235863821491521319557
- ChangFMKiddJRLivakKJPakstisAJKiddKKThe world-wide distribution of allele frequencies at the human dopamine D4 receptor locusHum Genet1996981911018682515
- DingYCChiHCGradyDLEvidence of positive selection acting at the human dopamine receptor D4 gene locusProc Natl Acad Sci U S A200299130931411756666
- LichterJBBarrCLKennedyJLVan TolHHKiddKKLivakKJA hypervariable segment in the human dopamine receptor D4 (DRD4) geneHum Mol Genet1993267677738353495
- WangEDingYCFlodmanPThe genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locusAm J Hum Genet200474593194415077199
- WangETKodamaGBaldiPMoyzisRKGlobal landscape of recent inferred Darwinian selection for Homo sapiensProc Natl Acad Sci U S A2006103113514016371466
- ChenCBurtonMGreenbergerEDmitrievaJPopulation migration and the variation of dopamine receptor (DRD4) allele frequencies around the globeEvol Hum Behav199920309324
- HarpendingHCochranGIn our genesProc Natl Acad Sci U S A2002991101211782544
- AsghariVSanyalSBuchwaldtSPatersonAJovanovicVVan TolHHModulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variantsJ Neurochem1995653115711657643093
- De La GarzaR2ndMadrasBK[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brainSynapse200037323224410881045
- PrimusRJThurkaufAXuJII. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1J Pharmacol Exp Ther19972822102010279262371
- DolanRJEmotion, cognition, and behaviorScience200229855961191119412424363
- DurstonSde ZeeuwPStaalWGImaging genetics in ADHD: A focus on cognitive controlNeurosci Biobehav Rev200933567468918789356
- RubinsteinMPhillipsTJBunzowJRMice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamineCell199790699110019323127
- AvaleMEFalzoneTLGelmanDMLowMJGrandyDKRubinsteinMThe dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorderMol Psychiatry20049771872614699433
- RubinsteinMCepedaCHurstRSDopamine D4 receptor-deficient mice display cortical hyperexcitabilityJ Neurosci200121113756376311356863
- SeamanMIFisherJBChangFKiddKKTandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)Am J Med Genet199988670570910581493
- KereszturiEKiralyOCsapoZAssociation between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: Genetic and molecular analysesAm J Med Genet B Neuropsychiatr Genet2007144B223123617171658
- YangJWJangWSHongSDA case-control association study of the polymorphism at the promoter region of the DRD4 gene in Korean boys with attention deficit-hyperactivity disorder: Evidence of association with the -521 C/T SNPProg Neuropsychopharmacol Biol Psychiatry200832124324817850946
- GradyDLHarxhiASmithMSequence variants of the DRD4 gene in autism: Further evidence that rare DRD4 7R haplotypes are ADHD specificAm J Med Genet B Neuropsychiatr Genet2005136B1333515892149
- LaHosteGJSwansonJMWigalSBDopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorderMol Psychiatry1996121211249118321
- FaraoneSVDoyleAEMickEBiedermanJMeta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorderAm J Psychiatry200115871052105711431226
- LiDShamPCOwenMJHeLMeta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD)Hum Mol Genet200615142276228416774975
- MaherBSMarazitaMLFerrellREVanyukovMMDopamine system genes and attention deficit hyperactivity disorder: A meta-analysisPsychiatr Genet200212420721512454525
- WohlMPurper-OuakilDMourenMCAdesJGorwoodPMeta-analysis of candidate genes in attention-deficit hyperactivity disorderEncephale2005314 Pt 1437447 French16389711
- CurranSMillJShamPQTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptomsAm J Med Genet2001105438739311378855
- Lasky-SuJLangeCBiedermanJFamily-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individualsAm J Med Genet B Neuropsychiatr Genet2008147B110010617579349
- MillJXuXRonaldAQuantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1BAm J Med Genet B Neuropsychiatr Genet2005133B1687315578613
- ToddRDNeumanRJLobosEAJongYJReichWHeathACLack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twinsAm J Med Genet2001105543243811449395
- GottesmanIIGouldTDThe endophenotype concept in psychiatry: Etymology and strategic intentionsAm J Psychiatry20031604636512668349
