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Review

Essential Function, Sophisticated Regulation and Pathological Impact of the Selective RNA-Binding Protein QKI in CNS Myelin Development

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Pages 655-668 | Published online: 28 Oct 2008

Bibliography

  • Chenard CA , RichardS: New implications for the QUAKING RNA binding protein in human disease.J. Neurosci. Res.86, 233–242 (2008).
  • McInnes LA , LauriatTL: RNA metabolism and dysmyelination in schizophrenia.Neurosci. Biobehav. Rev.30, 551–561 (2006).
  • Larocque D , GalarneauA, LiuHN, ScottM, AlmazanG, RichardS: Protection of p27kip1 mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation.Nat. Neurosci.8, 27–33 (2005).
  • Ebersole TA , ChenQ, JusticeMJ, ArtztK: The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins.Nat. Genet.12, 260–265 (1996).
  • Hardy RJ , LoushinCL, FriedrichVLJret al.: Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice. J. Neurosci.16, 7941–7949 (1996).
  • Wu J , ZhouL, TonissenK, TeeR, ArtztK: The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.J. Biol. Chem.274, 29202–29210 (1999).
  • Larocque D , PilotteJ, ChenTet al.: Nuclear retention of MBP mRNAs in the quaking viable mice.Neuron36, 815–829 (2002).
  • Pilotte J , LarocqueD, RichardS: Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer.Genes Dev.15, 845–858 (2001).
  • Galarneau A , RichardS: Target RNA motif and target mRNAs of the Quaking STAR protein.Nat. Struct. Mol. Biol.12, 691–698 (2005).
  • Ryder SP , FraterLA, AbramovitzDL, GoodwinEB, WilliamsonJR: RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1.Nat. Struct. Mol. Biol.11, 20–28 (2004).
  • Noveroske JK , LaiL, GaussinVet al.: Quaking is essential for blood vessel development.Genesis32, 218–230 (2002).
  • Dawson MR , PolitoA, LevineJM, ReynoldsR: NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS.Mol. Cell. Neurosci.24, 476–488 (2003).
  • Hardy RJ : Molecular defects in the dysmyelinating mutant quaking.J. Neurosci. Res.51, 417–422 (1998).
  • Vernet C , ArtztK: STAR, a gene family involved in signal transduction and activation of RNA.Trends Genet.13, 479–484 (1997).
  • Zhang Y , LuZ, KuL, ChenY, WangH, FengY: Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism.EMBO J.22, 1801–1810 (2003).
  • Chen Y , TianD, KuL, OsterhoutDJ, FengY: The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation.J. Biol. Chem.282, 23553–23560 (2007).
  • Sokolov BP : Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?Int. J. Neuropsychopharmacol.10, 547–555 (2007).
  • Karoutzou G , EmrichHM, DietrichDE: The myelin-pathogenesis puzzle in schizophrenia: a literature review.Mol. Psychiatry13, 245–260 (2008).
  • Segal D , KoschnickJR, SlegersLH, HofPR: Oligodendrocyte pathophysiology: a new view of schizophrenia.Int. J. Neuropsychopharmacol.10, 503–511 (2007).
  • Feng Y : Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction.Neurochem. Res.33(10), 1940–1949 (2008).
  • Aberg K , SaetreP, JareborgN, JazinE: Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.Proc. Natl Acad. Sci. USA103, 7482–7487 (2006).
  • Aberg K , SaetreP, LindholmEet al.: Human QKI, a new candidate gene for schizophrenia involved in myelination.Am. J. Med. Genet. B. Neuropsychiatr. Genet.141, 84–90 (2006).
  • Haroutunian V , KatselP, DrachevaS, DavisKL: The human homolog of the qkI gene affected in the severe dysmyelination ‘quaking‘ mouse phenotype: downregulated in multiple brain regions in schizophrenia.Am. J. Psychiatry163, 1834–1837 (2006).
  • Lauriat TL , ShiueL, HaroutunianVet al.: Developmental expression profile of quaking, a candidate gene for schizophrenia, and its target genes in human prefrontal cortex and hippocampus shows regional specificity.J. Neurosci. Res.86, 785–796 (2008).
