Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity

Bibliography

• Cao Y: Angiogenesis modulates adipogenesis and obesity. J. Clin. Invest. 117(9), 2362–2368 (2007).
   Google Scholar
• First review article that highlights the role of angiogenesis in modulating adipogenesis and obesity.
   Google Scholar
• Cao Y, Liu Q: Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis. Adv. Cancer Res. 97, 203–224 (2007)
   Google Scholar
• Brakenhielm E, Cao R, Gao B et al.: Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ. Res. 94(12), 1579–1588 (2004).
   Google Scholar
• First literature demonstrating that antiangiogenic agents could prevent and treat both genetic and high-fat dietinduced obesity in mice. Thus, this work has laid the first cornerstone in this field.
   Google Scholar
• Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1(1), 27–31 (1995)
   Google Scholar
• Brakenhielm E, Cao R, Cao Y: Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J. 15(10), 1798–1800 (2001)
   Google Scholar
• Cao Y, Cao R, Brakenhielm E: Antiangiogenic mechanisms of diet-derived polyphenols. J. Nutr. Biochem. 13(7), 380–390 (2002)
   Google Scholar
• Cao Y: Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat. Rev. Cancer 5(9), 735–743 (2005)
   Google Scholar
• Crandall DL, Hausman GJ, Kral JG: A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4(2), 211–232 (1997)
   Google Scholar
• Brakenhielm E, Veitonmaki N, Cao R et al.: Adiponectin-induced antiangiogenesis and antitumor activity involve caspasemediated endothelial cell apoptosis. Proc. Natl Acad. Sci. USA 101(8), 2476–2481 (2004).
   Google Scholar
• First paper describing adiponectin as the first antiangiogenic adipokine.
   Google Scholar
• Bukowiecki L, Lupien J, Follea N, Paradis A, Richard D, LeBlanc J: Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats. Am. J. Physiol. 239(6), E422–E429 (1980)
   Google Scholar
• Cannon B, Jacobsson A, Rehnmark S, Nedergaard J: Signal transduction in brown adipose tissue recruitment: noradrenaline and beyond. Int. J. Obes. Relat. Metab. Disord. 20(Suppl. 3), S36–S42 (1996)
   Google Scholar
• Himms-Hagen J, Desautels M: A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding. Biochem. Biophys. Res. Commun. 83(2), 628–634 (1978)
   Google Scholar
• Tonello C, Dioni L, Briscini L, Nisoli E, Carruba MO: SR59230A blocks 3-adrenoceptor-linked modulation of upcoupling protein-1 and leptin in rat brown adipocytes. Eur. J. Pharmacol. 352(1), 125–129 (1998)
   Google Scholar
• Bouloumie A, Lolmede K, Sengenes C, Galitzky J, Lafontan M: Angiogenesis in adipose tissue. Ann. Endocrinol. (Paris) 63(2 Pt 1), 91–95 (2002)
   Google Scholar
• Hutley LJ, Herington AC, Shurety W et al.: Human adipose tissue endothelial cells promote preadipocyte proliferation. Am. J. Physiol. Endocrinol. Metab. 281(5), E1037–E1044 (2001)
   Google Scholar
• Varzaneh FE, Shillabeer G, Wong KL, Lau DC: Extracellular matrix components secreted by microvascular endothelial cells stimulate preadipocyte differentiation in vitro. Metabolism 43(7), 906–912 (1994)
   Google Scholar
• Baillargeon J, Rose DP: Obesity, adipokines, and prostate cancer (review). Int. J. Oncol. 28(3), 737–745 (2006)
   Google Scholar
• Hiraoka Y, Yamashiro H, Yasuda K, Kimura Y, Inamoto T, Tabata Y: In situ regeneration of adipose tissue in rat fat pad by combining a collagen scaffold with gelatin microspheres containing basic fibroblast growth factor. Tissue Eng. 12(6), 1475–1487 (2006)
   Google Scholar
• Li J, Yu X, Pan W, Unger RH: Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Am. J. Physiol. Endocrinol. Metab. 282(6), E1334–E1341 (2002)
   Google Scholar
• Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y: Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc. Natl Acad. Sci. USA 98(11), 6390–6395 (2001).
