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Future Lipidology Volume 1, 2006 - Issue 1
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Targeted bioavailability of drugs by triggered release from liposomes

Ana PonceDuke University, Department of Biomedical Engineering, Department of Mechanical Engineering and Materials Science, Durham, NC 27708, USA, Tel.: +1 919 660 5535; Fax.: +1 919 660 8963, E-mail: [email protected], [email protected], [email protected], [email protected]
,
Alex WrightDuke University, Department of Biomedical Engineering, Department of Mechanical Engineering and Materials Science, Durham, NC 27708, USA, Tel.: +1 919 660 5535; Fax.: +1 919 660 8963, E-mail: [email protected], [email protected], [email protected], [email protected]
,
Mark DewhirstDuke University, Department of Biomedical Engineering, Department of Mechanical Engineering and Materials Science, Durham, NC 27708, USA, Tel.: +1 919 660 5535; Fax.: +1 919 660 8963, E-mail: [email protected], [email protected], [email protected], [email protected]
&
David NeedhamDuke University, Department of Biomedical Engineering, Department of Mechanical Engineering and Materials Science, Durham, NC 27708, USA, Tel.: +1 919 660 5535; Fax.: +1 919 660 8963, E-mail: [email protected], [email protected], [email protected], [email protected]Correspondence[email protected]
Pages 25-34 | Published online: 18 Jan 2017