- FlintJMunafoMRThe endophenotype concept in psychiatric geneticsPsychol Med200737216318016978446
- DoyleAEWillcuttEGSeidmanLJAttention-deficit/hyperactivity disorder endophenotypesBiol Psychiatry200557111324133515950005
- RommelseNNEndophenotypes in the genetic research of ADHD over the last decade: Have they lived up to their expectations?Expert Rev Neurother20088101425142918928337
- Slaats-WillemseDSwaab-BarneveldHde SonnevilleLvan der MeulenEBuitelaarJDeficient response inhibition as a cognitive endophenotype of ADHDJ Am Acad Child Adolesc Psychiatry200342101242124814560175
- BidwellLCWillcuttEGDefriesJCPenningtonBFTesting for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorderBiol Psychiatry200762999199817585884
- BitsakouPPsychogiouLThompsonMSonuga-BarkeEJDelay aversion in attention deficit/hyperactivity disorder: An empirical investigation of the broader phenotypeNeuropsychologia200947244645618929587
- KebirOTabbaneKSenguptaSJooberRCandidate genes and neuropsychological phenotypes in children with ADHD: Review of association studiesJ Psychiatry Neurosci20093428810119270759
- SwansonJOosterlaanJMuriasMAttention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attentionProc Natl Acad Sci U S A20009794754475910781080
- LangleyKMarshallLvan den BreeMAssociation of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHDAm J Psychiatry2004161113313814702261
- ManorITyanoSEisenbergJBachner-MelmanRKotlerMEbsteinRPThe short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA)Mol Psychiatry20027779079412192625
- WaldmanIDStatistical approaches to complex phenotypes: Evaluating neuropsychological endophenotypes for attention-deficit/hyperactivity disorderBiol Psychiatry200557111347135615950007
- SheeseBEVoelkerPMRothbartMKPosnerMIParenting quality interacts with genetic variation in dopamine receptor D4 to influence temperament in early childhoodDev Psychopathol20071941039104617931433
- MoffittTECaspiARutterMStrategy for investigating interactions between measured genes and measured environmentsArch Gen Psychiatry200562547348115867100
- RutterMSilbergJGene-environment interplay in relation to emotional and behavioral disturbanceAnnu Rev Psychol20025346349011752493
- BrookesKJMillJGuindaliniCA common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancyArch Gen Psychiatry2006631748116389200
- WeindrichDLauchtMEsserGSchmidtMHMarital discord and early child developmentActa Paedopsychiatr19925541871921283482
- NeumanRJLobosEReichWHendersonCASunLWToddRDPrenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtypeBiol Psychiatry200761121320132817157268
- LangleyKTuricDRiceFTesting for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behaviorAm J Med Genet B Neuropsychiatr Genet2008147B1495317579368
- SeegerGSchlossPSchmidtMHRuter-JungfleischAHennFAGene-environment interaction in hyperkinetic conduct disorder (HD = CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphismNeurosci Lett2004366328228615288435
- Bakermans-KranenburgMJVanIMHPijlmanFTMesmanJJufferFExperimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers’ externalizing behavior in a randomized controlled trialDev Psychol200844129330018194028
- AmaraSGKuharMJNeurotransmitter transporters: Recent progressAnnu Rev Neurosci19931673938096377
- FrazerAGerhardtGADawsLCNew views of biogenic amine transporter function: Implications for neuropsychopharmacologyInt J Neuropsychopharmacol19992430532011285147
- GainetdinovRRJonesSRFumagalliFWightmanRMCaronMGRe-evaluation of the role of the dopamine transporter in dopamine system homeostasisBrain Res Brain Res Rev1998262–31481539651511
- CiliaxBJHeilmanCDemchyshynLLThe dopamine transporter: immunochemical characterization and localization in brainJ Neurosci1995153 Pt 1171417237534339
- FreedCRevayRVaughanRADopamine transporter immunoreactivity in rat brainJ Comp Neurol199535923403497499533
- VandenberghDJPersicoAMHawkinsALHuman dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTRGenomics1992144110411061478653
- MitchellRJHowlettSEarlLDistribution of the 3’ VNTR polymorphism in the human dopamine transporter gene in world populationsHum Biol200072229530410803661