   Google Scholar
• First paper in the field demonstrating that leptin and other angiogenic factors, including FGF-2 and VEGF, can synergistically stimulate angiogenesis and vascular permeability in the adipose tissue.
   Google Scholar
• Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 395(6704), 763–770 (1998)
   Google Scholar
• Bouloumie A, Drexler HC, Lafontan M, Busse R: Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res. 83(10), 1059–1066 (1998)
   Google Scholar
• Sierra-Honigmann MR, Nath AK, Murakami C et al.: Biological action of leptin as an angiogenic factor. Science 281(5383), 1683–1686 (1998).
   Google Scholar
• First publication demonstrating that leptin as an adipose-derived hormone stimulates angiogenesis and might play an important role locally in promoting neovascularization.
   Google Scholar
• Arita Y, Kihara S, Ouchi N et al.: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257(1), 79–83 (1999)
   Google Scholar
• Voros G, Maquoi E, Demeulemeester D, Clerx N, Collen D, Lijnen HR: Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146(10), 4545–4554 (2005)
   Google Scholar
• Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J: Vascular-specific growth factors and blood vessel formation. Nature 407(6801), 242–248 (2000)
   Google Scholar
• Friedman JM: Obesity in the new millennium. Nature 404(6778), 632–634 (2000)
   Google Scholar
• Kopelman PG: Obesity as a medical problem. Nature 404(6778), 635–643 (2000)
   Google Scholar
• Korner J, Aronne LJ: The emerging science of body weight regulation and its impact on obesity treatment. J. Clin. Invest. 111(5), 565–570 (2003)
   Google Scholar
• Roth J, Qiang X, Marban SL, Redelt H, Lowell BC: The obesity pandemic: where have we been and where are we going? Obes. Res. 12(Suppl. 2), 88S–101S (2004)
   Google Scholar
• Carmeliet P: Angiogenesis in life, disease and medicine. Nature 438(7070), 932–936 (2005)
   Google Scholar
• Dvorak HF: Angiogenesis: update 2005. J. Thromb. Haemost. 3(8), 1835–1842 (2005)
   Google Scholar
• Ferrara N, Kerbel RS: Angiogenesis as a therapeutic target. Nature 438(7070), 967–974 (2005)
   Google Scholar
• Folkman J: Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N. Engl. J. Med. 333(26), 1757–1763 (1995)
   Google Scholar
• Lambert PD, Anderson KD, Sleeman MW et al.: Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc. Natl Acad. Sci. USA 98(8), 4652–4657 (2001)
   Google Scholar
• Lyden D, Hattori K, Dias S et al.: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7(11), 1194–1201 (2001)
   Google Scholar
• McDonald DM, Choyke PL: Imaging of angiogenesis: from microscope to clinic. Nat. Med. 9(6), 713–725 (2003)
   Google Scholar
• Rupnick MA, Panigrahy D, Zhang CY et al.: Adipose tissue mass can be regulated through the vasculature. Proc. Natl Acad. Sci. USA 99(16), 10730–10735 (2002).
   Google Scholar
• First literature demonstrating that antiangiogenic agents could prevent and treat both genetic and high-fat dietinduced obesity in mice. Thus, this work has laid the first cornerstone in this field.
   Google Scholar
• Dallabrida SM, Zurakowski D, Shih SC et al.: Adipose tissue growth and regression are regulated by angiopoietin-1. Biochem. Biophys. Res. Commun. 311(3), 563–571 (2003). o First paper demonstrating that Ang-1 is a crucial angiogenic factor in regulation of adipose angiogenesis and vascular remodeling.
