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Aging Health Volume 2, 2006 - Issue 6
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Review

Estrogen Therapy After Menopause: Role in Normal Cognition and Alzheimer’s Disease

Julie Dumas1 Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St., Burlington, VT05401, USA Tel.: +1 802 847 2523; Fax: +1 802 847 7889; E-mail: [email protected]
,
Christy Edgren1 Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St., Burlington, VT05401, USA Tel.: +1 802 847 2523; Fax: +1 802 847 7889; E-mail: [email protected]
&
Paul Newhouse1 Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St., Burlington, VT05401, USA Tel.: +1 802 847 2523; Fax: +1 802 847 7889; E-mail: [email protected]
Pages 955-966 | Published online: 14 Dec 2006

Bibliography

  • Hampson E : Estrogen-related cognitive abilities across the menstrual cycle.Brain Cogn.14, 26–43(1990).
  • Hampson E , KimuraD: Reciprocal effects of hormonal fluctuations on human motor and perceptual-spatial skills.Behav. Neurosci.102, 456–459(1988).
  • Komenich P , LaneDM, DickeyRP, Stone SC: Gonadal hormones and cognitive performance. Physiol. Psychol.6, 115–120(1978).
  • Wickham M : The effects of the menstrual cycle on test performance.Br. J. Psychol.49, 34–41(1958).
  • Sherwin BB : Hormones, mood, and cognitive functioning in postmenopausal women.Obstet. Gynecol.87(2 Suppl,) 20S–26S (1993).
  • Halbreich U , LumleyLA, PalterS, Manning C, Gengo F, Joe Sh: Possible acceleration of age effects on cognition following Menopause J. Psychiatr. Res.29(3), 153–163(1995).
  • Sherwin BB : Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women.Psychoneuroendocrinology13(4), 345–357(1988).
  • Phillips SM , SherwinBB: Effects of estrogen on memory function in surgically menopausal women.Psychoneuroendocrinology17(5), 485–495(1992).
  • Verghese J , KuslanskyG, KatzMJ et al.: Cognitive performance in surgically menopausal women on estrogen. Neurology55(6), 872–874(2000).
  • Kimura D : Estrogen replacement therapy may protect against intellectual decline in postmenopausal women.Horm. Behav.29, 312–321(1995).
  • Jacobs DM , TangMX, SternY et al.: Cognitive function in nondemented older women who took estrogen after menopause Neurology50, 368–373(1998).
  • Smith YR , GiordaniB, Lajiness-O’NeillR, ZubietaJ: Long-term estrogen replacement is associated with improved nonverbal memory and attentional measures in postmenopausal women.Fertil. Steril.76(6), 1101–1107(2001).
  • Resnick SM , MetterEJ, ZondermanAB: Estrogen replacement therapy and longitudinal decline in visual memory: a possible protective effect.Neurology49, 1491–1497(1997).
  • Duka T , TaskerR, McGowanJF: The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females.Psychopharmacology.149, 129–139(2000).
  • Barrett-Connor E , Kritz-SilversteinD: Estrogen replacement therapy and cognitive function in older women.JAMA269(20), 2637–2641(1993).
  • Binder EF , WilliamsDB, SchechtmanKB, JeffeDB, KohrtWM: Effects of hormone replacement therapy on serum lipids in elderly women. a randomized, placebo-controlled trial.Ann. Int. Med.134(9 Pt 1), 754–760(2001).
  • O’Hara R , SchroderCM, BlossC et al.: Hormone Replacement Therapy and Longitudinal Cognitive Performance in Postmenopausal Women. Am. J. Geriatr. Psychiatry13(12), 1107–1110(2005).
  • Ditkoff EC , CraryWG, CristoM, Lobo RA: Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet. Gynecol.78, 991–995(1991).
  • Polo-Kantola P , PortinR, PoloO, Helenius H, Irjala K, Erkkola R: The effect of short-term estrogen replacement therapy on cognition: a randomized, double-blind, cross-over trial in postmenopausal women. Obstet. Gynecol.91(3), 459–466(1998).