- FukeSSuoSTakahashiNKoikeHSasagawaNIshiuraSThe VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expressionPharmacogenomics J20011215215611911442
- MillJAshersonPBrowesCD’SouzaUCraigIExpression of the dopamine transporter gene is regulated by the 3’ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCRAm J Med Genet2002114897597912457396
- MillerGMMadrasBKPolymorphisms in the 3’-untranslated region of human and monkey dopamine transporter genes affect reporter gene expressionMol Psychiatry200271445511803445
- GreenwoodTAKelsoeJRPromoter and intronic variants affect the transcriptional regulation of the human dopamine transporter geneGenomics200382551152014559208
- HeinzAGoldmanDJonesDWGenotype influences in vivo dopamine transporter availability in human striatumNeuropsychopharmacology200022213313910649826
- van DyckCHMalisonRTJacobsenLKIncreased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 geneJ Nucl Med200546574575115872345
- KimmelHLCarrollFIKuharMJDopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76Neuropharmacology200039457858510728879
- XiaYGoebelDJKapatosGBannonMJQuantitation of rat dopamine transporter mRNA: Effects of cocaine treatment and withdrawalJ Neurochem1992593117911821494906
- ChenCKChenSLMillJThe dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sampleMol Psychiatry20038439339612740596
- GillMDalyGHeronSHawiZFitzgeraldMConfirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphismMol Psychiatry1997243113139246671
- RomanTSchmitzMPolanczykGEizirikMRohdeLAHutzMHAttention-deficit hyperactivity disorder: A study of association with both the dopamine transporter gene and the dopamine D4 receptor geneAm J Med Genet2001105547147811449401
- ToddRDJongYJLobosEAReichWHeathACNeumanRJNo association of the dopamine transporter gene 3’ VNTR polymorphism with ADHD subtypes in a population sample of twinsAm J Med Genet2001105874574811803523
- CurranSMillJTahirEAssociation study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samplesMol Psychiatry20016442542811443527
- AshersonPBrookesKFrankeBConfirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHDAm J Psychiatry2007164467467717403983
- MugliaPJainUInksterBKennedyJLA quantitative trait locus analysis of the dopamine transporter gene in adults with ADHDNeuropsychopharmacology200227465566212377402
- CornishKMWildingJMHollisCVisual search performance in children rated as good or poor attenders: The differential impact of DAT1 genotype, IQ, and chronological ageNeuropsychology200822221722518331164
- ToddRDHuangHSmalleySLCollaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypesJ Child Psychol Psychiatry200546101067107316178930
- LooSKSpecterESmolenAHopferCTealePDReiteMLFunctional effects of the DAT1 polymorphism on EEG measures in ADHDJ Am Acad Child Adolesc Psychiatry200342898699312874502
- Sonuga-BarkeEJSergeantJANiggJWillcuttEExecutive dysfunction and delay aversion in attention deficit hyperactivity disorder: Nosologic and diagnostic implicationsChild Adolesc Psychiatr Clin N Am200817236738418295151
- RommelseNNAltinkMEArias-VasquezAA review and analysis of the relationship between neuropsychological measures and DAT1 in ADHDAm J Med Genet B Neuropsychiatr Genet2008147B81536154618729135
- KahnRSKhouryJNicholsWCLanphearBPRole of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviorsJ Pediatr2003143110411012915833
- BeckerKEl-FaddaghMSchmidtMHEsserGLauchtMInteraction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptomsJ Pediatr2008152226326918206700
- LauchtMSkowronekMHBeckerKInteracting effects of the dopamine transporter gene and psychosocial adversity on attention-defiit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sampleArch Gen Psychiatry200764558559017485610
- Sonuga-BarkeEJOadesRDPsychogiouLDopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: The case of conduct and emotional problems in attention deficit/hyperactivity disorderJ Child Psychol Psychiatry20095091052106319490304
- StevensSEKumstaRKreppnerJMBrookesKJRutterMSonuga-BarkeEJDopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene-environment interplayAm J Med Genet B Neuropsychiatr Genet2009150B675376119655343