  • Estimated incidence, mortality, and site of failure of the most common types of cancer in the United States in 2001. Cancer facts and figures. Atlanta: American Cancer Society (2001).
  • Suit H: Assessment of the impact of local control on clinical outcome. Front Radiat. Ther. Oncol. 29, 17–23 (1996).
  • Papahadjopoulos D, Gabizon A: Liposomes designed to avoid the reticuloendothelial system. Prog. Clin. Biol. Res. 343, 85–93 (1990).
  • Allen TM, Cullis PR: Drug delivery systems: entering the mainstream. Science 303(5665), 1818–1822 (2004).
  • Concise review of drug delivery systems, offering an excellent perspective on the rationale and progress of liposomal drug delivery.
  • Kong G, Dewhirst MW: Hyperthermia and liposomes. Int. J. Hyperthermia 15(5), 345–370 (1999).
  • Detailed review discussing the combination of liposomal drugs and hyperthermia (HT), including mechanisms of synergism and early temperature-sensitive liposome formulations.
  • Husseini GA, Myrup GD, Pitt WG, Christensen DA, Rapoport NY: Factors affecting acoustically triggered release of drugs from polymeric micelles. J. Control. Release 69(1), 43–52 (2000).
  • Bisby RH, Mead C, Morgan CG: Active uptake of drugs into photosensitive liposomes and rapid release on UV photolysis. Photochem. Photobiol. 72(1), 57–61 (2000).
  • Bondurant B, Mueller A, O’Brien DF: Photoinitiated destabilization of sterically stabilized liposomes. Biochim. Biophys. Acta 1511(1), 113–122 (2001).
  • Guo X, Szoka FC Jr: Chemical approaches to triggerable lipid vesicles for drug and gene delivery. Acc. Chem. Res. 36(5), 335–341 (2003).
  • Jensen SS, Andresen TL, Davidsen J et al.: Secretory phospholipase A2 as a tumorspecific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids. Mol. Cancer Ther. 3(11), 1451–1458 (2004).
  • Szoka F Jr, Papahadjopoulos D: Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc. Natl Acad. Sci. USA 75(9), 4194–4198 (1978).
  • Szoka F, Olson F, Heath T, Vail W, Mayhew E, Papahadjopoulos D: Preparation of unilamellar liposomes of intermediate size (0.1–0.2 mol) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes. Biochim. Biophys. Acta 601(3), 559–571 (1980).
  • Nichols JW, Deamer DW: Catecholamine uptake and concentration by liposomes maintaining pH gradients. Biochim. Biophys. Acta 455(1), 269–271 (1976).
  • Mayer LD, Bally MB, Cullis PR: Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochim. Biophys. Acta 857(1), 123–126 (1986).
  • Sharpe M, Easthope SE, Keating GM, Lamb HM: Polyethylene glycol-liposomal doxorubicin: a review of its use in the management of solid and haematological malignancies and AIDS-related Kaposi’s sarcoma. Drugs 62(14), 2089–2126 (2002).
  • Szoka F, Jr., Papahadjopoulos D: Comparative properties and methods of preparation of lipid vesicles (liposomes). Ann. Rev. Biophys. Bioeng. 9, 467–508 (1980).
  • Allen TM, Hansen CB, Demenezes DEL: Pharmacokinetics of long-circulating liposomes. Adv. Drug Deliv. Rev. 16(2–3), 267–284 (1995).
  • Allen C, Dos Santos N, Gallagher R et al.: Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol). Biosci. Rep. 22(2), 225–250 (2002).
  • Kong G, Braun RD, Dewhirst MW: Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res. 60(16), 4440–4445 (2000).
  • Needham D, Dewhirst MW: The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv. Drug Deliv. Rev. 53(3), 285–305 (2001).
  • Yuan F, Dellian M, Fukumura D et al.: Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 55(17), 752–3756 (1995).
  • Wu NZ, Da D, Rudoll TL, Needham D, Whorton AR, Dewhirst MW: Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. Cancer Res. 53, 3765–3770 (1993).
  • Allen TM, Stuart DD: Liposome pharmacokinetics: classical, sterically stabilized, cationic liposomes and immunoliposomes. In: Liposomes: A Rational Design. Janoff A (Ed.), Marcel Dekker, Inc., New York, USA (1999).
  • Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R: Design of liposomes for enhanced local release of drugs by hyperthermia. Science 202(4374), 1290–1293 (1978).
  • Yatvin MB, Tegmo-Larsson IM, Dennis WH: Temperature- and pHsensitive liposomes for drug targeting. Methods Enzymol. 149, 77–87 (1987).
  • Dewhirst M, Jones E, Samulski T, Vujaskovic Z, Li C, Prosnitz L: Hyperthermia. Cancer Medicine. 6th Ed. BC Decker, PA, USA (2003).
  • Matteucci ML, Anyarambhatla G, Rosner G et al.: Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas. Clin. Cancer Res. 6(9), 3748–3755 (2000).
  • Gaber MH: Modulation of doxorubicin resistance in multi-drug resistance cells by targeted liposomes combined with hyperthermia. J. Biochem. Mol. Bio. Biophys. 6(5), 309–314 (2002).
  • Ishida O, Maruyama K, Yanagie H, Eriguchi M, Iwatsuru M: Targeting chemotherapy to solid tumors with longcirculating thermosensitive liposomes and local hyperthermia. Jpn J. Cancer Res. 91(1), 118–126 (2000).
  • Aoki H, Kakinuma K, Morita K et al.: Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome: evaluation of drug distribution in a rat glioma model. Int. J. Hyperthermia 20(6), 595–605 (2004).
  • Hosokawa T, Sami M, Kato Y, Hayakawa E: Alteration in the temperaturedependent content release property of thermosensitive liposomes in plasma. Chem. Pharm. Bull. 51(11), 1227–1232 (2003).
  • Ono A, Takeuchi K, Sukenari A, Suzuki T, Adachi I, Ueno M: Reconsideration of drug release from temperature-sensitive liposomes. Bio. Pharm. Bull. 25(1), 97–101 (2002).
  • Mouritsen O, Jorgensen, K, Honger, T: Permeability of lipid bilayers near the phase transition. In: Permeability and Stability of Lipid Bilayers. Disalvo EA, Simon SA (Eds), CRC Press, Boca Raton, FL, USA, 137–160 (1995).
  • Needham D, Anyarambhatla G, Kong G, Dewhirst MW: A new temperaturesensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. Cancer Res. 60(5), 1197–1201 (2000).
  • Initial study of in vivo efficacy using doxorubicin (Dox)-temperature sensitive liposomes (TSLs) and HT showed 11 complete regressions in mice bearing human squamous cell carcinoma (FaDu) xenografts. It also demonstrated the requirement of lysolipid for liposomal drug release.
  • Mills JK, Needham D: Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. Biochim. Biophys. Acta 1716(2), 77–96 (2005).
  • Presents in vitro evidence supporting the formation of stable membrane pores as the mechanism of lysolipidenhanced temperature-sensitive release of liposome contents. 36. Sandstrom MC, Ickenstein LM, Mayer LD, Edwards K: Effects of lipid segregation and lysolipid dissociation on drug release from thermosensitive liposomes. J. Control. Release 107(1), 131–142 (2005).
  • Anyarambhatla GR, Needham D: Enhancement of the phase transition permeability of DPPC liposomes by incorporation of MPPC: a new temperature-sensitive liposome for use with mild hyperthermia. J. Liposome Res. 9, 499–514 (1999).
  • Ickenstein LM: Drug Release From a Thermosensitive Liposome (Thesis). University of British Columbia, Canada (2003).
  • Lindner LH, Hossan M, Teichert N: Alkylphosphocholines enhance the drug release rate of thermosensitive liposomes (Abstract). Proceedings of the Annual Meeting for the Society for Thermal Medicine. Bethesda, MD (2005).
  • Wells J, Sen A, Hui SW: Localized delivery to CT-26 tumors in mice using thermosensitive liposomes. Int. J. Pharm. 261(1–2), 105–114 (2003).
  • Chandaroy P, Sen A, Hui SW: Temperature-controlled content release from liposomes encapsulating Pluronic F127. J. Control. Release 76(1–2), 27–37 (2001).
  • Kono K, Nakai R, Morimoto K, Takagishi T: Thermosensitive polymermodified liposomes that release contents around physiological temperature. Biochim. Biophys. Acta 1416(1–2), 239–250 (1999).
  • Kono K, Takagishi T: Temperaturesensitive liposomes. Methods Enzymol. 387, 73–82 (2004).
  • Hayashi H, Kono K, Takagishi T: Temperature sensitization of liposomes using co-polymers of Nisopropylacrylamide. Bioconjug. Chem. 10(3), 412–418 (1999).
  • Kono K, Yoshino K, Takagishi T: Effect of poly(ethylene glycol) grafts on temperature-sensitivity of thermosensitive polymer-modified liposomes. J. Control. Release 80(1–3), 321–332 (2002).
  • Chen Q, Tong S, Dewhirst MW, Yuan F: Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. Mol. Cancer Ther. 3(10), 1311–1317 (2004).
  • In vivo mechanistic study demonstrating the antivascular effects of Dox-TSL and HT in window chamber xenografts. These effects were not observed with free Dox.
  • Kong G, Anyarambhatla G, Petros WP et al.: Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res. 60(24), 6950–6957 (2000).
  • Second in vivo study using Dox-TSL and HT showed enhanced efficacy (6 out of 9 complete regressions) and increased tumor drug delivery in mice bearing human squamous cell carcinoma (FaDu) xenografts when compared with non-temperature sensitive and traditional temperature-sensitive formulations, as well as free Dox, with or without HT.
  • Viglianti BL, Abraham SA, Michelich CR et al.: In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn. Res. Med. 51(6), 1153–1162 (2004).

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