  • Linzmayer L , SemlitschHV, SaletuB et al.: Double-blind, placebo-controlled psychometric studies on the effects of a combined estrogen-progestin regimen versus estrogen alone on performance, mood and personality of menopausal syndrome patients. Arzneimittelforschung51(1), 238–245(2001).
  • Duff SJ , HampsonE: A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy.Horm. Behav.38, 262–276(2000).
  • Fluck E , FileSE, RymerJ: Cognitive effects of 10 years of hormone-replacement therapy with tibolone.J. Clin. Psychopharmacol.22, 1–6(2002).
  • LeBlanc ES , JanowskyJ, ChanBKS, Nelson HD: Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA285(11), 1489–1499(2001).
  • Maki P , ZondermanA, ResnickS: Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy.Am. J. Psychiatry158(2), 227–233(2001).
  • Bretsky PM , BuckwalterJG, SeemanTE et al.: Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer. Dis. Assoc. Disord.13(4), 216–221(1999).
  • Yaffe K , LuiL, GradyD, MassaS, StoneK, MorinP: Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women.Biol. Psychiatry51, 677–682(2002).
  • Xu H , GourasGK, GreenfieldJP et al.: Estrogen reduces neuronal generation of Alzheimer β-amyloid Peptides Nat. Med.4(4), 447–451(1998).
  • Paganini-Hill A , HendersonVW: Estrogen deficiency and risk of Alzheimer’s disease in women.Am. J. Epidemiol.140(3), 256–261(1994).
  • Tang MX , JacobsD, SternY et al.: Effect of estrogen during menopause on risk and age at onset of Alzheimer’s disease. Lancet348(9025), 429–432(1996).
  • Panidis DK , MatalliotakisIM, RoussoDH, KourtisAI, KoumantakisEE: The role of estrogen replacement therapy in Alzheimer’s disease.Eur. J. Obstet. Gynecol. Reprod. Biol.95, 86–91(2001).
  • Kawas C , ResnickS, MorrisonA et al.: A prospective study of estrogen replacement therapy and the risk of developing Alzheimer’s disease. Neurology48, 1517–1521(1997).
  • Zandi PP , CarlsonMC, PlassmanBL et al.: Hormone replacement therapy and incidence of Alzheimer disease in older women. JAMA288(17), 2123–2129(2002).
  • Fillit H : Estrogens in the pathogenesis and treatment of Alzheimer’s disease in postmenopausal women.Ann. N. Y. Acad. Sci.743, 233–238(1994).
  • Ohkura T , IsseK, AkawazK: Evaluation of estrogen treatment in female patients with dementia of the Alzheimer’s type.Endocr. J.41, 361–371(1994).
  • Henderson VW , Paganini-HillA, MillerBL et al.: Estrogen for Alzheimer’s disease in women. Randomized, double-blind, placebo-controlled trial. Neurology54, 295–301(2000).
  • Mulnard RA , CotmanCW, KawasC et al.: Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer’s Disease Cooperative Study. JAMA283(8), 1007–1015(2000).
  • Schneider LS , FarlowMR, HendersonVW, PogodaJM: Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer’s disease.Neurology46(6), 1580–1584(1996).
  • Grady D , YaffeK, KristofM, LinF, RichardsC, Barrett-ConnorE: Effect of postmenopausal hormone therapy on cognitive function: the heart and estrogen/progestin replacement study.Am. J. Med.113, 543–548(2002).
  • Binder EF , SchechtmanKB, BirgeSJ, WilliamsDB, KohrtWM: Effects of hormone replacement therapy on cognitive performance in elderly women.Maturitas38, 137–146(2001).
  • Shumaker SA , LegaultC, RappSR et al.: Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women. JAMA289(20), 2651–2662(2003).
  • Shumaker SA , LegaultC, KullerL et al.: Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women. JAMA291(24), 2947–2957(2004).
  • Rapp SR , EspelandMA, ShumakerSA et al.: Effect of estrogen plus progestin on global cognitive function in postmenopausal women. JAMA289(20), 2663–2672(2003).
  • Grady D , YaffeK, KristofM, LinF, RichardsC, Barrett-ConnorE: Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study.Am. J. Med.113(7), 543–548(2002).