   Google Scholar
• Tigno XT, Selaru IK, Angeloni SV, Hansen BC: Is microvascular flow rate related to ghrelin, leptin and adiponectin levels? Clin. Hemorheol. Microcirc. 29(3–4), 409–416 (2003)
   Google Scholar
• Silha JV, Krsek M, Sucharda P, Murphy LJ: Angiogenic factors are elevated in overweight and obese individuals. Int. J. Obes. (Lond.) 29(11), 1308–1314 (2005)
   Google Scholar
• Hellstrom M, Phng LK, Hofmann JJ et al.: Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445(7129), 776–780 (2007)
   Google Scholar
• Yancopoulos GD, Klagsbrun M, Folkman J: Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell 93(5), 661–664 (1998)
   Google Scholar
• Holash J, Maisonpierre PC, Compton D et al.: Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284(5422), 1994–1998 (1999)
   Google Scholar
• Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC: Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem. Biophys. Res. Commun. 332(2), 370–379 (2005)
   Google Scholar
• Lau DC: Nature and nurture in adipocyte development and growth. Int. J. Obes. 14(Suppl. 3), 153–157 (1990)
   Google Scholar
• Lau DC, Shillabeer G, Wong KL, Tough SC, Russell JC: Influence of paracrine factors on preadipocyte replication and differentiation. Int. J. Obes. 14(Suppl. 3), 193–201 (1990)
   Google Scholar
• Crandall DL, Busler DE, McHendry-Rinde B, Groeling TM, Kral JG: Autocrine regulation of human preadipocyte migration by plasminogen activator inhibitor-1. J. Clin. Endocrinol. Metab. 85(7), 2609–2614 (2000)
   Google Scholar
• Fukumura D, Ushiyama A, Duda DG et al.: Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ. Res. 93(9), E88–E97 (2003)
   Google Scholar
• Panigrahy D, Singer S, Shen LQ et al.: PPAR ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J. Clin. Invest. 110(7), 923–932 (2002)
   Google Scholar
• Rosen ED, Sarraf P, Troy AE et al.: PPAR is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4(4), 611–617 (1999)
   Google Scholar
• Xin H, Geng Y, Pramanik R, Choubey D: Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival. J. Cell. Biochem. 88(1), 191–204 (2003)
   Google Scholar
• Kawaguchi N, Xu X, Tajima R et al.: ADAM 12 protease induces adipogenesis in transgenic mice. Am. J. Pathol. 160(5), 1895–1903 (2002)
   Google Scholar
• Bergers G, Brekken R, McMahon G et al.: Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2(10), 737–744 (2000)
   Google Scholar
• Bouloumie A, Sengenes C, Portolan G, Galitzky J, Lafontan M: Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes 50(9), 2080–2086 (2001)
   Google Scholar
• Christiaens V, Lijnen HR: Role of the fibrinolytic and matrix metalloproteinase systems in development of adipose tissue. Arch. Physiol. Biochem. 112(4–5), 254–259 (2006)
   Google Scholar
• Fitzpatrick TE, Graham CH: Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen. Exp. Cell Res. 245(1), 155–162 (1998)
   Google Scholar
• Scannell G, Waxman K, Vaziri ND et al.: Hypoxia-induced alterations of neutrophil membrane receptors. J. Surg. Res. 59(1), 141–145 (1995)
   Google Scholar
• Cho CH, Jun Koh Y, Han J et al.: Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ. Res. 100(4), E47–E57 (2007)
   Google Scholar
• Grenier G, Scime A, Le Grand F et al.: Resident endothelial precursors in muscle, adipose and dermis contribute to post-natal vasculogenesis. Stem Cells 25, 3101–3110 (2007)
   Google Scholar
• Asano A, Irie Y, Saito M: Isoform-specific regulation of vascular endothelial growth factor (VEGF) family mRNA expression in cultured mouse brown adipocytes. Mol. Cell. Endocrinol. 174(1–2), 71–76 (2001)
   Google Scholar
• Saiki A, Watanabe F, Murano T, Miyashita Y, Shirai K: Hepatocyte growth factor secreted by cultured adipocytes promotes tube formation of vascular endothelial cells in vitro. Int. J. Obes. (Lond.) 30(11), 1676–1684 (2006)
   Google Scholar
