Advanced search
Publication Cover
Aging Health Volume 2, 2006 - Issue 6
Journal homepage
55
Views
0
CrossRef citations to date
0
Altmetric
Review

Erectile and Sexual Dysfunction in the Aging Diabetic Male

William O Brant1 Northstar Urology, P.O. Box 40,000, Vail Colorado, CO81658, USA Tel.: +1 970 569 7725; Fax: +1 970 569 7735; E-mail: [email protected];2 University of California, San Francisco, 400 Parnassus Ave, A633, San Francisco, CA94143–0738, USA Tel.: +1 415 476 1611; Fax: +1 415 476 8849; E-mail: [email protected]@urology.ucsf.edu
,
Anthony J Bella2 University of California, San Francisco, 400 Parnassus Ave, A633, San Francisco, CA94143–0738, USA Tel.: +1 415 476 1611; Fax: +1 415 476 8849; E-mail: [email protected]@urology.ucsf.edu
&
Tom F Lue2 University of California, San Francisco, 400 Parnassus Ave, A633, San Francisco, CA94143–0738, USA Tel.: +1 415 476 1611; Fax: +1 415 476 8849; E-mail: [email protected]@urology.ucsf.edu
Pages 1025-1034 | Published online: 14 Dec 2006

Bibliography

  • Feldman HA , GoldsteinI, HatzichristouDG, KraneRJ, McKinlayJB: Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study.J. Urol.151(1), 54–61(1994).
  • Braun M , WassmerG, KlotzTet al.: Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey’. Int. J. Impot. Res.12(6), 305–311(2000).
  • Rosen R , AltweinJ, BoylePet al.: Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur. Urol.44(6), 637–649(2003).
  • Nicolosi A , LaumannEO, GlasserDBet al.: Sexual behavior and sexual dysfunctions after age 40: the global study of sexual attitudes and behaviors. Urology64(5), 991–997(2004).
  • Araujo AB , MohrBA, McKinlayJB: Changes in sexual function in middle-aged and older men: longitudinal data from the Massachusetts Male Aging Study.J. Am. Geriatr. Soc.52(9), 1502–1509(2004).
  • Christ GJ , MaayaniS, ValcicM, MelmanA: Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in α-adrenoceptor responsiveness with age and disease in isolated tissues.Br. J. Pharmacol.101(2), 375–381(1990).
  • Kaiser FE , VioscaSP, MorleyJEet al.: Impotence and aging: clinical and hormonal factors. J. Am. Geriatr. Soc.36(6), 511–519(1988).
  • Rowland DL , GreenleafW, MasM, Myers L, Davidson JM: Penile and finger sensory thresholds in young, aging, and diabetic males. Arch. Sex Behav.18(1), 1–12(1989).
  • Corona G , MannucciE, MansaniRet al.: Aging and pathogenesis of erectile dysfunction. Int. J. Impot. Res.16(5), 395–402(2004).
  • Rosen MP , GreenfieldAJ, WalkerTGet al.: Cigarette smoking: an independent risk factor for atherosclerosis in the hypogastric-cavernous arterial bed of men with arteriogenic impotence. J. Urol.145(4), 759–763(1991).
  • Rajfer J , RosciszewskiA, MehringerM: Prevalence of corporeal venous leakage in impotent men.J. Urol.140(1), 69–71(1988).
  • Shiri R , KoskimakiJ, HakkinenJet al.: Cardiovascular drug use and the incidence of erectile dysfunction. Int. J. Impot. Res. DOI 10.1038/sj.ijir.3901516 (2006) (Epub ahead of print).
  • Grimm RH Jr, Grandits GA, Prineas RJ et al.: Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension29(1 Pt 1), 8–14(1997).
  • Papatsoris AG , KorantzopoulosPG: Hypertension, antihypertensive therapy, and erectile dysfunction.Angiology57(1), 47–52(2006).
  • Horowitz JD , GobleAJ: Drugs and impaired male sexual function.Drugs18(3), 206–217(1979).
  • Chang SW , FineR, SiegelDet al.: The impact of diuretic therapy on reported sexual function. Arch. Intern. Med.151(12), 2402–2408(1991).
  • Wolfe MM : Impotence on cimetidine treatment.N. Engl. J. Med.300(2), 94 (1979).
  • Shabsigh R , KleinLT, SeidmanSet al.: Increased incidence of depressive symptoms in men with erectile dysfunction. Urology52(5), 848–852(1998).
  • Araujo AB , DuranteR, FeldmanHA, GoldsteinI, McKinlayJB: The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study.Psychosom. Med.60(4), 458–465(1998).
  • Vermeulen A : Andropause.Maturitas34(1), 5–15(2000).
  • Tenover JS : Declining testicular function in aging men.Int. J. Impot. Res.15(Suppl.) 4S3–4S8 (2003).
