Current Trends in N-Acetyltransferase Research Arising from the 2007 International NAT Workshop

• Sim E , WestwoodI, FullamE: Arylamine N-acetyltransferases.Expert Opin. Drug. Metab. Toxicol.3(2), 169–184 (2007).
   PubMed Web of Science ®Google Scholar
• Minchin RF , HannaPE, Dupret J-M, Wagner CR, Rodrigues-Lima F, Butcher NJ: Arylamine N-acetyltransferase 1. Int. J. Biochem. Cell Biol.39(11), 1999–2005 (2007).
   PubMed Web of Science ®Google Scholar
• Ilett KF , KadlubarFF, MinchinRF: 1998 International meeting on the arylamine N-acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons and role in human disease risk.Drug Metab. Dispos.27(9), 957–959 (1999).
   PubMedGoogle Scholar
• Rodrigues-Lima F , BlömekeB, SimE, Dupret J-M: NAT – from bugs to brains: An overview of the 2nd International Workshop on the arylamine N-acetyltransferases. Pharmacogenomics J.2(3), 152–155 (2002).
   PubMedGoogle Scholar
• McQueen C : Summary of the third annual workshop on arylamine N-acetyltransferases.ISSX Newsletter24(3), 13 (2004).
   Google Scholar
• Wu H , DombrovskyL, TempelW et al.: Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. J. Biol. Chem.282(41), 30189–30197 (2007).
   PubMed Web of Science ®Google Scholar
• Zang Y , ZhaoS, DollMA, StatesJC, HeinDW: Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.Pharmacogenet. Genomics17(1), 37–45 (2007).
   PubMed Web of Science ®Google Scholar
• Zang Y , DollMA, ZhaoS, StatesJC, Hein DW: Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis28(8), 1665–1671 (2007).
   PubMed Web of Science ®Google Scholar
• Pluvinage B , DairouJ, PossotOM et al.: Cloning and molecular cheracterization of three arylamine N-acetyltransferase genes from Bacillus anthracis: identification of unusual enzymatic properties and their contribution to sulfamethoxazole resistance. Biochemistry46(23), 7069–7078 (2007).
   PubMed Web of Science ®Google Scholar
• Fullam E , WestwoodIM, AndertonMC, LoweED, SimE, NobleEM: Divergence of cofactor recognition across evolution: Coenzyme A binding in a prokaryotic arylamine N-acetyltransferase.J. Mol. Biol.375(1), 178–191 (2008).
   PubMed Web of Science ®Google Scholar
• Van der Geize R , YamK, HeuserT et al.: A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl Acad. Sci. USA104(6), 1947–1952 (2007).
   PubMed Web of Science ®Google Scholar
• Boukouvala S , FakisG: Arylamine N-acetyltransferases: What we learn from genes and genomes.Drug Metab. Rev.37(3), 511–564 (2005).
   PubMed Web of Science ®Google Scholar
• Fakis G , BoukouvalaS, KawamuraA, KennedyS: Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis.Pharmacogenet. Genomics17(3), 181–188 (2007).
   PubMed Web of Science ®Google Scholar
• Prowse AH , FakisG, ManekS et al.: Allelic loss studies do not provide evidence for the ‘endometriosis-as-tumor‘ theory. Fertil. Steril.83(Suppl. 1), 1134–1143 (2005).
   PubMed Web of Science ®Google Scholar
• Walraven JM , DollMA, HeinDW: Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2.J. Pharmacol. Exp. Ther.319(1), 369–375 (2006).
   PubMed Web of Science ®Google Scholar
• Walraven JM , BarkerDF, DollMA, HeinDW: Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and functional characterization of a novel rNat3*2 genetic variant.Toxicol. Sci.99(2), 413–421 (2007).
   PubMed Web of Science ®Google Scholar
• Wakefield L , CornishV, LongH et al.: Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: A potential marker for the developing neuroendocrine system. Biomarkers13(1), 106–118 (2008).
   PubMed Web of Science ®Google Scholar
• Wakefield L , CornishV, LongH, Griffiths WJ, Sim E: Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochem. Biophys. Res. Commun.364(3), 556–560 (2007).
   PubMed Web of Science ®Google Scholar
• Wakefield L , LongH, LackN, SimE: Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene.Mamm. Genome18(4), 270–276 (2007).
   PubMed Web of Science ®Google Scholar
• Wakefield L , RobinsonJ, LongH et al.: Arylamine N-acetyltransferase I expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors. Genes Chromosomes Cancer47(2), 118–126 (2008).
   PubMed Web of Science ®Google Scholar
• Butcher NJ , TetlowNL, CheungC et al.: Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res.67(1), 85–92 (2007).
   PubMed Web of Science ®Google Scholar
• Golka K , BlaszkewiczM, SamimiM, BoltHM, SelinskiS: Reconstruction of N-acetyltransferase 2 haplotypes using PHASE.Arch. Toxicol.82(4), 265–270 (2008).
   PubMed Web of Science ®Google Scholar
• Majumder M , SikdarN, GhoshS, RoyB: Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators.Int. J. Cancer120(10), 2148–2156 (2007).
   PubMed Web of Science ®Google Scholar
• Batra J , SharmaSK, GhoshB: Arylamine N-acetyltransferase gene polymorphisms: Markers for atopic asthma, serum IgE and blood eosinophil counts.Pharmacogenomics7(5), 673–682 (2006).
   PubMed Web of Science ®Google Scholar
• Hein DW , BoukouvalaS, GrantDM, MinchinRF, SimE: Changes in consensus arylamine N-acetyltransferase (NAT) gene nomenclature.Pharmacogenet. Genomics18(4), 367–368 (2008).
   PubMed Web of Science ®Google Scholar
• Sandy J , MushtaqA, KawamuraA, Sinclair J, Sim E, Noble M: The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis – an enzyme which inactivates the anti-tubercular drug isoniazid. J. Mol. Biol.318(4), 1071–1083 (2002).
   PubMed Web of Science ®Google Scholar
• Potterton L , McNicholasS, KrissinelE et al.: Developments in the CCP4 molecular-graphics project. Acta Crystallogr. D Biol. Crystallogr.60(12 Pt 1), 2288–2294 (2004).
   PubMedGoogle Scholar

Websites

• Consensus arylamine N-acetyltransferase (NAT) gene nomenclature http://louisville.edu/medschool/pharmacology/NAT.html
   Google Scholar
• Guidelines for human gene nomenclature www.genenames.org/guidelines.html
   Google Scholar