  • Larocque D , RichardS: QUAKING KH domain proteins as regulators of glial cell fate and myelination.RNA Biol.2, 37–40 (2005).
  • Lakiza O , FraterL, YooYet al.: STAR proteins quaking-6 and GLD-1 regulate translation of the homologues GLI1 and tra-1 through a conserved RNA 3´UTR-based mechanism.Dev. Biol.287, 98–110 (2005).
  • Volk T , IsraeliD, NirR, Toledano-KatchalskiH: Tissue development and RNA control: ‘HOW‘ is it coordinated?Trends Genet.24, 94–101 (2008).
  • Sidman S , DickieM, AppelS: Mutant mice (Quaking and Jimpy) with deficient myelination in the central nervous system.Science144, 309–311 (1964).
  • Campagnoni AT : Molecular biology of myelin proteins from the central nervous system.J. Neurochem.51, 1–14 (1988).
  • Cox RD , HugillA, ShedlovskyAet al.: Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene.Genomics57, 333–341 (1999).
  • Kondo T , FurutaT, MitsunagaKet al.: Genomic organization and expression analysis of the mouse qkI locus.Mamm. Genome10, 662–669 (1999).
  • Lorenzetti D , AntalffyB, VogelH, NoveroskeJ, ArmstrongD, JusticeM: The neurological mutant quaking(viable) is Parkin deficient.Mamm. Genome15, 210–217 (2004).
  • Lu Z , ZhangY, KuL, WangH, AhmadianA, FengY: The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system.Nucleic Acids Res.31, 4616–4624 (2003).
  • Noveroske JK , HardyR, DapperJD, VogelH, JusticeMJ: A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination.Mamm. Genome16, 672–682 (2005).
  • Zhao L , TianD, XiaM, MacklinWB, FengY: Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.J. Neurosci.26, 11278–11286 (2006).
  • Saccomanno L , LoushinC, JanE, PunkayE, ArtztK, GoodwinEB: The STAR protein QKI-6 is a translational repressor.Proc. Natl Acad. Sci. USA96, 12605–12610 (1999).
  • Li Z , ZhangY, LiD, FengY: Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins.J. Neurosci.20, 4944–4953 (2000).
  • Wu JI , ReedRB, GrabowskiPJ, ArtztK: Function of quaking in myelination: regulation of alternative splicing.Proc. Natl Acad. Sci. USA99, 4233–4238 (2002).
  • Ryder SP , WilliamsonJR: Specificity of the STAR/GSG domain protein QKI: implications for the regulation of myelination.RNA10, 1449–1458 (2004).
  • Chen T , DamajBB, HerreraC, LaskoP, RichardS: Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and QKI: role of the KH domain.Mol. Cell. Biol.17, 5707–5718 (1997).
  • Chen T , RichardS: Structure-function analysis of QKI: a lethal point mutation in mouse quaking prevents homodimerization.Mol. Cell. Biol.18, 4863–4871 (1998).
  • Hayes GM , CarriganPE, MillerLJ: Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas.Cancer Res.67, 2072–2080 (2007).
  • Rosenberg SS , PowellBL, ChanJR: Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination.Cell. Mol. Life Sci.64, 3059–3068 (2007).
  • Hardy RJ : QKI expression is regulated during neuron–glial cell fate decisions.J. Neurosci. Res.54, 46–57 (1998).
  • Casaccia-Bonnefil P , HardyRJ, TengKK, LevineJM, KoffA, ChaoMV: Loss of p27kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.Development126, 4027–4037 (1999).
  • Wegner M , StoltCC: From stem cells to neurons and glia: a Soxist‘s view of neural development.Trends Neurosci.28, 583–588 (2005).
  • Durand B , FeroML, RobertsJM, RaffMC: p27kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.Curr. Biol.8, 431–440 (1998).
  • Tikoo R , OsterhoutDJ, Casaccia-BonnefilP, SethP, KoffA, ChaoMV: Ectopic expression of p27kip1 in oligodendrocyte progenitor cells results in cell-cycle growth arrest.J. Neurobiol.36, 431–440 (1998).
  • Tang XM , BeesleyJS, GrinspanJB, SethP, KamholzJ, CambiF: Cell cycle arrest induced by ectopic expression of p27 is not sufficient to promote oligodendrocyte differentiation.J. Cell Biochem.76, 270–279 (1999).