  • Angulo J , CuevasP, GabanchoSet al.: Enhancement of both EDHF and NO/cGMP pathways is necessary to reverse erectile dysfunction in diabetic rats. J. Sex. Med.2(3), 341–346(2005).
  • Bancroft J , WuFC: Changes in erectile responsiveness during androgen replacement therapy.Arch. Sex Behav.12(1), 59–66(1983).
  • Juenemann KP , LueTF, LuoJAet al.: The effect of cigarette smoking on penile erection. J. Urol.138(2), 438–441(1987).
  • Miller NS , GoldMS: The human sexual response and alcohol and drugs.J. Subst. Abuse Treat.5(3), 171–177(1988).
  • Sun P , CameronA, SeftelAet al.: Erectile dysfunction – an observable marker of diabetes mellitus? A large national epidemiological study. J. Urol.176(3), 1081–1085(2006).
  • Maatman TJ , MontagueDK, MartinLM: Erectile dysfunction in men with diabetes mellitus.Urology29(6), 589–592(1987).
  • Deutsch S , ShermanL: Previously unrecognized diabetes mellitus in sexually impotent men.JAMA244(21), 2430–2432(1980).
  • Berardinucci D , MoralesA, HeatonJP, FenemoreJ, BloomS: Surgical treatment of penile veno-occlusive dysfunction: is it justified?Urology47(1), 88–92(1996).
  • Sarramon JP , BertrandN, MalavaudB, RischmannP: Microrevascularisation of the penis in vascular impotence.Int. J. Impot. Res.9(3), 127–133(1997).
  • Manning M , JunemannKP, ScheepeJRet al.: Long-term followup and selection criteria for penile revascularization in erectile failure. J. Urol.160(5), 1680–1684(1998).
  • Schultheiss D , TrussMC, BeckerAJ, Stief CG, Jonas U: Long-term results following dorsal penile vein ligation in 126 patients with veno-occlusive dysfunction. Int. J. Impot. Res.9(4), 205–209(1997).
  • Desai KM , DembnyK, MorganH, Gingell JC, Prothero D: Neurophysiological investigation of diabetic impotence. Are sacral response studies of value? Br. J. Urol.61(1), 68–73(1988).
  • Kaneko S , BradleyWE: Penile electrodiagnosis. Value of bulbocavernosus reflex latency versus nerve conduction velocity of the dorsal nerve of the penis in diagnosis of diabetic impotence.J. Urol.137(5), 933–935(1987).
  • Parazzini F , Menchini Fabris F, Bortolotti A et al.: Frequency and determinants of erectile dysfunction in Italy. Eur. Urol.37(1), 43–49(2000).
  • Fedele D , CoscelliC, SanteusanioFet al.: Erectile dysfunction in diabetic subjects in Italy. Gruppo Italiano Studio Deficit Erettile nei Diabetici. Diabetes Care21(11), 1973–1977(1998).
  • Fedele D , BortolottiA, CoscelliCet al.: Erectile dysfunction in Type 1 and Type 2 diabetics in Italy. On behalf of Gruppo Italiano Studio Deficit Erettile nei Diabetici. Int. J. Epidemiol.29(3), 524–531(2000).
  • McCulloch DK , YoungRJ, PrescottRJ, CampbellIW, ClarkeBF: The natural history of impotence in diabetic men.Diabetologia26(6), 437–440(1984).
  • Herman A , AdarR, RubinsteinZ: Vascular lesions associated with impotence in diabetic and nondiabetic arterial occlusive disease.Diabetes27(10), 975–981(1978).
  • Wang CJ , ShenSY, WuCC, HuangCH, ChiangCP: Penile blood flow study in diabetic impotence.Urol. Int.50(4), 209–212(1993).
  • Morano S : Pathophysiology of diabetic sexual dysfunction.J. Endocrinol. Invest.26(3 Suppl), 65–69(2003).
  • Italiano G , PetrelliL, MarinAet al.: Ultrastructural analysis of the cavernous and dorsal penile nerves in experimental diabetes. Int. J. Impot. Res.5(3), 149–160(1993).
  • Faerman I , GlocerL, FoxD, JadzinskyMN, RapaportM: Impotence and diabetes. Histological studies of the autonomic nervous fibers of the corpora cavernosa in impotent diabetic males.Diabetes23(12), 971–976(1974).
  • Vernet D , CaiL, GarbanHet al.: Reduction of penile nitric oxide synthase in diabetic BB/WORdp (Type I) and BBZ/WORdp (type II) rats with erectile dysfunction. Endocrinology136(12), 5709–5717(1995).
  • Ehmke H , JunemannKP, MayerB, KummerW: Nitric oxide synthase and vasoactive intestinal polypeptide colocalization in neurons innervating the human penile circulation.Int. J. Impot. Res.7(3), 147–156(1995).