• Han RN, Post M, Tanswell AK, Lye SJ: Insulin-like growth factor-I receptormediated vasculogenesis/angiogenesis in human lung development. Am. J. Respir. Cell Mol. Biol. 28(2), 159–169 (2003)
   Google Scholar
• Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Zurakowski A, Glinianowicz M: The role of tumor necrosis factor (TNF- ) in control of metabolism. Wiad. Lek. 58(11–12), 670–674 (2005)
   Google Scholar
• Wellen KE, Hotamisligil GS: Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 112(12), 1785–1788 (2003)
   Google Scholar
• Coppack SW: Pro-inflammatory cytokines and adipose tissue. Proc. Nutr. Soc. 60(3), 349–356 (2001)
   Google Scholar
• Dobson DE, Kambe A, Block E et al.: 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell 61(2), 223–230 (1990)
   Google Scholar
• Ekstrand AJ, Cao R, Bjorndahl M et al.: Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing. Proc. Natl Acad. Sci. USA 100(10), 6033–6038 (2003)
   Google Scholar
• Kuo LE, Zukowska Z: Stress, NPY and vascular remodeling: implications for stress-related diseases. Peptides 28(2), 435–440 (2007)
   Google Scholar
• Lijnen HR, Christiaens V, Scroyen I et al.: Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55(10), 2698–2704 (2006)
   Google Scholar
• Mu H, Ohashi R, Yan S et al.: Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc. Res. 70(1), 146–157 (2006)
   Google Scholar
• Samad F, Pandey M, Loskutoff DJ: Tissue factor gene expression in the adipose tissues of obese mice. Proc. Natl Acad. Sci. USA 95(13), 7591–7596 (1998)
   Google Scholar
• Wilkison WO, Choy L, Spiegelman BM: Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity. J. Biol. Chem. 266(25), 16886–16891 (1991)
   Google Scholar
• Shoshani O, Livne E, Armoni M et al.: The effect of interleukin-8 on the viability of injected adipose tissue in nude mice. Plast. Reconstr. Surg. 115(3), 853–859 (2005)
   Google Scholar
• Maeda N, Shimomura I, Kishida K et al.: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med. 8(7), 731–737 (2002)
   Google Scholar
• Lawler J, Sunday M, Thibert V et al.: Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J. Clin. Invest. 101(5), 982–992 (1998)
   Google Scholar
• O’Reilly MS, Boehm T, Shing Y et al.: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88(2), 277–285 (1997)
   Google Scholar
• Makino Y, Cao R, Svensson K et al.: Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414(6863), 550–554 (2001)
   Google Scholar
• Wu Y, Zhong Z, Huber J et al.: Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer. Clin. Cancer Res. 12(21), 6573–6584 (2006)
   Google Scholar
• Zhu Z: Targeted cancer therapies based on antibodies directed against epidermal growth factor receptor: status and perspectives. Acta Pharmacol. Sin. 28(9), 1476–1493 (2007)
   Google Scholar
• Polverino A, Coxon A, Starnes C et al.: AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 66(17), 8715–8721 (2006)
   Google Scholar
• O’Farrell AM, Abrams TJ, Yuen HA et al.: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101(9), 3597–3605 (2003)
   Google Scholar
• Deininger MW, Goldman JM, Lydon N, Melo JV: The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 90(9), 3691–3698 (1997)
   Google Scholar
• Cao Y, Xue L: Angiostatin. Seminars in thrombosis and hemostasis, 30(1), 83–93 (2004)
   Google Scholar
• O’Reilly MS, Holmgren L, Shing Y et al.: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79(2), 315–328 (1994)
   Google Scholar
• Adya R, Tan BK, Punn A et al.: Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signaling pathway: novel insight into visfatin-induced angiogenesis. Cardiovasc Res. doi: 10.1093/cvr/cvm111 (2007) (Epub ahead of print)
   Google Scholar
• Bell LN, Cai L, Johnstone BH et al.: A central role for hepatocyte growth factor in adipose tissue angiogenesis. Am. J. Physiol. Endocrinol. Metab. 294(2), E336–E344 (2008).
   Google Scholar