  • Vouyiouklis DA , BrophyPJ: Microtubule-associated protein MAP1B expression precedes the morphological differentiation of oligodendrocytes.J. Neurosci. Res.35, 257–267 (1993).
  • Fischer I , KonolaJ, CocharyE: Microtubule associated protein (MAP1B) is present in cultured oligodendrocytes and co-localizes with tubulin.J. Neurosci. Res.27, 112–124 (1990).
  • Zhao L , KuL, ChenY, XiaM, LoPrestiP, FengY: QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development.Mol. Biol. Cell17, 4179–4186 (2006).
  • Wu HY , DawsonMR, ReynoldsR, HardyRJ: Expression of QKI proteins and MAP1B identifies actively myelinating oligodendrocytes in adult rat brain.Mol. Cell.Neurosci.17, 292–302 (2001).
  • Deber CM , ReynoldsSJ: Central nervous system myelin: structure, function, and pathology.Clin. Biochem.24, 113–134 (1991).
  • Barbarese E : Spatial distribution of myelin basic protein mRNA and polypeptide in quaking oligodendrocytes in culture.J. Neurosci. Res.29, 271–281 (1991).
  • Fujita N , SatoS, KuriharaT, InuzukaT, TakahashiY, MiyatakeT: Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse.FEBS Lett.232, 323–327 (1988).
  • Lu Z , KuL, ChenY, FengY: Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation.J. Biol. Chem.280, 389–395 (2005).
  • Wei Q , MiskiminsWK, MiskiminsR: The Sp1 family of transcription factors is involved in p27kip1-mediated activation of myelin basic protein gene expression.Mol. Cell. Biol.23, 4035–4045 (2003).
  • Marquardt T , PfaffSL: Cracking the transcriptional code for cell specification in the neural tube.Cell106, 651–654 (2001).
  • Gokhan S , Marin-HusstegeM, YungSY, FontanezD, Casaccia-BonnefilP, MehlerMF: Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression.J. Neurosci.25, 8311–8321 (2005).
  • Kubicki M , McCarleyRW, ShentonME: Evidence for white matter abnormalities in schizophrenia.Curr. Opin Psychiatry18, 121–134 (2005).
  • Havlioglu N , WangJ, FushimiKet al.: An intronic signal for alternative splicing in the human genome.PLoS ONE2, E1246 (2007).
  • Wang E , DimovaN, CambiF: PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes.Nucleic Acids Res.35, 4164–4178 (2007).
  • Baralle D , BaralleM: Splicing in action: assessing disease causing sequence changes.J. Med. Genet.42, 737–748 (2005).
  • Zhang MQ : Statistical features of human exons and their flanking regions.Hum. Mol. Genet.7, 919–932 (1998).
  • Garneau NL , WiluszJ, WiluszCJ: The highways and byways of mRNA decay.Nat. Rev. Mol. Cell Biol.8, 113–126 (2007).
  • Guhaniyogi J , BrewerG: Regulation of mRNA stability in mammalian cells.Gene265, 11–23 (2001).
  • Schlessinger J : SH2/SH3 signaling proteins.Curr. Opin. Genet. Dev.4, 25–30 (1994).
  • Gmeiner WH , HoritaDA: Implications of SH3 domain structure and dynamics for protein regulation and drug design.Cell Biochem. Biophys.35, 127–140 (2001).
  • Umemori H , SatoS, YagiT, AizawaS, YamamotoT: Initial events of myelination involve Fyn tyrosine kinase signalling.Nature367, 572–576 (1994).
  • Osterhout DJ , WolvenA, WolfRM, ReshMD, ChaoMV: Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase.J. Cell Biol.145, 1209–1218 (1999).
  • Kramer EM , KleinC, KochT, BoytinckM, TrotterJ: Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination.J. Biol. Chem.274, 29042–29049 (1999).
  • Umemori H , KadowakiY, HirosawaKet al.: Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination.J. Neurosci.19, 1393–1397 (1999).
  • Seiwa C , SugiyamaI, YagiT, IguchiT, AsouH: Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system.Neurosci. Res.37, 21–31 (2000).