  • Seftel AD , VaziriND, NiZet al.: Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. Urology50(6), 1016–1026(1997).
  • Angulo J , CuevasP, FernandezAet al.: Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF. Biochem. Biophys. Res. Commun.312(4), 1202–1208(2003).
  • Cartledge JJ , EardleyI, MorrisonJF: Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes.BJU Int.87(4), 402–407(2001).
  • Saenz de Tejada I , GoldsteinI, AzadzoiK, KraneRJ, CohenRA: Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence.N. Engl. J. Med.320(16), 1025–1030(1989).
  • Murray FT , WyssHU, ThomasRG, SpevackM, GlarosAG: Gonadal dysfunction in diabetic men with organic impotence.J. Clin. Endocrinol. Metab.65(1), 127–135(1987).
  • Murray FT , JohnsonRD, SciadiniMet al.: Erectile and copulatory dysfunction in chronically diabetic BB/WOR rats. Am. J. Physiol.263(1 Pt 1), E151–E157 (1992).
  • Nakanishi S , YamaneK, KameiN, Okubo M, Kohno N: Erectile dysfunction is strongly linked with decreased libido in diabetic men. Aging Male7(2), 113–119(2004).
  • Salonia A , BrigantiA, MontorsiPet al.: Safety and tolerability of oral erectile dysfunction treatments in the elderly. Drugs Aging22(4), 323–338(2005).
  • Fujisawa M , SawadaK: Clinical efficacy and safety of sildenafil in elderly patients with erectile dysfunction.Arch. Androl.50(4), 255–260(2004).
  • Goldstein I , LueTF, Padma-NathanHet al.: Oral sildenafil in the treatment of erectile dysfunction. 1998. J. Urol.167(2 Pt 2), 1197–1204(2002).
  • Rendell MS , RajferJ, WickerPA, Smith MD: Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. JAMA281(5), 421–426(1999).
  • Park K , KuJH, KimSW, PaickJS: Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction.BJU Int.95(3), 366–370(2005).
  • Stuckey BG , JadzinskyMN, MurphyLJet al.: Sildenafil citrate for treatment of erectile dysfunction in men with Type 1 diabetes: results of a randomized controlled trial. Diabetes Care26(2), 279–284(2003).
  • Goldstein I , YoungJM, FischerJet al.: Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care26(3), 777–783(2003).
  • Saenz de Tejada I , AnglinG, KnightJR, EmmickJT: Effects of tadalafil on erectile dysfunction in men with diabetes.Diabetes Care25(12), 2159–2164(2002).
  • Behrend L , Vibe-PetersenJ, PerrildH: Sildenafil in the treatment of erectile dysfunction in men with diabetes: demand, efficacy and patient satisfaction.Int. J. Impot. Res.17(3), 264–269(2005).
  • Wagner G , MontorsiF, AuerbachS, Collins M: Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup analysis. J. Gerontol. A. Biol. Sci. Med. Sci.56(2), M113–M119 (2001).
  • Linet OI , NeffLL: Intracavernous prostaglandin E1 in erectile dysfunction.Clin. Investig.72(2), 139–149(1994).
  • Porst H : The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience.J. Urol.155(3), 802–815(1996).
  • Chew KK , StuckeyBG: Clinical course of penile fibrosis in intracavernosal prostaglandin E1 injection therapy: a follow-up of 44 patients.Int. J. Impot. Res.15(2), 94–98(2003).
  • Canale D , GiorgiPM, LencioniRet al.: Long-term intracavernous self-injection with prostaglandin E1 for the treatment of erectile dysfunction. Int. J. Androl.19(1), 28–32(1996).
  • Bennett AH , CarpenterAJ, BaradaJH: An improved vasoactive drug combination for a pharmacological erection program.J. Urol.146(6), 1564–1565(1991).
  • Heaton JP , LordingD, LiuSNet al.: Intracavernosal alprostadil is effective for the treatment of erectile dysfunction in diabetic men. Int. J. Impot. Res.13(6), 317–321(2001).
  • Perimenis P , KonstantinopoulosA, Perimeni PP et al.: Long-term treatment with intracavernosal injections in diabetic men with erectile dysfunction. Asian J. Androl.8(2), 219–224(2006).
  • Ryder RE , CloseCF, MoriartyKT, Moore KT, Hardisty CA: Impotence in diabetes: aetiology, implications for treatment and preferred vacuum device. Diabet. Med.9(10), 893–898(1992).
  • Padma-Nathan H , HellstromWJ, KaiserFEet al.: Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N. Engl. J. Med.336(1), 1–7(1997).
  • Williams G , AbbouCC, AmarETet al.: Efficacy and safety of transurethral alprostadil therapy in men with erectile dysfunction. MUSE Study Group. Br. J. Urol.81(6), 889–894(1998).