  • Vermeer SE , PrinsND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MMB: Silent brain infarcts and the risk of dementia and cognitive decline. N. Engl. J. Med.348(13), 1215–1222(2003).
  • Wassertheil-Smoller S , HendrixSL, LimacherM et al.: Effect of estrogen plus progestin on stroke in postmenopausal women. JAMA289(20), 2673–2684(2003).
  • Yaffe K : Hormone therapy and the brain: déjà vu all over again?JAMA289(20), 2717–2719(2003).
  • Resnick SM , MakiPM, RappSR et al.: Effects of combination estrogen plus progestin hormone treatment on cognition and affect. J. Clin. Endocrinol. Metab.91(5), 1802–1810(2006).
  • Henderson VW , GuthrieJR, DudleyEC, BurgerHG, DennersteinL: Estrogen exposures and memory at midlife: a population-based study of women.Neurology60(8), 1369–1371(2003).
  • Shaywitz SE , NaftolinF, ZeltermanD et al.: Better oral reading and short-term memory in midlife, postmenopausal women taking estrogen. Menopause10(5), 420–426(2003).
  • Dunkin J , RasgonN, Wagner-StehK, DavidSP, AltshulerL, RapkinA: Reproductive events modify the effects of estrogen replacement therapy on cognition in healthy postmenopausal women.Psychoneuroendocrinology30(3), 284–296(2005).
  • Resnick SM , HendersonVW: Hormone therapy and risk of Alzheimer disease: a critical time.JAMA288(17), 2170–2172(2002).
  • Gleason CE , CarlssonCM, JohnsonS, AtwoodC, AsthanaS: Clinical pharmacology and differential cognitive efficacy of estrogen preparations.Ann. N. Y. Acad. Sci.1052, 93–115(2005).
  • Natchigall LE , RajuU, BanerjeeS, WanL, LevitzM: Serum estradiol-binding profiles in postmenopausal women undergoing three comone estrogen replacement therapies: Associations with sex hormone-binding globulin, estradiol, and estrone levels.Menopause7(4), 243–250(2000).
  • Thal L , ThomasRG, MulnardR, SanoM, GrundmanM, SchneiderL: Estrogen levels do not correlate with improvement in cognition.Arch. Neurol.60, 209–212(2003).
  • Asthana S , CraftS, BakerLD et al.: Cognitive and neuroendocrine response to transdermal estrogen in postmenopasual women with Alzheimer’s disease: Results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology24(6), 657–677(1999).
  • Singh M , DykensJA, SimpkinsJW: Novel mechanisms for estrogen-induced neuroprotection.Exp. Biol. Med.231(5), 514–521(2006).
  • Wise PM : Estrogen therapy: does it help or hurt the adult and aging brain? Insights derived from animal models.Neuroscience138, 831–835(2006).
  • Green PS , GridleyKE, SimpkinsJW: Estradiol protects against β-amyloid (25035)-induced toxicity in SK-N-SH human neuroblastoma cells.Neurosci. Lett.218, 165–168(1996).
  • Zaulyanov LL , GreenPS, SimpkinsJW: Glutamate receptor requirement for neuronal death fron anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens.Cell Mol. Neurobiol.9(6), 705–718(1999).
  • Toran-Allerand CD : The estrogen/neurotrophin connection during neural development: is co-localization of estrogen receptors with the neurotrophins and their receptors biologically relevant?Dev. Neurosci.18(1–2), 36–48(1996).
  • Lee SJ , McEwenBS: Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications.Annu. Rev. Pharmacol. Toxicol.41, 569–591(2001).
  • Osterlund MK , HurdYL: Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders.Prog. Neurobiol.64(3), 251–267(2001).
  • Gould E , WoolleyCS, FrankfurtM, McEwenBS: Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood.J. Neurosci.10, 1286–1291(1990).
  • Woolley CS , McEwenBS: Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat.J. Comp. Neurol.336, 293–306(1993).
  • Bi R , FoyMR, VouimbaRM, ThompsonRF, BaudryM: Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway.Proc. Natl Acad. Sci. U.S.A.98(23), 13391–13395(2001).
