Bibliography
- Ludwig S , PleschkaS, WolffT: A fatal relationship: influenza virus interactions with the host cell.Viral Immunol.12, 175–196 (1999).
- Ludwig S , PlanzO, PleschkaS, WolffT: Influenza virus induced signaling pathways – targets for antiviral therapy?Trends Mol. Med.9, 46–51 (2003).
- Ludwig S , PleschkaS, PlanzO, WolffT: Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells.Cell Microbiol.8, 375–386 (2006).
- Garcia-Sastre A : Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses.Curr. Top. Microbiol. Immunol.283, 249–280 (2004).
- Krug RM , YuanW, NoahDL, LathamAG: Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein.Virology309, 181–189 (2003).
- Hayden FG , FritzR, LoboMCet al.: Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.J. Clin. Invest.101, 643–649 (1998).
- Geiss GK , SalvatoreM, TumpeyTMet al.: Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza.Proc. Natl Acad. Sci. USA99, 10736–10741 (2002).
- Albrecht T , BoldoghI, FonsM, AbuBakarS, DengCZ: Cell activation signals and the pathogenesis of human cytomegalovirus.InterVirology31, 68–75 (1990).
- Wathelet MG , LinCH, ParekhBSet al.: Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo.Mol. Cell1, 507–518 (1998).
- Samuel CE : Antiviral actions of interferons.Clin. Microbiol. Rev.14, 778–809 (2001).
- Majde JA : Viral double-stranded RNA, cytokines, and the flu.J. Interferon Cytokine Res.20, 259–272 (2000).
- Akira S , TakedaK: Toll-like receptor signalling.Nat. Rev. Immunol.4, 499–511 (2004).
- Alexopoulou L , HoltAC, MedzhitovR, FlavellRA: Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3.Nature413, 732–738 (2001).
- Kawai T , SatoS, IshiiKJet al.: Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.Nat. Immunol.5, 1061–1068 (2004).
- Heil F , HemmiH, HochreinHet al.: Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.Science303, 1526–1529 (2004).
- Guillot L , Le GofficR, BlochSet al.: Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.J. Biol. Chem.280, 5571–5580 (2005).
- Lopez CB , MoltedoB, AlexopoulouLet al.: TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses.J. Immunol.173, 6882–6889 (2004).
- Edelmann KH , Richardson-BurnsS, AlexopoulouLet al.: Does Toll-like receptor 3 play a biological role in virus infections?Virology322, 231–238 (2004).
- Barchet W , KrugA, CellaMet al.: Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways.Eur. J. Immunol.35, 236–242 (2005).
- Yoneyama M , KikuchiM, NatsukawaTet al.: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.Nat. Immunol.5, 730–737 (2004).
- Kato H , SatoS, YoneyamaMet al.: Cell type-specific involvement of RIG-I in antiviral response.Immunity23, 19–28 (2005).
- Andrejeva J , ChildsKS, YoungDFet al.: The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, MDA-5, and inhibit its activation of the IFN-β promoter.Proc. Natl Acad. Sci. USA101, 17264–17269 (2004).
- Siren J , ImaizumiT, SarkarDet al.: Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.Microbes Infect.8(8), 2013–2020 (2006).
- Pichlmair A , SchulzO, TanCPet al.: RIG-I-mediated antiviral responses to single-stranded RNA bearing 5´ phosphates.Science (2006) (Epub ahead of print).
- Hornung V , EllegastJ, KimSet al.: 5´-triphosphate RNA is the ligand for RIG-I.Science (2006) (Epub ahead of print).
- Kawai T , TakahashiK, SatoSet al.: IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.Nat. Immunol.6, 981–988 (2005).
- Seth RB , SunL, EaCK, ChenZJ: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3.Cell122, 669–682 (2005).
- Xu LG , WangYY, HanKJet al.: VISA is an adapter protein required for virus-triggered IFN-β signaling.Mol. Cell19, 727–740 (2005).
- Meylan E , CurranJ, HofmannKet al.: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.Nature437, 1167–1172 (2005).
- Fitzgerald KA , McWhirterSM, FaiaKLet al.: IKKε and TBK1 are essential components of the IRF3 signaling pathway.Nat. Immunol.4, 491–496 (2003).
