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Review

Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk

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Pages 793-799 | Published online: 21 Sep 2009

References

  • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)Lancet19943448934138313897968073
  • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study GroupN Engl J Med199833919134913579841303
  • SacksFMThe effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigatorsN Engl J Med199633514100110098801446
  • ShepherdJPrevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study GroupN Engl J Med199533320130113077566020
  • DownsJRPrimary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention StudyJAMA199827920161516229613910
  • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final reportCirculation2002106253143342112485966
  • ChapmanMJRaising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid – a position paper developed by the European Consensus Panel on HDL-CCurr Med Res Opin20042081253126815324528
  • MillerMImpact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trialJ Am Coll Cardiol200851772473018279736
  • ShepherdJPravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trialLancet200236093461623163012457784
  • SeverPSPrevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial – Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trialLancet200336193641149115812686036
  • DavidsonMHReducing residual risk for patients on statin therapy: the potential role of combination therapyAm J Cardiol2005969A3K13Kdiscussion 34K–35K.
  • CollinsRMRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trialLancet200336193742005201612814710
  • ShepherdJEffect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) studyDiabetes Care20062961220122616731999
  • KearneyPMEfficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysisLancet2008371960711712518191683
  • BaigentCEfficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statinsLancet200536694931267127816214597
  • GarveyWTEffects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceDiabetes200352245346212540621
  • OtvosJDMeasurement issues related to lipoprotein heterogeneityAm J Cardiol2002908A22i29i
  • GordonDJHigh-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studiesCirculation19897918152642759
  • BarterPHDL cholesterol, very low levels of LDL cholesterol, and cardiovascular eventsN Engl J Med2007357131301131017898099
  • BerlinerJAAtherosclerosis: basic mechanisms. Oxidation, inflammation, and geneticsCirculation1995919248824967729036
  • GrundySMLow-density lipoprotein, non-high-density lipoprotein, and apolipoprotein B as targets of lipid-lowering therapyCirculation2002106202526252912427645
  • BrunzellJDLipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology FoundationJ Am Coll Cardiol200851151512152418402913
  • BaysHESafety considerations with omega-3 fatty acid therapyAm J Cardiol2007996A35C43C
  • BaysHEPrescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implicationsExpert Rev Cardiovasc Ther20086339140918327998
  • YokoyamaMEffects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysisLancet200736995671090109817398308
  • DavidsonMHEfficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled studyClin Ther20072971354136717825687
  • HolmanRRAtorvastatin in Factorial with Omega-3 EE90 Risk Reduction in Diabetes (AFORRD): a randomised controlled trialDiabetologia2009521505919002433
  • BrownBGExpert commentary: niacin safetyAm J Cardiol2007996A32C34C
  • The Coronary Drug Project Research GroupClofibrate and niacin in coronary artery diseaseJAMA19752313603811088963
  • GansDJLetter: Coronary drug projectJAMA1975234121221174217
  • CannerPLFifteen year mortality in Coronary Drug Project patients: long-term benefit with niacinJ Am Coll Cardiol198686124512553782631
  • McKenneyJNew perspectives on the use of niacin in the treatment of lipid disordersArch Intern Med2004164769770515078639
  • GanjiSHNiacin and cholesterol: role in cardiovascular disease (review)J Nutr Biochem200314629830512873710
  • Lamon-FavaSExtended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteinsArterioscler Thromb Vasc Biol20082891672167818566298
  • RubicTStimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacinBiochem Pharmacol200467341141915037193
  • BallantyneCMComparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study)Am J Cardiol2008101101428143618471454
  • KarasRHLong-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS studyAm J Cardiovasc Drugs200882698118422390
  • BrownBGSimvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary diseaseN Engl J Med2001345221583159211757504
  • TaylorAJArterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statinsCirculation2004110233512351715537681
  • TaylorAJThe effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER3Curr Med Res Opin200622112243225017076985
  • TaylorAJHDL-C response to extended release NiacinJ Clin Lipidiol20082285288
  • ManninenVJoint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatmentCirculation199285137451728471
  • GoldenbergISecondary prevention with bezafibrate therapy for the treatment of dyslipidemia: an extended follow-up of the BIP trialJ Am Coll Cardiol200851445946518222357
  • FruchartJCPeroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosisCurr Opin Lipidol199910324525710431661
  • BarbierOPleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosisArterioscler Thromb Vasc Biol200222571772612006382
  • KeechAEffects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trialLancet200536695001849186116310551
  • KeechACEffect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trialLancet200737096001687169717988728
  • GrundySMClinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to managementCirculation2004109455155614757684
  • DavidsonMHCombination therapy for dyslipidemia: safety and regulatory considerationsAm J Cardiol20029010B50K60K
  • MartinPDAn open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteersClin Ther200325245947112749507
  • BergmanAJSimvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humansJ Clin Pharmacol20044491054106215317833
  • BackmanJTRifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolitesClin Pharmacol Ther200578215416716084850
  • SchneckDWThe effect of gemfibrozil on the pharmacokinetics of rosuvastatinClin Pharmacol Ther200475545546315116058
  • DavidsonMHSafety considerations with fibrate therapyAm J Cardiol2007996A3C18C
  • GrundySMImplications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelinesCirculation2004110222723915249516
  • CannonCPCombination therapy in the management of mixed dyslipidaemiaJ Intern Med2008263435336518324928
  • DevinePJDesign and rationale of the ARBITER 6 trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol)-6-HDL and LDL Treatment Strategies in Atherosclerosis (HALTS)Cardiovasc Drugs Ther200721322122517404825
  • BrousseauMEEffects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterolN Engl J Med2004350151505151515071125
  • NissenSEEffect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trialJAMA2003290172292230014600188