  • Yankova M , HartSA, WoolleyCS: Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study.Proc. Natl Acad. Sci. U.S.A.98(6), 2941–3624(2001).
  • Rune G , WehrenbergU, Prange-KielJ, HeimrichB, AdelmannG, FrotscherM: Presynaptic effects of estrogen in rat hippocampus.Abstr. - Soc. Neurosci.31, 247.243 (2001).
  • Lee SJ , AlvesSE, BrakeWG, McEwenBS: Phosphorylation of creb in the rat hippocampus is differentially activated following estrogen or SERM (CI6328 or Tamoxifen) Treatment.Soc. Neurosci.31, 407–408(2001).
  • Sharrow KM , RissmanEF, GustafssonJA, FosterTC: Estrogen receptors α and β differentially regulate hippocampal calcineurin activity.Abstr. - Soc. Neurosci.31, 534.536 (2001).
  • Rapp PR , MorrisonJH, RobertsJA: Cyclic estrogen replacement improves cognitive function in aged overiectomized rhesus monkeys.J. Neurosci.23(13), 5708–5714(2003).
  • Hao J , RappPR, LefflerAE et al.: Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys. J. Neurosci.26(9), 2571–2578(2006).
  • Selkoe DJ : Alzheimer’s disease: a central role for amyloid.J. Neuropathol. Exp. Neurol.53(5), 438–447(1994).
  • Hardy J : Amyloid, the presenilins and Alzheimer’s disease.Trends Neurosci.4, 154–159(1997).
  • Zhang S , HuangY, ZhuY, YaoT: Estrogen stimulates release of secreted amyloid precursor protein from primary rat cortical neurons via protein kinase C pathway.Acta Pharmacol. Sin.26(2), 171–176(2005).
  • Evin G , WeidemannA: Biogenesis and metabolism of Alzheimer’s disease Aβ amyloidPeptides23, 1285–1297(2002).
  • Gandy S : Cerebral α-β amyloidosis and postmenopausal hormone deficiency: roles in the genesis of Alzheimer’s Disease.Hum. Pathol.35(3), 271–274(2004).
  • Jaffe AB , Toran-AllerandCD, GreengardP, GandySE: Estrogen regulates metabolism of Alzheimer amyloid β precursor protein.J. Biol. Chem.269(18), 13065–13068(1994).
  • Petanceska S , NaggyV, FrailD, GandyS: Ovariectomy and 17β-estradiol modulate the levels of Alzheimer’s amyloid β peptides in the brain.Exp. Gerontol.35, 1317–1325(2000).
  • Green PS , BalesK, PaulS, BuG: Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer’s disease.Endocrinology146(6), 2774–2781(2005).
  • Zheng H , XuH, UljonSN et al.: Modulation of A(β) peptides by estrogen in mouse models. J. Neurochem.80, 191–196(2002).
  • Heikkinen T , KalesnykasG, RissanenA et al.: Estrogen treatment improves spatial learning in APP+PS1 mice but does not affect β amyloid accumulation and plaque formation. Exp. Neurol.187, 105–117(2004).
  • Wang HL , LeeDH, DavisCB, ShankRP: Amyloid peptide Aβ (1–42) binds selectively with picomolar affinity to α 7 nicotinic acetylcholine receptors.J. Neurochem.75, 1155–1161(2000).
  • Burghaus L , SchutzU, KrempelU et al.: Quantative assessment of nicontinc acetylcholine receptor proteins in the cerebral cortex of Alzheimer’s patients. Brain Res. Mol. Brain Res.76, 385–388(2000).
  • Dumas JA , Hancur-BucciC, NaylorM, SitesC, NewhousePA: Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal post-menopausal women.NeuroPsychopharmacology31, 2065–2078(2006).
  • McMillan PJ , SingerCA, DorsaDM: The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female sprague-dawley rat.J. Neurosci.16(5), 1860–1865(1996).
  • Gibbs RB : Expression of estrogen receptor-like immunoreactivity by different subgroups of basal forebrain cholinergic neurons in gonadectomized male and female rats.Brain Res.72, 61–68(1996).