  • Sperber BR , Boyle-WalshEA, EnglekaMJet al.: A unique role for Fyn in CNS myelination.J. Neurosci.21, 2039–2047 (2001).
  • Goto J , TezukaT, NakazawaT, SagaraH, YamamotoT: Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.Mol. Cell. Neurosci.38, 203–212 (2008).
  • Grant SG , KarlKA, KieblerMA, KandelER: Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.Genes Dev.9, 1909–1921 (1995).
  • Lew J , HuangQQ, QiZet al.: A brain-specific activator of cyclin-dependent kinase 5.Nature371, 423–426 (1994).
  • Tsai LH , DelalleI, CavinessVS Jr, Chae T, Harlow E: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature371, 419–423 (1994).
  • Miyamoto Y , YamauchiJ, ChanJRet al.: Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.J. Cell Sci.120, 4355–4366 (2007).
  • Flores AI , NarayananSP, MorseENet al.: Constitutively active Akt induces enhanced myelination in the CNS.J. Neurosci.28, 7174–7183 (2008).
  • Fragoso G , HainesJD, RoberstonJ, PedrazaL, MushynskiWE, AlmazanG: p38 mitogen-activated protein kinase is required for central nervous system myelination.Glia55, 1531–1541 (2007).
  • Frost EE , ZhouZ, KrasneskyK, ArmstrongRC: Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway.Neurochem. Res. (2008) (Epub ahead of print).
  • Cote J , BoisvertFM, BoulangerMC, BedfordMT, RichardS: Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.Mol. Biol. Cell14, 274–287 (2003).
  • Li ZZ , KondoT, MurataTet al.: Expression of Hqk encoding a KH RNA binding protein is altered in human glioma.Jpn J. Cancer Res.93, 167–177 (2002).
  • Lindholm E , EkholmB, ShawSet al.: A schizophrenia-susceptibility locus at 6q25, in one of the world‘s largest reported pedigrees.Am. J. Hum. Genet.69, 96–105 (2001).
  • Tastemir D , DemirhanO, SertdemirY: Chromosomal fragile site expression in Turkish psychiatric patients.Psychiatry Res.144, 197–203 (2006).
  • McCullumsmith RE , GuptaD, BeneytoMet al.: Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia.Schizophr. Res.90, 15–27 (2007).
  • Yeo G , HoonS, VenkateshB, BurgeCB: Variation in sequence and organization of splicing regulatory elements in vertebrate genes.Proc. Natl Acad. Sci. USA101, 15700–15705 (2004).
  • Fairbrother WG , YehRF, SharpPA, BurgeCB: Predictive identification of exonic splicing enhancers in human genes.Science297, 1007–1013 (2002).
  • Katsel P , DavisKL, HaroutunianV: Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study.Schizophr. Res.79, 157–173 (2005).
  • Hafner H : Onset and course of the first schizophrenic episode.Kaohsiung J. Med. Sci.14, 413–431 (1998).
  • Steen RG , MullC, McClureR, HamerRM, LiebermanJA: Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.Br. J. Psychiatry188, 510–518 (2006).
  • Steinman L , MartinR, BernardC, ConlonP, OksenbergJR: Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.Annu. Rev. Neurosci.25, 491–505 (2002).
  • Howe CL : Immunological aspects of axon injury in multiple sclerosis.Curr. Top. Microbiol. Immunol.318, 93–131 (2008).
  • Vanderlocht J , HellingsN, HendriksJJ, StinissenP: Current trends in multiple sclerosis research: an update on pathogenic concepts.Acta Neurol. Belg.106, 180–190 (2006).
  • Seiwa C , YamamotoM, TanakaKet al.: Restoration of FcRg/Fyn signaling repairs central nervous system demyelination.J. Neurosci. Res.85, 954–966 (2007).
  • Ichimura K , MungallAJ, FieglerHet al.: Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH.Oncogene25, 1261–1271 (2006).
  • Sukumar S , WangS, HoangKet al.: Subtle overlapping deletions in the terminal region of chromosome 6q24.2-q26: three cases studied using FISH.Am. J. Med. Genet.87, 17–22 (1999).
  • Lim J , HaoT, ShawCet al.: A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.Cell125, 801–814 (2006).

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