  • Lewis RW : Transurethral alprostadil with MUSE (medicated urethral system for erection) vs intracavernous alprostadil – a comparative study in 103 patients with erectile dysfunction.Int. J. Impot. Res.10(1), 61–62(1998).
  • Ekman P , SjogrenL, EnglundG, Persson BE: Optimizing the therapeutic approach of transurethral alprostadil. BJU Int.86(1), 68–74(2000).
  • Akoz T , KargiE, KapucuMR, ErdoganB: The use of iliac bone flap as a penile stiffener in a diabetic patient with erectile dysfunction.Plast. Reconstr. Surg.103(7), 1975–1978(1999).
  • Mulcahy JJ , AustoniE, BaradaJHet al.: The penile implant for erectile dysfunction. J. Sex. Med.1(1), 98–109(2004).
  • Levine LA , EstradaCR, MorgentalerA: Mechanical reliability and safety of, and patient satisfaction with the Ambicor inflatable penile prosthesis: results of a 2 center study.J. Urol.166(3), 932–937(2001).
  • Montorsi F , RigattiP, CarmignaniGet al.: AMS three-piece inflatable implants for erectile dysfunction: a long-term multi-institutional study in 200 consecutive patients. Eur. Urol.37(1), 50–55(2000).
  • Bishop JR , MoulJW, SihelnikSAet al.: Use of glycosylated hemoglobin to identify diabetics at high risk for penile periprosthetic infections. J. Urol.147(2), 386–388(1992).
  • Wilson SK , CarsonCC, ClevesMA, Delk JR 2nd: Quantifying risk of penile prosthesis infection with elevated glycosylated hemoglobin. J. Urol.159(5), 1537–1540(1998).
  • Cakan M , DemirelF, KarabacakO, YalcinkayaF, AltugU: Risk factors for penile prosthetic infection.Int. Urol. Nephrol.35(2), 209–213(2003).
  • Bejany DE , PeritoPE, LustgartenM, RhamyRK: Gangrene of the penis after implantation of penile prosthesis: case reports, treatment recommendations and review of the literature.J. Urol.150(1), 190–192(1993).
  • Gerig NE , MeachamRB, OhlDA: Use of electroejaculation in the treatment of ejaculatory failure secondary to diabetes mellitus.Urology49(2), 239–242(1997).
  • Kamischke A , NieschlagE: Update on medical treatment of ejaculatory disorders.Int. J. Androl.25(6), 333–344(2002).
  • Tomasi PA , FanciulliG, DelitalaG: Successful treatment of retrograde ejaculation with the α1-adrenergic agonist methoxamine: case study.Int. J. Impot. Res.17(3), 297–299(2005).
  • Jannini EA , LenziA: Epidemiology of premature ejaculation.Curr. Opin. Urol.15(6), 399–403(2005).
  • Basile Fasolo C , MironeV, GentileV, ParazziniF, RicciE: Premature ejaculation: prevalence and associated conditions in a sample of 12,558 men attending the andrology prevention week 2001 – a study of the Italian Society of Andrology (SIA).J. Sex. Med.2(3), 376–382(2005).
  • Corona G , PetroneL, MannucciEet al.: Psycho–biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. Eur. Urol.46(5), 615–622(2004).
  • El-Sakka AI : Premature ejaculation in non-insulin-dependent diabetic patients.Int. J. Androl.26(6), 329–334(2003).
  • Jannini EA , LombardoF, LenziA: Correlation between ejaculatory and erectile dysfunction.Int. J. Androl.28(Suppl.) 240–245(2005).
  • Wylie KR , RalphD: Premature ejaculation: the current literature.Curr. Opin. Urol.15(6), 393–398(2005).
  • Usta MF , KendirciM, GurSet al.: The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment. J. Sex. Med.3(2), 242–252(2006).
  • Gholami SS , RogersR, ChangJet al.: The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia. J. Urol.169(4), 1577–1581(2003).
  • Wessells H , TealTH, LuttrellIP, Sullivan CJ: Effect of endothelial cell-based iNOS gene transfer on cavernosal eNOS expression and mouse erectile responses. Int. J. Impot. Res. (2006).
  • Cross WR , ThomasDF, SouthgateJ: Tissue engineering and stem cell research in urology.BJU Int.92(2), 165–171(2003).
  • Bochinski D , LinGT, NunesLet al.: The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int.94(6), 904–909(2004).
  • Yoo JJ , ParkHJ, AtalaA: Tissue-engineering applications for phallic reconstruction.World J. Urol.18(1), 62–66(2000).
  • Kwon TG , YooJJ, AtalaA: Autologous penile corpora cavernosa replacement using tissue engineering techniques.J. Urol.168(4 Pt 2), 1754–1758(2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.