  • Luine VN , KhylchevskayaRI, McEwenBS: Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain.Brain Res.86(2), 293–306(1975).
  • Luine VN , RennerKJ, McEwenBS: Sex-dependent differences in estrogen regulation of choline acetyltransferase are altered by neonatal treatments.Endocrinology119(2), 874–878(1986).
  • Gibbs RB , WuD, HershLB, PfaffDW: Effects of estrogen replacement on the relative levels of choline acetytransferase, trkA, and nerve growth factor messenger RNAs in the basal forebrain and hippocampal formation of adult rats.Exp. Neurol.129, 70–80(1994).
  • Singh M , MeyerEM, HuangFS, MillardWJ, SimpkinsJW: Ovariectomy reduced ChAT activity and NGF mRNA levels in the frontal cortex and hippocampus of the female Sprague-Dawley rat.Abstr. - Soc. Neurosci.19, 514–511(1993).
  • Singh M , MeyerEM, MillardWJ, Simpkins JW: Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Res.644, 305–312(1994).
  • Singh M , MeyerEM, SimpkinsJW: The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor mRNA expression in brain regions of female Sprague-Dawley rats.Endocrinology136, 2320–2324(1995).
  • Gibbs RB : Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function.Neuroscience101(4), 931–938(2000).
  • Dohanich GP , FaderAJ, JavorskyDJ: Estrogen and estrogen-progesterone treatments counteract the effect of scopolamine on reinforced T-maze alternation in female rats.Behav. Neurosci.108(5), 988–992(1994).
  • Gibbs RB : Estrogen replacement enhances acquisition of a spatial memory task and reduces deficits associated with hippocampal muscarinic receptor inhibition.Horm. Behav.36(3), 222–233(1999).
  • Fader AJ , JohnsonPEM, DohanichGP: Estrogen improves working but not reference memory and prevents amnestic effects of scopolamine on a radial-arm maze.Pharmacol. Biochem. Behav.62(4), 711–717(1999).
  • Gibbs RB , BurkeAM, JohnsonDA: Estrogen replacement attenuates effects of scopolamine and lorazepam on memory acquisition and retention.Horm. Behav.34, 412–125(1998).
  • Gibbs RB : Estrogen enhancement of learning requires intact basal forebrain cholinergic neutrons.Abstr. - Soc. Neurosci.31, 312 (2001).
  • Savonenko AV , MarkowskaAL: The cognitive effects of ovariectomy and estrogen replacement are modulated by aging.Neuroscience119, 821–830(2003).
  • Tinkler GP , VoytkoML: Estrogen modulates cognitive and cholinergic processes in surgically menopausal monkeys.Prog. Neuropsychopharmacol. Biol. Psychiatry29, 423–431(2005).
  • Voytko ML : Estrogen and the cholinergic system modulate visuospatial attention in monkeys (Macaca fascicularis).Behav. Neurosci.116(2), 187–197(2002).
  • Caine ED , WeingartnerH, LudlowCL, CudahyEA, WehryS: Qualitative analysis of scopolamine-induced amnesia.Psychopharmacology74, 74–80(1981).
  • Drachman D , LeavittJ: Human memory and the cholinergic system. A relationship to aging?Arch. Neurol.30(2), 113–121(1974).
  • Ghoneim MM , MewaldtSP: Studies on human memory: the interactions of diazepam, scopolamine, and physostigmine.Psychopharmacology52, 1–6(1977).
  • Newhouse PA , PotterA, KeltonM, Corwin J: Nicotinic treatment of Alzheimer’s disease. Biol. Psychiatry49(3), 269–278(2001).
  • Peterson R : Scopolamine-induced learning failures in man.Psychopharmacology52, 283–289(1977).
  • Sitaram N , WeingartnerH, GillinJC: Human serial learning: enhancement with arecoline and choline and impairment with scopolamine.Science201, 274–276(1978).
  • Sarter M , HasselmoME, BrunoJP, Givens B: Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. Brain Res. Rev.48, 88–111(2005).
  • Cushman M , KullerLH, PrenticeR et al.: Estrogen plus progesterone and risk of venus thrombosis. JAMA282(13), 1573–1580(2004).

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