- BradleyCThe behavior of children receiving benzedrineAm J Psychiatry193794577585
- ChavezBSopkoMAJrEhretMJAn update on central nervous system stimulant formulations in children and adolescents with attention-deficit/hyperactivity disorderAnn Pharmacother20094361084109519470858
- MaloneMASwansonJMEffects of methylphenidate on impulsive responding in children with attention-deficit hyperactivity disorderJ Child Neurol1993821571638505479
- PatrickKSStraughnABPerkinsJSGonzalezMAEvolution of stimulants to treat ADHD: Transdermal methylphenidateHum Psychopharmacol200924111719051222
- WilensTEBiedermanJPrinceJSix-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorderAm J Psychiatry19961539114711538780417
- SpencerTBiedermanJHeiligensteinJAn open-label, dose-ranging study of atomoxetine in children with attention deficit hyperactivity disorderJ Child Adolesc Psychopharmacol200111325126511642475
- Sonuga-BarkeEJVan LierPSwansonJMHeterogeneity in the pharmacodynamics of two long-acting methylphenidate formulations for children with attention deficit/hyperactivity disorder. A growth mixture modelling analysisEur Child Adolesc Psychiatry200817424525418071840
- CoghillDRRhodesSMMatthewsKThe neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorderBiol Psychiatry200762995496217543895
- CornforthCCoghillDSonuga-BarkeESex and age effects in MPH response in ADHDPsychopharmacology (Berl)2010In press
- Sonuga-BarkeEJCoghillDMarkowitzJSSwansonJMVandenbergheMHatchSJSex differences in the response of children with ADHD to once-daily formulations of methylphenidateJ Am Acad Child Adolesc Psychiatry200746670171017513982
- SteinMAMcGoughJJThe pharmacogenomic era: Promise for personalizing attention deficit hyperactivity disorder therapyChild Adolesc Psychiatr Clin N Am200817247549018295157
- LevyFWhat do dopamine transporter and catechol-o-methyltransferase tell us about attention deficit-hyperactivity disorder? Pharmacogenomic implicationsAust N Z J Psychiatry2007411101617464676
- WinsbergBGComingsDEAssociation of the dopamine transporter gene (DAT1) with poor methylphenidate responseJ Am Acad Child Adolesc Psychiatry199938121474147710596245
- RomanTSzobotCMartinsSBiedermanJRohdeLAHutzMHDopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorderPharmacogenetics200212649749912172219
- CheonKARyuYHKimJWChoDYThe homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: Relating to treatment response to methylphenidateEur Neuropsychopharmacol20051519510115572278
- KirleyALoweNHawiZAssociation of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHDAm J Med Genet B Neuropsychiatr Genet2003121B1505412898575
- SteinMAWaldmanIDSarampoteCSDopamine transporter genotype and methylphenidate dose response in children with ADHDNeuropsychopharmacology20053071374138215827573
- JooberRGrizenkoNSenguptaSDopamine transporter 3’-UTR VNTR genotype and ADHD: A pharmaco-behavioural genetic study with methylphenidateNeuropsychopharmacology20073261370137617063150
- LangleyKTuricDPeirceTRNo support for association between the dopamine transporter (DAT1) gene and ADHDAm J Med Genet B Neuropsychiatr Genet2005139B171016082688
- McGoughJMcCrackenJSwansonJPharmacogenetics of methylphenidate response in preschoolers with ADHDJ Am Acad Child Adolesc Psychiatry200645111314132217023870
- TharoorHLobosEAToddRDReiersenAMAssociation of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHDAm J Med Genet B Neuropsychiatr Genet2008147B452753017948872
- van der MeulenEMBakkerSCPaulsDLHigh sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHDJ Child Psychol Psychiatry200546101074108016178931
- ZeniCPGuimaraesAPPolanczykGVNo significant association between response to methylphenidate and genes of the dopaminergic and serotonergic systems in a sample of Brazilian children with attention-deficit/hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2007144B339139417171656
- HamarmanSFossellaJUlgerCBrimacombeMDermodyJDopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: A pharmacogenetic studyJ Child Adolesc Psychopharmacol200414456457415662148