- Sharma S , tenoeverBR, GrandvauxNet al.: Triggering the interferon antiviral response through an IKK-related pathway.Science300, 1148–1151 (2003).
- Ehrhardt C , KardinalC, WurzerWJet al.: Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3 (IRF-3).FEBS Lett..567, 230–238 (2004).
- Haller O , KochsG, WeberF: The interferon response circuit: induction and suppression by pathogenic viruses.Virology344, 119–130 (2006).
- Sarkar SN , PetersKL, ElcoCPet al.: Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.Nat. Struct. Mol. Biol.11, 1060–1067 (2004).
- Ehrhardt C , MarjukiH, WolffTet al.: Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence.Cell Microbiol.8, 1336–1348 (2006).
- Dhand R , HilesI, PanayotouGet al.: PI3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.EMBO J.13, 522–533 (1994).
- Neri LM , BorgattiP, CapitaniS, MartelliAM: The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.Biochim. Biophys. Acta1584, 73–80 (2002).
- Cooray S : The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.J. Gen. Virol.85, 1065–1076 (2004).
- Hale BG , JacksonD, ChenYH, LambRA, RandallRE: Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling.Proc. Natl Acad. Sci. USA103, 14194–14199 (2006).
- Hiscott J , KwonH, GeninP: Hostile takeovers: viral appropriation of the NF-κB pathway.J. Clin. Invest.107, 143–151 (2001).
- Karin M , Ben-NeriahY: Phosphorylation meets ubiquitination: the control of NF-(κ)B activity.Annu. Rev. Immunol.18, 621–663 (2000).
- Ludwig S , PlanzO, PleschkaS, WolffT: Influenza-virus-induced signaling cascades: targets for antiviral therapy?Trends Mol. Med.9, 46–52 (2003).
- Flory E , KunzM, SchellerCet al.: Influenza virus-induced NF-κB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IκB kinase.J. Biol. Chem.275, 8307–8314 (2000).
- Chu WM , OstertagD, LiZWet al.: JNK2 and IKKβ are required for activating the innate response to viral infection.Immunity11, 721–731 (1999).
- Wang X , LiM, ZhengHet al.: Influenza A virus NS1 protein prevents activation of NF-κB and induction of α/β interferon.J. Virol.74, 11566–11573 (2000).
- Wurzer WJ , EhrhardtC, PleschkaSet al.: NF-κB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation.J. Biol. Chem.279, 30931–30937 (2004).
- Nimmerjahn F , DudziakD, DirmeierUet al.: Active NF-κB signalling is a prerequisite for influenza virus infection.J. Gen. Virol.85, 2347–2356 (2004).
- Wurzer WJ , PlanzO, EhrhardtCet al.: Caspase 3 activation is essential for efficient influenza virus propagation.EMBO J.22, 2717–2728. (2003).
- Wei L , SandbulteMR, ThomasPGet al.: NFκB negatively regulates interferon-induced gene expression and anti-influenza activity.J. Biol. Chem.281, 11678–11684 (2006).
- Widmann C , GibsonS, JarpeMB, JohnsonGL: Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.Physiol. Rev.79, 143–180 (1999).
- Pearson G , RobinsonF, BeersGibson Tet al.: Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.Endocr. Rev.22, 153–183 (2001).
- Dong C , DavisRJ, FlavellRA: MAP kinases in the immune response.Annu. Rev. Immunol.20, 55–72 (2002).
- Pleschka S , WolffT, EhrhardtCet al.: Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade.Nat. Cell Biol.3, 301–305 (2001).
- Ludwig S , WolffT, EhrhardtCet al.: MEK inhibition impairs influenza B virus propagation without emergence of resistant variants.FEBS Lett.561, 37–43 (2004).
- Olschlager V , PleschkaS, FischerTet al.: Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice.Oncogene23, 6639–6646 (2004).
- Marjuki H , AlamMI, EhrhardtCet al.: Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Cα-mediated activation of ERK signaling.J. Biol. Chem.281, 16707–16715 (2006).
- Cohen P : Protein kinases – the major drug targets of the twenty-first century?Nat. Rev. Drug Discov.1, 309–315 (2002).