- CheonKAKimBNChoSCAssociation of 4-repeat allele of the dopamine D4 receptor gene exon III polymorphism and response to methylphenidate treatment in Korean ADHD childrenNeuropsychopharmacology20073261377138317077808
- FroehlichTEMcGoughJJSteinMAProgress and promise of attention-deficit hyperactivity disorder pharmacogeneticsCNS Drugs20102429911720088618
- McCarthyMIAbecasisGRCardonLRGenome-wide association studies for complex traits: Consensus, uncertainty and challengesNat Rev Genet20089535636918398418
- McCarthyMIHirschhornJNGenome-wide association studies: Potential next steps on a genetic journeyHum Mol Genet200817R2R156R16518852205
- MaherBPersonal genomes: The case of the missing heritabilityNature20084567218182118987709
- FrankeBNealeBMFaraoneSVGenome-wide association studies in ADHDHum Genet20091261135019384554
- LeungPWLeeCCHungSFDopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD): Increased prevalence of the 2-repeat alleleAm J Med Genet B Neuropsychiatr Genet2005133B1545615578612
- GabrielaMLJohnDGMagadelaBVGenetic interaction analysis for DRD4 and DAT1 genes in a group of Mexican ADHD patientsNeurosci Lett2009451325726019146920
- GordonDHaynesCJohnnidisCPatelSBBowcockAMOttJA transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parentsEur J Hum Genet200412975276115162128
- CurtisDShamPCA note on the application of the transmission disequilibrium test when a parent is missingAm J Hum Genet19955638118127887437
- SwansonJMMoyzisRKMcGoughJJEffects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)J Child Adolesc Psychopharmacol200717563564617979583
- WestALangleyKHamshereMLEvidence to suggest biased phenotypes in children with attention deficit hyperactivity disorder from completely ascertained triosMol Psychiatry20027996296612399949
- PearsonTAManolioTAHow to interpret a genome-wide association studyJAMA2008299111335134418349094
- WeedonMNLangoHLindgrenCMGenome-wide association analysis identifies 20 loci that influence adult heightNat Genet200840557558318391952
- VisscherPMSizing up human height variationNat Genet200840548949018443579
- PritchardJKCoxNJThe allelic architecture of human disease genes: common disease-common variant...or not?Hum Mol Genet200211202417242312351577
- SchorkNJMurraySSFrazerKATopolEJCommon vs rare allele hypotheses for complex diseasesCurr Opin Genet Dev200919321221919481926
- RobinsonRCommon disease, multiple rare (and distant) variantsPLoS Biol201081e100029320126253
- DicksonSPWangKKrantzIHakonarsonHGoldsteinDBRare variants create synthetic genome-wide associationsPLoS Biol201081e100029420126254
- DeFriesJCFulkerDWMultiple regression analysis of twin dataBehav Genet19851554674734074272
- SwansonJDeutschCCantwellDGenes and attention-deficit hyperactivity disorderClin Neurosci Res20011217216
- ZametkinADopamine reward pathway in adult ADHD (Letter to editor)JAMA2010303323223420085952
- HayDABennettKSLevyFSergeantJSwansonJA twin study of attention-deficit/hyperactivity disorder dimensions rated by the strengths and weaknesses of ADHD-symptoms and normal-behavior (SWAN) scaleBiol Psychiatry200761570070516962074
- YoungDJLevyFMartinNCHayDAAttention deficit hyperactivity disorder: A Rasch analysis of the SWAN Rating ScaleChild Psychiatry Hum Dev200940454355919455417
- AulchenkoYSStruchalinMVBelonogovaNMPredicting human height by Victorian and genomic methodsEur J Hum Genet20091781070107519223933
- GaudermanWJSample size requirements for matched case-control studies of gene-environment interactionStat Med2002211355011782049
- GluckmanPDHansonMACooperCThornburgKLEffect of in utero and early-life conditions on adult health and diseaseN Engl J Med20083591617318596274
- LouHCEtiology and pathogenesis of attention-deficit hyperactivity disorder (ADHD): Significance of prematurity and perinatal hypoxic-haemodynamic encephalopathyActa Paediatr19968511126612718955450
- Rosa NetoPLouHCummingPPrydsOGjeddeAMethylphenidate-evoked potentiation of extracellular dopamine in the brain of adolescents with premature birth: Correlation with attentional deficitAnn N Y Acad Sci200296543443912105118